MX363872B - Anticuerpos anti-pd-l1 y antagonistas de vegf y su uso en el tratamiento del cáncer. - Google Patents
Anticuerpos anti-pd-l1 y antagonistas de vegf y su uso en el tratamiento del cáncer.Info
- Publication number
- MX363872B MX363872B MX2014014485A MX2014014485A MX363872B MX 363872 B MX363872 B MX 363872B MX 2014014485 A MX2014014485 A MX 2014014485A MX 2014014485 A MX2014014485 A MX 2014014485A MX 363872 B MX363872 B MX 363872B
- Authority
- MX
- Mexico
- Prior art keywords
- antagonists
- methods
- axis binding
- treating cancer
- vegf
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 101100372758 Danio rerio vegfaa gene Proteins 0.000 title 1
- 101150030763 Vegfa gene Proteins 0.000 title 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 abstract 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 238000011284 combination treatment Methods 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 230000005851 tumor immunogenicity Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere una composición para usarse en tatar o retardar la progresión del cáncer en un individuo que comprende una cantidad eficaz de un anticuerpo anti.PD.L1, en donde la composición es para uso en combinación con un anticuerpo anti-VEGF, oxaliplatino, leucovorina y 5-FU, en donde el anticuerpo anti-PD.L1 comprende una región variable de cadena pesada y una región variable de cadena ligera, en donde: (a) la región variable de cadena pesada comprende una HVR-H1, HVR-H2 y HVR-H3, y en donde: (i) la HVR-H1 comprende la secuencia de aminoácidos de SEQ ID NO: 15; (ii) la HVR-H2 comprende la secuencia de aminoácidos de SEQ ID NO: 16; y (iii) la HVR-H3 comprende la secuencia de aminoácidos de SEQ ID NO: 3; (b) la región variable de cadena ligera comprende una HVR-L1, HVR-L2 y HVR-L3, y en donde: (iv) la HVR-L1 comprende la secuencia de aminoácidos de SEQ ID NO: 17; (v) la HVR-L2 comprende la secuencia de aminoácidos de SEQ ID NO: 18; y (vi) la HVR-L3 comprende la secuencia de aminoácidos de SEQ ID NO: 19, y donde el anticuerpo anti-VEGF comprende una región variable de cadena pesada y una región variable de cadena ligera, en donde: (a) la región variable de cadena pesada comprende una CDRH1, CDRH2 y CDRH3, y en donde: (i) la CDRH1 comprende la secuencia de aminoácidos de SEQ ID NO: 24; (ii) la CDRH2 comprende la secuencia de aminoácidos de SEQ ID NO: 25; y (iii) la CDRH3 comprende la secuencia de aminoácidos de SEQ ID NO: 26, (b) la región variable de cadena ligera comprende u na CDRL, CDRL2 y CDRL3, y en donde: (iv) la CDRL1 comprende la secuencia de aminoácidos de SEQ ID NO: 27; (v) la CDRL2 comprende la secuencia de aminoácidos de SEQ ID NO: 28; y (vi) la CDRL3 comprende la secuencia de aminoácidos de SEQ ID NO: 29.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261653861P | 2012-05-31 | 2012-05-31 | |
| PCT/US2013/043452 WO2013181452A1 (en) | 2012-05-31 | 2013-05-30 | Methods of treating cancer using pd-l1 axis binding antagonists and vegf antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014014485A MX2014014485A (es) | 2015-05-15 |
| MX363872B true MX363872B (es) | 2019-04-05 |
Family
ID=48626639
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014014485A MX363872B (es) | 2012-05-31 | 2013-05-30 | Anticuerpos anti-pd-l1 y antagonistas de vegf y su uso en el tratamiento del cáncer. |
| MX2019003942A MX2019003942A (es) | 2012-05-31 | 2014-11-27 | Anticuerpos anti-pd-l1 y antagonistas de vegf y su uso en el tratamiento del cancer. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019003942A MX2019003942A (es) | 2012-05-31 | 2014-11-27 | Anticuerpos anti-pd-l1 y antagonistas de vegf y su uso en el tratamiento del cancer. |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9895441B2 (es) |
| EP (2) | EP3556776A1 (es) |
| JP (3) | JP6312659B2 (es) |
| KR (2) | KR102129636B1 (es) |
| CN (1) | CN104271601B (es) |
| AR (1) | AR091220A1 (es) |
| AU (3) | AU2013267267B2 (es) |
| BR (1) | BR112014029887A8 (es) |
| CA (1) | CA2874144C (es) |
| ES (1) | ES2742379T3 (es) |
| HK (1) | HK1200857A1 (es) |
| IL (2) | IL235779B (es) |
| MX (2) | MX363872B (es) |
| MY (1) | MY186099A (es) |
| PL (1) | PL2855528T3 (es) |
| RU (1) | RU2689760C2 (es) |
| SG (2) | SG10201603055WA (es) |
| WO (1) | WO2013181452A1 (es) |
| ZA (1) | ZA201408852B (es) |
Families Citing this family (103)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| NZ717213A (en) | 2008-12-09 | 2017-10-27 | Genentech Inc | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| RS57704B1 (sr) | 2012-07-13 | 2018-12-31 | Roche Glycart Ag | Bispecifična anti-vegf/anti-ang-2 antitela i njihova primena u lečenju vaskularnih bolesti oka |
| JP6329170B2 (ja) | 2012-12-07 | 2018-05-23 | ケモセントリックス，インコーポレイティド | ジアゾールラクタム |
| CA2910278C (en) | 2013-05-02 | 2021-09-28 | Anaptysbio, Inc. | Antibodies directed against programmed death-1 (pd-1) |
| US10570204B2 (en) | 2013-09-26 | 2020-02-25 | The Medical College Of Wisconsin, Inc. | Methods for treating hematologic cancers |
| KR102256152B1 (ko) | 2013-12-12 | 2021-05-27 | 샹하이 헨그루이 파마수티컬 컴퍼니 리미티드 | Ｐｄ-1 항체, 이의 항원 결합 단편, 및 이의 의약 용도 |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗ｐｄ-ｌ１之人類抗體 |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| CN118286440A (zh) | 2014-02-04 | 2024-07-05 | 辉瑞大药厂 | 用于治疗癌症的pd-1拮抗剂和vegfr抑制剂的组合 |
| PE20161096A1 (es) | 2014-02-10 | 2016-10-22 | Merck Patent Gmbh | INHIBICION DIRIGIDA DEL FACTOR DE CRECIMIENTO TRANSFORMADOR ß (TGFß) |
| RU2016151757A (ru) * | 2014-05-29 | 2018-07-02 | Медиммьюн Лимитед | Антагонисты pdl-1 и pd-1 для лечения hpv-отрицательных форм рака |
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| US20170216403A1 (en) | 2014-08-12 | 2017-08-03 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2, a therapeutic antibody, and an immune checkpoint blocker |
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| ES2771926T3 (es) | 2014-09-13 | 2020-07-07 | Novartis Ag | Terapias de combinación |
| CN107428825A (zh) * | 2014-10-10 | 2017-12-01 | 创祐生技股份有限公司 | 治疗及/或预防肿瘤生长、侵袭及/或转移的方法 |
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| EP3227337A1 (en) * | 2014-12-05 | 2017-10-11 | F. Hoffmann-La Roche AG | Methods and compositions for treating cancer using pd-1 axis antagonists and hpk1 antagonists |
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| US10660954B2 (en) | 2015-07-31 | 2020-05-26 | University Of Florida Research Foundation, Incorporated | Hematopoietic stem cells in combinatorial therapy with immune checkpoint inhibitors against cancer |
| AR105654A1 (es) | 2015-08-24 | 2017-10-25 | Lilly Co Eli | Anticuerpos pd-l1 (ligando 1 de muerte celular programada) |
| IL298355A (en) * | 2015-09-25 | 2023-01-01 | Genentech Inc | Anti-tigit antibodies and methods of use |
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| GB201522311D0 (en) | 2015-12-17 | 2016-02-03 | Photocure Asa | Use |
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