MA53388A - Inhibiteurs d'inflammasome nlrp3 - Google Patents

Inhibiteurs d'inflammasome nlrp3

Info

Publication number
MA53388A
MA53388A MA053388A MA53388A MA53388A MA 53388 A MA53388 A MA 53388A MA 053388 A MA053388 A MA 053388A MA 53388 A MA53388 A MA 53388A MA 53388 A MA53388 A MA 53388A
Authority
MA
Morocco
Prior art keywords
inflammasome
nlrp3 inhibitors
nlrp3
inhibitors
Prior art date
Application number
MA053388A
Other languages
English (en)
French (fr)
Inventor
Christopher Farady
Nina Gommermann
Philipp Janser
Angela Mackay
Henri Mattes
Nikolaus Johannes Stiefl
Juraj Velcicky
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA53388A publication Critical patent/MA53388A/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • A61K31/612Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D515/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D515/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA053388A 2018-07-25 2019-07-23 Inhibiteurs d'inflammasome nlrp3 MA53388A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18185580 2018-07-25
EP19175246 2019-05-17

Publications (1)

Publication Number Publication Date
MA53388A true MA53388A (fr) 2021-06-02

Family

ID=67989037

Family Applications (1)

Application Number Title Priority Date Filing Date
MA053388A MA53388A (fr) 2018-07-25 2019-07-23 Inhibiteurs d'inflammasome nlrp3

Country Status (22)

Country Link
US (1) US20210308140A1 (ja)
EP (1) EP3827008B1 (ja)
JP (1) JP2021532124A (ja)
KR (1) KR20210038877A (ja)
CN (1) CN112424207B (ja)
AU (1) AU2019309727B2 (ja)
BR (1) BR112021000964A2 (ja)
CA (1) CA3103943A1 (ja)
CL (1) CL2021000191A1 (ja)
CO (1) CO2021000537A2 (ja)
CR (1) CR20210045A (ja)
CU (1) CU20210009A7 (ja)
DO (1) DOP2021000019A (ja)
EC (1) ECSP21004787A (ja)
IL (1) IL280336A (ja)
JO (1) JOP20210017A1 (ja)
MA (1) MA53388A (ja)
MX (1) MX2021000925A (ja)
PE (1) PE20210406A1 (ja)
PH (1) PH12021550166A1 (ja)
SG (1) SG11202012321PA (ja)
WO (1) WO2020021447A1 (ja)

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WO2021209539A1 (en) 2020-04-15 2021-10-21 Janssen Pharmaceutica Nv Pyrrolo[1,2-d][1,2,4]triazine-2-yl-acetamides as inhibitors of the nlrp3 inflammasome pathway
WO2021214284A1 (en) 2020-04-23 2021-10-28 Janssen Pharmaceutica Nv Tricyclic compounds as inhibitors of nlrp3
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KR20230028425A (ko) 2020-06-19 2023-02-28 에이씨 이뮨 에스에이 Nlrp3 인플라마좀 경로를 조절하는 디하이드로옥사졸 및 티오우레아 또는 우레아 유도체
IL300289A (en) * 2020-08-14 2023-04-01 Denali Therapeutics Inc Compounds, preparations and methods
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CN114478537B (zh) * 2020-11-13 2024-02-02 上海拓界生物医药科技有限公司 环酰胺并环化合物及其医药用途
JP2024508017A (ja) 2021-03-04 2024-02-21 ヤンセン ファーマシューティカ エヌ.ベー. Nlrp3を調節する4-アルコキシ-6-オキソ-ピリダジン誘導体
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Also Published As

Publication number Publication date
CN112424207A (zh) 2021-02-26
IL280336A (en) 2021-03-01
WO2020021447A1 (en) 2020-01-30
US20210308140A1 (en) 2021-10-07
EP3827008A1 (en) 2021-06-02
CL2021000191A1 (es) 2021-08-20
MX2021000925A (es) 2021-03-31
JP2021532124A (ja) 2021-11-25
CA3103943A1 (en) 2020-01-30
CN112424207B (zh) 2024-03-19
CO2021000537A2 (es) 2021-01-29
BR112021000964A2 (pt) 2021-04-20
EP3827008B1 (en) 2024-07-31
KR20210038877A (ko) 2021-04-08
DOP2021000019A (es) 2021-02-15
PH12021550166A1 (en) 2021-09-13
CU20210009A7 (es) 2021-08-06
JOP20210017A1 (ar) 2021-01-21
AU2019309727B2 (en) 2021-12-23
AU2019309727A1 (en) 2021-01-07
CR20210045A (es) 2021-06-18
SG11202012321PA (en) 2021-02-25
ECSP21004787A (es) 2021-03-31
PE20210406A1 (es) 2021-03-02

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