MX9707194A - Thiazole derivatives. - Google Patents
Thiazole derivatives.Info
- Publication number
- MX9707194A MX9707194A MX9707194A MX9707194A MX9707194A MX 9707194 A MX9707194 A MX 9707194A MX 9707194 A MX9707194 A MX 9707194A MX 9707194 A MX9707194 A MX 9707194A MX 9707194 A MX9707194 A MX 9707194A
- Authority
- MX
- Mexico
- Prior art keywords
- thiazole derivatives
- alkyl
- optionally substituted
- nitrogen
- phenyl
- Prior art date
Links
- 150000007979 thiazole derivatives Chemical class 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229940124243 Dopamine D4 receptor antagonist Drugs 0.000 abstract 1
- 208000027776 Extrapyramidal disease Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 230000000561 anti-psychotic effect Effects 0.000 abstract 1
- 208000018300 basal ganglia disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Thiazole derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof, wherein Ar1 represents optionally substituted phenyl or thienyl; Y1 and Y2 are different from each other and each represents nitrogen or sulfur; R1 represents hydrogen, C1-5 alkyl, phenyl or amino which may be mono- or di-substituted by C1-5 alkyl; and R2 represents an optionally substituted nitrogen-containing heterocycle. The compounds are a dopamine D4 receptor antagonist which has an antipsychotic effect without causing any extrapyramidal disorder.
Applications Claiming Priority (22)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7-62328 | 1995-03-22 | ||
| JP6232795 | 1995-03-22 | ||
| JP6232695 | 1995-03-22 | ||
| JP7/62327 | 1995-03-22 | ||
| JP7/62326 | 1995-03-22 | ||
| JP7-62327 | 1995-03-22 | ||
| JP7/62329 | 1995-03-22 | ||
| JP7/62328 | 1995-03-22 | ||
| JP7-62326 | 1995-03-22 | ||
| JP7-62329 | 1995-03-22 | ||
| JP6232895 | 1995-03-22 | ||
| JP6232995 | 1995-03-22 | ||
| JP28774195 | 1995-11-07 | ||
| JP7-287742 | 1995-11-07 | ||
| JP28774295 | 1995-11-07 | ||
| JP28774395 | 1995-11-07 | ||
| JP7/287741 | 1995-11-07 | ||
| JP7/287742 | 1995-11-07 | ||
| JP7-287743 | 1995-11-07 | ||
| JP7/287744 | 1995-11-07 | ||
| JP7/287743 | 1995-11-07 | ||
| JP7-287741 | 1995-11-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9707194A true MX9707194A (en) | 1997-11-29 |
| MXPA97007194A MXPA97007194A (en) | 1998-07-03 |
Family
ID=
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