MEP34208A - Hapten-carrier conjugates for treating and preventing nicotine addiction - Google Patents
Hapten-carrier conjugates for treating and preventing nicotine addictionInfo
- Publication number
- MEP34208A MEP34208A MEP-342/08A MEP34208A MEP34208A ME P34208 A MEP34208 A ME P34208A ME P34208 A MEP34208 A ME P34208A ME P34208 A MEP34208 A ME P34208A
- Authority
- ME
- Montenegro
- Prior art keywords
- hapten
- nicotine
- conjugates
- treating
- carrier
- Prior art date
Links
- 206010057852 Nicotine dependence Diseases 0.000 title abstract 2
- 208000025569 Tobacco Use disease Diseases 0.000 title abstract 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract 3
- 229960002715 nicotine Drugs 0.000 abstract 3
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 abstract 3
- 238000002649 immunization Methods 0.000 abstract 2
- 230000003053 immunization Effects 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0013—Therapeutic immunisation against small organic molecules, e.g. cocaine, nicotine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
- Y10S436/816—Alkaloids, amphetamines, and barbiturates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/807—Hapten conjugated with peptide or protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Addiction (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/201,800 US6232082B1 (en) | 1998-12-01 | 1998-12-01 | Hapten-carrier conjugates for treating and preventing nicotine addiction |
| PCT/US1999/028272 WO2000032239A1 (en) | 1998-12-01 | 1999-12-01 | Hapten-carrier conjugates for treating and preventing nicotine addiction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MEP34208A true MEP34208A (en) | 2011-02-10 |
Family
ID=22747358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-342/08A MEP34208A (en) | 1998-12-01 | 1999-12-01 | Hapten-carrier conjugates for treating and preventing nicotine addiction |
Country Status (26)
| Country | Link |
|---|---|
| US (7) | US6232082B1 (de) |
| EP (3) | EP1135166B9 (de) |
| JP (2) | JP4971542B2 (de) |
| KR (1) | KR100656836B1 (de) |
| CN (2) | CN100586481C (de) |
| AT (1) | ATE279211T1 (de) |
| AU (1) | AU763001B2 (de) |
| BR (1) | BR9915852A (de) |
| CA (1) | CA2352765C (de) |
| DE (1) | DE69921178T2 (de) |
| DK (1) | DK1135166T3 (de) |
| EA (1) | EA004956B1 (de) |
| ES (1) | ES2229800T3 (de) |
| HK (3) | HK1042428B (de) |
| HU (1) | HUP0104365A3 (de) |
| IL (2) | IL143474A0 (de) |
| ME (1) | MEP34208A (de) |
| MX (1) | MXPA01005511A (de) |
| NO (1) | NO331998B1 (de) |
| NZ (1) | NZ512103A (de) |
| PL (1) | PL199253B1 (de) |
| PT (1) | PT1135166E (de) |
| RS (1) | RS51273B (de) |
| TR (1) | TR200102411T2 (de) |
| WO (1) | WO2000032239A1 (de) |
| ZA (1) | ZA200104477B (de) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020032316A1 (en) * | 1995-03-31 | 2002-03-14 | Cantab Pharmaceuticals Research Limited | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
| US6232082B1 (en) * | 1998-12-01 | 2001-05-15 | Nabi | Hapten-carrier conjugates for treating and preventing nicotine addiction |
| WO2002058635A2 (en) * | 2001-01-26 | 2002-08-01 | The Scripps Research Institute | Nicotine immunogens and antibodies and uses thereof |
| SE521512C2 (sv) * | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
| US20030148260A1 (en) * | 2001-08-07 | 2003-08-07 | Bernard Levin | Method of diagnosing colorectal adenomas and cancer using proton maggnetic resonance spectroscopy |
| WO2003082329A2 (en) * | 2002-03-01 | 2003-10-09 | The Board Of Regents Of The University Of Nebraska | Compositions and compounds for use as molecular adjuvant for a nicotine vaccine |
| IL165249A0 (en) | 2002-07-18 | 2005-12-18 | Cytos Biotechnology Ag | Hapten-carrier conjugates and uses thereof |
| US20040115244A1 (en) * | 2002-12-17 | 2004-06-17 | Holgate Eric Jamison | Methods and compositions for nicotine replacement therapy |
| ES2285233T3 (es) * | 2002-12-20 | 2007-11-16 | Niconovum Ab | Un material en particulas que contiene nicotina y celulosa microcristalina fisicamente y quimicamente estable. |
| WO2005040338A2 (en) * | 2003-05-21 | 2005-05-06 | The Scripps Research Institute | Constrained alkaloid immunogens and antibodies and uses thereof |
| GB0313916D0 (en) | 2003-06-16 | 2003-07-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
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| US7678551B2 (en) * | 2004-10-25 | 2010-03-16 | Seradyn, Inc. | Immunoassays for lamotrigine |
| US9492400B2 (en) | 2004-11-04 | 2016-11-15 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
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| US9267937B2 (en) | 2005-12-15 | 2016-02-23 | Massachusetts Institute Of Technology | System for screening particles |
| WO2007100755A1 (en) * | 2006-02-27 | 2007-09-07 | Nabi Biopharmaceuticals | Method for decreasing the toxic effects of nicotine on fetuses in pregnant women |
| WO2007104573A2 (en) | 2006-03-16 | 2007-09-20 | Niconovum Ab | Improved snuff composition |
| WO2008105773A2 (en) * | 2006-03-31 | 2008-09-04 | Massachusetts Institute Of Technology | System for targeted delivery of therapeutic agents |
| EP1849780A1 (de) * | 2006-04-21 | 2007-10-31 | De Staat der Nederlanden, vert. door de minister van VWS | Impfstoff gegen Nikotinsucht |
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| JP5630998B2 (ja) * | 2006-05-15 | 2014-11-26 | マサチューセッツ インスティテュート オブ テクノロジー | 機能的粒子のためのポリマー |
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| US9381477B2 (en) * | 2006-06-23 | 2016-07-05 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
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| WO2008098165A2 (en) | 2007-02-09 | 2008-08-14 | Massachusetts Institute Of Technology | Oscillating cell culture bioreactor |
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| WO2008124632A1 (en) * | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Amphiphilic compound assisted nanoparticles for targeted delivery |
| EP3424525A1 (de) | 2007-10-12 | 2019-01-09 | Massachusetts Institute Of Technology | Impfstoffnanotechnologie |
| EP2065398A1 (de) * | 2007-11-29 | 2009-06-03 | Cytos Biotechnology AG | Humane, monoklonale, nikotinspezifische Antikörper |
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| CN102056624A (zh) * | 2008-06-04 | 2011-05-11 | 康奈尔大学 | 用于防治成瘾的疫苗 |
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| US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
| US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
| US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
| US8552165B2 (en) * | 2008-12-09 | 2013-10-08 | Heather Davis | Immunostimulatory oligonucleotides |
| JP5016733B2 (ja) | 2008-12-09 | 2012-09-05 | コーリー ファーマシューティカル グループ，インコーポレイテッド | 免疫賦活性オリゴヌクレオチド |
| WO2011014679A1 (en) | 2009-07-31 | 2011-02-03 | Nabi Biopharmaceuticals | Method and kit for treating nicotine addiction |
| WO2011031298A1 (en) * | 2009-08-26 | 2011-03-17 | Selecta Biosciences, Inc. | Compositions that induce t cell help |
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| US20110182831A1 (en) * | 2010-01-25 | 2011-07-28 | Aradigm Corporation | Systems and methods used in conjunction with nicotine vaccines for effecting cessation of tobacco use |
| CN102892429B (zh) | 2010-03-17 | 2016-08-31 | 康奈尔大学 | 基于被破坏的腺病毒的抗滥用药物疫苗 |
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| TWI578997B (zh) | 2010-06-04 | 2017-04-21 | 輝瑞疫苗有限責任公司 | 用於預防或治療菸鹼成癮之共軛體 |
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| CN103826657A (zh) | 2011-04-04 | 2014-05-28 | 衣阿华大学研究基金会 | 改进疫苗免疫原性的方法 |
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-
1998
- 1998-12-01 US US09/201,800 patent/US6232082B1/en not_active Expired - Fee Related
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1999
- 1999-12-01 PL PL349012A patent/PL199253B1/pl not_active IP Right Cessation
- 1999-12-01 EP EP99964009A patent/EP1135166B9/de not_active Revoked
- 1999-12-01 AU AU20335/00A patent/AU763001B2/en not_active Ceased
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- 1999-12-01 TR TR2001/02411T patent/TR200102411T2/xx unknown
- 1999-12-01 CN CN200510092438A patent/CN100586481C/zh not_active Expired - Fee Related
- 1999-12-01 WO PCT/US1999/028272 patent/WO2000032239A1/en active IP Right Grant
- 1999-12-01 EA EA200100610A patent/EA004956B1/ru not_active IP Right Cessation
- 1999-12-01 HU HU0104365A patent/HUP0104365A3/hu unknown
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- 1999-12-01 DK DK99964009T patent/DK1135166T3/da active
- 1999-12-01 CA CA2352765A patent/CA2352765C/en not_active Expired - Fee Related
- 1999-12-01 AT AT99964009T patent/ATE279211T1/de active
- 1999-12-01 DE DE69921178T patent/DE69921178T2/de not_active Expired - Lifetime
- 1999-12-01 KR KR1020017006805A patent/KR100656836B1/ko not_active IP Right Cessation
- 1999-12-01 EP EP04024278A patent/EP1512414A1/de not_active Withdrawn
- 1999-12-01 ME MEP-342/08A patent/MEP34208A/xx unknown
- 1999-12-01 EP EP10179154A patent/EP2324855A1/de not_active Withdrawn
- 1999-12-01 NZ NZ512103A patent/NZ512103A/en not_active IP Right Cessation
- 1999-12-01 IL IL14347499A patent/IL143474A0/xx active IP Right Grant
- 1999-12-01 ES ES99964009T patent/ES2229800T3/es not_active Expired - Lifetime
- 1999-12-01 JP JP2000584928A patent/JP4971542B2/ja not_active Expired - Fee Related
- 1999-12-01 CN CNB998139564A patent/CN1220521C/zh not_active Expired - Fee Related
- 1999-12-01 BR BR9915852-3A patent/BR9915852A/pt not_active IP Right Cessation
- 1999-12-01 PT PT99964009T patent/PT1135166E/pt unknown
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2001
- 2001-02-16 US US09/784,139 patent/US6518031B2/en not_active Expired - Fee Related
- 2001-05-25 NO NO20012589A patent/NO331998B1/no not_active IP Right Cessation
- 2001-05-31 ZA ZA200104477A patent/ZA200104477B/xx unknown
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2002
- 2002-03-26 HK HK02102329.6A patent/HK1042428B/zh not_active IP Right Cessation
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- 2002-12-30 US US10/330,676 patent/US6773891B2/en not_active Expired - Fee Related
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2004
- 2004-08-03 US US10/909,841 patent/US7247502B2/en not_active Expired - Fee Related
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2006
- 2006-11-06 HK HK06112172.9A patent/HK1091415A1/xx not_active IP Right Cessation
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2007
- 2007-07-20 US US11/780,742 patent/US7776620B2/en not_active Expired - Fee Related
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2010
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