MX2009006730A - Antagonists of the trpv1 receptor and uses thereof. - Google Patents
Antagonists of the trpv1 receptor and uses thereof.Info
- Publication number
- MX2009006730A MX2009006730A MX2009006730A MX2009006730A MX2009006730A MX 2009006730 A MX2009006730 A MX 2009006730A MX 2009006730 A MX2009006730 A MX 2009006730A MX 2009006730 A MX2009006730 A MX 2009006730A MX 2009006730 A MX2009006730 A MX 2009006730A
- Authority
- MX
- Mexico
- Prior art keywords
- antagonists
- trpv1 receptor
- trpv1
- antagonictc
- exacerbated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
Abstract
The present application is directed to compounds that are TRPV1 antagonictc and have formula(I): wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2, and Y3, are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87589006P | 2006-12-20 | 2006-12-20 | |
PCT/US2007/087163 WO2008079683A2 (en) | 2006-12-20 | 2007-12-12 | N- (5, 6, 7, 8-tetrahydronaphthalen-1-yl) urea derivatives and related compounds as trpv1 vanilloid receptor antagonists for the treatment of pain |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009006730A true MX2009006730A (en) | 2009-06-30 |
Family
ID=39102978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009006730A MX2009006730A (en) | 2006-12-20 | 2007-12-12 | Antagonists of the trpv1 receptor and uses thereof. |
Country Status (7)
Country | Link |
---|---|
US (3) | US8030504B2 (en) |
EP (2) | EP2450346A1 (en) |
JP (1) | JP2010513557A (en) |
CN (1) | CN101563318A (en) |
CA (1) | CA2672196A1 (en) |
MX (1) | MX2009006730A (en) |
WO (1) | WO2008079683A2 (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8765815B2 (en) | 2007-09-20 | 2014-07-01 | Ramot At Tel-Aviv University Ltd. | N-phenyl anthranilic acid derivatives and uses thereof |
WO2010023512A1 (en) * | 2008-08-28 | 2010-03-04 | Matrix Laboratories Ltd. | Novel vanilloid receptor modulators, process for their preparation and pharmaceutical compositions containing them |
CA2737775A1 (en) * | 2008-10-17 | 2010-04-22 | Abbott Laboratories | Trpv1 antagonists |
MX2011004081A (en) * | 2008-10-17 | 2011-05-31 | Abbott Lab | Trpv1 antagonists. |
US9012651B2 (en) | 2011-03-24 | 2015-04-21 | Abbvie Inc. | TRPV3 modulators |
MX351165B (en) * | 2011-03-25 | 2017-10-04 | Abbvie Inc | Trpv1 antagonists. |
US8859584B2 (en) | 2011-12-19 | 2014-10-14 | Abbvie, Inc. | TRPV1 antagonists |
WO2013096226A1 (en) | 2011-12-19 | 2013-06-27 | Abbvie Inc. | Trpv1 antagonists |
US8796328B2 (en) | 2012-06-20 | 2014-08-05 | Abbvie Inc. | TRPV1 antagonists |
EP2700431A1 (en) | 2012-08-24 | 2014-02-26 | AnalytiCon Discovery GmbH | Plant extracts for modulating TRPV1 function |
US11849727B2 (en) | 2013-11-13 | 2023-12-26 | Bedoukian Research, Inc. | Synergistic formulations for control and repellency of biting arthropods |
JP7441042B2 (en) | 2016-12-02 | 2024-02-29 | シムライズ アーゲー | cosmetic blend |
EP3401307A1 (en) * | 2017-05-11 | 2018-11-14 | Antalgenics, S.L. | Trpv1 modulator compounds |
EP3694833A4 (en) | 2017-10-09 | 2021-06-30 | Ramot at Tel-Aviv University Ltd. | Modulators of potassium ion and trpv1 channels and uses thereof |
CN111548313A (en) * | 2019-02-11 | 2020-08-18 | 绍兴从零医药科技有限公司 | Guanidine compounds as medicine for preventing and treating chronic pain |
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FR1344579A (en) | 1961-11-23 | 1963-11-29 | Sandoz Sa | New indole derivatives and their preparation |
US3647819A (en) | 1969-09-19 | 1972-03-07 | Sterling Drug Inc | Indazolylphenylureas and indazolyl-phenylthioureas |
US3647910A (en) | 1970-03-20 | 1972-03-07 | Standard Oil Co Ohio | Dehydrogenation of hydrocarbons employing a catalyst of iron oxide-containing activated carbon |
US3711610A (en) | 1971-06-01 | 1973-01-16 | Sterling Drug Inc | Anticoccidiosis method and compositions involving indazolylphenylureas and indazolylphenylthioureas |
US3814711A (en) | 1971-07-26 | 1974-06-04 | Mallinckrodt Chemical Works | 10-acetamido-s-triazolo-(3,4-a)-isoquinolines |
NL7902993A (en) | 1978-04-24 | 1979-10-26 | Rhone Poulenc Ind | NEW ISOQUEINOLINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THE NEW ISOQUEINOLINE DERIVATIVES. |
WO1986001204A1 (en) | 1984-08-15 | 1986-02-27 | Schering Aktiengesellschaft | New dopamine derivatives, process for their production, and their use as medicinal products |
WO1991004027A1 (en) | 1989-09-15 | 1991-04-04 | Pfizer Inc. | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
WO1991013874A1 (en) | 1990-03-07 | 1991-09-19 | Rhone-Poulenc Rorer S.A. | Derivatives of glycinamide, their preparation and medicaments containing them |
JPH04178362A (en) | 1990-11-13 | 1992-06-25 | Tosoh Corp | Urea derivative and pest controlling agent containing the same |
JPH04178363A (en) * | 1990-11-13 | 1992-06-25 | Tosoh Corp | Urea derivative and pest controlling agent containing the same |
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SK142694A3 (en) | 1992-05-28 | 1995-06-07 | Pfizer | N-aryl and n-heteroarylurea derivatives as inhibitors of acylcoenzyme a:cholesterol-acyltransferase, pharmaceutical preparations contains these compounds and use |
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JP2008532956A (en) | 2005-03-05 | 2008-08-21 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | Use of hydroxytetrahydro-naphthalene derivatives |
-
2007
- 2007-12-12 CA CA002672196A patent/CA2672196A1/en not_active Abandoned
- 2007-12-12 CN CNA2007800471116A patent/CN101563318A/en active Pending
- 2007-12-12 EP EP12152641A patent/EP2450346A1/en not_active Withdrawn
- 2007-12-12 MX MX2009006730A patent/MX2009006730A/en active IP Right Grant
- 2007-12-12 EP EP07855088A patent/EP2134678A2/en not_active Withdrawn
- 2007-12-12 JP JP2009543075A patent/JP2010513557A/en active Pending
- 2007-12-12 WO PCT/US2007/087163 patent/WO2008079683A2/en active Application Filing
- 2007-12-12 US US11/954,875 patent/US8030504B2/en not_active Expired - Fee Related
-
2011
- 2011-09-29 US US13/249,010 patent/US8350083B2/en active Active
-
2012
- 2012-12-06 US US13/706,468 patent/US20130165479A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2134678A2 (en) | 2009-12-23 |
US8350083B2 (en) | 2013-01-08 |
WO2008079683A3 (en) | 2008-08-28 |
CN101563318A (en) | 2009-10-21 |
WO2008079683A2 (en) | 2008-07-03 |
EP2450346A1 (en) | 2012-05-09 |
JP2010513557A (en) | 2010-04-30 |
CA2672196A1 (en) | 2008-07-03 |
US20080153871A1 (en) | 2008-06-26 |
US20130165479A1 (en) | 2013-06-27 |
US20120022103A1 (en) | 2012-01-26 |
US8030504B2 (en) | 2011-10-04 |
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Legal Events
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FG | Grant or registration | ||
GB | Transfer or rights |