MX2019002301A - Nueva sal de (r)-(1-metilpirrolidin-3-il) metil (3'-chloro-4'-fluoro- [1,1'-bifenil]-2-il) carbamato y una forma cristalina del misma. - Google Patents

Nueva sal de (r)-(1-metilpirrolidin-3-il) metil (3'-chloro-4'-fluoro- [1,1'-bifenil]-2-il) carbamato y una forma cristalina del misma.

Info

Publication number
MX2019002301A
MX2019002301A MX2019002301A MX2019002301A MX2019002301A MX 2019002301 A MX2019002301 A MX 2019002301A MX 2019002301 A MX2019002301 A MX 2019002301A MX 2019002301 A MX2019002301 A MX 2019002301A MX 2019002301 A MX2019002301 A MX 2019002301A
Authority
MX
Mexico
Prior art keywords
methylpyrrolidin
carbamate
chloro
methyl
crystal form
Prior art date
Application number
MX2019002301A
Other languages
English (en)
Inventor
Young Kwak Woo
- Yong Shin Chang
Reddy Ullapu Punna
- Ho CHOI Sun
- Jung Lee Min
- Su Kim Ji
Original Assignee
Dong A St Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dong A St Co Ltd filed Critical Dong A St Co Ltd
Publication of MX2019002301A publication Critical patent/MX2019002301A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La presente invención se refiere a una nueva sal de (R)-(1-metilpirrolidin- 3-il)metil(3'-cloro-4'-fluoro-[1,1'-bifeni l]-2-il)carbamato y a una forma cristalina de la misma. Además, la nueva sal de (R)-(1-metilpirrolidin-3-il)metil(3'-cloro-4'-fluo ro- [1,1'-bifenil]-2-il)carbamato y la forma cristalina de la misma, de acuerdo con los ejemplos de la presente invención, tienen una muy excelente estabilidad, higroscopicidad y solubilidad.
MX2019002301A 2016-08-26 2016-08-26 Nueva sal de (r)-(1-metilpirrolidin-3-il) metil (3'-chloro-4'-fluoro- [1,1'-bifenil]-2-il) carbamato y una forma cristalina del misma. MX2019002301A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/KR2016/009558 WO2018038297A1 (ko) 2016-08-26 2016-08-26 (r)-(1-메틸피롤리딘-3-일)메틸(3'-클로로-4'-플루오로-[1,1'-비페닐]-2-일)카바메이트의 신규염 및 이의 결정형

Publications (1)

Publication Number Publication Date
MX2019002301A true MX2019002301A (es) 2019-12-11

Family

ID=61245026

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019002301A MX2019002301A (es) 2016-08-26 2016-08-26 Nueva sal de (r)-(1-metilpirrolidin-3-il) metil (3'-chloro-4'-fluoro- [1,1'-bifenil]-2-il) carbamato y una forma cristalina del misma.

Country Status (10)

Country Link
US (1) US10894768B2 (es)
AU (1) AU2016420300B2 (es)
BR (1) BR112019003949B1 (es)
CA (1) CA3034535C (es)
CO (1) CO2019001740A2 (es)
MX (1) MX2019002301A (es)
PH (1) PH12019500380A1 (es)
SG (1) SG11201901431PA (es)
UA (1) UA124156C2 (es)
WO (1) WO2018038297A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102611847B1 (ko) * 2023-03-27 2023-12-12 주식회사 이플라스크 무스카린 수용체 길항 활성을 갖는 신규한 피롤리디늄 화합물 및 이의 용도

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0747355A4 (en) 1994-02-10 1997-04-09 Yamanouchi Pharma Co Ltd NEW CARBAMATES AND MEDICINAL PRODUCTS CONTAINING THEM
TW200534855A (en) * 2004-01-13 2005-11-01 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
EP2119716A4 (en) * 2007-02-09 2011-06-01 Astellas Pharma Inc AZA BRIDGE CYCLE COMPOUND
EP2701699B1 (en) 2011-04-28 2019-10-16 The Broad Institute, Inc. Inhibitors of histone deacetylase
KR101538846B1 (ko) * 2013-07-30 2015-07-22 동아에스티 주식회사 신규한 바이페닐 유도체 및 그의 제조방법

Also Published As

Publication number Publication date
CA3034535A1 (en) 2018-03-01
WO2018038297A1 (ko) 2018-03-01
CA3034535C (en) 2021-07-06
US10894768B2 (en) 2021-01-19
SG11201901431PA (en) 2019-03-28
BR112019003949A2 (pt) 2019-05-21
CO2019001740A2 (es) 2019-03-29
PH12019500380A1 (en) 2019-11-25
UA124156C2 (uk) 2021-07-28
BR112019003949B1 (pt) 2023-12-12
AU2016420300B2 (en) 2019-11-21
AU2016420300A1 (en) 2019-03-14
US20190194129A1 (en) 2019-06-27

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