MX9704440A - Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses. - Google Patents

Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses.

Info

Publication number
MX9704440A
MX9704440A MX9704440A MX9704440A MX9704440A MX 9704440 A MX9704440 A MX 9704440A MX 9704440 A MX9704440 A MX 9704440A MX 9704440 A MX9704440 A MX 9704440A MX 9704440 A MX9704440 A MX 9704440A
Authority
MX
Mexico
Prior art keywords
method
reversal
induction
b7
reagent
Prior art date
Application number
MX9704440A
Other languages
Spanish (es)
Inventor
Leonid Beigelman
Daniel T Stinchcomb
Thale Jarvis
Kenneth Draper
Pamela Pavco
James Mcswiggen
John Gustofson
Nassim Usman
Francine Wincott
Original Assignee
Ribozyme Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US35492094A priority Critical
Priority to US08/363,254 priority patent/US5891684A/en
Priority to US08/363,253 priority patent/US5891683A/en
Priority to US08/390,850 priority patent/US5612215A/en
Priority to US08/426,124 priority patent/US5716824A/en
Priority to US08/432,874 priority patent/US5627053A/en
Priority to US43450995A priority
Priority to US97495P priority
Priority to US95195P priority
Priority to US08/512,861 priority patent/US6146886A/en
Priority to US08/541,365 priority patent/US5672501A/en
Application filed by Ribozyme Pharm Inc filed Critical Ribozyme Pharm Inc
Priority to PCT/US1995/015516 priority patent/WO1996018736A2/en
Publication of MX9704440A publication Critical patent/MX9704440A/en

Links

Abstract

An enzymatic nucleic acid molecule which cleaves RNA associated with development or maintenance of an arthritic condition, induction of graft tolerance or reversal of an immune response. In particular, the ribozyme sequences are directed to an mRNA encoding B7-1, B7-2, B7-3, CD40 and/or stromelysin. Also provided are ribozymes where the uracil in positions 4 and/or 7 are substituted, as well as methods for the synthesis of 2'-alkylnucleotides, 2'-O-alkylthioalkyl, or 2'-alkylthioalkylnucleotides. The application further describes a method for diprotection of RNA with aqueous ethylamine, a method for synthesis of a basic ribonucleoside mimetics, and transcription units comprising an RNA polymerase II promoter, a U6 small nuclear promoter, or an adenovirus VA1 promoter system.
MX9704440A 1992-10-15 1995-11-22 Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses. MX9704440A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
US35492094A true 1994-12-13 1994-12-13
US08/363,254 US5891684A (en) 1992-10-15 1994-12-23 Base-modified enzymatic nucleic acid
US08/363,253 US5891683A (en) 1993-09-02 1994-12-23 Non-nucleotide containing enzymatic nucleic acid
US08/390,850 US5612215A (en) 1992-12-07 1995-02-17 Stromelysin targeted ribozymes
US08/426,124 US5716824A (en) 1995-04-20 1995-04-20 2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes)
US08/432,874 US5627053A (en) 1994-03-29 1995-05-02 2'deoxy-2'-alkylnucleotide containing nucleic acid
US43450995A true 1995-05-04 1995-05-04
US97495P true 1995-07-07 1995-07-07
US95195P true 1995-07-07 1995-07-07
US08/512,861 US6146886A (en) 1994-08-19 1995-08-07 RNA polymerase III-based expression of therapeutic RNAs
US08/541,365 US5672501A (en) 1994-12-23 1995-10-05 Base-modified enzymatic nucleic acid
PCT/US1995/015516 WO1996018736A2 (en) 1994-12-13 1995-11-22 Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses

Publications (1)

Publication Number Publication Date
MX9704440A true MX9704440A (en) 1997-10-31

Family

ID=56289668

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9704440A MX9704440A (en) 1992-10-15 1995-11-22 Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses.

Country Status (2)

Country Link
EP (1) EP0799313A2 (en)
MX (1) MX9704440A (en)

Also Published As

Publication number Publication date
EP0799313A2 (en) 1997-10-08

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