MY189159A - Multispecific antigen-binding molecules and uses thereof - Google Patents

Multispecific antigen-binding molecules and uses thereof

Info

Publication number
MY189159A
MY189159A MYPI2017704363A MYPI2017704363A MY189159A MY 189159 A MY189159 A MY 189159A MY PI2017704363 A MYPI2017704363 A MY PI2017704363A MY PI2017704363 A MYPI2017704363 A MY PI2017704363A MY 189159 A MY189159 A MY 189159A
Authority
MY
Malaysia
Prior art keywords
binding
antigen
target molecule
multispecific antigen
effector protein
Prior art date
Application number
MYPI2017704363A
Inventor
Julian Andreev
Nithya Thambi
Frank Delfino
Joel Martin
Gavin Thurston
Katherine Cygnar
Nicholas Papadopoulos
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MY189159A publication Critical patent/MY189159A/en

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Abstract

The present invention provides multispecific antigen-binding molecules and uses thereof. The multispecific antigen-binding molecules comprise a first antigen-binding domain that specifically binds a target molecule, and a second antigen-binding domain that specifically binds an internalizing effector protein. The multispecific antigen-binding molecules of the present invention can, in some embodiments, be bispecific antibodies that are capable of binding both a target molecule and an internalizing effector protein. In certain embodiments of the invention, the simultaneous binding of the target molecule and the internalizing effector protein by the multispecific antigen-binding molecule of the present invention results in the attenuation of the activity of the target molecule to a greater extent than the binding of the target molecule alone. In other embodiments of the invention, the target molecule is a tumor associated antigen, and the simultaneous binding of the tumor associated antigen and the internalizing effector protein by the multispecific antigen-binding molecule of the present invention causes or facilitates the targeted killing of tumor cells. (Figure 1)
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IL313163A (en) 2024-07-01
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US20170007715A1 (en) 2017-01-12
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EP3319994A1 (en) 2018-05-16
KR20180025865A (en) 2018-03-09
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WO2017007796A1 (en) 2017-01-12
WO2017007796A4 (en) 2017-03-23
CN107849131A (en) 2018-03-27
IL313163B1 (en) 2025-02-01
IL256416A (en) 2018-04-30
US20190000984A1 (en) 2019-01-03
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US11191844B2 (en) 2021-12-07
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