MX9605646A - Preparacion de nifedipino de liberacion prolongada. - Google Patents
Preparacion de nifedipino de liberacion prolongada.Info
- Publication number
- MX9605646A MX9605646A MX9605646A MX9605646A MX9605646A MX 9605646 A MX9605646 A MX 9605646A MX 9605646 A MX9605646 A MX 9605646A MX 9605646 A MX9605646 A MX 9605646A MX 9605646 A MX9605646 A MX 9605646A
- Authority
- MX
- Mexico
- Prior art keywords
- niphedipine
- percent
- hours
- essay
- dissolution
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Esta invencion proporciona una preparacion solida de nifedipino, de liberacion prolongada, que presenta un efecto clínicamente suficiente cuando se administra una vez al día. Un comprimido recubierto a presion, cuyo nucleo y envoltura contienen nifedipino, siendo la velocidad de disolucion de nifedipino desde el citado comprimido: (a) en el ensayo de disolucion que usa un dispositivo de inmersion, de acuerdo con el procedimiento 2 del procedimiento del ensayo de disolucion prescrito por la Farmacopea del Japon: después de 2 horas 10-40% después de 4 horas 30-65% después de 6 horas por lo menos 55% y (b) en el ensayo de disolucion de acuerdo con el método del ensayo de desintegracion prescrito por la Farmacopea del Japon: después de 3 horas 20-45% después de 4 horas 30-65%.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP331217-95 | 1995-11-28 | ||
JP33121795A JP3220373B2 (ja) | 1995-11-28 | 1995-11-28 | 持続性ニフエジピン製剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
MXPA96005646A MXPA96005646A (es) | 1997-06-01 |
MX9605646A true MX9605646A (es) | 1997-06-28 |
Family
ID=18241212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9605646A MX9605646A (es) | 1995-11-28 | 1996-11-18 | Preparacion de nifedipino de liberacion prolongada. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5861173A (es) |
EP (1) | EP0776660B1 (es) |
JP (1) | JP3220373B2 (es) |
KR (1) | KR970025607A (es) |
AT (1) | ATE220898T1 (es) |
AU (1) | AU709887B2 (es) |
CA (1) | CA2191178C (es) |
DE (1) | DE69622510T2 (es) |
ES (1) | ES2180683T3 (es) |
IL (1) | IL119684A (es) |
MX (1) | MX9605646A (es) |
NZ (1) | NZ299818A (es) |
SG (1) | SG48492A1 (es) |
ZA (1) | ZA969945B (es) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN190974B (es) * | 1999-09-10 | 2003-09-06 | Ranbaxy Lab Ltd | |
AU767812B2 (en) * | 2000-02-04 | 2003-11-27 | Depomed, Inc. | Shell-and-core dosage form approaching zero-order drug release |
JP4637338B2 (ja) * | 2000-09-22 | 2011-02-23 | 大塚製薬株式会社 | シロスタゾール有核錠 |
SE0004671D0 (sv) | 2000-12-15 | 2000-12-15 | Amarin Dev Ab | Pharmaceutical formulation |
KR100685945B1 (ko) | 2000-12-29 | 2007-02-23 | 엘지.필립스 엘시디 주식회사 | 액정표시장치 및 그 제조방법 |
US7883721B2 (en) | 2001-01-30 | 2011-02-08 | Smithkline Beecham Limited | Pharmaceutical formulation |
GB0102342D0 (en) * | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
US20050175687A1 (en) * | 2001-01-30 | 2005-08-11 | Mcallister Stephen M. | Pharmaceutical formulations |
US6987123B2 (en) * | 2001-07-26 | 2006-01-17 | Cadila Healthcare Limited | Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine |
JP4817562B2 (ja) * | 2001-09-26 | 2011-11-16 | 東和薬品株式会社 | 長時間持続型ニフエジピン有核錠 |
DE60237294D1 (de) * | 2001-09-28 | 2010-09-23 | Mcneil Ppc Inc | Pharmazeutische zusammensetzung auf fondantbasis |
US20030104052A1 (en) * | 2001-10-25 | 2003-06-05 | Bret Berner | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
CA2409552A1 (en) | 2001-10-25 | 2003-04-25 | Depomed, Inc. | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
US20030091630A1 (en) * | 2001-10-25 | 2003-05-15 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data |
US20030152622A1 (en) * | 2001-10-25 | 2003-08-14 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral diuretic |
US6682759B2 (en) | 2002-02-01 | 2004-01-27 | Depomed, Inc. | Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs |
WO2003080057A1 (fr) * | 2002-03-27 | 2003-10-02 | Bayer Aktiengesellschaft | Comprime-noyau de taille reduite contenant de la nifedipine |
ES2312525T3 (es) * | 2002-05-21 | 2009-03-01 | Watson Laboratories, Inc. | Formulacion farmaceutica con liberacion prolongada. |
JP4563642B2 (ja) * | 2002-05-31 | 2010-10-13 | ワトソン ラボラトリーズ、インコーポレイテッド | 医薬製剤 |
JP4933033B2 (ja) * | 2003-03-17 | 2012-05-16 | 武田薬品工業株式会社 | 放出制御組成物 |
CA2519208A1 (en) * | 2003-03-17 | 2004-09-30 | Takeda Pharmaceutical Company Limited | Controlled release composition |
PT1631251E (pt) | 2003-04-24 | 2011-09-19 | Jagotec Ag | Comprimido de libertação retardada com geometria de núcleo definida |
US20040219210A1 (en) * | 2003-05-01 | 2004-11-04 | Jian-Hwa Guo | Controlled release solid dosage nifedipine formulations |
US20040241234A1 (en) * | 2003-06-02 | 2004-12-02 | Alpharma, Inc. | Controlled release press-coated formulations of water-soluble active agents |
US20050013863A1 (en) | 2003-07-18 | 2005-01-20 | Depomed, Inc., A Corporation Of The State Of California | Dual drug dosage forms with improved separation of drugs |
TW200526274A (en) | 2003-07-21 | 2005-08-16 | Smithkline Beecham Plc | Pharmaceutical formulations |
US20060024368A1 (en) * | 2004-07-30 | 2006-02-02 | Reza Fassihi | Compressed composite delivery system for release-rate modulation of bioactives |
US7470293B2 (en) * | 2004-10-29 | 2008-12-30 | Idatech, Llc | Feedstock delivery systems, fuel processing systems, and hydrogen generation assemblies including the same |
US8673352B2 (en) * | 2005-04-15 | 2014-03-18 | Mcneil-Ppc, Inc. | Modified release dosage form |
DE102005031577A1 (de) | 2005-07-06 | 2007-01-11 | Bayer Healthcare Ag | Pharmazeutische Darreichungsformen enthaltend eine Wirkstoffkombination von Nifedipin und/oder Nisoldipin und einem Angiotensin-II Antagonisten |
US8637078B2 (en) * | 2005-11-24 | 2014-01-28 | Boehringer Ingelheim International Gmbh | Bilayer tablet comprising telmisartan and diuretic |
KR100774250B1 (ko) | 2006-04-14 | 2007-11-07 | 넨시스(주) | 1,4-디히드로피리딘 유도체 용출 제어형 과립제, 이의 정제및 이의 제조방법 |
ES2400446T5 (es) | 2006-08-03 | 2017-03-13 | Horizon Pharma Ag | Tratamiento con glucocorticoides de liberación retardada de una enfermedad reumática |
BRPI0812337A2 (pt) * | 2007-06-11 | 2015-01-27 | Appleton Paper Inc | Agente de benefício contendo partícula de liberação |
WO2009028598A1 (ja) | 2007-08-31 | 2009-03-05 | Daiichi Sankyo Company, Limited | 徐放性製剤及びその製造方法 |
EP2214651A1 (en) * | 2007-10-25 | 2010-08-11 | Bayer Yakuhin, Ltd. | Nifedipine-containing press coated tablet and method of preparing the same |
WO2009140527A1 (en) * | 2008-05-14 | 2009-11-19 | Capricorn Pharma, Inc. | Modified release formulations of dihydropyridine compounds and methods of making same |
DE102008059206A1 (de) | 2008-11-27 | 2010-06-10 | Bayer Schering Pharma Aktiengesellschaft | Pharmazeutische Darreichungsform enthaltend Nifedipin oder Nisoldipin und einen Angiotensin-II Antagonisten und/oder ein Diuretikum |
MX339452B (es) | 2010-06-16 | 2016-05-27 | Teijin Pharma Ltd | Tableta con nucleo recubierto de liberacion controlada. |
WO2015186693A1 (ja) * | 2014-06-02 | 2015-12-10 | ニプロ株式会社 | レーザー印刷用錠剤及びその製造方法 |
WO2016128971A1 (en) * | 2015-02-09 | 2016-08-18 | Entera Bio Ltd. | Treatment of bone fractures and defects |
WO2017111178A1 (en) | 2015-12-24 | 2017-06-29 | Takeda Pharmaceutical Company Limited | Solid preparation |
CN115192538B (zh) * | 2022-08-02 | 2023-09-15 | 沈阳信康药物研究有限公司 | 一种压制包衣型硝苯地平缓释片及其制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3033919A1 (de) | 1980-09-09 | 1982-04-22 | Bayer Ag, 5090 Leverkusen | Feste arzneizubereitungen enthaltend nifedipin und verfahren zu ihrer herstellung |
DE3720757A1 (de) * | 1987-06-24 | 1989-01-05 | Bayer Ag | Dhp-manteltablette |
NO883326L (no) * | 1987-08-11 | 1989-02-13 | Bayer Ag | Dhp-retard-tilberedning. |
DE3814532A1 (de) * | 1988-04-29 | 1989-11-09 | Bayer Ag | Dhp-retard-zubereitung |
HU203041B (en) * | 1989-03-14 | 1991-05-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing pharmaceutical compositions of controlled releasing factor containing nifedipin |
-
1995
- 1995-11-28 JP JP33121795A patent/JP3220373B2/ja not_active Expired - Lifetime
-
1996
- 1996-11-15 EP EP96118311A patent/EP0776660B1/en not_active Expired - Lifetime
- 1996-11-15 ES ES96118311T patent/ES2180683T3/es not_active Expired - Lifetime
- 1996-11-15 DE DE69622510T patent/DE69622510T2/de not_active Expired - Lifetime
- 1996-11-15 AT AT96118311T patent/ATE220898T1/de not_active IP Right Cessation
- 1996-11-18 MX MX9605646A patent/MX9605646A/es unknown
- 1996-11-21 US US08/755,381 patent/US5861173A/en not_active Expired - Lifetime
- 1996-11-25 SG SG1996011422A patent/SG48492A1/en unknown
- 1996-11-25 IL IL11968496A patent/IL119684A/xx not_active IP Right Cessation
- 1996-11-25 AU AU71960/96A patent/AU709887B2/en not_active Ceased
- 1996-11-25 NZ NZ299818A patent/NZ299818A/en unknown
- 1996-11-25 CA CA002191178A patent/CA2191178C/en not_active Expired - Fee Related
- 1996-11-27 ZA ZA969945A patent/ZA969945B/xx unknown
- 1996-11-27 KR KR1019960058350A patent/KR970025607A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0776660A3 (en) | 1998-01-21 |
NZ299818A (en) | 1998-08-26 |
SG48492A1 (en) | 1998-04-17 |
JP3220373B2 (ja) | 2001-10-22 |
DE69622510D1 (de) | 2002-08-29 |
JPH09143073A (ja) | 1997-06-03 |
AU709887B2 (en) | 1999-09-09 |
KR970025607A (ko) | 1997-06-24 |
US5861173A (en) | 1999-01-19 |
DE69622510T2 (de) | 2002-11-07 |
IL119684A (en) | 2000-09-28 |
EP0776660B1 (en) | 2002-07-24 |
CA2191178C (en) | 2005-10-04 |
ATE220898T1 (de) | 2002-08-15 |
CA2191178A1 (en) | 1997-05-29 |
ZA969945B (en) | 1997-06-23 |
IL119684A0 (en) | 1997-02-18 |
ES2180683T3 (es) | 2003-02-16 |
EP0776660A2 (en) | 1997-06-04 |
AU7196096A (en) | 1997-06-05 |
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