NL176071C - N-alkylpiperidinederivaten; werkwijze voor de bereiding van farmaceutische preparaten met anti-diabetische werking. - Google Patents

N-alkylpiperidinederivaten; werkwijze voor de bereiding van farmaceutische preparaten met anti-diabetische werking.

Info

Publication number
NL176071C
NL176071C NLAANVRAGE7805253,A NL7805253A NL176071C NL 176071 C NL176071 C NL 176071C NL 7805253 A NL7805253 A NL 7805253A NL 176071 C NL176071 C NL 176071C
Authority
NL
Netherlands
Prior art keywords
preparation
pharmaceutical preparations
diabetic action
alkylpiperidine derivatives
alkylpiperidine
Prior art date
Application number
NLAANVRAGE7805253,A
Other languages
English (en)
Dutch (nl)
Other versions
NL176071B (nl
NL7805253A (nl
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of NL7805253A publication Critical patent/NL7805253A/xx
Publication of NL176071B publication Critical patent/NL176071B/xx
Application granted granted Critical
Publication of NL176071C publication Critical patent/NL176071C/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NLAANVRAGE7805253,A 1977-06-25 1978-05-16 N-alkylpiperidinederivaten; werkwijze voor de bereiding van farmaceutische preparaten met anti-diabetische werking. NL176071C (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52075936A JPS5943459B2 (ja) 1977-06-25 1977-06-25 Ｎ−アルキルピペリジン誘導体

Publications (3)

Publication Number Publication Date
NL7805253A NL7805253A (nl) 1978-12-28
NL176071B NL176071B (nl) 1984-09-17
NL176071C true NL176071C (nl) 1985-02-18

Family

ID=13590624

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7805253,A NL176071C (nl) 1977-06-25 1978-05-16 N-alkylpiperidinederivaten; werkwijze voor de bereiding van farmaceutische preparaten met anti-diabetische werking.

Country Status (12)

Country Link
US (1) US4182767A (fr)
JP (1) JPS5943459B2 (fr)
AT (1) AT365576B (fr)
BE (1) BE868329A (fr)
CH (1) CH633264A5 (fr)
DE (1) DE2824781C3 (fr)
DK (1) DK149749C (fr)
FR (1) FR2420529A1 (fr)
GB (1) GB1555654A (fr)
IT (1) IT1104743B (fr)
NL (1) NL176071C (fr)
SE (1) SE430333B (fr)

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DE2830469A1 (de) * 1978-07-11 1980-01-24 Bayer Ag Herstellung von l-desoxy-nojirimycin und n-substituierten derivaten
DE2835069A1 (de) * 1978-08-10 1980-02-21 Bayer Ag N-amino-3,4,5-trihydroxypiperidine, ihre herstellung und verwendung
DE2839309A1 (de) * 1978-09-09 1980-03-27 Bayer Ag 3,4,5-trihydroxypiperidin-derivate
DE2848117A1 (de) * 1978-11-06 1980-05-14 Bayer Ag Derivate des 2-hydroxymethyl-3,4,5- trihydroxy-piperidins, ihre herstellung und verwendung zur beeinflussung des kohlenhydrat- und fettstoffwechsels
JPS55118415A (en) * 1979-02-28 1980-09-11 Pii Papahadojiyopo Dometoriosu Method of encapsulating biologically active substance in lipoid cell
DE2925943A1 (de) * 1979-06-27 1981-01-29 Bayer Ag 1-alkadien-2,4-yl-2-hydroxymethyl3,4,5-trihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2942365A1 (de) * 1979-10-19 1981-05-14 Bayer Ag, 5090 Leverkusen 2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS56108767A (en) * 1980-01-28 1981-08-28 Nippon Shinyaku Co Ltd Bismoranoline derivative
JPS56108768A (en) * 1980-01-28 1981-08-28 Nippon Shinyaku Co Ltd Cinnamylmoranoline derivative
DE3007078A1 (de) * 1980-02-26 1981-09-10 Bayer Ag, 5090 Leverkusen Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung
DE3620645A1 (de) * 1985-12-20 1987-07-02 Bayer Ag 3-amino-4,5-dihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung
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US4849430A (en) * 1988-03-09 1989-07-18 Monsanto Company Method of inhibiting virus
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US5043416A (en) * 1988-09-26 1991-08-27 Monsanto Company Method of inhibiting virus
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US4876268A (en) * 1988-11-03 1989-10-24 G. D. Searle & Co. Antiviral compounds and use thereof
US5003072A (en) * 1988-11-03 1991-03-26 G. D. Searle & Co. 1,5-dideoxy-1,5-imino-D-glucitol derivatives
US4957926A (en) * 1988-12-22 1990-09-18 Monsanto Company Method of treating herpesviruses
US5103008A (en) * 1989-08-17 1992-04-07 Monsanto Company Compound, N-butyl-deoxynojirimycin-6-phosphate
US5043273A (en) * 1989-08-17 1991-08-27 Monsanto Company Phosphorylated glycosidase inhibitor prodrugs
US5536732A (en) * 1990-04-27 1996-07-16 Merrell Pharmaceuticals Inc. N-derivatives of 1-deoxy nojirimycin
EP0453692A1 (fr) * 1990-04-27 1991-10-30 Merrell Dow Pharmaceuticals Inc. Nouveaux dérivés de nojirimycine
US5252587A (en) * 1990-04-27 1993-10-12 Merrell Dow Pharmaceuticals, Inc. N-derivatives of 1-deoxy nojirimycin
US5151519A (en) * 1990-05-07 1992-09-29 G. D. Searle & Co. Process for the preparation of 1,5-(alkylimino)-1,5-dideoxy-d-glucitol and derivatives thereof
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US5798366A (en) * 1993-05-13 1998-08-25 Monsanto Company Method for treatment of CNS-involved lysosomal storage diseases
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US20030100532A1 (en) * 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
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EA004705B1 (ru) 1998-02-12 2004-06-24 Дж.Д.Серл Энд Ко. Применение n-замещенных 1,5-дидезокси-1,5-имино-d-глюцитных производных для лечения инфекций, вызываемых вирусами гепатита
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
US6545021B1 (en) * 1999-02-12 2003-04-08 G.D. Searle & Co. Use of substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
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US20050032841A1 (en) * 1999-04-20 2005-02-10 Steven Walkley Therapeutic compositions and methods of treating glycolipid storage related disorders
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CA2627599A1 (fr) * 2005-11-08 2007-05-18 Ranbaxy Laboratories Limited Procede de preparation de sel hemicalcique d'acide (3r,5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxymethylphenylamino)carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoique
US20070238716A1 (en) * 2006-03-14 2007-10-11 Murthy Ayanampudi S R Statin stabilizing dosage formulations
PL2032134T3 (pl) * 2006-05-09 2015-11-30 Genzyme Corp Sposoby leczenia stłuszczeniowej choroby wątroby obejmujące hamowanie syntezy glikosfingolipidów
US20080153896A1 (en) * 2006-07-14 2008-06-26 Gyan Chand Yadav Polymorphic Forms of an HMG-CoA Reductase Inhibitor and Uses Thereof
WO2008063727A2 (fr) * 2006-08-21 2008-05-29 United Therapeutics Corporation Polytherapie destinée a traiter des infections virales
US8097728B2 (en) * 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
WO2008150486A2 (fr) 2007-05-31 2008-12-11 Genzyme Corporation Inhibiteurs de glucosylcéramide synthase de type 2-acylaminopropanol
BRPI0817864A2 (pt) * 2007-10-05 2012-12-25 Genzyme Corp uso de um composto derivado de ceramida
CA2731685A1 (fr) 2008-07-28 2010-02-04 Genzyme Corporation Inhibition de synthase de glucosylceramide pour le traitement du glomerulopathie avec collapsus, et d'un autre trouble glomerulaire
US8309593B2 (en) 2008-10-03 2012-11-13 Genzyme Corporation 2-acylaminopropoanol-type glucosylceramide synthase inhibitors
CN102655746B (zh) 2009-02-23 2016-08-03 联合治疗公司 亚氨基糖以及治疗病毒性疾病的方法
WO2010099064A1 (fr) * 2009-02-24 2010-09-02 United Therapeutics Corporation Iminosucres et procédés de traitement d'infections arénavirales
JP5634510B2 (ja) 2009-06-12 2014-12-03 ユナイテッド セラピューティクス コーポレイション イミノ糖ならびにブニヤウイルスおよびトガウイルス疾患を治療する方法
US20110065753A1 (en) * 2009-09-04 2011-03-17 United Therapeutics Corporation Methods of treating poxviral infections
CN105748476A (zh) * 2009-09-04 2016-07-13 联合治疗公司 亚氨基糖以及治疗丝状病毒性疾病的方法
BR112012004676A2 (pt) * 2009-09-04 2019-09-24 United Therapeutics Corp método de tratar infecções orotomixovirais.
BR112018072298A2 (pt) 2016-05-02 2019-02-12 Florida State University Research Foundation, Inc. tratamento de infecções pelo vírus da zika usando inibidores da alfa-glicosidase
US11369592B2 (en) 2020-02-21 2022-06-28 Florida State University Research Foundation, Inc. Treatment of human coronavirus infections using alpha-glucosidase glycoprotein processing inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065562A (en) * 1975-12-29 1977-12-27 Nippon Shinyaku Co., Ltd. Method and composition for reducing blood glucose levels
DE2660486C2 (de) * 1975-12-29 1984-03-08 Nippon Shinyaku Co., Ltd., Kyoto Verwendung von 2-Hydroxymethyl-3,4,5-trihydroxypiperidin als Arzneimittel

Also Published As

Publication number Publication date
AT365576B (de) 1982-01-25
GB1555654A (en) 1979-11-14
US4182767A (en) 1980-01-08
SE7805329L (sv) 1978-12-26
DK149749B (da) 1986-09-22
CH633264A5 (de) 1982-11-30
DK269178A (da) 1978-12-26
FR2420529A1 (fr) 1979-10-19
NL176071B (nl) 1984-09-17
IT1104743B (it) 1985-10-28
DE2824781B2 (fr) 1980-01-31
JPS5943459B2 (ja) 1984-10-22
DE2824781C3 (de) 1980-09-18
BE868329A (fr) 1978-10-16
NL7805253A (nl) 1978-12-28
ATA451778A (de) 1981-06-15
FR2420529B1 (fr) 1984-10-12
IT7849760A0 (it) 1978-06-07
JPS5412381A (en) 1979-01-30
DK149749C (da) 1987-03-02
DE2824781A1 (de) 1979-01-04
SE430333B (sv) 1983-11-07

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Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
V1 Lapsed because of non-payment of the annual fee

Effective date: 19971201