KR920021521A - Method for preparing 2-methyl-4-isothiazolin-3-one - Google Patents

Method for preparing 2-methyl-4-isothiazolin-3-one Download PDF

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Publication number
KR920021521A
KR920021521A KR1019910007541A KR910007541A KR920021521A KR 920021521 A KR920021521 A KR 920021521A KR 1019910007541 A KR1019910007541 A KR 1019910007541A KR 910007541 A KR910007541 A KR 910007541A KR 920021521 A KR920021521 A KR 920021521A
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South Korea
Prior art keywords
formula
chx
reacted
compound
molar ratio
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KR1019910007541A
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Korean (ko)
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KR940000239B1 (en
Inventor
한순종
김진만
Original Assignee
이승동
주식회사 선경인더스트리
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Application filed by 이승동, 주식회사 선경인더스트리 filed Critical 이승동
Priority to KR1019910007541A priority Critical patent/KR940000239B1/en
Priority to JP4509538A priority patent/JPH07119219B2/en
Priority to US08/146,172 priority patent/US5453507A/en
Priority to GB9323198A priority patent/GB2274283B/en
Priority to PCT/KR1992/000014 priority patent/WO1992020664A1/en
Priority to DE4291487T priority patent/DE4291487T1/en
Publication of KR920021521A publication Critical patent/KR920021521A/en
Application granted granted Critical
Publication of KR940000239B1 publication Critical patent/KR940000239B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음No content

Description

2-메틸-4-이소티아졸린-3-온의 제조 방법Method for preparing 2-methyl-4-isothiazolin-3-one

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (6)

3,3'-디티오디프로피온산과 티오닐클로라이드를 반응시켜서 다음 구조식(Ⅱ)로 표시되는 3,3'-디티오디프로피오닐디클로라이드를 제조하고, 이를 메틸아민과 반응시켜 다음 구조식(Ⅲ)으로 표시되는 N,N'-디메틸-3,3-디티오디프로피온아미드를 제조한 다음, 여기에 다음 구조식(Ⅳ)로 표시되는 설프릴클로라이드를 첨가하여 유기용매중에서 고리화시켜서 선택적으로 다음 구조식(Ⅰ)로 표시되는 2-메틸-4-이소티아졸린-3-온을 제조하는 방법.3,3'-dithiodipropionic acid and thionyl chloride are reacted to prepare 3,3'-dithiodipropionyldichloride represented by the following structural formula (II), which is reacted with methylamine to the following structural formula (III) Prepared N, N'-dimethyl-3,3-dithiodipropionamide, which is added to the sulfyl chloride represented by the following structural formula (IV), and cyclized in an organic solvent, and optionally A method for producing 2-methyl-4-isothiazolin-3-one represented by). 상기 식에서, X는 할로겐원자를 나타낸다.Wherein X represents a halogen atom. 제1항에 있어서, 상기 3,3'-디티오디프로피온산과 티오닐클로라이드는 1:2 내지 1:4의 몰비로 반응시킴을 특징으로 하는 제조방법.The method of claim 1, wherein the 3,3'-dithiodipropionic acid and thionyl chloride are reacted in a molar ratio of 1: 2 to 1: 4. 제1항에 있어서. 상기 구조식(Ⅱ)의 화합물과 메틸아민은 1:2 내지 1:6의 몰비로 반응시킴을 특징으로 하는 제조방법.The method of claim 1. The compound of formula (II) and the methylamine is characterized in that the reaction in a molar ratio of 1: 2 to 1: 6. 제1항에 있어서, 상기 구조식(Ⅲ)의 화합물과 상기 구조식(Ⅳ)의 화합물은 50℃이하의 반응온도에서 1:1 내지 1:5의 몰비로 반응시켜 고리화시킴을 특징으로 하는 제조방법.The method according to claim 1, wherein the compound of formula (III) and the compound of formula (IV) are cyclized by reacting at a molar ratio of 1: 1 to 1: 5 at a reaction temperature of 50 ° C or less. . 제4항에 있어서, 상기 반응온도는 -20℃∼50℃로 유지함을 특징으로 하는 제조방법.The method of claim 4, wherein the reaction temperature is maintained at −20 ° C. to 50 ° C. 6. 제1항에 있어서, 상기 유기용매로는 CH2X2, CHX3. CHX2CHX2및 CX3CH3(여기서, X는 할로겐원소이다)중에서 선택된 유기할로겐 용매를 사용함을 특징으로 하는 제조방법.The method of claim 1, wherein the organic solvent is CH 2 X 2 , CHX 3 . A process characterized by using an organic halogen solvent selected from CHX 2 CHX 2 and CX 3 CH 3 , wherein X is a halogen element. ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.※ Note: This is to be disclosed by the original application.
KR1019910007541A 1991-05-10 1991-05-10 Process for preparing 2-methyl-4-isothiazoline-3-one KR940000239B1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
KR1019910007541A KR940000239B1 (en) 1991-05-10 1991-05-10 Process for preparing 2-methyl-4-isothiazoline-3-one
JP4509538A JPH07119219B2 (en) 1991-05-10 1992-05-11 Method for producing 4-isothiazolin-3-one
US08/146,172 US5453507A (en) 1991-05-10 1992-05-11 Process for preparing 4-isothiazolin-3-one
GB9323198A GB2274283B (en) 1991-05-10 1992-05-11 A process for preparing 4-isothiazolin-3-one
PCT/KR1992/000014 WO1992020664A1 (en) 1991-05-10 1992-05-11 A process for preparing 4-isothiazolin-3-one
DE4291487T DE4291487T1 (en) 1991-05-10 1992-05-11 Process for the preparation of 4-isothiazolin-3-one

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019910007541A KR940000239B1 (en) 1991-05-10 1991-05-10 Process for preparing 2-methyl-4-isothiazoline-3-one

Publications (2)

Publication Number Publication Date
KR920021521A true KR920021521A (en) 1992-12-18
KR940000239B1 KR940000239B1 (en) 1994-01-12

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Application Number Title Priority Date Filing Date
KR1019910007541A KR940000239B1 (en) 1991-05-10 1991-05-10 Process for preparing 2-methyl-4-isothiazoline-3-one

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KR940000239B1 (en) 1994-01-12

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