KR970069028A - 화학색전용 에멀젼의 제조방법 - Google Patents

화학색전용 에멀젼의 제조방법 Download PDF

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Publication number
KR970069028A
KR970069028A KR1019960009753A KR19960009753A KR970069028A KR 970069028 A KR970069028 A KR 970069028A KR 1019960009753 A KR1019960009753 A KR 1019960009753A KR 19960009753 A KR19960009753 A KR 19960009753A KR 970069028 A KR970069028 A KR 970069028A
Authority
KR
South Korea
Prior art keywords
group
surfactant
contrast agent
oil
oil phase
Prior art date
Application number
KR1019960009753A
Other languages
English (en)
Inventor
정서영
권익찬
김용희
Original Assignee
김은영
한국과학기술연구원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 김은영, 한국과학기술연구원 filed Critical 김은영
Priority to KR1019960009753A priority Critical patent/KR970069028A/ko
Priority to AU23085/97A priority patent/AU2308597A/en
Priority to PCT/KR1997/000054 priority patent/WO1997036576A1/en
Publication of KR970069028A publication Critical patent/KR970069028A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명에 따라 수상으로 수용성 항암제를 수성조영제를 사용하고 유상으로 계면활성제를 용해시킨 유성 조영제를 사용하는 것으로 되는 화학색전용 에멀젼의 제조방법이 제공된다. 본 발명의 방법에 따라 제조된 화학색전용 에멀젼은 수상과 유상의 비중치가 적어도 항암제가 지속적으로 서서히 방출되는 효과를 달성할 수 있다.

Description

화학색전용 에멀젼의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 내부수상으로서 항암제가 포함된 수성조영제를 사용하고 유상으로서 계면활성제가 포함된 유성조영제를 사용하여 이들을 혼합한 후 격렬히 교반하는 것으로 되는 화학색전용 에멀젼의 제조방법.
  2. 제1항에 있어서, 유성조영제는 리피오돌이고 수성조영제는 이오파미로 또는 헥사브릭스인 제조방법.
  3. 제1항에 있어서, 유상 중 계면활성제를 0.01~10w/v%로 사용하는 방법.
  4. 제3항에 있어서, 유상 중 계면활성제를 1 내지 5w/v%로 사용하는 방법.
  5. 제3항에 있어서, 계면활성제가 지방산계, 지방족 알코올 설페이트계, 황산화 유지류, 인산 에스테르계, 폴리옥시에틸렌계, 포스파타이드계, 폴리옥시에틸렌 하이드록지네이티드 캐스터 오일(HCO)류 중에서 선택되는 방법.
  6. 제1항에 있어서, 수상과 유상의 용적비가 1:2 내지 1:6인 방법.
  7. 제1항에 있어서, 내부수상에 황산화제를 첨가하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960009753A 1996-04-01 1996-04-01 화학색전용 에멀젼의 제조방법 KR970069028A (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1019960009753A KR970069028A (ko) 1996-04-01 1996-04-01 화학색전용 에멀젼의 제조방법
AU23085/97A AU2308597A (en) 1996-04-01 1997-03-31 Preparation method of emulsion for chemoembolization
PCT/KR1997/000054 WO1997036576A1 (en) 1996-04-01 1997-03-31 Preparation method of emulsion for chemoembolization

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019960009753A KR970069028A (ko) 1996-04-01 1996-04-01 화학색전용 에멀젼의 제조방법

Publications (1)

Publication Number Publication Date
KR970069028A true KR970069028A (ko) 1997-11-07

Family

ID=19454792

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960009753A KR970069028A (ko) 1996-04-01 1996-04-01 화학색전용 에멀젼의 제조방법

Country Status (3)

Country Link
KR (1) KR970069028A (ko)
AU (1) AU2308597A (ko)
WO (1) WO1997036576A1 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100423859B1 (ko) * 1999-05-03 2004-03-22 이 규 호 복합 기능성 혈관색전용 물질

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9822158D0 (en) * 1998-10-09 1998-12-02 Nycomed Imaging As Compositions
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
CN105579030A (zh) * 2013-09-16 2016-05-11 生物兼容英国有限公司 油性组合物
CN110302434A (zh) * 2019-07-14 2019-10-08 大连医科大学 一种易于推注的碘化油栓塞剂及其制备方法
CN114099764B (zh) * 2021-11-29 2023-02-03 广东粤港澳大湾区国家纳米科技创新研究院 一种w/o/w型温敏栓塞剂的制备方法
CN114042042B (zh) * 2021-11-29 2023-07-25 广东粤港澳大湾区国家纳米科技创新研究院 一种w/o/w型温敏栓塞剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2803869C2 (de) * 1978-01-30 1983-12-29 Ethicon, Inc., 08876 Somerville, N.J. Injizierbare Embolisations- und Okklusionslösung
DE69114782T2 (de) * 1990-08-08 1996-04-18 Takeda Chemical Industries Ltd Intravaskulär embolisierendes Mittel mit Gehalt an einem die Angiogenesis hemmenden Stoff.
DE4341478C2 (de) * 1993-12-02 1998-10-08 Max Delbrueck Centrum Mittel zur Antitumortherapie

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100423859B1 (ko) * 1999-05-03 2004-03-22 이 규 호 복합 기능성 혈관색전용 물질

Also Published As

Publication number Publication date
WO1997036576A1 (en) 1997-10-09
AU2308597A (en) 1997-10-22

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