LV12805A - Phenylindole compounds - Google Patents

Phenylindole compounds Download PDF

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Publication number
LV12805A
LV12805A LV010178A LV010178A LV12805A LV 12805 A LV12805 A LV 12805A LV 010178 A LV010178 A LV 010178A LV 010178 A LV010178 A LV 010178A LV 12805 A LV12805 A LV 12805A
Authority
LV
Latvia
Prior art keywords
ethyl
chloro
fluorophenyl
piperidin
indol
Prior art date
Application number
LV010178A
Other languages
English (en)
Other versions
LV12805B (lv
Inventor
Jens Kristian Perregaard
Ejner Knud Moltzen
Kim Andersen
Henrik Pedersen
Klaus Peter Bogeso
Andre Pernet
Barbara Bopp
Darcy Mulford
Kiyoshi Sakamoto
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of LV12805A publication Critical patent/LV12805A/lv
Publication of LV12805B publication Critical patent/LV12805B/lv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Sewing Machines And Sewing (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Claims (5)

  1. LV 12805 IZGUDROJUMA FORMULA 1. Fenilindola savienojums ar vispārējo formulu I R2 R3
    i kur R1 - R4 ir neatkarīgi izvēlēti no grupas, kas sastāv no ūdeņraža atoma, deitērija atoma, C^alkilgrupas un zemākās C^alkoksigrupas, ar nosacījumu, ka visi četri aizvietotāji nevar būt ūdeņraža atomi; vai vismaz viens aizvietotāju pāris (R1, R2 vai R3, R4) veido oksogrupu un gadījumā, ja ir pārstāvēta tikai viena oksogrupa, tad divi citi aizvietotāji ir izvēlēti no iepriekš minētās grupas, kas noteikta aizvietotājiem R1 - R4, ar nosacījumu, ka tie abi nav ūdeņraža atomi; vai R1 un R2 un/vai R3 un R4 attiecīgi ir savienoti kopā, veidojot 3 - 8 locekļu spirociklu; vai tā pievienotās skābes sāls.
  2. 2. Savienojums saskaņā ar 1. punktu raksturīgs ar to, ka vismaz viena aizvietotāju (R1, R2 vai R3, R4) pāra abi aizvietotāji atšķiras no ūdeņraža atoma vai kopā veido oksogrupu, vai ir savienoti kopā, veidojot spirociklu. 2
  3. 3. Savienojums saskaņā ar 1. punktu, kas ir izvēlēts no 1 -[2-[4-[5-hlor-1 -(4-fluorfenil)-1 H-indol-3-il]piperidin-1 -il]etil]-5-metoksi-imidazolidin-2-ons, 5 10 15 20 1 -[2-[4-[5-hlor-1 -(4-fluorfenii)-1 H-indol-3-il]piperidin-1 -il]etil]-4,4,5,5-tet-radeiterimidazolidin-2-ons, 1 -[2-[4-[5-hlor-1 -(4-fluorfenil)-1 H-indol-3-il]piperidin-1 -il]etil]-4,4-didei-terimidazolidin-2-ons, 1 -[2-[4-[5-hlor-1 -(4-fluorfenil)-1 H-indol-3-il]piperidin-1 -il]etil]-5,5-didei-terimidazolidin-2-ons, 1 -[2-[4-[5-hlor-1 -(4-fluorfenil)-1 H-indol-3-il]piperidin-1 -il]etil]-4,4-dime-tilimidazolidin-2-ons, 1 -[2-[4-[5-hlor-1 -(4-fluorfenil)-1 H-indol-3-il]piperidin-1 -il]etil]-5,5-dime-tilimidazolidin-2-ons, 1 -[2-[4-[5-hlor-1 -(4-fluorfenil)-1 H-indol-3-ii]piperidin-1 -il]etil]-5,5-dime-tilimidazolidin-2,4-dions, 3-[2-[4-[5-hlor-1 -(4-fluorfenil)-1 H-indol-3-il]piperidin-1 -il]etil]-1,3-diaza-spiro[4,4]nonan-2-ons vai 1 -[2-[4-[5-hlor-1 -(4-fluorfenil)-1 H-indol-3-il]piperidin-1 -il]etii]-1,3-diaza-spiro[4,4]nonan-2-ons.
  4. 4. Farmaceitiska kompozīcija raksturīga ar to, ka tā satur savienojumu saskaņā ar jebkuru no 1. punkta līdz 3. punktam kopā ar farmaceitiski pieņemamu nesēju vai atšķaidītāju. 25
  5. 5. Savienojuma saskaņā ar jebkuru no 1. punkta līdz 3. punktam izmantošana farmaceitiskas kompozīcijas izgatavošanai psihozes, depresijas, šizofrēnijas negatīvo simptomu, hipertonijas vai antipsihotisku zāļu inducētu ekstrapiramidālu blakusefektu ārstēšanai. 30
LV010178A 1993-11-01 2001-12-20 Fenilindola savienojumi LV12805B (lv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK931234A DK123493D0 (da) 1993-11-01 1993-11-01 Compounds

Publications (2)

Publication Number Publication Date
LV12805A true LV12805A (lv) 2002-03-20
LV12805B LV12805B (lv) 2002-05-20

Family

ID=8102507

Family Applications (1)

Application Number Title Priority Date Filing Date
LV010178A LV12805B (lv) 1993-11-01 2001-12-20 Fenilindola savienojumi

Country Status (27)

Country Link
US (1) US5703087A (lv)
EP (1) EP0726898B1 (lv)
JP (1) JP3898219B2 (lv)
KR (1) KR100350550B1 (lv)
CN (1) CN1134149A (lv)
AT (1) ATE198199T1 (lv)
AU (1) AU683700B2 (lv)
CA (1) CA2175498C (lv)
CZ (1) CZ291403B6 (lv)
DE (1) DE69426462T2 (lv)
DK (2) DK123493D0 (lv)
ES (1) ES2154303T3 (lv)
FI (1) FI116623B (lv)
GR (1) GR3035462T3 (lv)
HK (1) HK1013817A1 (lv)
HU (1) HUT76063A (lv)
IL (2) IL111395A (lv)
LV (1) LV12805B (lv)
NO (1) NO309038B1 (lv)
NZ (1) NZ275086A (lv)
PL (1) PL176391B1 (lv)
PT (1) PT726898E (lv)
RU (1) RU2156249C2 (lv)
SI (1) SI0726898T1 (lv)
SK (1) SK281761B6 (lv)
WO (1) WO1995012591A1 (lv)
ZA (1) ZA948589B (lv)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6489341B1 (en) 1999-06-02 2002-12-03 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using sertindole derivatives
EP1214312B1 (en) * 1999-09-09 2004-04-14 H. Lundbeck A/S 5-aminoalkyl and 5-aminocarbonyl substituted indoles
US20070212412A1 (en) * 2005-09-08 2007-09-13 H. Lundbeck A/S Stable solid formulation of sertindole
TW200821296A (en) * 2006-06-01 2008-05-16 Lundbeck & Co As H Use of sertindole for the preventive treatment of suicidal behaviour
JP5788404B2 (ja) 2009-12-11 2015-09-30 アウトイフオンイ トヘラペウトイクス リミテッド イミダゾリジンジオン誘導体
WO2011159760A1 (en) 2010-06-16 2011-12-22 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
CN103328467B (zh) 2010-12-06 2016-08-10 奥蒂福尼疗法有限公司 用作kv3抑制剂的乙内酰脲衍生物
WO2012168710A1 (en) * 2011-06-07 2012-12-13 Autifony Therapeutics Limited Hydantoin derivates as kv3 inhibitors
MX356813B (es) * 2011-12-06 2018-06-13 Autifony Therapeutics Ltd Derivados de hidantoina utiles como inhibidores de kv3.
BR112014028991A2 (pt) 2012-05-22 2017-06-27 Autifony Therapeutics Ltd triazóis como inibidores de kv3
JP2015517563A (ja) 2012-05-22 2015-06-22 アウトイフオンイ トヘラペウトイクス リミテッド Ｋｖ３阻害剤としてのヒダントイン誘導体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
GB8908085D0 (en) * 1989-04-11 1989-05-24 Lundbeck & Co As H New therapeutic use
DK152090D0 (da) * 1990-06-22 1990-06-22 Lundbaek A S H Piperidylsubstituerede indolderivater

Also Published As

Publication number Publication date
SK281761B6 (sk) 2001-07-10
CZ124896A3 (en) 1996-09-11
DE69426462T2 (de) 2001-04-26
CN1134149A (zh) 1996-10-23
NO961746L (no) 1996-06-28
NO309038B1 (no) 2000-12-04
RU2156249C2 (ru) 2000-09-20
SK53496A3 (en) 1996-11-06
FI961844A0 (fi) 1996-04-30
NZ275086A (en) 1997-10-24
IL111394A0 (en) 1994-12-29
WO1995012591A1 (en) 1995-05-11
EP0726898A1 (en) 1996-08-21
NO961746D0 (no) 1996-04-30
AU683700B2 (en) 1997-11-20
CA2175498A1 (en) 1995-05-11
EP0726898B1 (en) 2000-12-20
IL111395A (en) 1999-06-20
IL111394A (en) 1998-08-16
SI0726898T1 (en) 2001-04-30
ZA948589B (en) 1995-06-26
ES2154303T3 (es) 2001-04-01
JPH09506083A (ja) 1997-06-17
HU9601144D0 (en) 1996-07-29
AU8057794A (en) 1995-05-23
CA2175498C (en) 2005-07-26
IL111395A0 (en) 1994-12-29
KR960705814A (ko) 1996-11-08
PL314181A1 (en) 1996-08-19
DK0726898T3 (da) 2001-04-30
PT726898E (pt) 2001-05-31
GR3035462T3 (en) 2001-05-31
LV12805B (lv) 2002-05-20
CZ291403B6 (cs) 2003-03-12
PL176391B1 (pl) 1999-05-31
HK1013817A1 (en) 1999-09-10
DK123493D0 (da) 1993-11-01
JP3898219B2 (ja) 2007-03-28
US5703087A (en) 1997-12-30
KR100350550B1 (ko) 2002-12-12
FI961844A (fi) 1996-04-30
DE69426462D1 (de) 2001-01-25
ATE198199T1 (de) 2001-01-15
HUT76063A (en) 1997-06-30
FI116623B (fi) 2006-01-13

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