LV12766B - L-DOFA ESTERS COMPOSITION - Google Patents

L-DOFA ESTERS COMPOSITION Download PDF

Info

Publication number
LV12766B
LV12766B LVP-01-124A LV010124A LV12766B LV 12766 B LV12766 B LV 12766B LV 010124 A LV010124 A LV 010124A LV 12766 B LV12766 B LV 12766B
Authority
LV
Latvia
Prior art keywords
dopa
ethyl ester
dopa ethyl
composition
pharmaceutically acceptable
Prior art date
Application number
LVP-01-124A
Other languages
English (en)
Latvian (lv)
Other versions
LV12766A (lv
Inventor
Isaac Milman
Daphne Atlas
Alexander Veinberg
Eldad Melamed
Original Assignee
Teva Pharmaceutical Industries Ltd.
Yissum Research Development Company Of The Hebrew University Of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd., Yissum Research Development Company Of The Hebrew University Of Jerusalem filed Critical Teva Pharmaceutical Industries Ltd.
Publication of LV12766A publication Critical patent/LV12766A/xx
Publication of LV12766B publication Critical patent/LV12766B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LVP-01-124A 1992-12-24 2001-08-21 L-DOFA ESTERS COMPOSITION LV12766B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/995,847 US5354885A (en) 1992-12-24 1992-12-24 Process for preparing ethyl ester of L-DOPA

Publications (2)

Publication Number Publication Date
LV12766A LV12766A (lv) 2001-12-20
LV12766B true LV12766B (en) 2002-03-20

Family

ID=25542272

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-01-124A LV12766B (en) 1992-12-24 2001-08-21 L-DOFA ESTERS COMPOSITION

Country Status (21)

Country Link
US (2) US5354885A (zh)
EP (2) EP0610595B1 (zh)
JP (1) JPH07285860A (zh)
CN (1) CN1083262C (zh)
AT (2) ATE178793T1 (zh)
AU (1) AU684053B2 (zh)
CA (1) CA2112160A1 (zh)
CY (1) CY2214B1 (zh)
DE (2) DE69324466T2 (zh)
DK (2) DK0610595T3 (zh)
ES (2) ES2150294T3 (zh)
FI (1) FI107994B (zh)
GR (2) GR3030073T3 (zh)
HK (1) HK1012577A1 (zh)
HU (1) HU218906B (zh)
IL (1) IL108147A (zh)
LV (1) LV12766B (zh)
NO (1) NO305932B1 (zh)
NZ (1) NZ250541A (zh)
PT (1) PT867179E (zh)
ZA (1) ZA939573B (zh)

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SE9203594D0 (sv) * 1992-11-30 1992-11-30 Christer Nystroem Laekemedel i dispersa system
US5840756A (en) * 1995-07-21 1998-11-24 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition of L-DOPA ester
WO1997016181A1 (en) * 1995-11-03 1997-05-09 University Of Kentucky Method for the intranasal administration of l-dopa prodrugs
CN1207675A (zh) * 1995-11-06 1999-02-10 萨默塞特药品有限公司 丙炔苯丙胺的经颊和舌下给药法
IL119417A (en) * 1996-10-13 2003-02-12 Moshe Kushnir Pharmaceutical composition for transdermal administration of levodopa for parkinson's disease
US6746688B1 (en) 1996-10-13 2004-06-08 Neuroderm Ltd. Apparatus for the transdermal treatment of Parkinson's disease
AU768154B2 (en) * 1996-10-13 2003-12-04 Neuroderm Ltd Treatment of Parkinson's disease
US6166081A (en) * 1997-10-09 2000-12-26 Kushnir; Moshe Methods and apparatus for treatment of Parkinson's disease
WO1999047133A1 (en) 1998-03-16 1999-09-23 Somerset Pharmaceuticals, Inc. Use of selegiline or desmethylselegiline for treating wounds, burns and dermatological damage
EP1135118A1 (en) * 1998-11-10 2001-09-26 Teva Pharmaceutical Industries Ltd. Dispersible compositions containing l-dopa ethyl ester
AU764844B2 (en) 1998-11-10 2003-09-04 Teva Pharmaceutical Industries Ltd. Process for manufacture of L-DOPA ethyl ester
RU2157196C1 (ru) * 1999-06-17 2000-10-10 Васильев Виталий Николаевич Фармацевтическая композиция в.н. васильева для восстановления функции симпатико-адреналовой системы, способ оценки индивидуальной эффективности этой композиции для терапии пациентов
US6613308B2 (en) * 2000-09-19 2003-09-02 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US6514482B1 (en) * 2000-09-19 2003-02-04 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US6531153B2 (en) * 2001-05-29 2003-03-11 Drugtech Corporation Composition with sustained release of levodopa and carbidopa
IL159813A0 (en) * 2001-07-12 2004-06-20 Teva Pharma Dual release formulation comprising levodopa ethyl ester and a decarboxylase inhibitor in immediate release layer with levodopa ethyl ester and a decarboxylase inhibitor in a controlled release core
AU2002340470A1 (en) * 2001-11-13 2003-05-26 Teva Pharmaceutical Industries, Ltd. L-dopa ethyl ester salts and uses thereof
WO2003042136A2 (en) * 2001-11-13 2003-05-22 Teva Pharmaceutical Industries, Ltd. Process for the production of l-dopa ethyl ester
EP2630954B1 (en) 2002-03-20 2016-10-05 Civitas Therapeutics, Inc. Pulmonary delivery for levodopa
US6930137B2 (en) * 2002-05-31 2005-08-16 Fina Technology, Inc. Method of improving blown film processing performance and physical properties
DE10261807A1 (de) 2002-12-19 2004-07-01 Turicum Drug Development Ag Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel
WO2004069146A2 (en) * 2003-02-07 2004-08-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem L-dopa amide derivatives and uses thereof
EP1622450A4 (en) * 2003-04-25 2009-11-18 Endo Pharmaceuticals Solutions PROCESS FOR PROMOTING UNINTERRUPTED SLEEP BY ADMINISTERING TROPIUM CHLORIDE
KR100525358B1 (ko) * 2003-08-21 2005-11-04 주식회사 이엔에프테크놀로지 카르복실 벤조트리아졸 알킬에스테르의 제조방법
US8815950B2 (en) 2003-08-29 2014-08-26 Janssen Biotech, Inc. Pharmaceutical compositions and method of using levodopa and carbidopa
WO2005023185A2 (en) * 2003-08-29 2005-03-17 Transform Pharmaceuticals, Inc. Pharmaceutical compositions and method of using levodopa and carbidopa
EP1680144B1 (en) * 2003-10-08 2011-10-05 Mallinckrodt LLC Methylphenidate solution and associated methods of administration and production
SE0401842D0 (sv) * 2004-07-12 2004-07-12 Dizlin Medical Design Ab Infusion and injection solution of levodopa
PL1991522T3 (pl) * 2006-02-17 2017-07-31 Ratiopharm Gmbh Deuterowane pochodne katecholaminy i leki zawierające te związki
CN101623278B (zh) * 2008-07-09 2013-02-27 北京德众万全药物技术开发有限公司 一种含有左旋多巴和盐酸苄丝肼的药物组合物
JP6982870B2 (ja) 2015-05-06 2021-12-17 シンアジャル コーポレイション 薬物粒子を含有する医薬懸濁液、それらの投与のためのデバイス、およびそれらの使用方法
EP3341380B1 (en) * 2015-08-27 2019-11-13 Prexton Therapeutics SA Brain-penetrant chromone oxime derivative for the therapy of levodopa-induced dyskinesia
WO2018059739A1 (en) 2016-09-29 2018-04-05 Berlirem Gmbh L-dopa derivatives for the treatment of neurological diseases
HUE064010T2 (hu) 2021-02-09 2024-02-28 Biobab R&D S L A 3,4-dihidroxi-fenilalanin (dopa) enantiomerjeinek felhasználása a növények vonzerejének növelésére hasznos rovarok számára és az erre szolgáló eljárás

Family Cites Families (9)

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ZA716958B (en) * 1970-10-30 1973-01-31 Hoffmann La Roche Phenylalanine amides
US3803120A (en) * 1971-09-28 1974-04-09 Hoffmann La Roche Di-and tripeptides of 3-(3,4-dihydroxyphenyl)-alanine
US3939253A (en) * 1973-11-02 1976-02-17 Interx Research Corporation Novel, transient pro-drug forms of l-dopa useful in the treatment of parkinson's disease
JPS5157813A (en) * 1974-11-14 1976-05-20 Sankyo Co Ll dooba mataha sonojudotaiseizaino seiho
US4035507A (en) * 1975-04-17 1977-07-12 Interx Research Corporation Novel, transient pro-drug forms of L-DOPA to treat Parkinson's disease
US4916151A (en) * 1985-12-05 1990-04-10 Merrell Dow Pharmaceuticals Inc. Method of treating parkinson's syndrome
US4771073A (en) * 1985-12-30 1988-09-13 Merck & Co., Inc. Rectally absorbable form of L-dopa
US4663349A (en) * 1985-12-30 1987-05-05 Merck & Co., Inc. Rectally absorbable form of L-dopa
ES2042520T3 (es) * 1986-06-10 1993-12-16 Chiesi Farma Spa Composiciones farmaceuticas que contienen el ester metilico de levodopa, preparacion y aplicaciones terapeuticas del mismo.

Also Published As

Publication number Publication date
NO305932B1 (no) 1999-08-23
DE69329400D1 (de) 2000-10-12
EP0610595A2 (en) 1994-08-17
LV12766A (lv) 2001-12-20
HU9303748D0 (en) 1994-04-28
FI107994B (fi) 2001-11-15
JPH07285860A (ja) 1995-10-31
AU5257793A (en) 1994-07-07
HU218906B (hu) 2000-12-28
GR3034867T3 (en) 2001-02-28
PT867179E (pt) 2000-12-29
CN1083262C (zh) 2002-04-24
CN1094950A (zh) 1994-11-16
EP0867179B1 (en) 2000-09-06
DK0867179T3 (da) 2000-11-06
US5525631A (en) 1996-06-11
EP0610595B1 (en) 1999-04-14
EP0867179A1 (en) 1998-09-30
FI935847A (fi) 1994-06-25
ATE178793T1 (de) 1999-04-15
DE69324466T2 (de) 1999-11-25
NO934768L (no) 1994-06-27
IL108147A (en) 1998-09-24
IL108147A0 (en) 1994-04-12
ES2132170T3 (es) 1999-08-16
DE69324466D1 (de) 1999-05-20
FI935847A0 (fi) 1993-12-23
DE69329400T2 (de) 2001-01-18
CA2112160A1 (en) 1994-06-25
EP0610595A3 (en) 1994-09-21
ES2150294T3 (es) 2000-11-16
US5354885A (en) 1994-10-11
ATE196081T1 (de) 2000-09-15
DK0610595T3 (da) 1999-10-25
AU684053B2 (en) 1997-12-04
ZA939573B (en) 1994-08-11
NO934768D0 (no) 1993-12-22
HUT68498A (en) 1995-06-28
GR3030073T3 (en) 1999-07-30
NZ250541A (en) 1995-12-21
CY2214B1 (en) 2002-11-08
HK1012577A1 (en) 1999-08-06

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