MX2017007638A - Regimen de dosificacion para un agonista selectivo de receptor s1p1. - Google Patents

Regimen de dosificacion para un agonista selectivo de receptor s1p1.

Info

Publication number
MX2017007638A
MX2017007638A MX2017007638A MX2017007638A MX2017007638A MX 2017007638 A MX2017007638 A MX 2017007638A MX 2017007638 A MX2017007638 A MX 2017007638A MX 2017007638 A MX2017007638 A MX 2017007638A MX 2017007638 A MX2017007638 A MX 2017007638A
Authority
MX
Mexico
Prior art keywords
dosing regimen
selective
receptor agonist
propylimino
thiazolidin
Prior art date
Application number
MX2017007638A
Other languages
English (en)
Inventor
Dingemanse Jasper
Hoch Matthias
Krause Andreas
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54843844&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017007638(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MX2017007638A publication Critical patent/MX2017007638A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54Nitrogen and either oxygen or sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225Polycarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)

Abstract

La presente invención se refiere a un régimen de dosificación para (R)-5-[3-cloro-4-(2,3-dihidroxi-propoxi)-benz[Z]iliden]-2-([Z ]- propilimino)-3-o-tolil-tiazolidin-4-ona.
MX2017007638A 2014-12-11 2015-12-10 Regimen de dosificacion para un agonista selectivo de receptor s1p1. MX2017007638A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2014077469 2014-12-11
EP2015058202 2015-04-15
PCT/EP2015/079208 WO2016091996A1 (en) 2014-12-11 2015-12-10 Dosing regimen for a selective s1p1 receptor agonist

Publications (1)

Publication Number Publication Date
MX2017007638A true MX2017007638A (es) 2017-09-11

Family

ID=54843844

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017007638A MX2017007638A (es) 2014-12-11 2015-12-10 Regimen de dosificacion para un agonista selectivo de receptor s1p1.
MX2020011182A MX2020011182A (es) 2014-12-11 2015-12-10 Regimen de dosificacion para un agonista selectivo de receptor s1p1.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2020011182A MX2020011182A (es) 2014-12-11 2015-12-10 Regimen de dosificacion para un agonista selectivo de receptor s1p1.

Country Status (31)

Country Link
US (4) US10220023B2 (es)
EP (2) EP4056179A1 (es)
JP (1) JP6244497B1 (es)
KR (4) KR102590068B1 (es)
CN (2) CN106999461A (es)
AU (2) AU2015359346B2 (es)
CA (1) CA2968180C (es)
CL (1) CL2017001457A1 (es)
CY (1) CY1125170T1 (es)
DK (1) DK3256125T3 (es)
EA (1) EA036075B1 (es)
ES (1) ES2909071T3 (es)
FR (1) FR22C1021I2 (es)
HR (1) HRP20220359T8 (es)
HU (2) HUE057865T2 (es)
IL (1) IL252727B (es)
LT (2) LT3256125T (es)
MX (2) MX2017007638A (es)
MY (1) MY188764A (es)
NL (1) NL301174I2 (es)
NO (1) NO2022023I1 (es)
PH (1) PH12017501059A1 (es)
PL (1) PL3256125T3 (es)
PT (1) PT3256125T (es)
RS (1) RS63048B1 (es)
SG (1) SG11201704563RA (es)
SI (1) SI3256125T1 (es)
TW (1) TW201625242A (es)
UA (1) UA122064C2 (es)
WO (1) WO2016091996A1 (es)
ZA (1) ZA201704624B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101980704A (zh) 2008-03-17 2011-02-23 埃科特莱茵药品有限公司 选择性s1p1受体激动剂的给药方案
EP4056179A1 (en) 2014-12-11 2022-09-14 Actelion Pharmaceuticals Ltd Dosing regimen for ponesimod, a selective s1p1 receptor agonist
MA41139A (fr) 2014-12-11 2017-10-17 Actelion Pharmaceuticals Ltd Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1
JOP20190207A1 (ar) * 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود
US11013723B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms of a thiazolidinone compound, compositions and methods of use thereof
US11186556B1 (en) 2018-10-16 2021-11-30 Celgene Corporation Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof
US11014897B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof
US11014940B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Thiazolidinone and oxazolidinone compounds and formulations
CA3145269A1 (en) 2019-07-22 2021-01-28 Michel BURCKLEN Use of ponesimod for the treatment of multiple sclerosis
IL292529A (en) 2019-10-31 2022-06-01 Idorsia Pharmaceuticals Ltd Combination of cxcr7 antagonist with s1p1 receptor modulator
CA3170688A1 (en) 2020-03-06 2021-09-10 Actelion Pharmaceuticals Ltd Methods of slowing brain volume loss
AU2022236428A1 (en) 2021-03-17 2023-11-02 Actelion Pharmaceuticals Ltd Pharmaceutical dosage system
US20230114486A1 (en) 2021-10-11 2023-04-13 Actelion Pharmaceuticals Ltd Methods Of Treating Multiple Sclerosis
US20230144895A1 (en) 2021-10-11 2023-05-11 Actelion Pharmaceuticals Ltd Methods Of Treating Multiple Sclerosis
CA3220715A1 (en) 2021-10-11 2023-04-20 Krista Spiller Methods of treating multiple sclerosis
US11951097B2 (en) * 2021-10-11 2024-04-09 Vanda Pharmaceuticals Inc. Methods of treating multiple sclerosis
WO2023079079A1 (en) 2021-11-05 2023-05-11 Actelion Pharmaceuticals Ltd Methods for treating multiple sclerosis
WO2023152290A1 (en) 2022-02-11 2023-08-17 Actelion Pharmaceuticals Ltd Methods of slowing an increase in brain ventricular volume

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0217152D0 (en) 2002-07-24 2002-09-04 Novartis Ag Organic compounds
KR100783835B1 (ko) 2003-11-21 2007-12-10 액테리온 파마슈티칼 리미티드 면역억제제로서 5-(벤즈-(z)-일리덴-티아졸리딘-4-원유도체
USRE43833E1 (en) 2003-11-21 2012-11-27 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
BRPI0518674A2 (pt) 2004-11-29 2008-12-02 Novartis Ag regime de dosagem de um agonista de receptor s1p
US7879821B2 (en) 2006-01-26 2011-02-01 University Of Medicine And Dentistry Of New Jersey Method for modulating inflammatory responses by altering plasma lipid levels
KR101255879B1 (ko) 2006-11-23 2013-04-17 액테리온 파마슈티칼 리미티드 2-이미노-티아졸리딘-4-원 유도체의 신규한 제조 방법
US8912340B2 (en) 2006-11-23 2014-12-16 Actelion Pharmaceuticals Ltd. Process for the preparation of 2-imino-thiazolidin-4-one derivatives
CN101980704A (zh) * 2008-03-17 2011-02-23 埃科特莱茵药品有限公司 选择性s1p1受体激动剂的给药方案
GB0819182D0 (en) 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms
PL3409274T3 (pl) 2008-12-22 2020-06-01 Novartis Ag Schemat dawkowania dla agonisty receptora s1p
HUE026400T2 (en) 2008-12-22 2016-06-28 Novartis Ag Dosage Scheme for S1P Receptor Agonist
ES2795105T3 (es) 2012-08-17 2020-11-20 Actelion Pharmaceuticals Ltd Proceso para la preparación de (2Z,5Z)-5-(3-cloro-4-((R)-2,3-dihidroxipropoxi)bencilideno)-2-(propilimino)-3-(o-tolil)tiazolidin-4-ona y producto intermedio usado en dicho proceso
MA41139A (fr) 2014-12-11 2017-10-17 Actelion Pharmaceuticals Ltd Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1
EP4056179A1 (en) * 2014-12-11 2022-09-14 Actelion Pharmaceuticals Ltd Dosing regimen for ponesimod, a selective s1p1 receptor agonist

Also Published As

Publication number Publication date
TW201625242A (zh) 2016-07-16
EA201791286A1 (ru) 2017-12-29
EP4056179A1 (en) 2022-09-14
PL3256125T3 (pl) 2022-05-09
NZ768672A (en) 2023-10-27
LTPA2022505I1 (es) 2022-06-10
NL301174I2 (nl) 2022-06-09
RS63048B1 (sr) 2022-04-29
MY188764A (en) 2021-12-30
DK3256125T3 (da) 2022-03-21
CN106999461A (zh) 2017-08-01
US20230131600A1 (en) 2023-04-27
AU2020202684A1 (en) 2020-05-14
KR102590068B1 (ko) 2023-10-16
HRP20220359T1 (hr) 2022-05-13
CN117137912A (zh) 2023-12-01
HUS2200021I1 (hu) 2022-05-28
FR22C1021I2 (fr) 2023-04-14
US10857134B2 (en) 2020-12-08
WO2016091996A1 (en) 2016-06-16
CY1125170T1 (el) 2022-07-22
KR20210126792A (ko) 2021-10-20
IL252727B (en) 2021-02-28
US10220023B2 (en) 2019-03-05
NL301174I1 (es) 2022-05-09
KR20230147768A (ko) 2023-10-23
JP2017538706A (ja) 2017-12-28
KR20200013086A (ko) 2020-02-05
KR102427123B1 (ko) 2022-07-28
AU2015359346B2 (en) 2020-05-07
US20190151292A1 (en) 2019-05-23
AU2015359346A1 (en) 2017-07-27
CA2968180A1 (en) 2016-06-16
US20210052555A1 (en) 2021-02-25
US20180147188A9 (en) 2018-05-31
CA2968180C (en) 2020-01-28
EA036075B1 (ru) 2020-09-23
NO2022023I1 (no) 2022-06-10
JP6244497B1 (ja) 2017-12-06
ZA201704624B (en) 2022-03-30
MX2020011182A (es) 2022-10-03
SI3256125T1 (sl) 2022-04-29
KR20170094335A (ko) 2017-08-17
US11771683B2 (en) 2023-10-03
NZ733463A (en) 2023-10-27
AU2015359346A8 (en) 2017-08-03
CL2017001457A1 (es) 2018-02-09
HUE057865T2 (hu) 2022-06-28
LT3256125T (lt) 2022-04-11
SG11201704563RA (en) 2017-07-28
PT3256125T (pt) 2022-05-06
PH12017501059A1 (en) 2017-11-27
EP3256125A1 (en) 2017-12-20
HRP20220359T8 (hr) 2022-05-27
FR22C1021I1 (fr) 2022-07-15
UA122064C2 (uk) 2020-09-10
US20170319555A1 (en) 2017-11-09
EP3256125B1 (en) 2022-01-26
ES2909071T3 (es) 2022-05-05
IL252727A0 (en) 2017-08-31

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