KR960007620A - Method for preparing low molecular weight water soluble chitosan - Google Patents

Method for preparing low molecular weight water soluble chitosan Download PDF

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Publication number
KR960007620A
KR960007620A KR1019940019757A KR19940019757A KR960007620A KR 960007620 A KR960007620 A KR 960007620A KR 1019940019757 A KR1019940019757 A KR 1019940019757A KR 19940019757 A KR19940019757 A KR 19940019757A KR 960007620 A KR960007620 A KR 960007620A
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South Korea
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water
chitosan
iii
hydrogen peroxide
volume
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KR1019940019757A
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Korean (ko)
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KR0164881B1 (en
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전동원
정은주
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전동원
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Sustainable Development (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

본 발명은 수분이 존재하는 상태에서, 초산, 과산화수소 및 황산의 혼합액중에서 키토산을 가열함으로써 저분자량 수용성 키토산을 제조하는 방법에 관한 것으로, 과량의 초산, 과산화수소 및 황산을 사용하는 대신 적정량의 물을 첨가시켜 줌으로서 키토산의 저분자 공해유발의 가능성을 감소시켜 주는 경제적인 저분자량 수용성 키토산의 제조방법을 제공한다.The present invention relates to a method for producing a low molecular weight water-soluble chitosan by heating chitosan in a mixture of acetic acid, hydrogen peroxide and sulfuric acid in the presence of water, and an appropriate amount of water is added instead of using excess acetic acid, hydrogen peroxide and sulfuric acid. The present invention provides an economical method for producing low molecular weight water soluble chitosan, which reduces the possibility of low molecular pollution of chitosan.

Description

저분자량 수용성 키토산의 제조방법Method for preparing low molecular weight water soluble chitosan

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (11)

(ⅰ)초산, 과산화수소, 황산 및 물로 이루어진 혼합물을 가열하고, (ⅱ)상기 혼합물이 일정온도에 도달하면 임사의학용 키토산을 가하고, (ⅲ)(ⅱ)에서 얻은 일정시간동안 다시 가열하여 키토산을 저분자화 수용화하고, (ⅳ)(ⅲ)에서 생성된 용액을 냉각후 NaOH수용액으로 알칼리화하고 다시 HCl수용액으로 중화시키며, (ⅴ)(ⅳ)에서 얻은 수용액을 투석 및 여과한 후 동결건조시킴을 포함하는 저분자량 수용성 키토산의 제조방법.(Iii) heating the mixture consisting of acetic acid, hydrogen peroxide, sulfuric acid, and water, (ii) adding the NCT for chitosan when the mixture reaches a certain temperature, and heating it again for a predetermined time obtained in (iii) (ii). After low molecular weight solubilization, the solution produced in (iii) was cooled and alkalized with aqueous NaOH solution and neutralized again with aqueous HCl solution, and the aqueous solution obtained in (iii) was dialyzed and filtered and then lyophilized. Method for producing a low molecular weight water-soluble chitosan containing. 제1하에 있어서, 키토산 1몰에 대하여 상기 초산은 0.84 내지 5.7몰, 상기 과산화수소는 3.7 내지 18.8몰 및 상기 황산은 0.02 내지 0.07몰로 첨가하는 것을 특징으로 하는 방법.The method of claim 1, wherein 0.81 to 5.7 mol of acetic acid, 3.7 to 18.8 mol of hydrogen peroxide and 0.02 to 0.07 mol of sulfuric acid are added to 1 mol of chitosan. 제1항에 있어서, 키토산 1몰에 대하여 상기 초산, 과산화수소 및 황산과 물의 합계 체적이 800 내지 8100㎖임을 특징으로 하는 방법.The method according to claim 1, wherein the total volume of acetic acid, hydrogen peroxide, sulfuric acid, and water is 800 to 8100 ml per 1 mole of chitosan. 제1항에 있어서, 키토산 1몰에 대하여 상기 물의 체적이 160 내지 1600㎖임을 특징으로 하는 방법.The method of claim 1, wherein the volume of water is 160 to 1600 ml per 1 mole of chitosan. 제1,3 또는 4항에 있어서, 초산, 과산화수소, 황산 및 물 혼합액의 합계 체적에 대하여 부피비로 상기 초산의 체적은 5 내지 33%, 상기 과산화수소의 체적은 30 내지 80%, 상기 황산의 체적은 0.15 내지 0.5% 및 상기 물의 체적은 15 내지 65%임을 특징으로 하는 방법.The volume of the acetic acid is 5 to 33%, the volume of the hydrogen peroxide is 30 to 80%, the volume of the sulfuric acid according to claim 1, 3 or 4 with respect to the total volume of acetic acid, hydrogen peroxide, sulfuric acid and water mixture 0.15 to 0.5% and the volume of water is 15 to 65%. 제1항에 있어서, 상기 (i)단계에서 35 내지 60℃로 가열함을 특징으로 하는 방법.The method of claim 1, wherein in step (i), characterized in that the heating to 35 to 60 ℃. 제1항에 있어서, 상기 (ⅱ)단계에서 45 내지 75℃로 가열함을 특징으로 하는 방법.The method according to claim 1, wherein the heating is carried out at 45 to 75 ° C in step (ii). 제1항에 있어서, 상기 (ⅲ)단계에서 NaOH수용액을 사용한 알칼리화로서 초기에 4~10% NaOH수용액을 사용하고, 이어서 30~40% NaOH수용액을 가함을 특징으로 하는 방법.The method according to claim 1, wherein in the step (iii), 4-10% NaOH aqueous solution is initially used as alkalizing with NaOH aqueous solution, and then 30-40% NaOH aqueous solution is added. 제1항에 있어서, 상기 (ⅰ) 및 (ⅱ)단계에서 키토산을 상온에서 물에 5~15시간 침지시켜 사용함을 특징으로 하는 방법.The method according to claim 1, wherein the chitosan is immersed in water at room temperature for 5 to 15 hours in steps (iii) and (ii). 제1항에 있어서, 상기 (ⅰ) 및 (ⅱ)단계에서 키토산을 물에 침지시켜 40 내지 100℃에서 1 내지 6시간 가열하여 사용함을 특징으로 하는 방법.The method according to claim 1, wherein the chitosan is immersed in water and heated at 40 to 100 ° C. for 1 to 6 hours in steps (iii) and (ii). 제9항 또는 제10항에 있어서, 상기 키토산중 물의 함량이 65 내지 85중량%임을 특징으로 하는 방법.The method of claim 9 or 10, wherein the content of water in the chitosan is 65 to 85% by weight. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940019757A 1994-08-11 1994-08-11 Process for the preparation of soluble chitosan having a low molecular weight KR0164881B1 (en)

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KR1019940019757A KR0164881B1 (en) 1994-08-11 1994-08-11 Process for the preparation of soluble chitosan having a low molecular weight

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100472029B1 (en) * 2002-05-07 2005-03-08 동부아남반도체 주식회사 Method for controling selectivity of photoresist

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100370929B1 (en) * 2000-03-28 2003-02-05 조훈형 Preparing Methode for Aqueous Chitosan
KR20190061828A (en) 2017-11-27 2019-06-05 이보균 Method for producing chitosan for forage use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100472029B1 (en) * 2002-05-07 2005-03-08 동부아남반도체 주식회사 Method for controling selectivity of photoresist

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