NL2025657A - Smart inhalation drug delivery device - Google Patents
Smart inhalation drug delivery device Download PDFInfo
- Publication number
- NL2025657A NL2025657A NL2025657A NL2025657A NL2025657A NL 2025657 A NL2025657 A NL 2025657A NL 2025657 A NL2025657 A NL 2025657A NL 2025657 A NL2025657 A NL 2025657A NL 2025657 A NL2025657 A NL 2025657A
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- drug
- drug delivery
- delivery device
- inhalation
- dose
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- 238000012377 drug delivery Methods 0.000 title claims abstract description 32
- 239000003814 drug Substances 0.000 claims abstract description 51
- 229940079593 drug Drugs 0.000 claims abstract description 50
- 239000002245 particle Substances 0.000 claims abstract description 27
- 239000000443 aerosol Substances 0.000 claims abstract description 8
- 238000005054 agglomeration Methods 0.000 claims abstract description 6
- 238000010801 machine learning Methods 0.000 claims abstract description 5
- 230000036541 health Effects 0.000 claims abstract description 4
- 238000013473 artificial intelligence Methods 0.000 claims abstract 2
- 230000009897 systematic effect Effects 0.000 claims abstract 2
- 230000000241 respiratory effect Effects 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 9
- 239000012530 fluid Substances 0.000 claims description 4
- 230000007246 mechanism Effects 0.000 claims description 4
- 238000012546 transfer Methods 0.000 claims description 3
- 230000002776 aggregation Effects 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 abstract description 13
- 238000012544 monitoring process Methods 0.000 abstract description 4
- 230000029058 respiratory gaseous exchange Effects 0.000 abstract description 4
- 230000005484 gravity Effects 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 2
- 230000001276 controlling effect Effects 0.000 abstract description 2
- 230000008859 change Effects 0.000 description 6
- 230000006399 behavior Effects 0.000 description 5
- 238000013135 deep learning Methods 0.000 description 4
- 238000012549 training Methods 0.000 description 4
- 230000003993 interaction Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000004088 simulation Methods 0.000 description 3
- 238000013459 approach Methods 0.000 description 2
- 238000013528 artificial neural network Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
- A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0066—Inhalators with dosage or measuring devices with means for varying the dose size
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/087—Measuring breath flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/0083—Timers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
- A61M16/16—Devices to humidify the respiration air
- A61M16/161—Devices to humidify the respiration air with means for measuring the humidity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
- A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
- A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/10—General characteristics of the apparatus with powered movement mechanisms
- A61M2205/103—General characteristics of the apparatus with powered movement mechanisms rotating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/21—General characteristics of the apparatus insensitive to tilting or inclination, e.g. spill-over prevention
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3368—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3546—Range
- A61M2205/3553—Range remote, e.g. between patient's home and doctor's office
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3546—Range
- A61M2205/3569—Range sublocal, e.g. between console and disposable
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/502—User interfaces, e.g. screens or keyboards
- A61M2205/505—Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/70—General characteristics of the apparatus with testing or calibration facilities
- A61M2205/702—General characteristics of the apparatus with testing or calibration facilities automatically during use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/40—Respiratory characteristics
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Claims (1)
- 2 ~ 6 Conclusies Wat wordt geclaimd is:1. Een geneesmiddelentoedieningsapparaat door middel van inhalatie 1 met drukvalregeling van de leidingen van het apparaat, volgens de ademhalingskarakteristicken van een patiënt en de morfologie van medicijndeeltjes, om de systematische en lokale medicijnatyifie te optimaliseren, Dit apparaat bestaat uit: a. een acrosolbron 33, b. een dosislader 36 die het medicijn van de aërosolbron naar de mediciinafleverleidingen 26 van het apparaat overbrengt, en c. een hol lichaam 26 als een pad om ten minste één vloeistof te laten stromen om het medicijn over te brengen van dosislader 36 naar mondstuk 3, omvattende ten minste $én inlaat 24 van dosislader 36 en ten minste één inlaat 25 van verse locht en ien minste één uitlaat 23, waarbij de drukval in het holle lichaam wordt geregeld door frisse luchtstroming.d. besturingssysteem dat bestaat uit een stroomsnelheidssensor en een klep en een pmocessor, waarbij de processor de drukval van de klep regelt volgens het verschil in gemeten en optimale stroomsnelheden.2. Een geneesmiddelentoedieningsapparaat door middel van inhalatie volgens claim 1, waarbij het regelmechanisme voor drukval wordt geregeld door een ‘machine learning” methode en kunstmatige intelligentie.3. Een geneesmiddelentoedieningsapparaat door middel van inhalatie volgens claim 1, waarbij het holle lichaam een aantal curvaturen 27 heeft om mogelijke agglomerstie van medicijndeeltjes te minimaliseren.4. Iwichting voor het geneesmiddelentosdieningsapparaat door middel van inhalatie volgens claim 1, waarbij de aerosolbron een capsule-gebaseerde, reservoir-gebaseerde en blister- gebaseerde bron is.5, Geneesmiddelentoedieningsapparaat door middel van inhalatie volgens claim 4, waarbij de aërosolbron van het reservoir bestaat uit een plaat 37 en een aantal veren, waarbij het medicijn in een veelvoud van perforaties op de plaat wordt geladen met gebruikmaking van een drukkracht, 6, Geneesmiddelentoedieningsapparaat door middel van inhalatie volgens claim 4, waarbij de aërosolbron van het reservoir bestaat uit cen plaat 37 en samengeperste lucht, waarbij het medicijn met behulp van een drukkracht in cen veelvoud van perforaties op de plaat wordt geladen,7. Geneesmiddelentoedieningsapparaat door middel van inhalatie volgens claim 1, waarbij de acrosolbron vervangbaar is.8. Geneesmiddelentoedieningsapparaat door middel van inhalatie volgens claim 4, waarbij de aërosolbron van het reservoir bestaat uit ten minste één sensor om de medicijnconditie te bewaken. 3, Gencesmiddelentoedieningsapparaat door middel van inhalatie met aanpassing van de geneesmiddelen dat bestaat uit: a. een aantal perforaties 29 van de dosislader 36, en been controlemechanisme om het aantal perforaties van de dosislader die op de weg van het holle lichaam moet worden geplaatst, te regelen om de vereiste dosering te bereiken, waarbij de vereiste dosis wordt geïdentificeerd door middel van machine learing- technieken, waarbij, een aantal sensoren worden gebruikt om een dataset te verzamelen met gezondheidsindexen van patiënten als input en hun overeenkomstige output in real- time te voorspellen,10. Geneesmiddelentoedieningsapparaat door middel van inhalatie volgens claim 9, waarbij het controlemechanisme de aanwijzingen van een arts gebruikt om het aantal perforaties van de doseerlader to regelen dat op de weg van de medicijnafgifteleidingen moet worden geplaast om de vereiste dosering te bereiken,
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2025657A NL2025657B1 (en) | 2020-05-25 | 2020-05-25 | Smart inhalation drug delivery device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2025657A NL2025657B1 (en) | 2020-05-25 | 2020-05-25 | Smart inhalation drug delivery device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NL2025657A true NL2025657A (en) | 2020-11-02 |
| NL2025657B1 NL2025657B1 (en) | 2021-09-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL2025657A NL2025657B1 (en) | 2020-05-25 | 2020-05-25 | Smart inhalation drug delivery device |
Country Status (1)
| Country | Link |
|---|---|
| NL (1) | NL2025657B1 (nl) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170368273A1 (en) * | 2010-08-23 | 2017-12-28 | Darren Rubin | Systems and methods of aerosol delivery with airflow regulation |
| WO2018104805A1 (en) * | 2016-12-09 | 2018-06-14 | Trudell Medical International | Smart nebulizer |
-
2020
- 2020-05-25 NL NL2025657A patent/NL2025657B1/en not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170368273A1 (en) * | 2010-08-23 | 2017-12-28 | Darren Rubin | Systems and methods of aerosol delivery with airflow regulation |
| WO2018104805A1 (en) * | 2016-12-09 | 2018-06-14 | Trudell Medical International | Smart nebulizer |
Also Published As
| Publication number | Publication date |
|---|---|
| NL2025657B1 (en) | 2021-09-29 |
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| MM | Lapsed because of non-payment of the annual fee |
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