MX359200B - Inhibidores de cinasa. - Google Patents

Inhibidores de cinasa.

Info

Publication number
MX359200B
MX359200B MX2014006724A MX2014006724A MX359200B MX 359200 B MX359200 B MX 359200B MX 2014006724 A MX2014006724 A MX 2014006724A MX 2014006724 A MX2014006724 A MX 2014006724A MX 359200 B MX359200 B MX 359200B
Authority
MX
Mexico
Prior art keywords
kinase inhibitors
formula
diseases
compounds
useful
Prior art date
Application number
MX2014006724A
Other languages
English (en)
Other versions
MX2014006724A (es
Inventor
Armani Elisabetta
Bodil Van Niel Monique
Charles Ray Nicholas
Alcaraz Lilian
Aaron Panchal Terry
Stephen Robert Jennings Andrew
Peter Cridland Andrew
Hurley Christopher
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47471708&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX359200(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of MX2014006724A publication Critical patent/MX2014006724A/es
Publication of MX359200B publication Critical patent/MX359200B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/02—Formic acid
    • C07C53/06—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline

Abstract

La presente invención se refiere a compuestos de Fórmula (I): (ver Fórmula) en donde R2, W, A, Y, y R1 tienen los valores definidos en la descripción, o una sal farmacéuticamente aceptable de los mismos; que son inhibidores de la MAPK p38, útiles como agentes antiinflamatorios en el tratamiento de enfermedades del tracto respiratorio, entre otras.
MX2014006724A 2011-12-09 2012-12-05 Inhibidores de cinasa. MX359200B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11192871 2011-12-09
EP12187931 2012-10-10
PCT/EP2012/074446 WO2013083604A1 (en) 2011-12-09 2012-12-05 Kinase inhibitors

Publications (2)

Publication Number Publication Date
MX2014006724A MX2014006724A (es) 2014-08-29
MX359200B true MX359200B (es) 2018-09-19

Family

ID=47471708

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014006724A MX359200B (es) 2011-12-09 2012-12-05 Inhibidores de cinasa.

Country Status (35)

Country Link
US (5) US8907094B2 (es)
EP (1) EP2788349B1 (es)
JP (1) JP6128449B2 (es)
KR (1) KR101994381B1 (es)
CN (3) CN105968110B (es)
AR (1) AR089189A1 (es)
AU (1) AU2012347350C1 (es)
BR (1) BR112014013760A2 (es)
CA (1) CA2858447C (es)
CL (1) CL2014001486A1 (es)
CO (1) CO6970602A2 (es)
CY (1) CY1118340T1 (es)
DK (1) DK2788349T3 (es)
EA (1) EA025268B1 (es)
ES (1) ES2612259T3 (es)
GE (1) GEP201706735B (es)
HK (2) HK1222647A1 (es)
HR (1) HRP20161714T1 (es)
HU (1) HUE029826T2 (es)
IL (1) IL232958A (es)
LT (1) LT2788349T (es)
ME (1) ME02624B (es)
MX (1) MX359200B (es)
MY (1) MY170656A (es)
PE (1) PE20141370A1 (es)
PH (1) PH12014501277B1 (es)
PL (1) PL2788349T3 (es)
PT (1) PT2788349T (es)
RS (1) RS55602B1 (es)
SG (1) SG11201402985VA (es)
SI (1) SI2788349T1 (es)
TW (1) TWI618703B (es)
UA (1) UA115320C2 (es)
WO (1) WO2013083604A1 (es)
ZA (1) ZA201404156B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201604656YA (en) 2011-12-09 2016-07-28 Chiesi Farma Spa Kinase inhibitors
CN103987708B (zh) * 2011-12-09 2016-06-22 奇斯药制品公司 4-羟基-1,2,3,4-四氢萘-1-基脲的衍生物及其在呼吸道疾病治疗中的用途
UA115320C2 (uk) * 2011-12-09 2017-10-25 К'Єзі Фармачеутічі С.П.А. Інгібітори кінази
GB201214750D0 (en) 2012-08-17 2012-10-03 Respivert Ltd Compounds
WO2014033449A1 (en) 2012-08-29 2014-03-06 Respivert Limited Kinase inhibitors
US20150210722A1 (en) 2012-08-29 2015-07-30 Respivert Limited Kinase inhibitors
EP2890695A2 (en) 2012-08-29 2015-07-08 Respivert Limited Kinase inhibitors
US9732063B2 (en) 2012-11-16 2017-08-15 Respivert Limited Kinase inhibitors
US20160016934A1 (en) 2013-03-14 2016-01-21 Respivert Limited Kinase inhibitors
CA2907663A1 (en) 2013-04-02 2014-10-09 Respivert Limited Urea derivatives useful as kinase inhibitors
US9771353B2 (en) 2013-04-02 2017-09-26 Topivert Pharma Limited Kinase inhibitors based upon N-alkyl pyrazoles
EP3004098B1 (en) * 2013-06-06 2017-08-09 Chiesi Farmaceutici S.p.A. Kinase inhibitors
EP3004097B1 (en) 2013-06-06 2018-01-17 Chiesi Farmaceutici S.p.A. Kinase inhibitors
CA2914457A1 (en) 2013-06-06 2014-12-11 Chiesi Farmaceutici S.P.A. Kinase inhibitors
EP2818471A1 (en) * 2013-06-27 2014-12-31 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Nitrogen bicyclic compounds as inhibitors for Scyl1 and Grk5
JP6514703B2 (ja) 2013-12-20 2019-05-15 トピバート ファーマ リミテッド キナーゼインヒビターとして有用な尿素誘導体
DK3105222T3 (en) 2014-02-14 2018-07-23 Respivert Ltd AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY COMPOUNDS
MA40775A (fr) 2014-10-01 2017-08-08 Respivert Ltd Dérivé d'acide 4-(4-(4-phényluréido-naphtalén -1-yl) oxy-pyridin-2-yl) amino-benzoïque utilisé en tant qu'inhibiteur de la kinase p38
US10206949B2 (en) 2015-09-21 2019-02-19 Ofer Agam Composition that relieves heartburn, GERD and hangovers
AR107164A1 (es) 2015-12-23 2018-03-28 Chiesi Farm Spa INHIBIDORES DE QUINASA p38
AR107163A1 (es) 2015-12-23 2018-03-28 Chiesi Farm Spa Inhibidores de quinasa
EP3394059B1 (en) 2015-12-23 2020-11-25 Chiesi Farmaceutici S.p.A. 1-(3-tert-butyl-phenyl)-3-(4-([1,2,4]triazolo[4,3-a]pyridin-6-yloxy)-1,2,3,4-tetrahydro- naphthalen-1-yl)-urea derivatives and their use as p38 mapk inhibitors
WO2017174995A1 (en) 2016-04-06 2017-10-12 Respivert Limited Kinase inhibitors
US10364245B2 (en) 2017-06-07 2019-07-30 Chiesi Farmaceutici S.P.A. Kinase inhibitors
MX2020003594A (es) 2017-10-05 2021-04-07 Fulcrum Therapeutics Inc Inhibidores de la quinasa p38 que reducen la expresión de dux4 y de los genes corriente abajo para el tratamiento de fshd.
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
CN108424372B (zh) * 2018-05-11 2021-08-10 浙江华贝药业有限责任公司 2，2，2-三氟-n-[(s)-4-羰基四氢萘-1-基]-乙酰胺的纯化工艺
CN108707086B (zh) * 2018-05-15 2021-08-10 浙江华贝药业有限责任公司 一种(1s，4s)-n-（4-羟基四氢萘-1-基）叔丁氧基碳酰胺的纯化工艺
AR116628A1 (es) 2018-10-18 2021-05-26 Syngenta Crop Protection Ag Compuestos microbiocidas
CA3169012A1 (en) 2020-03-05 2021-09-10 Syngenta Crop Protection Ag Fungicidal compositions
CN112174870B (zh) * 2020-10-12 2023-07-21 蔡霈 (r)-1-烷烃酰基-2-取代吡咯烷-2-甲酰胺的制备方法及其药用用途

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
US5756533A (en) 1995-03-10 1998-05-26 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6034057A (en) 1995-07-06 2000-03-07 Zeneca Limited Peptide inhibitors of fibronectine
US6248713B1 (en) 1995-07-11 2001-06-19 Biogen, Inc. Cell adhesion inhibitors
YU25500A (sh) 1999-05-11 2003-08-29 Pfizer Products Inc. Postupak za sintezu analoga nukleozida
GB0028383D0 (en) 2000-11-21 2001-01-03 Novartis Ag Organic compounds
EP1241176A1 (en) 2001-03-16 2002-09-18 Pfizer Products Inc. Purine derivatives for the treatment of ischemia
WO2002083628A1 (en) * 2001-04-13 2002-10-24 Boehringer Ingelheim Pharmaceuticals, Inc. 1,4-disubstituted benzo-fused compounds
US7199136B2 (en) 2001-12-20 2007-04-03 Bayer Healthcare Ag 1,4-dihydro-1,4-diphenylpyridine derivatives
WO2004014870A1 (en) * 2002-08-08 2004-02-19 Boehringer Ingelheim Pharmaceuticals, Inc. Fluorinated phenyl-naphthalenyl-urea compounds as inhibitors of cytokines involved in inflammatory processes
JP2006517580A (ja) 2003-02-14 2006-07-27 ファイザー・プロダクツ・インク 抗炎症化合物としてのトリアゾロピリジン
SE0302487D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
MXPA06012613A (es) * 2004-05-07 2007-01-31 Amgen Inc Derivados heterociclicos nitrogenados como moduladores de proteina cinasa y uso para el tratamiento de angiogenesis y cancer.
EP1609789A1 (en) 2004-06-23 2005-12-28 Eli Lilly And Company Ureido-pyrazole derivatives and their use as kinase inhibitors
PL1761520T3 (pl) 2004-06-23 2008-12-31 Lilly Co Eli Inhibitory kinazy
GB0418015D0 (en) * 2004-08-12 2004-09-15 Pfizer Ltd New compounds
PT1778686E (pt) 2004-08-12 2008-12-26 Pfizer Derivados de triazolopiridinilsufanilo como inibidores da p38 map-cinase
EP1781655A2 (en) 2004-08-18 2007-05-09 Pharmacia & Upjohn Company LLC Triazolopyridine compounds useful for the treatment of inflammation
GB0502258D0 (en) 2005-02-03 2005-03-09 Argenta Discovery Ltd Compounds and their use
CA2610509A1 (en) 2005-06-03 2006-12-14 Bayer Healthcare Ag 1-methyl-1h-pyrazole-4-carboxamides useful as cancer chemotherapeutic agents
EP1984363A1 (en) * 2006-02-09 2008-10-29 Pfizer Limited Triazolopyridine compounds
CN101146029B (zh) * 2006-09-13 2011-12-28 华为技术有限公司 一种分组重排序方法和系统
US8188113B2 (en) 2006-09-14 2012-05-29 Deciphera Pharmaceuticals, Inc. Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
CL2007002867A1 (es) 2006-10-04 2008-06-27 Pharmacopeia Inc Compuestos derivados de 2-(bencimidazolil)purina, inhibidores de janus quinasa 3; composicion farmaceutica que los contiene; y su uso para tratar enfermedades autoinmune, inflamatorias, cardiovasculares, rechazo de implante, entre otras.
WO2008063287A2 (en) 2006-10-06 2008-05-29 Abbott Laboratories Novel imidazothiazoles and imidazoxazoles
WO2008125014A1 (fr) 2007-04-13 2008-10-23 Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. Composés d'urée, leurs procédés de préparation et leurs utilisations pharmaceutiques
US8202899B2 (en) 2007-07-25 2012-06-19 Array Biopharma Inc. Pyrazole urea derivatives used as kinase inhibitors
US20110207729A1 (en) 2007-08-10 2011-08-25 Astellas Pharma Inc. Bicyclic acylguanidine derivative
TWI496779B (zh) 2008-08-19 2015-08-21 Array Biopharma Inc 作為ｐｉｍ激酶抑制劑之三唑吡啶化合物
NZ593460A (en) 2008-12-08 2013-11-29 Gilead Connecticut Inc Imidazopyrazine syk inhibitors
CN102333770B (zh) * 2008-12-11 2015-01-28 瑞斯比维特有限公司 P38map激酶抑制剂
WO2010077836A2 (en) 2009-01-05 2010-07-08 Boehringer Ingelheim International Gmbh Pyrrolidine compounds which modulate the cb2 receptor
SG174134A1 (en) 2009-02-17 2011-10-28 Chiesi Farma Spa Triazolopyridine derivatives as p38 map kinase inhibitors
WO2010108058A2 (en) 2009-03-20 2010-09-23 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Small molecule inhibitors of dusp6 and uses therefor
US8721380B2 (en) 2009-08-12 2014-05-13 Konica Minolta Holdings, Inc. Method for manufacturing display panel
EP2308866A1 (de) 2009-10-09 2011-04-13 Bayer CropScience AG Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
GB0921731D0 (en) 2009-12-11 2010-01-27 Respivert Ltd Theraputic uses
GB201005589D0 (en) * 2010-04-01 2010-05-19 Respivert Ltd Novel compounds
WO2011124930A1 (en) * 2010-04-08 2011-10-13 Respivert Limited P38 map kinase inhibitors
GB201009731D0 (en) * 2010-06-10 2010-07-21 Pulmagen Therapeutics Inflamma Kinase inhibitors
SG10201604656YA (en) 2011-12-09 2016-07-28 Chiesi Farma Spa Kinase inhibitors
UA115320C2 (uk) 2011-12-09 2017-10-25 К'Єзі Фармачеутічі С.П.А. Інгібітори кінази
CN103987708B (zh) 2011-12-09 2016-06-22 奇斯药制品公司 4-羟基-1,2,3,4-四氢萘-1-基脲的衍生物及其在呼吸道疾病治疗中的用途
EP3004097B1 (en) 2013-06-06 2018-01-17 Chiesi Farmaceutici S.p.A. Kinase inhibitors
CA2914457A1 (en) 2013-06-06 2014-12-11 Chiesi Farmaceutici S.P.A. Kinase inhibitors
EP3004098B1 (en) 2013-06-06 2017-08-09 Chiesi Farmaceutici S.p.A. Kinase inhibitors

Also Published As

Publication number Publication date
CN105503861A (zh) 2016-04-20
MX2014006724A (es) 2014-08-29
AU2012347350C1 (en) 2017-01-19
TWI618703B (zh) 2018-03-21
IL232958A0 (en) 2014-08-03
HRP20161714T1 (hr) 2017-02-10
US8907094B2 (en) 2014-12-09
US20150080375A1 (en) 2015-03-19
AU2012347350A1 (en) 2014-07-03
HK1200828A1 (en) 2015-08-14
GEP201706735B (en) 2017-09-25
AR089189A1 (es) 2014-08-06
MY170656A (en) 2019-08-24
CL2014001486A1 (es) 2014-11-14
PH12014501277A1 (en) 2014-09-08
US9139584B2 (en) 2015-09-22
ZA201404156B (en) 2016-07-27
UA115320C2 (uk) 2017-10-25
US9145413B2 (en) 2015-09-29
PH12014501277B1 (en) 2014-09-08
CY1118340T1 (el) 2017-06-28
SI2788349T1 (sl) 2017-01-31
US20130150343A1 (en) 2013-06-13
CN104039787A (zh) 2014-09-10
KR20140105516A (ko) 2014-09-01
EA025268B1 (ru) 2016-12-30
AU2012347350B2 (en) 2016-09-08
DK2788349T3 (en) 2017-01-30
KR101994381B1 (ko) 2019-06-28
CA2858447C (en) 2020-10-27
ME02624B (me) 2017-06-20
PL2788349T3 (pl) 2017-04-28
CN104039787B (zh) 2016-06-29
PT2788349T (pt) 2017-02-02
NZ625965A (en) 2016-08-26
TW201336833A (zh) 2013-09-16
ES2612259T3 (es) 2017-05-16
HK1222647A1 (zh) 2017-07-07
CN105968110A (zh) 2016-09-28
EP2788349B1 (en) 2016-10-26
CA2858447A1 (en) 2013-06-13
CN105968110B (zh) 2018-04-27
SG11201402985VA (en) 2014-08-28
WO2013083604A1 (en) 2013-06-13
US20140323470A1 (en) 2014-10-30
US9527846B2 (en) 2016-12-27
LT2788349T (lt) 2016-12-27
US20160229852A1 (en) 2016-08-11
HUE029826T2 (en) 2017-04-28
RS55602B1 (sr) 2017-06-30
BR112014013760A2 (pt) 2017-06-13
JP2015500260A (ja) 2015-01-05
US20150344475A1 (en) 2015-12-03
EA201490949A1 (ru) 2014-11-28
IL232958A (en) 2017-08-31
CO6970602A2 (es) 2014-06-13
CN105503861B (zh) 2017-08-01
EP2788349A1 (en) 2014-10-15
US9315503B2 (en) 2016-04-19
JP6128449B2 (ja) 2017-05-17
PE20141370A1 (es) 2014-10-17

Similar Documents

Publication Publication Date Title
PH12014501277A1 (en) Kinase inhibitors
PH12014501278A1 (en) Kinase inhibitors
PH12015502628B1 (en) Pyrazolopyrrolidine derivatives and their use in the treatment of disease
MX345928B (es) Composiciones terapeuticamente activas y metodos de uso de las mismas.
SA515360469B1 (ar) مركبات حلقية غير متجانسة لتثبيط إنزيم جلوتاميناز والطرق الخاصة باستخدامها
UA111382C2 (uk) Інгібітори протеїнкінази
MX2015016344A (es) Derivados de imidazo-pirrolidinona y su uso en el tratamiento de enfermedades.
AU2012214029A8 (en) Rorgammat inhibitors
EA201792116A1 (ru) Ингибитор янус-киназы
MY184306A (en) Compounds for the treatment and prophylaxis of respiratory syncytial virus disease
JO2885B1 (en) Protein kinase inhibitors
MX2014001595A (es) Compuestos de imidazol, composiciones y metodos de uso.
SG178591A1 (en) Jak2 inhibitors and their use for the treatment of myeloproliferative diseases and cancer
MX2015016421A (es) Derivados de pirazolo-pirrolidin-4-ona como inhibidores de bet y su uso en el tratamiento de enfermedades.
JO3115B1 (ar) مركبات بيريدازينون واستخدامها كمثبطات daao
EA201400521A1 (ru) Гетероциклические соединения, лекарственные средства, содержащие указанные соединения, их применение и способы их получения
MX2015016425A (es) Derivados de pirazolo-pirrolidin-4-ona y su uso en el tratamiento de enfermedades.
GB201209587D0 (en) Therapeutic compounds
MX2015013414A (es) N-(2-ciano heterociclil)pirazolo piridonas como inhibidores de janus quinasa.
MX2014003701A (es) Compuestos para el tratamiento y profilaxis de enfermedad por el virus sincitial respiratorio.
TN2014000218A1 (en) Kinase inhibitors
TN2014000077A1 (en) Pyridazinone compounds and their use as daao inhibitors
TH131154B (th) อนุพันธ์ยูเรียซึ่งเป็นสารยับยั้งไคเนสและการใช้อนุพันธ์ดังกล่าวทางการบำบัด
UA110849C2 (uk) Сполуки для лікування та профілактики респіраторного синцитіального вірусного захворювання
TH131154A (th) อนุพันธ์ยูเรียซึ่งเป็นสารยับยั้งไคเนสและการใช้อนุพันธ์ดังกล่าวทางการบำบัด

Legal Events

Date Code Title Description
FG Grant or registration