MEP40108A - Novel tiotropium-containing inhalation powder - Google Patents

Novel tiotropium-containing inhalation powder

Info

Publication number
MEP40108A
MEP40108A MEP-401/08A MEP40108A MEP40108A ME P40108 A MEP40108 A ME P40108A ME P40108 A MEP40108 A ME P40108A ME P40108 A MEP40108 A ME P40108A
Authority
ME
Montenegro
Prior art keywords
inhalation powder
containing inhalation
novel tiotropium
preparation
treatment
Prior art date
Application number
MEP-401/08A
Other languages
Bosnian (bs)
English (en)
Inventor
Karoline Bechtold-Peters
Michael Walz
Georg Boeck
Rolf Doerr
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659578&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MEP40108(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MEP40108A publication Critical patent/MEP40108A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MEP-401/08A 2000-10-12 2001-09-28 Novel tiotropium-containing inhalation powder MEP40108A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10050635 2000-10-12
PCT/EP2001/011227 WO2002030389A1 (de) 2000-10-12 2001-09-28 Neue tiotropium-haltige inhalationspulver
YUP-363/02A RS50197B (sr) 2000-10-12 2001-09-28 Novi tiotropiumski preparati- koji sadrže prah za inhaliranje

Publications (1)

Publication Number Publication Date
MEP40108A true MEP40108A (en) 2011-02-10

Family

ID=7659578

Family Applications (2)

Application Number Title Priority Date Filing Date
MEP-2008-401A ME00245B (me) 2000-10-12 2001-09-28 Novi tiotropijumski preparati-koji sadrže prah za in haliranje
MEP-401/08A MEP40108A (en) 2000-10-12 2001-09-28 Novel tiotropium-containing inhalation powder

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MEP-2008-401A ME00245B (me) 2000-10-12 2001-09-28 Novi tiotropijumski preparati-koji sadrže prah za in haliranje

Country Status (49)

Country Link
US (4) US7070800B2 (sv)
EP (2) EP1292281B1 (sv)
JP (1) JP3870159B2 (sv)
KR (1) KR100488644B1 (sv)
CN (1) CN1210017C (sv)
AP (1) AP1712A (sv)
AR (1) AR031819A1 (sv)
AT (1) ATE275391T1 (sv)
AU (1) AU757008B2 (sv)
BG (1) BG65753B1 (sv)
BR (1) BR0107304A (sv)
CA (1) CA2395653C (sv)
CR (1) CR6937A (sv)
CU (1) CU23284B7 (sv)
CZ (1) CZ301465B6 (sv)
DE (1) DE50103551C5 (sv)
DK (1) DK1292281T3 (sv)
DZ (1) DZ3477A1 (sv)
EA (1) EA004034B1 (sv)
EC (2) ECSP024268A (sv)
EE (1) EE04414B1 (sv)
EG (1) EG24139A (sv)
ES (1) ES2227268T3 (sv)
GE (1) GEP20063865B (sv)
HK (1) HK1051812A1 (sv)
HR (1) HRP20020437B1 (sv)
HU (1) HU226982B1 (sv)
IL (2) IL149984A0 (sv)
IS (1) IS2360B (sv)
MA (1) MA25843A1 (sv)
ME (2) ME00245B (sv)
MX (1) MXPA02005666A (sv)
MY (1) MY123544A (sv)
NO (1) NO331956B1 (sv)
NZ (1) NZ519406A (sv)
OA (1) OA12522A (sv)
PE (1) PE20020577A1 (sv)
PL (1) PL200063B1 (sv)
PT (1) PT1292281E (sv)
RS (1) RS50197B (sv)
SA (1) SA01220460B1 (sv)
SI (1) SI1292281T1 (sv)
SK (1) SK285389B6 (sv)
TR (1) TR200402367T4 (sv)
TW (1) TWI285553B (sv)
UA (1) UA72014C2 (sv)
UY (1) UY26959A1 (sv)
WO (1) WO2002030389A1 (sv)
ZA (1) ZA200204378B (sv)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1292281T3 (da) * 2000-10-12 2004-10-11 Boehringer Ingelheim Pharma Nye tiotropiumholdige inhalationspulvere
ATE446085T1 (de) 2000-11-30 2009-11-15 Vectura Ltd Partikel zur verwendung in einer pharmazeutischen zusammensetzung
EP3269360A1 (en) 2000-11-30 2018-01-17 Vectura Limited Method of making particles for use in a pharmaceutical composition
US20030055026A1 (en) 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
US20030008001A1 (en) * 2001-06-13 2003-01-09 Boehringer Ingelheim Pharma Kg Process for cleaning hard gelatine capsules
DE10128779A1 (de) * 2001-06-13 2003-01-02 Boehringer Ingelheim Pharma Verfahren zur Reinigung von Hartgelatinekapseln
DE10141377A1 (de) 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
DE10141376A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Inhalationspulvern
US7309707B2 (en) * 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US7244415B2 (en) * 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
BR0308984A (pt) * 2002-04-04 2005-02-09 Boehringer Ingelheim Pharma Formulações em pó adequadas para inalação
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
KR20060011783A (ko) * 2002-06-12 2006-02-03 에피제네시스 파마슈티칼스 아이엔씨 데하이드로에피안드로스테론 스테로이드 및항-무스카린제와 더불어 호흡기 및 폐 질환을 치료하기위한 조성물, 제제 및 키트
JP2006516531A (ja) * 2002-08-21 2006-07-06 ノートン　ヘルスケアー　リミテッド 吸入組成物
GB0219511D0 (en) * 2002-08-21 2002-10-02 Norton Healthcare Ltd Method of preparing dry powder inhalation compositions
GB0219513D0 (en) 2002-08-21 2002-10-02 Norton Healthcare Ltd Inhalation compositions including coarse carrier
ATE520405T1 (de) * 2002-08-21 2011-09-15 Norton Healthcare Ltd Inhalationszusammensetzung
US7763280B2 (en) 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
DE10255387A1 (de) * 2002-11-28 2004-06-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Tiotropium-haltige Pulverformulierung für die Inhalation
US20050058606A1 (en) * 2002-12-16 2005-03-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing HFC solution formulations
US20040152720A1 (en) * 2002-12-20 2004-08-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powdered medicaments containing a tiotropium salt and salmeterol xinafoate
DE10317461A1 (de) 2003-04-16 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
US20040226556A1 (en) 2003-05-13 2004-11-18 Deem Mark E. Apparatus for treating asthma using neurotoxin
WO2004112702A2 (en) * 2003-06-13 2004-12-29 Advanced Inhalation Research, Inc. Low dose pharmaceutical powders for inhalation
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
US20050038004A1 (en) * 2003-07-31 2005-02-17 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
UY28590A1 (es) * 2003-11-03 2005-06-30 Boehringer Ingelheim Int Procedimiento para la preparación de nuevas sales de tiotropio, nuevas sales de tiotropio como tales, así como las formulaciones medicamentosas que las contienen.
AU2004285685B2 (en) * 2003-11-03 2011-03-24 Boehringer Ingelheim International Gmbh Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same
SE0303270L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
CA2547782A1 (en) * 2003-12-03 2005-06-16 Microdrug Ag Medical product containing tiotropium
CA2547245A1 (en) * 2003-12-03 2005-06-16 Microdrug Ag Pre-metered dry powder inhaler for moisture-sensitive medicaments
SE0303269L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Medicinsk produkt
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
DE102004048389A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
BRPI0606364A2 (pt) 2005-02-10 2010-03-23 Glaxo Group Ltd processo para formar lactose adequada para uso em uma formulaÇço farmacÊutica
EP1881980B1 (en) * 2005-05-02 2012-08-22 Boehringer Ingelheim International GmbH Novel crystalline forms of tiotropium bromide
BRPI0611763A2 (pt) * 2005-06-15 2010-09-28 Boehringer Ingelheim Int processo para a preparação de sais de tiotrópio, sais de tiotrópio como tais e composições farmacêuticas dos mesmos
TWI274641B (en) * 2005-08-30 2007-03-01 Rexon Ind Corp Ltd Cutting machine
RU2453547C2 (ru) * 2005-12-19 2012-06-20 Сикор Инк. Новые формы тиотропия бромида и способы их получения
US20070167480A1 (en) * 2005-12-19 2007-07-19 Sicor Inc. Pure and stable tiotropium bromide
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
ATE552256T1 (de) * 2005-12-19 2012-04-15 Sicor Inc Neuartige form von tiotropium-bromid und herstellungsverfahren dafür
MX2007009987A (es) * 2005-12-19 2007-10-02 Sicor Inc Bromuro de tiotropio puro y estable.
US20080051582A1 (en) * 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
CA2694280A1 (en) * 2007-07-27 2009-02-05 Cargill, Incorporated Micronization of polyols
US8483831B1 (en) 2008-02-15 2013-07-09 Holaira, Inc. System and method for bronchial dilation
CN102014779B (zh) 2008-05-09 2014-10-22 赫莱拉公司 用于治疗支气管树的系统、组件和方法
EP2172190A1 (en) 2008-10-02 2010-04-07 Laboratorios Liconsa, S.A. Inhalable particles comprising tiotropium
NZ595723A (en) 2009-03-17 2012-10-26 Daiichi Sankyo Co Ltd Amide derivative
CN104042322B (zh) 2009-10-27 2017-06-06 赫莱拉公司 具有可冷却的能量发射组件的递送装置
US8911439B2 (en) 2009-11-11 2014-12-16 Holaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
JP6000851B2 (ja) 2009-11-11 2016-10-05 ホライラ， インコーポレイテッド 組織治療および狭窄制御のためのシステム、装置、および方法
US8834931B2 (en) 2009-12-25 2014-09-16 Mahmut Bilgic Dry powder formulation containing tiotropium for inhalation
US9259376B2 (en) 2010-06-03 2016-02-16 Sima Patent Ve Lisanslama Hizmetleri Ltd. Sti. Process for dry powder formulations
TR201007251A2 (tr) * 2010-09-01 2012-03-21 Bi̇lgi̇ç Mahmut Kalsiyum kanal blokörü formülasyonu.
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
WO2014007773A1 (en) * 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Compositions comprising muscarinic receptor antagonist and sorbitol
WO2013127738A1 (de) 2012-02-28 2013-09-06 Boehringer Ingelheim International Gmbh Neue treibgashaltige tiotropium-formulierung
RU2522213C2 (ru) * 2012-06-07 2014-07-10 Шолекс Девелопмент Гмбх, Фармацевтический ингаляционный препарат для лечения бронхиальной астмы и хронической обструктивной болезни легких, содержащих в качестве активного вещества микронизированный тиотропия бромид, и способ его получения
US20150150802A1 (en) 2012-07-05 2015-06-04 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Dry powder inhaler compositions comprising long acting muscarinic antagonists
US20150224197A1 (en) * 2012-07-05 2015-08-13 Arven Ilac Sanayi Ve Ticaret A.S. Inhalation compositions
US10111957B2 (en) 2012-07-05 2018-10-30 Arven Ilac Snayi ve Ticaret A.S. Inhalation compositions comprising glucose anhydrous
US20150165037A1 (en) * 2012-07-05 2015-06-18 Arven llac Sanayi Ve Ticaret A.S. Inhalation compositions comprising corticosteroid and sorbitol
WO2014007769A1 (en) * 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Compositions comprising muscarinic receptor antagonist and glucose anhydrous
WO2014007771A2 (en) * 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Inhalation compositions comprising muscarinic receptor antagonist
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
US9398933B2 (en) 2012-12-27 2016-07-26 Holaira, Inc. Methods for improving drug efficacy including a combination of drug administration and nerve modulation
WO2015065222A1 (ru) * 2013-10-28 2015-05-07 Шолекс Девелопмент Гмбх Фармацевтический ингаляционный препарат для лечения бронхиальной астмы и хронической обструктивной болезни легких, содержащий в качестве активного вещества микронизированный тиотропия бромид, и способ его получения
EP2913332A1 (en) 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
US20180236188A1 (en) 2015-10-23 2018-08-23 Arven Ilac Sanayi Ve Ticaret A.S. Blister for inhalable formulation of tiotropium bromide
KR101728116B1 (ko) * 2015-11-03 2017-04-18 한미약품 주식회사 티오트로피움 또는 이의 약학적으로 허용가능한 염을 함유하는 흡입용 건조분말 조성물
AU2016376027B2 (en) 2015-12-24 2022-06-30 Philip Morris Products S.A. Flavoured nicotine powder
EP3600306A4 (en) 2017-03-23 2020-12-02 Singapore Health Services Pte Ltd AGENT FOR PREVENTION OF MYOPIA, TREATMENT OF MYOPIA, AND / OR PREVENTION OF THE PROGRESSION OF MYOPIA INCLUDING TIOTROPIUM AS ACTIVE INGREDIENT
EP4108230A1 (en) 2021-06-24 2022-12-28 Laboratoires SMB New dry powder composition of tiotropium for inhalation
GR1010358B (el) * 2021-09-14 2022-12-16 Elpen Ανωνυμος Εταιρεια Φαρμακευτικη Βιομηχανια, Σταθερο φαρμακευτικο σκευασμα που περιεχει βρωμιουχο τιοτροπιο, για χορηγηση απο το αναπνευστικο

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1242211A (en) * 1967-08-08 1971-08-11 Fisons Pharmaceuticals Ltd Pharmaceutical composition
US3860618A (en) * 1967-08-08 1975-01-14 Philip Saxton Hartley Chromone
US3957965A (en) * 1967-08-08 1976-05-18 Fisons Limited Sodium chromoglycate inhalation medicament
DE2540633A1 (de) * 1975-09-12 1977-04-28 Boehringer Sohn Ingelheim Neue quartaere n-beta-substituierte benzilsaeure-n-alkyl-nortropinester und verfahren zu deren herstellung
DE3211185A1 (de) * 1982-03-26 1983-09-29 Boehringer Ingelheim KG, 6507 Ingelheim Neue quartaere 6,11-dihydro-dibenzo-(b,e)-thiepin-11-n-alkyl- norscopinether und verfahren zu deren herstellung
DE3215493A1 (de) * 1982-04-26 1983-11-03 Boehringer Ingelheim KG, 6507 Ingelheim Neue zwischenprodukte, verfahren zu ihrer herstellung und ihre verwendung
JPS60172442A (ja) 1984-02-20 1985-09-05 Fanuc Ltd ならい加工およびνｃ加工による機械加工装置
US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE4108393A1 (de) * 1991-03-15 1992-09-17 Boehringer Ingelheim Kg Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
US5498422A (en) * 1991-04-08 1996-03-12 Nippon Shinyaku Company Limited Sustained release capsule
DE4140689B4 (de) * 1991-12-10 2007-11-22 Boehringer Ingelheim Kg Inhalationspulver und Verfahren zu ihrer Herstellung
US5770738A (en) * 1992-03-05 1998-06-23 Boehringer Ingelheim Kg Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions
DE4318455A1 (de) * 1993-06-03 1994-12-08 Boehringer Ingelheim Kg Kapselhalterung
US5819730A (en) 1993-06-09 1998-10-13 Glaxo Wellcome Australia Ltd. Device for administering pharmaceutical substances
ES2152281T3 (es) * 1993-09-28 2001-02-01 Scherer Gmbh R P Fabricacion de capsulas de gelatina blanda.
GB9322014D0 (en) * 1993-10-26 1993-12-15 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
GB9404945D0 (en) * 1994-03-15 1994-04-27 Glaxo Group Ltd Pharmaceutical composition
DE4425255A1 (de) 1994-07-16 1996-01-18 Asta Medica Ag Formulierung zur inhalativen Applikation
DE19515625C2 (de) * 1995-04-28 1998-02-19 Boehringer Ingelheim Kg Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern
FR2757173A1 (fr) * 1996-12-17 1998-06-19 Warner Lambert Co Compositions polymeres d'origine non-animale pour la formation de films
US6228394B1 (en) * 1997-10-14 2001-05-08 Boehringer Ingelheim Pharmaceuticals, Inc. Supercritical fluid extraction of mould lubricant from hard shell capsules
US6235725B1 (en) * 1998-10-30 2001-05-22 Baker Norton Pharmaceuticals, Inc. Methods and compositions for the prevention of tolerance to medications
PT1283036E (pt) * 1998-11-13 2008-03-06 Jagotec Ag Inalador de pó seco de dose múltipla com um reservatório de pó
GB9902689D0 (en) * 1999-02-08 1999-03-31 Novartis Ag Organic compounds
US20040002548A1 (en) * 1999-05-12 2004-01-01 Boehringer Ingelheim Pharma Kg Medicament compositions containing anticholinergically-effective compounds and betamimetics
JP3931486B2 (ja) * 1999-06-24 2007-06-13 住友化学株式会社 ポジ型レジスト組成物
DK1292281T3 (da) 2000-10-12 2004-10-11 Boehringer Ingelheim Pharma Nye tiotropiumholdige inhalationspulvere
US6908928B2 (en) * 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
UA75375C2 (en) * 2000-10-12 2006-04-17 Boehringer Ingelheim Pharma Method for producing powdery preparations for inhaling
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
US6506900B1 (en) * 2001-01-31 2003-01-14 Boehringer Ingelheim Pharma Ag Process for preparing a scopine ester intermediate
DE10126924A1 (de) 2001-06-01 2002-12-05 Boehringer Ingelheim Pharma Inhalationskapseln
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
US6482429B1 (en) * 2001-06-20 2002-11-19 Boehringer Ingelheim Pharmaceuticals, Inc. Stable powder inhalation dosage formulation
DE10141376A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Inhalationspulvern
DE10141377A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US7309707B2 (en) * 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
BR0308984A (pt) 2002-04-04 2005-02-09 Boehringer Ingelheim Pharma Formulações em pó adequadas para inalação
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
UA80123C2 (en) 2002-04-09 2007-08-27 Boehringer Ingelheim Pharma Inhalation kit comprising inhalable powder of tiotropium
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation

Also Published As

Publication number Publication date
US20080292563A1 (en) 2008-11-27
ECSP034546A (es) 2003-06-25
CN1392795A (zh) 2003-01-22
PT1292281E (pt) 2004-11-30
HRP20020437A2 (en) 2004-08-31
PE20020577A1 (es) 2002-08-08
UY26959A1 (es) 2002-06-20
IS2360B (is) 2008-05-15
US7070800B2 (en) 2006-07-04
SI1292281T1 (en) 2004-12-31
EA004034B1 (ru) 2003-12-25
HUP0203885A2 (hu) 2003-03-28
AU757008B2 (en) 2003-01-30
ES2227268T3 (es) 2005-04-01
US20060039868A1 (en) 2006-02-23
EE04414B1 (et) 2005-02-15
EE200200428A (et) 2003-02-17
HU226982B1 (en) 2010-04-28
NO20022414L (no) 2002-05-30
EA200200551A1 (ru) 2002-12-26
DE50103551D1 (de) 2004-10-14
GEP20063865B (en) 2006-07-10
AU8993501A (en) 2002-04-22
BG106730A (bg) 2003-03-31
HRP20020437B1 (en) 2005-10-31
CA2395653A1 (en) 2002-04-18
KR100488644B1 (ko) 2005-05-11
PL356840A1 (en) 2004-07-12
HUP0203885A3 (en) 2005-01-28
RS50197B (sr) 2009-05-06
CZ301465B6 (cs) 2010-03-10
TR200402367T4 (tr) 2004-12-21
UA72014C2 (en) 2005-01-17
CA2395653C (en) 2006-05-09
SA01220460B1 (ar) 2006-10-31
EG24139A (en) 2008-08-06
ECSP024268A (es) 2002-08-01
TWI285553B (en) 2007-08-21
EP1292281B1 (de) 2004-09-08
NO20022414D0 (no) 2002-05-22
WO2002030389A1 (de) 2002-04-18
CU23284B7 (es) 2008-06-30
AR031819A1 (es) 2003-10-08
NZ519406A (en) 2003-07-25
AP1712A (en) 2007-01-24
PL200063B1 (pl) 2008-12-31
SK285389B6 (sk) 2006-12-07
DK1292281T3 (da) 2004-10-11
MXPA02005666A (es) 2002-11-29
DZ3477A1 (sv) 2002-04-18
IL149984A (en) 2007-06-03
AP2003002774A0 (en) 2003-03-31
OA12522A (en) 2006-05-30
DE50103551C5 (de) 2014-08-21
MY123544A (en) 2006-05-31
BR0107304A (pt) 2002-08-13
KR20020063912A (ko) 2002-08-05
IL149984A0 (en) 2002-12-01
YU36302A (sh) 2002-09-19
NO331956B1 (no) 2012-05-14
MA25843A1 (fr) 2003-07-01
HK1051812A1 (en) 2003-08-22
BG65753B1 (bg) 2009-10-30
IS6771A (is) 2003-04-08
SK7062002A3 (en) 2002-10-08
ME00245B (me) 2011-02-10
US20040228806A1 (en) 2004-11-18
EP1292281A1 (de) 2003-03-19
JP2004510805A (ja) 2004-04-08
EP1430887A1 (de) 2004-06-23
JP3870159B2 (ja) 2007-01-17
ZA200204378B (en) 2003-05-19
US20020110529A1 (en) 2002-08-15
ATE275391T1 (de) 2004-09-15
CZ20021785A3 (cs) 2002-09-11
CN1210017C (zh) 2005-07-13
CR6937A (es) 2003-11-28

Similar Documents

Publication Publication Date Title
MEP40108A (en) Novel tiotropium-containing inhalation powder
HRP20050570A2 (en) Powdered medicament for inhalation comprising a tiotropium salt and salmetrol xinafoate
MY155912A (en) New inhalable powder containing tiotropium
MEP30108A (en) Formoterol superfine formulation
CY1114157T1 (el) Αλατα του τιοτροπιου, μεθοδος για την παραγωγη τους και φαρμακευτικα σκευασματα που τα περιεχουν
HRP20050468A2 (en) Pulverulent formulation for inhalation containing tiotropium
ME00349B (me) Novi kristalni anhidrat sa antiholinergij skim dejstvom
EA200600854A1 (ru) Новые соли тиотропия, способ их получения, а также содержащие их лекарственные композиции
DE60308497D1 (de) Pulverzubereitungen zur inhalation
ATE452639T1 (de) Arzneimittelkompositionen aus tiotropiumsalzen und epinastin zur therapie von atemswegserkrankungen
CY1113392T1 (el) Νεες κρυσταλλικες μορφες του βρωμιουχου τιοτροπιου