MX9705309A - Analogos de n-acetilardeemina, metodo de preparacion y sus usos. - Google Patents

Analogos de n-acetilardeemina, metodo de preparacion y sus usos.

Info

Publication number
MX9705309A
MX9705309A MX9705309A MX9705309A MX9705309A MX 9705309 A MX9705309 A MX 9705309A MX 9705309 A MX9705309 A MX 9705309A MX 9705309 A MX9705309 A MX 9705309A MX 9705309 A MX9705309 A MX 9705309A
Authority
MX
Mexico
Prior art keywords
cr3r3
hydrogen
linear
branched chain
chr4
Prior art date
Application number
MX9705309A
Other languages
English (en)
Inventor
Samuel Danishefsky
Kristopher Depew
Stephen P Marsden
William Bornmann
Jonathan C G Woo
Ting Chao Chou
Jeffrey Schkeryantz
Andrej Zatorski
Original Assignee
Sloan Kettering Inst Cancer
Univ Columbia
In The City Of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Inst Cancer, Univ Columbia, In The City Of New York filed Critical Sloan Kettering Inst Cancer
Publication of MX9705309A publication Critical patent/MX9705309A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invencion proporciona un compuesto que tiene la estructura (I), en donde R1, R6 y R7 son independientemente hidrogeno, OH, NH2, SH, halogeno, alquilo de 1 a 9 átomos de carbono, de cadena lineal o ramificada, alquilmercapto, alquilamino, dialquilamino, alcoxi, fenilo, etc.; en donde R0 y R2 son independientemente hidrogeno, OH, alquilo de cadena lineal o ramificada, -CR3R3-CH(O)CH2, -CR3R3-CH2CH3, -CR3R3-CH2CH2OH, -CR3R3-CH(OH)R4 o -CR3R3-CH(OH)R4 o -CR3R3-CH=CHR4, en donde R3 y R4 son independientemente hidrogeno, halogeno, alquilo de 1 a 9 átomos de carbono de cadena lineal o ramificada, fenilo, etc., en donde R5 es hidrogeno, alquilo de 1 a 9 átomos de carbono, de cadena lineal o ramificada, fenilo, etc.; en donde R8 es hidrogeno, acilo de 1 a 9 átomos de carbono, de cadena lineal o ramificada, benzoilo, etc.; con la condicion que (a) cuando R 2 es -CR3R3-CH(O)CH2, -CR3R3-CH2CH3, -CR3R3- CH2CH2OH, -CR3R3-CH(OH)R4 o -CR3R3-CH=CHR4, entonces R0 es hidrogeno; (b) cuando R0 es -CR3R3-CH(O)CH2, -CR3R3-CH2CH3, -CR3R3-CH2CH2OH, -CR3R3-CH(OH)R4 o -CR3R3-CH=CHR4, entonces R2 es OH; y (c) cuando (i) R0 o R2 es CR3R3-CH=CHR4, (ii) R3 y R5 son CH3 y (iii) R4 es hidrogeno, entonces R1, R6 y R7 no son todos hidrogeno. También se proporcionan compuestos relacionados y composiciones, y métodos para inhibir el crecimiento de células resistentes a varios fármacos por medio de la inversion MDR, sensibilidad colateral y sinergismo cuantitativo.
MX9705309A 1995-11-15 1997-07-14 Analogos de n-acetilardeemina, metodo de preparacion y sus usos. MX9705309A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US675095P 1995-11-15 1995-11-15

Publications (1)

Publication Number Publication Date
MX9705309A true MX9705309A (es) 1998-06-30

Family

ID=21722393

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9705309A MX9705309A (es) 1995-11-15 1997-07-14 Analogos de n-acetilardeemina, metodo de preparacion y sus usos.

Country Status (9)

Country Link
US (1) US6147076A (es)
EP (1) EP0815111B1 (es)
JP (1) JPH10512899A (es)
AT (1) ATE375348T1 (es)
AU (1) AU729877B2 (es)
CA (1) CA2209775C (es)
DE (1) DE69637283D1 (es)
MX (1) MX9705309A (es)
WO (1) WO1997018215A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355639B1 (en) 1997-09-22 2002-03-12 Sloan-Kettering Institute For Cancer Research Reverse prenyl compounds as immunosuppressants
CN100352805C (zh) 2000-11-08 2007-12-05 鲁汶天主教大学研究开发部 用作造影剂的取代的联吲哚衍生物、包含它们的药物组合物以及制造它们的中间体
CN102276615B (zh) * 2011-08-26 2013-10-23 四川大学 一种制备甲酰阿地咪的方法
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
CN103113376B (zh) * 2013-02-04 2015-03-04 浙江工业大学 一种生物碱及制备方法和应用
WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
WO2020247054A1 (en) 2019-06-05 2020-12-10 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
CN110724149B (zh) * 2019-10-17 2022-04-05 中山大学 一种海洋真菌来源的吲哚生物碱二聚体化合物及制备方法与抗海洋污损生物防除剂中的应用
US12030888B2 (en) 2021-02-24 2024-07-09 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58152487A (ja) * 1982-03-05 1983-09-10 Fujisawa Pharmaceut Co Ltd Ｆｒ−９００２２０物質およびその製造法
JPS6041678A (ja) * 1983-08-16 1985-03-05 Fujisawa Pharmaceut Co Ltd インド−ル誘導体
EP0569487A1 (en) * 1991-01-31 1993-11-18 Abbott Laboratories Endothelin converting enzyme inhibitors
US5196420A (en) * 1991-07-19 1993-03-23 The United States Of America As Represented By The Secretary Of Agriculture Cycloechinulin antiinsectan metabolite
US5284947A (en) * 1992-09-15 1994-02-08 Abbott Laboratories Multiple drug resistance-attenuating compounds
US5338845A (en) * 1992-12-02 1994-08-16 Sterling Winthrop Inc. Aspergillus species, cyclic dimeric dipeptide derivative substance P antagonist biosynthetic products thereof, and process for preparation thereof

Also Published As

Publication number Publication date
EP0815111A4 (en) 1998-05-06
DE69637283D1 (de) 2007-11-22
WO1997018215A1 (en) 1997-05-22
EP0815111B1 (en) 2007-10-10
JPH10512899A (ja) 1998-12-08
CA2209775A1 (en) 1997-05-22
CA2209775C (en) 2006-01-24
AU1142597A (en) 1997-06-05
AU729877B2 (en) 2001-02-15
US6147076A (en) 2000-11-14
EP0815111A1 (en) 1998-01-07
ATE375348T1 (de) 2007-10-15

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