MX2014004516A - Micro-arns en trastornos neurodegenerativos. - Google Patents

Micro-arns en trastornos neurodegenerativos.

Info

Publication number
MX2014004516A
MX2014004516A MX2014004516A MX2014004516A MX2014004516A MX 2014004516 A MX2014004516 A MX 2014004516A MX 2014004516 A MX2014004516 A MX 2014004516A MX 2014004516 A MX2014004516 A MX 2014004516A MX 2014004516 A MX2014004516 A MX 2014004516A
Authority
MX
Mexico
Prior art keywords
subject
level
micrornas
neurodegenerative disorder
monocyte
Prior art date
Application number
MX2014004516A
Other languages
English (en)
Inventor
Howard Weiner
Oleg Butovsky
Original Assignee
Brigham & Womens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham & Womens Hospital filed Critical Brigham & Womens Hospital
Publication of MX2014004516A publication Critical patent/MX2014004516A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Abstract

La invención proporciona métodos para diagnosticar trastornos neurodegenerativos (por ejemplo, esclerosis lateral amiotrófica y esclerosis múltiple) en un sujeto, identificar sujetos en riesgo de desarrollar un trastorno neurodegenerativo, predecir la tasa de progresión de la enfermedad en un sujeto que tiene un trastorno neurodegenerativo, seleccionar un sujeto para tratamiento de un trastorno neurodegenerativo, seleccionar un sujeto para su participación en un estudio clínico, y determinar la eficacia del tratamiento de un trastorno neurodegenerativo. Estos métodos incluyen determinar el nivel de uno o más microARNs y/o uno o más marcadores inflamatorios en un monocito (por ejemplo, un monocito CD14+CD16- o CD14+CD16-) o en fluido cerebroespinal (CSF) del sujeto y comparar el nivel de uno o más microARNs y/o el nivel de uno o más marcadores inflamatorios con un nivel(es) de referencia. También se proporcionan los métodos para tratar un trastorno neurodegenerativo que incluyen administrar a un sujeto al menos un agente que disminuya o incremente el nivel o actividad de uno o más microARNs o uno o más marcadores inflamatorios en un monocito (por ejemplo, un monocito CD14+CD16- o CD14+CD16- o en el CSF de un sujeto.
MX2014004516A 2011-10-11 2012-10-11 Micro-arns en trastornos neurodegenerativos. MX2014004516A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161545968P 2011-10-11 2011-10-11
US201261601205P 2012-02-21 2012-02-21
PCT/US2012/059671 WO2013055865A1 (en) 2011-10-11 2012-10-11 Micrornas in neurodegenerative disorders

Publications (1)

Publication Number Publication Date
MX2014004516A true MX2014004516A (es) 2015-01-16

Family

ID=48082415

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014004516A MX2014004516A (es) 2011-10-11 2012-10-11 Micro-arns en trastornos neurodegenerativos.

Country Status (11)

Country Link
US (3) US10184151B2 (es)
EP (2) EP2766482B1 (es)
JP (1) JP6234370B2 (es)
KR (1) KR20140074997A (es)
CN (1) CN104011210B (es)
AU (1) AU2012322788B2 (es)
BR (1) BR112014008925A2 (es)
CA (1) CA2851280C (es)
HK (1) HK1201294A1 (es)
MX (1) MX2014004516A (es)
WO (1) WO2013055865A1 (es)

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