KR920702974A - 폐쇄 혈관신생 이식 물질 - Google Patents

폐쇄 혈관신생 이식 물질

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KR920702974A
KR920702974A KR1019920701549A KR920701549A KR920702974A KR 920702974 A KR920702974 A KR 920702974A KR 1019920701549 A KR1019920701549 A KR 1019920701549A KR 920701549 A KR920701549 A KR 920701549A KR 920702974 A KR920702974 A KR 920702974A
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membrane
host
membrane porosity
porosity
vascular
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제임스 에이취 브라우커
로버트 씨. 존슨
로라 에이. 마틴슨
로널드 에스 힐
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쥐. 마샬 애비
벡스터 인터내셔널 인크
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Abstract

내용 없음

Description

폐쇄 혈관신생 이식 물질
[도면의 간단한 설명]
제1(a)도는 이식된 장치에 반응하는 전형적인 이물질을 나타내는 현미경 사진.
제1(b)도는 이식된 장치에 반응하는 전형적인 이물질을 나타내는 도면.
제2(a)도는 본 발명의 일 실시태양의 현미경 사진.
제2(b)도는 숙주-물질 접촉면에 성장하는 혈관 구조물을 갖는 본 발명의 일 실시태양의 단면도.
제3도는 막의 공극 내의 이물질 캡슐의 단면도.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (37)

  1. 숙주와 장치 사이의 접촉면에 물질을 갖고, 이 물질은 접촉면에 근접한 숙주에 의해 혈관 구조물을 성장시키는 형태를 갖는, 숙주내 이식 장치.
  2. 제1항에 있어서, 상기 숙주는 표준 3층 이물질 반응물을 형성하고, 상기 형태는 상기 물질에 인접하는 숙주 이물질 반응물의 제1 및 제2층에 혈관 구조물을 형성하는 장치.
  3. 제1항에 있어서, 상기 물질의 형태가 2차원 구멍을 가지며 상호 연결된 3차원 공동을 형성하는 프레임을 형성하는 상호 연결된 스트랜드에 의해 결정되며, 여기서, (a)상기 스트랜드는 1차원이 다른 2차원 보다 큰 3차원이고, 상기 스트랜드의 대부분은 작은 차원이 약 5미크론을 초과하지 않으며, (b)상기 구멍은 평균 차원이 약 0.6미크론 이상 및 약 20미크론 이하인 장치.
  4. 제1항에 있어서, 상기 물질은 이 물질과 접촉하는 적어도 몇몇 숙주 염증성 세포가 평평해지지 않도록 형성되는 장치.
  5. 제4항에 있어서, 상기 물질의 형태는 공동 또는 부정형 공동과 접촉하는 숙주 염증성 세포를 공동 및 부정형 공동에 일치시켜 유입시키며, 평평해지지 않도록 3차원 공동 및 부정형 공동을 포함하는 장치.
  6. 제1항에 있어서, 혈관 구조물이 상기 물질의 약 하나의 세포층 내에서 성장하는 장치.
  7. 제1항에 있어서, 혈관 구조물이 이 혈관 구조물로부터 분자를 접촉면으로 확산시키기에 충분히 상기 물질에 근접하여 성장하는 장치.
  8. 제1항에 있어서, (a)상기 장치는 살아있는 세포를 함유하도록 적용된 챔버를 형성하고, (b)상기 혈관 구조물은 이 혈관 구조물로부터 분자를 상기 챔버로 확산시키기에 충분히 상기 물질에 근접하여 성장하고, (c)상기 확산은 상기 살아있는 세포를 지속시키기에 충분히 빠른 장치.
  9. 제1항에 있어서, 상기 물질이
    1)밀리포어, 혼합 에스테르 셀룰로스, 막 공극도 1.2; 2)밀리포어, 혼합 에스테르 셀룰로스, 막 공극도 8.0; 3)사토리우스, 셀룰로스 아세테이트, 막 공극도 0.8; 4)사토리우스, 셀룰로스 아세테이트, 막 공극도 1.2; 5)사토리우스, 셀룰로스 아세테이트, 막 공극 8.0; 6)사토리우스, 셀룰로스 아세테이트, 막 공극도 5.0; 7)사토리우스, 셀룰로스 아세테이트, 막 공극도 3.0; 8)고어, PTFE/폴리에스테르, 막 공극도 1.0; 9)고어, PTFE/폴리에스테르, 막 공극도 3.0; 10)고어, PTFE/폴리에스테르, 막 공극도 5.0; 11)고어, PTFE/폴리에스테르, 막 공극도 10-15; 12)고어, PTFE/폴리프로필렌, 막 공극도 3.0; 13)겔맨, 버사포 어, 막 공극도 0.8; 14)겔맨, 버사포어, 막 공극도 1.2; 15)겔맨, 버사포어, 막 공극도 3.0; 16)겔맨, 버사포어, 막 공극도 5.0; 으로 이루어진 군으로부터 선택되는 장치.
  10. 제1항에 있어서, 상기 물질이 면역원성 인자에 대해 불투과성인 장치.
  11. 숙주와 장치 사이의 접촉면에 제1물질 및 제1물질의 아래에 놓인 제2물질을 갖고, 상기 제1물질은 접촉면에 근접한 숙주에 의해 혈관 구조물을 성장시키는 형태를 갖고, 상기 제2물질은 면역원성 인자에 대해 블투과성인, 숙주내 이식장치.
  12. 제11항에 있어서, 내부가 살아있는 세포를 유지하도록 적용된 챔버를 한정하고, 상기 제1 및 제2물질은 혈관 구조물 내에 존재하는 영양분에 대해 투과성인 장치.
  13. 제1항에 있어서, 상기 장치가 유치 카테테르인 장치.
  14. 제1항에 있어서, 상기 장치가 유치 감지기이고, 상기 물질이 상기 감지기에 의해 검출되는 숙주의 분해물 대해 투과성인 장치.
  15. 제1항에 있어서, 상기 장치가 유방 보철인 장치.
  16. (a)이식된 제1항에 따른 장치; 및 (b)이 장치의 약 하나의 세포층 내의 숙주 혈관 구조물로 이루어진, 이식된 장치 및 이 이식된 장치에 대한 국한성 숙주 반응물.
  17. (a)숙주와 장치 사이의 접촉면에 물질을 갖는 장치를 이식하고, (b)상기 물질은 접촉면에 근접한 숙주에 의해 혈관 구조물을 성장시키는 형태를 갖는 것으로 이루어진 방법.
  18. 제17항에 있어서, 상기 숙주가 표준 3층 이물질 반응물을 형성하고, 상기 형태가 상기 물질에 인접한 숙주 이물질 반응물의 제1 및 제2층에 혈관 구조물을 형성하는 방법.
  19. 제17항에 있어서, 상기 물질의 형태가 2차원 구멍을 가지며 상호 연결된 3차원 공동을 형성하는 프레임을 형성하는 상호 연결된 스트랜드에 의해 결정되며, 여기서, (a)상기 스트랜드는 1차원이 다른 2차원 보다 큰 3차원이고 상기 스트랜드의 대부분은 작은 차원이 약 5미크론을 초과하지 않으며, (b)상기 구멍은 평균차원이 약 0.6미크론 이상 및 약 20미크론 이하인 방법.
  20. 제17항에 있어서, 상기 물질은 이 물질과 접촉하는 적어도 몇몇 숙주 염증성 세포가 평평해지지 않도록 형성되는 방법.
  21. 제20항에 있어서, 상기 물질의 형태는 공동 또는 부정형 공동과 접촉하는 숙주 염증성 세포를 공동 및 부정형 공동에 일치시켜 유입시키며, 평평해지지 않도록 3차원 공동 및 부정형 공동을 포함하는 방법.
  22. 제17항에 있어서, 혈관 구조물이 상기 물질의 약 하나의 세포층 내에서 성장하는 방법.
  23. 제17항에 있어서, 혈관 구조물이 이 혈관 구조물로부터 분자를 접촉면으로 확산시키기에 충분히 상기 물질에 근접하여 성장하는 방법.
  24. 제17항에 있어서, (a)상기 장치는 살아있는 세포를 함유하도록 적응된 챔버를 형성하고, (b)상기 혈관 구조물은 이 혈관 구조물로부터 분자를 상기 챔버로 확산시키기에 충분히 상기 물질에 근접하여 성장하고, (c)상기 확산은 상기 살아있는 세포를 지속시키기에 충분히 빠른 방법.
  25. 제17항에 있어서, 상기 물질이
    1)밀리포어, 혼합 에스테르 셀룰로스, 막 공극도 1.2; 2)밀리포어, 혼합 에스테르 셀룰로스, 막 공극도 8.0; 3)사토리우스, 셀룰로스 아세테이트, 막 공극도 0.8; 4)사토리우스, 셀룰로스 아세테이트, 막 공극도 1.2; 5)사토리우스, 셀룰로스 아세테이트, 막 공극 3.0; 6)사토리우스, 셀룰로스 아세테이트, 막 공극도 5.0; 7)사토리우스, 셀룰로스 아세테이트, 막 공극도 8.0; 8)고어, PTFE/폴리에스테르, 막 공극도 1.0; 9)고어 t-29, PTFE/폴리에스테르, 막 공극도 3.0; 10)고어, PTFE/폴리에스테르, 막 공극도 5.0; 11)고어, PTFE/폴리에스테르, 막 공극도 10-15; 12)고어, PTFE/폴리프로필렌, 막 공극도 3.0; 13)겔맨, 버사포 어, 막 공극도 0.8; 14)겔맨, 버사포어, 막 공극도 1.2; 15)겔맨, 버사포어, 막 공극도 3.0; 및 16)겔맨, 버사포어, 막 공극도 5.0; 으로 이루어진 군으로부터 선택되는 장치.
  26. 제17항에 있어서, 상기 물질이 면역원성 인자에 대해 불투과성인 장치.
  27. (a)장치가 숙주와 장치 사이의 접촉면에 제1물질을 갖고, (b)상기 제1물질은 접촉면에 근접한 숙주에 의해 혈관 구조물은 성장시키는 형태를 갖고, (c)상기 장치는 제1물질의 아래에 놓인 제2물질을 갖고, (d)상기 제2물질은 면역원성 인자에 대해 불투과성인. 숙주내 이식 방법.
  28. 제27항에 있어서, 내부가 살아 있는 세포 유지하도록 적용된 챔버를 한정하고, 상기 제1 및 제2물질은 혈관 구조물 내에 존재하는 영양분에 대해 투과성인 방법.
  29. 제17항에 있어서, 상기 장치가 유치 카테테르인 방법.
  30. 제17항에 있어서, 상기 장치가 유치 감지기이고, 상기 물질이 상기 감지기에 의해 검출되는 숙주의 분해물에 대해 투과성인 방법.
  31. 제17항에 있어서. 상기 장치가 유방 보철인 방법.
  32. (a)적어도 몇몇 공극은 대식세포가 공극에 유입되어 적어도 몇몇 혈관 구조물이 제1막과 접촉하기에 충분한 크기와 구조의 공극을 갖는 제1막, 및 (b)대식세포가 용기 내부로 유입되는 것을 방지하기에 충분히 작은 공극을 갖는 제2다공성 막으로 이루어진 면역단리 용기.
  33. 제32항에 있어서, 제1막의 공칭 공극도가 약 0.6 미크론 내지 약 20미크론인 용기.
  34. 제32항에 있어서, 제1막의 적어도 몇몇 공극이 이 공극 내에 적어도 몇몇 혈관 구조물을 생성하기에 충분한 크기를 갖는 용기.
  35. 제32항에 있어서, 제1막이 약 0.6미크론 내지 약 20미크론 크기의 공극을 적어도 약 50% 포함하는 용기.
  36. 제32항에 있어서, 제1막의 공극을 한정하는 대부분의 구조물이 약 5미크론 미만의 직경 갖는 용기.
  37. 제32항에 있어서, 제2막이 모든 세포가 용기의 내부로 유입 또는 이탈되는 것을 방지하기에 충분히 작은 공극을 갖는 용기.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920701549A 1990-10-31 1991-10-10 폐쇄 혈관신생 이식 물질 KR0169495B1 (ko)

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IE75706B1 (en) 1997-09-10
US5882354A (en) 1999-03-16
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NO300993B1 (no) 1997-09-01
US5782912A (en) 1998-07-21
ATE138256T1 (de) 1996-06-15
US5741330A (en) 1998-04-21
KR0169495B1 (ko) 1999-01-15
IL99732A (en) 1996-03-31
AU8951491A (en) 1992-05-26
ES2090364T3 (es) 1996-10-16
CA2070816A1 (en) 1992-05-01
JP3508023B2 (ja) 2004-03-22
IL99732A0 (en) 1992-08-18
DE69119748T2 (de) 1996-12-05
WO1992007525A1 (en) 1992-05-14
CN1063046A (zh) 1992-07-29
MX9101734A (es) 1992-06-05
FI923023A0 (fi) 1992-06-29
DK0507933T3 (da) 1996-06-17
AU645155B2 (en) 1994-01-06
DE69119748D1 (de) 1996-06-27
US5800529A (en) 1998-09-01
EP0507933A1 (en) 1992-10-14
EP0507933B1 (en) 1996-05-22
GR3020673T3 (en) 1996-10-31
NO922566D0 (no) 1992-06-29
US5964804A (en) 1999-10-12
IE913802A1 (en) 1992-05-22
NO922566L (no) 1992-06-29
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JPH05504704A (ja) 1993-07-22
FI923023A (fi) 1992-06-29

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