NL1044088A

NL1044088A - Combination of Magnesium, Rhodiola Extract, Nicotinamide Mononucleotide (NMN) and Resveratrol as Healthy Functional Food (Dietary Supplement)

Info

Publication number: NL1044088A
Application number: NL1044088A
Authority: NL
Inventors: Barjaktarovic Jelena
Original assignee: Dr Jelena Barjaktarovic Md
Priority date: 2020-08-12
Filing date: 2021-07-06
Publication date: 2022-04-04
Also published as: NL1044088B1

Abstract

Magnesium (Mg) (1) is very important for normal energy utilization of the cell, and normal maintenance of the nerve and muscle. Rhodiola extract (2) has proven effect on fatigue relief. In a preclinical and clinical studies, beside other effects, nicotine amide mononucleotide (NMN) (3) has been associated with properties such as mood and sleep improvement and depression reduction, white resveratrol has a large number of overall health benefits. Healthy food supplement, containing a combination of Magnesium (1), Rhodiola extract (2), nicotinamide mononucleotide (NMN) (3) and resveratrol (4) is expected to have positive effects on mood and should help with sleep improvement, and fatigue relief.

Description

i Combination of Magnesium, Rhodiola Extract, Nicotinamide Mononucleotide (NMN) and Resveratrol as Healthy Functional Food {Dietary Supplement)

Discussion & While positive effects of Magnesium and Rhodiola extract have been known for centuries, NMN and resveratrol are getting in the focus in the last years, As this is a novel combination, below are presented effects of each of these products individually.

Magnesium (Mg) (1) Magnesium is the fourth most abundant mineral in the human body, One of magnesiimt's main roles is acting as a cofactor or helper molecule in the blochamical reactions comtingously performed by enzymes. Magnesium is a mineral that supports hundreds of chemical reactions in your body. However, many people get less than they need. Magnesium plays a critical role m brain function and mood. and low levels are linked to an increased risk of depression, There may be a Bak between depression and magnesium deficiency. Supplementing with it can reduce symptoms of depression in some people.

Magnesium is safe and widely available. Rbaodivla extract (2) Rhodiola has long been kaown as an adaptogen, a natural substance that increases your bodys resistance to stress in non-specific ways, Consaming adaptogens during stresstud times is thought to help you handle stressful situations better, Stress, anxiety and inadequate sleep are just a few factors that can contribute to fatigue, which can cause feelings of physical and mental tiredness. Due to its adaptogenic properties, rhodiola is thought to help alleviate fatigue. One four-week study in 60 people with stress-related fatigue looked at its effects on quality of life and symptoms of fatigue, depression and attention, Participants received either $76 mg of rhodiola or a placebo pill daily. It found that thodinla had a positive effect on fatigue levels and attention compared to the placebo, In a similar study, 100 people with chronic fatigue symptoms received 400 mg of rhodiola every day for eight weeks, They experienced significant improvements in stress symptoms, fatigue, quality of {ife, mood and concentration {8 Trusted Source). These improvements were observed after only ong week of treatment and contineed to improve through the final wesk of the study.

NMN (Nicotinamide Monenucleotide} Molecule (3) NMN naturally exists in avocadoes, tomatoes, cucumber, cabbages, broccoli, and raw beef. In the laboratory, it is available as nicotinamide mononucleotide bull powder, In the human body, NMN is the principal source of energy within the cells. As we age, cellalar energy decreases due to the low levels of nicotinamide mononucleotide and subsequent reduction of NAD. Administering NMN will reverse the process and compensate for the defieit. NMN exists in both alpha (1) and beta (5) forms, However, B-NMN is the most active form, This bioactive nucleotide is an intermediate in the biosynthesis of nicotinamide adenine dinaclectide or NAD. FDA recommends that any human being needs approximately 560 mg of NMN per day.

Human Clinical Trials with NIN

~ There are 113 ongoing clinical trials in humans that are investigating NAD precursors INMN, NR and Niacin}, majority of them are not completed and only few have results published. The most important study in humans was a study in Japanese man, that showed that the single oral administration of NMN up to 500 mg was safe and well-tolerated in healthy men without causing any significant deleterious effects. It has demonstrated that the oral. ~ administration of NMN is feasible and could be a therapeutic strategy to replenish cellular NAD™ levels to mitigate aging-related functional disorders in humans. - Trials in humans with results are: An international collaborative team including researchers from Keio University in Tokyo and Washington University School of Medicine in St. Louis is running a phase | study of NMN in Japan, Clinical trials examining the safety and efficacy of NMN are also currently being run at Washington University, investigating the effect on insulin sensitivity, endothelial function, lipids, body and liver fat and markers of cardiovascular and metabolic health.

© Arandomizeg, double-blind, three-arm crossover pharmacokinetic study in 12 human subjects showed that NR raises NAD+ by as much as 2.7-fold in human blood with a single oral dose of 1000 mg. Researchers at the University of Washington have completed a clinical trial with 140 participants showing that orally administered NR gives a dose o dependent increase in NAD+ from 250-1000 mg/d plateauing at a 2-fold increase in NAD+ at day nine.

o Researchers have also reported positive effects of NR on vascular endothelial function in healthy middle-aged and older adults, with further investigations of motor and cognitive changes to come.

-Recently, researchers have found that a resveratrol analog called pterostilbene combined with NR seemed to help ALS/Lou Gehrig's patients.

-Most recently, a placebo-controlled study assessing 500 mg of NR, taken twice daily by 70- to 80-year olds, showed increases in NAD+ in blood (but not muscle.) inflammation fell and, unexpectedly, mitochondrial activity did too.

-Muitiple other studies are now underway assessing the effects of NR on muscle mitochondrial function, cognition, immune function, kidney function, traumatic brain injury, brown fat activity, lipid accumulation, energy metabolism, cardiovascular risk, body composition, and acetylcarnitine levels, Clinical trials results should be available in the new few years. What we can claim with certainly at this moment, based on clinical research data is that NMN is safe and welt toleratad in healthy men and that it is able to successfully replenish cellular NAD+ levels, And we know that decline in NAD levels is associated with aging. NAN Animal Studies Animal studies are confirming that the pharmacological activities of MIN include its rede in 18 - cetidlar biochemical functions, cardio protection, diabetes, Alzheimer's disease, and complications associated with obesity. The recent groundbreaking discovery of anti- ageing activities of this chemical molety has added a valuable essence in the research involving this molecule, Studies confirmed that manipulation of mitochondrial NAD levels by NMN resulls in - metabolic changes that pralect mitochondria against reactive oxygen species and gxcessive fragmentation, offering therapeutic approaches for pathophysiologic stress conditions, Resveratrol (4) Resveratrol is a nutrient fund abundantly in the skin of red grapes that is known to have robust antioxidant and anti-inflaspmatory properties.

The efficacy, safety, and pharmacokinetics of Resveratrol have been documented in over 244 clinical trials, with an additional 27 clinical trials currently ongoing.

Resveratrol has various biochemical and physiological effects such as antiinflammatory, antioxidative, antiprofiferative and chemo-praventive effects. Recent studies have shown iis positive effects especially on cardiovascular diseases, cancer, type 2 diabetes and neurological disorders.

Resveratrol is reported to potentially improve the therapeutic outcome in patients suffering from diabetes mellitus, obesity, colorectal cancer, breast cancer, multiple myeloma, metabolic syndrome, hypertension, Alzheimer's disease, stroke, cardiovascular diseases, kidney diseases, inflammatory diseases, and rhinopharyngitis.

it was also proven that it mimics caloric restriction, which has numerous positive effects, Resveratrol is reported to be safe al doses up to 5 g/d, when used either alone or as a combination therapy.

Claims

5 Human clinical trial data suggest that smagaesium (1), a mineral that supports hundreds of chemical reactions in your body, plays a critical role in brain function and mood, and low levels are linked to an increased risk of depression. Rhodiela extract (2) has strong adaptogenic properties and is effective in relieving fatigue.

In preliminary and clinical studies, nicotine gmide mononucleotide (NMB) {3} has been associated with properties such as anti-aging, cardio- and brain protection, while animal studies confirm the potential for lifespan extension. It has anti-aging properties as it replenishes cellular NAD+ levels to reduce aging-related functional impairment in humans, helps reduce inflammation, increase energy by increasing mitochondrial activity, and protect mitochondria from reactive oxygen species and excessive fragmentation , and provides therapeutic approaches for pathophysiological stress conditions. It improves energy metabolism and body composition and has cardio- and brain-protective effects. Other possible effects of NMN include: extending the lifespan of any animal it has been tested on to date; It impairs cognitive function, mood and sleep; it has a strong effect on increasing female fertility, It is effective in reducing depression and weight loss, Recent studies of resvergtroi {3} have shown its preventive effects for cardiovascular disease and stroke, prolonging lifespan, improving fat metabolism and overall health. It reduces energy expenditure and improves metabolism, vascular function, decreases metabolism, reduces fat in liver, lowers blood pressure and lowers blood sugar. It is effective for restoring libido as it increases testosterone without shutting down the testis.

A sweetened dietary supplement containing a combination of magnesium (1), rhodiola extract {2), nicotinamide mononucleotide (NMN)}3)} and resveratrol (4) is expected to have a positive effect on mood and should help in improving sleep and reducing fatigue, Note: All references to the statements in this document are available upon request.