MX2021008479A - Enzimas dependientes de aril sulfato modificadas por ingenieria genetica. - Google Patents
Enzimas dependientes de aril sulfato modificadas por ingenieria genetica.Info
- Publication number
- MX2021008479A MX2021008479A MX2021008479A MX2021008479A MX2021008479A MX 2021008479 A MX2021008479 A MX 2021008479A MX 2021008479 A MX2021008479 A MX 2021008479A MX 2021008479 A MX2021008479 A MX 2021008479A MX 2021008479 A MX2021008479 A MX 2021008479A
- Authority
- MX
- Mexico
- Prior art keywords
- engineered
- sulfotransferase
- activity
- glucosaminyl
- heparosan
- Prior art date
Links
- CTYRPMDGLDAWRQ-UHFFFAOYSA-N phenyl hydrogen sulfate Chemical compound OS(=O)(=O)OC1=CC=CC=C1 CTYRPMDGLDAWRQ-UHFFFAOYSA-N 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 230000001419 dependent effect Effects 0.000 title 1
- 102000004896 Sulfotransferases Human genes 0.000 abstract 7
- 108090001033 Sulfotransferases Proteins 0.000 abstract 7
- 230000000694 effects Effects 0.000 abstract 4
- 150000004676 glycans Chemical class 0.000 abstract 4
- 229920001282 polysaccharide Polymers 0.000 abstract 4
- 239000005017 polysaccharide Substances 0.000 abstract 4
- 125000002566 glucosaminyl group Chemical group 0.000 abstract 3
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 3
- GACDQMDRPRGCTN-KQYNXXCUSA-N 3'-phospho-5'-adenylyl sulfate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](OP(O)(O)=O)[C@H]1O GACDQMDRPRGCTN-KQYNXXCUSA-N 0.000 abstract 1
- 229920002971 Heparan sulfate Polymers 0.000 abstract 1
- 239000000370 acceptor Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- -1 heparan sulfate Chemical class 0.000 abstract 1
- 239000006225 natural substrate Substances 0.000 abstract 1
- 230000014508 negative regulation of coagulation Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/64—Preparation of S-glycosides, e.g. lincomycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y208/00—Transferases transferring sulfur-containing groups (2.8)
- C12Y208/02—Sulfotransferases (2.8.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y208/00—Transferases transferring sulfur-containing groups (2.8)
- C12Y208/02—Sulfotransferases (2.8.2)
- C12Y208/02008—[Heparan sulfate]-glucosamine N-sulfotransferase (2.8.2.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y208/00—Transferases transferring sulfur-containing groups (2.8)
- C12Y208/02—Sulfotransferases (2.8.2)
- C12Y208/02023—[Heparan sulfate]-glucosamine 3-sulfotransferase 1 (2.8.2.23)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962792440P | 2019-01-15 | 2019-01-15 | |
| US201962797466P | 2019-01-28 | 2019-01-28 | |
| US201962808074P | 2019-02-20 | 2019-02-20 | |
| US201962853261P | 2019-05-28 | 2019-05-28 | |
| PCT/US2020/013677 WO2020150350A1 (en) | 2019-01-15 | 2020-01-15 | Engineered aryl sulfate-dependent enzymes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021008479A true MX2021008479A (es) | 2021-10-13 |
Family
ID=69529057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021008479A MX2021008479A (es) | 2019-01-15 | 2020-01-15 | Enzimas dependientes de aril sulfato modificadas por ingenieria genetica. |
Country Status (10)
| Country | Link |
|---|---|
| US (9) | US11692180B2 (https=) |
| EP (1) | EP3911737A1 (https=) |
| JP (1) | JP2022523638A (https=) |
| KR (1) | KR20210126019A (https=) |
| CN (1) | CN113646427A (https=) |
| AU (1) | AU2020209822A1 (https=) |
| BR (1) | BR112021013890A2 (https=) |
| CA (1) | CA3126805A1 (https=) |
| MX (1) | MX2021008479A (https=) |
| WO (1) | WO2020150350A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113646427A (zh) * | 2019-01-15 | 2021-11-12 | 奥普蒂姆维亚有限公司 | 工程化芳基硫酸酯依赖性酶 |
| WO2022015794A1 (en) | 2020-07-14 | 2022-01-20 | Optimvia, Llc | Methods for synthesizing non-anticoagulant heparan sulfate |
| CA3144968A1 (en) * | 2019-07-09 | 2021-01-14 | Optimvia Llc | Methods for synthesizing anticoagulant polysaccharides |
| CN114763570B (zh) * | 2021-09-10 | 2024-02-27 | 江南大学 | 制备不同分子量肝素的磺酸化修饰体系构建及其应用 |
| CN117467632B (zh) * | 2022-07-27 | 2024-09-24 | 江南大学 | 一种肝素n-磺基转移酶突变体构建方法 |
| CN115975040B (zh) * | 2022-07-28 | 2026-02-27 | 重庆东渝中能实业有限公司 | 埃氏拟杆菌肝素酶i融合蛋白及其编码基因和制备方法 |
| CN119662591B (zh) * | 2025-01-20 | 2025-11-04 | 江南大学 | 一种肝素2-o-磺基转移酶高活性突变体的构建方法 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US5541095A (en) | 1992-06-16 | 1996-07-30 | University Of Massachusetts Medical Center | Glycosaminoglycan specific sulfotransferases |
| JP3818676B2 (ja) | 1994-07-22 | 2006-09-06 | 生化学工業株式会社 | ヘパラン硫酸６−ｏ−硫酸基転移酵素 |
| US5919673A (en) | 1995-03-22 | 1999-07-06 | The Scripps Research Institute | One-pot enzymatic sulfation process using 3'-phosphoadenosine-5'-phosphosulfate and recycled phosphorylated adenosine intermediates |
| JP3672359B2 (ja) | 1995-07-24 | 2005-07-20 | 生化学工業株式会社 | ヘパラン硫酸 ２−ｏ−硫酸基転移酵素 |
| JP3964982B2 (ja) | 1997-06-19 | 2007-08-22 | 生化学工業株式会社 | ヘパラン硫酸６−ｏ硫酸基転移酵素のポリペプチド及びそれをコードするｄｎａ |
| AU1199799A (en) * | 1997-10-24 | 1999-05-17 | Massachusetts Institute Of Technology | Heparan sulfate d-glucosaminyl 3-(o)-sulfotransferases, an uses therefor |
| US6861254B1 (en) | 1997-10-24 | 2005-03-01 | Massachusetts Institute Of Technology | Heparan sulfate D-glucosaminyl 3-O-sulfotransferases, and uses therefor |
| US7307159B2 (en) | 2001-05-08 | 2007-12-11 | The Board Of Regents Of The University Of Oklahoma | Heparin/heparosan synthase from P. multocida and methods of making and using same |
| US20060188966A1 (en) | 1998-04-02 | 2006-08-24 | Deangelis Paul L | Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same |
| US8088604B2 (en) | 1998-04-02 | 2012-01-03 | The Board Of Regents Of The University Of Oklahoma | Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases |
| DE69934890D1 (de) | 1998-06-16 | 2007-03-08 | Univ Oklahoma | Glykosulfopeptide und verfahren zu deren herstellung und deren verwendung |
| US6255088B1 (en) | 1999-05-11 | 2001-07-03 | The Scripps Research Institute | Enzymatic sulfation of biomolecules |
| DE10002005A1 (de) | 2000-01-19 | 2001-08-09 | Bosch Gmbh Robert | Zerstäubungsdüse |
| ITMI20010397A1 (it) | 2001-02-27 | 2002-08-27 | Giorgio Zoppetti | Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione |
| US8067196B2 (en) | 2001-03-28 | 2011-11-29 | Massachusetts Institute Of Technology | 6-O sulfated polysaccharides and methods of preparation thereof |
| US8580290B2 (en) | 2001-05-08 | 2013-11-12 | The Board Of Regents Of The University Of Oklahoma | Heparosan-based biomaterials and coatings and methods of production and use thereof |
| WO2004005475A2 (en) | 2002-07-05 | 2004-01-15 | University Of North Carolina At Chapel Hill | Purified and isolated heparan sulfate 3-o-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same |
| US20040147469A1 (en) | 2002-11-01 | 2004-07-29 | Case Western Reserve University | Methods of inhibiting glial scar formation |
| AU2003293122A1 (en) | 2002-11-27 | 2004-06-23 | Massachusetts Institute Of Technology | Methods for synthesizing polysaccharides |
| US7655445B2 (en) * | 2003-11-12 | 2010-02-02 | Massachusetts Institute Of Technology | Methods for synthesis of sulfated saccharides |
| WO2006023487A2 (en) | 2004-08-16 | 2006-03-02 | Massachusetts Institute Of Technology | Rapid two-step synthesis of anti-coagulants |
| US20060154894A1 (en) | 2004-09-15 | 2006-07-13 | Massachusetts Institute Of Technology | Biologically active surfaces and methods of their use |
| CA2594013A1 (en) | 2005-01-12 | 2006-07-20 | Massachusetts Institute Of Technology | Methods and compositions related to modulating the extracellular stem cell environment |
| WO2006124801A2 (en) * | 2005-05-12 | 2006-11-23 | The University Of North Carolina At Chapel Hill | Enzymatic synthesis of sulfated polysaccharides |
| BRPI0612687B1 (pt) | 2005-07-05 | 2019-05-14 | Huawei Technologies Co., Ltd. | Método de autenticação em subsistema multimídia ip |
| WO2009014715A2 (en) | 2007-07-23 | 2009-01-29 | The University Of North Carolina At Chapel Hill | Enzymatic synthesis of sulfated polysaccharides without iduronic acid residues |
| WO2010003023A2 (en) | 2008-07-01 | 2010-01-07 | Zacharon Pharmaceuticals, Inc. | Heparan sulfate inhibitors |
| CN101724086B (zh) | 2009-11-25 | 2012-09-26 | 深圳海王药业有限公司 | 低聚凤梨参糖胺聚糖及其制备方法 |
| US11203772B2 (en) | 2010-12-23 | 2021-12-21 | The University Of North Carolina At Chapel Hill | Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins |
| TW201309305A (zh) | 2011-02-22 | 2013-03-01 | Rensselaer Polytech Inst | 用於製造生物工程肝素之單一步驟肝素前體之ｎ－去乙醯化作用及解聚合作用 |
| US8815529B2 (en) | 2011-05-23 | 2014-08-26 | Research & Diagnostics Systems, Inc. | Sulfotransferase assay |
| CA2869128C (en) | 2012-03-30 | 2022-07-26 | The Board Of Regents Of The University Of Oklahoma | High molecular weight heparosan polymers and methods of production and use thereof |
| US20140349962A1 (en) | 2013-05-24 | 2014-11-27 | Massachusetts Institute Of Technology | Rapid two-step synthesis of anti-coagulants |
| ES2924830T3 (es) | 2013-06-17 | 2022-10-11 | Univ North Carolina Chapel Hill | Moléculas de heparina reversibles |
| HUE047658T2 (hu) | 2014-08-22 | 2020-05-28 | Cysbio Aps | Biológiai eljárás szulfatált fenolvegyület elõállítására |
| JP6879216B2 (ja) | 2015-12-28 | 2021-06-02 | 味の素株式会社 | 抗凝固活性を有するヘパラン硫酸の製造法 |
| EP3420095A1 (en) | 2016-02-24 | 2019-01-02 | Danmarks Tekniske Universitet | Improved biological processes for the production of aryl sulfates |
| TWI769176B (zh) | 2016-09-07 | 2022-07-01 | 瑞瑟勒綜合技術協會 | 生合成肝素 |
| CN110191958B (zh) | 2017-01-19 | 2024-06-25 | 味之素株式会社 | 生产具有经异构化的己糖醛酸残基的肝素前体化合物的方法 |
| CN110446511B (zh) | 2017-03-10 | 2024-04-02 | 北卡罗来纳大学查珀尔希尔分校 | 短效的基于肝素的抗凝血剂化合物和方法 |
| CN117417912A (zh) | 2017-09-05 | 2024-01-19 | 味之素株式会社 | 2-o-硫酸化酶突变体和3-o-硫酸化酶突变体及其使用方法 |
| CN113646427A (zh) * | 2019-01-15 | 2021-11-12 | 奥普蒂姆维亚有限公司 | 工程化芳基硫酸酯依赖性酶 |
| US11708593B2 (en) * | 2019-01-15 | 2023-07-25 | Optimvia, Llc | Engineered aryl sulfate-dependent enzymes |
-
2020
- 2020-01-15 CN CN202080021311.XA patent/CN113646427A/zh active Pending
- 2020-01-15 JP JP2021541244A patent/JP2022523638A/ja active Pending
- 2020-01-15 KR KR1020217025890A patent/KR20210126019A/ko not_active Withdrawn
- 2020-01-15 MX MX2021008479A patent/MX2021008479A/es unknown
- 2020-01-15 WO PCT/US2020/013677 patent/WO2020150350A1/en not_active Ceased
- 2020-01-15 BR BR112021013890-0A patent/BR112021013890A2/pt not_active IP Right Cessation
- 2020-01-15 AU AU2020209822A patent/AU2020209822A1/en not_active Abandoned
- 2020-01-15 EP EP20704737.4A patent/EP3911737A1/en not_active Withdrawn
- 2020-01-15 CA CA3126805A patent/CA3126805A1/en active Pending
-
2021
- 2021-07-15 US US17/376,341 patent/US11692180B2/en active Active
- 2021-07-15 US US17/376,322 patent/US11572549B2/en active Active
- 2021-07-15 US US17/376,335 patent/US11473068B2/en active Active
- 2021-07-15 US US17/376,332 patent/US11572550B2/en active Active
-
2022
- 2022-08-24 US US17/894,933 patent/US11708567B2/en active Active
- 2022-08-24 US US17/894,932 patent/US11767518B2/en active Active
- 2022-08-24 US US17/894,929 patent/US11773382B2/en active Active
-
2023
- 2023-07-24 US US18/225,213 patent/US20240002819A1/en not_active Abandoned
- 2023-09-25 US US18/473,809 patent/US20240093166A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20220340888A9 (en) | 2022-10-27 |
| US11572549B2 (en) | 2023-02-07 |
| US11692180B2 (en) | 2023-07-04 |
| AU2020209822A1 (en) | 2021-09-09 |
| US11773382B2 (en) | 2023-10-03 |
| US20220042062A1 (en) | 2022-02-10 |
| US20210363503A1 (en) | 2021-11-25 |
| CA3126805A1 (en) | 2020-07-23 |
| US20240002819A1 (en) | 2024-01-04 |
| BR112021013890A2 (pt) | 2021-09-21 |
| US20230029317A1 (en) | 2023-01-26 |
| CN113646427A (zh) | 2021-11-12 |
| US11473068B2 (en) | 2022-10-18 |
| US20240093166A1 (en) | 2024-03-21 |
| US20230051957A1 (en) | 2023-02-16 |
| US11572550B2 (en) | 2023-02-07 |
| US20210363505A1 (en) | 2021-11-25 |
| JP2022523638A (ja) | 2022-04-26 |
| EP3911737A1 (en) | 2021-11-24 |
| US11767518B2 (en) | 2023-09-26 |
| US20210363504A1 (en) | 2021-11-25 |
| KR20210126019A (ko) | 2021-10-19 |
| WO2020150350A1 (en) | 2020-07-23 |
| US20230092183A1 (en) | 2023-03-23 |
| US11708567B2 (en) | 2023-07-25 |
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