ME00293B - Compositions of estrogen-cyclodextrin complexes - Google Patents

Compositions of estrogen-cyclodextrin complexes

Info

Publication number
ME00293B
ME00293B MEP-2008-381A MEP2008381A ME00293B ME 00293 B ME00293 B ME 00293B ME P2008381 A MEP2008381 A ME P2008381A ME 00293 B ME00293 B ME 00293B
Authority
ME
Montenegro
Prior art keywords
estrogen
composition
cyclodextrin
compositions
provided
Prior art date
Application number
MEP-2008-381A
Other languages
Unknown language (me)
Inventor
Thomas Backensfeld
Wolfgang Heil
Ralph Lipp
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP00610135A priority Critical patent/EP1216713A1/en
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Priority to PCT/IB2001/002605 priority patent/WO2002049675A1/en
Publication of ME00293B publication Critical patent/ME00293B/en

Links

Abstract

Obezbeđeni su farmaceutski sastavi koji obuhvataju niske doze osetljivih kompleksa između estrogena i ciklodekstrina sa poboljšanom stabilnošću. Provided are pharmaceutical compositions comprising low doses of sensitive complexes between an estrogen and cyclodextrin having improved stability. U specifičnoj realizaciji sastav obuhvata kompleks između etinil estradiola i ?-ciklodekstrin u granulatnom preparatu au još jednoj realizaciji sastav obuhvata limitiranu količinu polivinilpirolidona pošto je za ovaj inertni punilac pronađeno da degradira etinil estradiol. In a specific embodiment, the composition comprises a complex between ethinyl estradiol and? -Cyclodextrin in a granulate preparation and in yet another embodiment the composition comprises a limited amount of polyvinylpyrrolidone since this excipient is found to degrade ethinyl estradiol. Dalje, obezbeđen je postupak za poboljšanje stabilnosti estrogena u sastavu i za proizvodnju takvog stabilnog sastava. Further, a method is provided for improving the stability of an estrogen in a composition and for manufacturing such a stable composition. U osnovi, granulatni preparat je proizveden uz pažljivu kontrolu relativne vlažnosti. Basically, the granular composition is prepared by careful control of the relative humidity.
MEP-2008-381A 2000-12-20 2001-12-20 Compositions of estrogen-cyclodextrin complexes ME00293B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00610135A EP1216713A1 (en) 2000-12-20 2000-12-20 Compositions of estrogen-cyclodextrin complexes
PCT/IB2001/002605 WO2002049675A1 (en) 2000-12-20 2001-12-20 Compositions of estrogen-cyclodextrin complexes

Publications (1)

Publication Number Publication Date
ME00293B true ME00293B (en) 2011-05-10

Family

ID=37516219

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-381A ME00293B (en) 2000-12-20 2001-12-20 Compositions of estrogen-cyclodextrin complexes

Country Status (7)

Country Link
CN (1) CN101116666B (en)
AR (1) AR032205A1 (en)
ME (1) ME00293B (en)
PE (1) PE07092002A1 (en)
UA (1) UA77626C2 (en)
UY (1) UY27088A1 (en)
ZA (1) ZA200305532B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102512688A (en) * 2011-12-29 2012-06-27 上海新华联制药有限公司 Nilestriol-beta-cyclodextrin inclusion compound and preparation method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727064A (en) 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US5324718A (en) 1992-07-14 1994-06-28 Thorsteinn Loftsson Cyclodextrin/drug complexation
DE19848303A1 (en) 1998-10-14 2000-04-20 Schering Ag Stable combination of 14,17-over-bridged steroid gestagen and cyclodextrin compound, useful for treating climacteric disorders or for contraception

Also Published As

Publication number Publication date
CN101116666A (en) 2008-02-06
CN101116666B (en) 2014-01-08
AR032205A1 (en) 2003-10-29
UY27088A1 (en) 2002-07-31
ZA200305532B (en) 2006-06-28
PE07092002A1 (en) 2002-08-23
UA77626C2 (en) 2003-10-15

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