Patents
Search within
Search within the title, abstract, claims, or full patent document: You can restrict your search to a specific field using field names.
Use TI= to search in the title, AB= for the abstract, CL= for the claims, or TAC= for all three. For example, TI=(safety belt).
Search by Cooperative Patent Classifications (CPCs): These are commonly used to represent ideas in place of keywords, and can also be entered in a search term box. If you're searching forseat belts, you could also search for B60R22/00 to retrieve documents that mention safety belts or body harnesses. CPC=B60R22 will match documents with exactly this CPC, CPC=B60R22/low matches documents with this CPC or a child classification of this CPC.
Learn More
Title
Abstract
Claims
Full Document
Find patents
Keywords and boolean syntax (USPTO or EPO format): seat belt searches these two words, or their plurals and close synonyms. "seat belt" searches this exact phrase, in order. -seat -belt searches for documents not containing either word.
For searches using boolean logic, the default operator is AND with left associativity. Note: this means safety OR seat belt is searched as (safety OR seat) AND belt. Each word automatically includes plurals and close synonyms. Adjacent words that are implicitly ANDed together, such as (safety belt), are treated as a phrase when generating synonyms.
Learn More
Search by
Chemistry searches match terms (trade names, IUPAC names, etc. extracted from the entire document, and processed from .MOL files.)
Substructure (use SSS=) and similarity (use ~) searches are limited to one per search at the top-level AND condition. Exact searches can be used multiple times throughout the search query.
Searching by SMILES or InChi key requires no special syntax. To search by SMARTS, use SMARTS=.
To search for multiple molecules, select "Batch" in the "Type" menu. Enter multiple molecules separated by whitespace or by comma.
Learn More
Patent numbers
Search specific patents by importing a CSV or list of patent publication or application numbers.
Combination of Magnesium, Rhodiola Extract, Nicotinamide Mononucleotide (NMN) and Resveratrol as Healthy Functional Food (Dietary Supplement)
NL1044088A
Netherlands
- Other languages
Dutch - Inventor
Barjaktarovic Jelena
Worldwide applications
2021
NL
Application NL1044088A events
2022-04-04
2022-07-13
Application granted
2022-07-13
Description
translated from
i Combination of Magnesium, Rhodiola Extract, Nicotinamide Mononucleotide (NMN) and Resveratrol as Healthy Functional Food {Dietary Supplement)
Discussion & While positive effects of Magnesium and Rhodiola extract have been known for centuries, NMN and resveratrol are getting in the focus in the last years, As this is a novel combination, below are presented effects of each of these products individually.
Magnesium (Mg) (1) Magnesium is the fourth most abundant mineral in the human body, One of magnesiimt's main roles is acting as a cofactor or helper molecule in the blochamical reactions comtingously performed by enzymes. Magnesium is a mineral that supports hundreds of chemical reactions in your body. However, many people get less than they need. Magnesium plays a critical role m brain function and mood. and low levels are linked to an increased risk of depression, There may be a Bak between depression and magnesium deficiency. Supplementing with it can reduce symptoms of depression in some people.
Magnesium is safe and widely available. Rbaodivla extract (2) Rhodiola has long been kaown as an adaptogen, a natural substance that increases your bodys resistance to stress in non-specific ways, Consaming adaptogens during stresstud times is thought to help you handle stressful situations better, Stress, anxiety and inadequate sleep are just a few factors that can contribute to fatigue, which can cause feelings of physical and mental tiredness. Due to its adaptogenic properties, rhodiola is thought to help alleviate fatigue. One four-week study in 60 people with stress-related fatigue looked at its effects on quality of life and symptoms of fatigue, depression and attention, Participants received either $76 mg of rhodiola or a placebo pill daily. It found that thodinla had a positive effect on fatigue levels and attention compared to the placebo, In a similar study, 100 people with chronic fatigue symptoms received 400 mg of rhodiola every day for eight weeks, They experienced significant improvements in stress symptoms, fatigue, quality of {ife, mood and concentration {8 Trusted Source). These improvements were observed after only ong week of treatment and contineed to improve through the final wesk of the study.
NMN (Nicotinamide Monenucleotide} Molecule (3) NMN naturally exists in avocadoes, tomatoes, cucumber, cabbages, broccoli, and raw beef. In the laboratory, it is available as nicotinamide mononucleotide bull powder, In the human body, NMN is the principal source of energy within the cells. As we age, cellalar energy decreases due to the low levels of nicotinamide mononucleotide and subsequent reduction of NAD. Administering NMN will reverse the process and compensate for the defieit. NMN exists in both alpha (1) and beta (5) forms, However, B-NMN is the most active form, This bioactive nucleotide is an intermediate in the biosynthesis of nicotinamide adenine dinaclectide or NAD. FDA recommends that any human being needs approximately 560 mg of NMN per day.
Human Clinical Trials with NIN
~ There are 113 ongoing clinical trials in humans that are investigating NAD precursors INMN, NR and Niacin}, majority of them are not completed and only few have results published. The most important study in humans was a study in Japanese man, that showed that the single oral administration of NMN up to 500 mg was safe and well-tolerated in healthy men without causing any significant deleterious effects. It has demonstrated that the oral. ~ administration of NMN is feasible and could be a therapeutic strategy to replenish cellular NAD™ levels to mitigate aging-related functional disorders in humans. - Trials in humans with results are: An international collaborative team including researchers from Keio University in Tokyo and Washington University School of Medicine in St. Louis is running a phase | study of NMN in Japan, Clinical trials examining the safety and efficacy of NMN are also currently being run at Washington University, investigating the effect on insulin sensitivity, endothelial function, lipids, body and liver fat and markers of cardiovascular and metabolic health.
© Arandomizeg, double-blind, three-arm crossover pharmacokinetic study in 12 human subjects showed that NR raises NAD+ by as much as 2.7-fold in human blood with a single oral dose of 1000 mg. Researchers at the University of Washington have completed a clinical trial with 140 participants showing that orally administered NR gives a dose o dependent increase in NAD+ from 250-1000 mg/d plateauing at a 2-fold increase in NAD+ at day nine.
o Researchers have also reported positive effects of NR on vascular endothelial function in healthy middle-aged and older adults, with further investigations of motor and cognitive changes to come.
-Recently, researchers have found that a resveratrol analog called pterostilbene combined with NR seemed to help ALS/Lou Gehrig's patients.
-Most recently, a placebo-controlled study assessing 500 mg of NR, taken twice daily by 70- to 80-year olds, showed increases in NAD+ in blood (but not muscle.) inflammation fell and, unexpectedly, mitochondrial activity did too.
-Muitiple other studies are now underway assessing the effects of NR on muscle mitochondrial function, cognition, immune function, kidney function, traumatic brain injury, brown fat activity, lipid accumulation, energy metabolism, cardiovascular risk, body composition, and acetylcarnitine levels, Clinical trials results should be available in the new few years. What we can claim with certainly at this moment, based on clinical research data is that NMN is safe and welt toleratad in healthy men and that it is able to successfully replenish cellular NAD+ levels, And we know that decline in NAD levels is associated with aging. NAN Animal Studies Animal studies are confirming that the pharmacological activities of MIN include its rede in 18 - cetidlar biochemical functions, cardio protection, diabetes, Alzheimer's disease, and complications associated with obesity. The recent groundbreaking discovery of anti- ageing activities of this chemical molety has added a valuable essence in the research involving this molecule, Studies confirmed that manipulation of mitochondrial NAD levels by NMN resulls in - metabolic changes that pralect mitochondria against reactive oxygen species and gxcessive fragmentation, offering therapeutic approaches for pathophysiologic stress conditions, Resveratrol (4) Resveratrol is a nutrient fund abundantly in the skin of red grapes that is known to have robust antioxidant and anti-inflaspmatory properties.
The efficacy, safety, and pharmacokinetics of Resveratrol have been documented in over 244 clinical trials, with an additional 27 clinical trials currently ongoing.
Resveratrol has various biochemical and physiological effects such as antiinflammatory, antioxidative, antiprofiferative and chemo-praventive effects. Recent studies have shown iis positive effects especially on cardiovascular diseases, cancer, type 2 diabetes and neurological disorders.
Resveratrol is reported to potentially improve the therapeutic outcome in patients suffering from diabetes mellitus, obesity, colorectal cancer, breast cancer, multiple myeloma, metabolic syndrome, hypertension, Alzheimer's disease, stroke, cardiovascular diseases, kidney diseases, inflammatory diseases, and rhinopharyngitis.
it was also proven that it mimics caloric restriction, which has numerous positive effects, Resveratrol is reported to be safe al doses up to 5 g/d, when used either alone or as a combination therapy.
Claims (1)
Hide Dependent
translated from English
Claims (1)
Hide Dependent
translated from English