KR910016729A - 살균 활성을 나타내는 아민 유도체 - Google Patents
살균 활성을 나타내는 아민 유도체 Download PDFInfo
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- KR910016729A KR910016729A KR1019910004009A KR910004009A KR910016729A KR 910016729 A KR910016729 A KR 910016729A KR 1019910004009 A KR1019910004009 A KR 1019910004009A KR 910004009 A KR910004009 A KR 910004009A KR 910016729 A KR910016729 A KR 910016729A
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- 150000001412 amines Chemical class 0.000 title claims 5
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 20
- -1 dimethyl-phenyl-silanyl group Chemical group 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 238000009423 ventilation Methods 0.000 claims 3
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 238000005984 hydrogenation reaction Methods 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000006677 (C1-C3) haloalkoxy group Chemical group 0.000 claims 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- PTGQYZXUURFBKB-UHFFFAOYSA-N 1-(2,6-dimethylmorpholin-4-yl)-1-[4-(2-phenylsilylpropan-2-yloxy)phenyl]propan-2-ol Chemical compound C=1C=C(OC(C)(C)[SiH2]C=2C=CC=CC=2)C=CC=1C(C(O)C)N1CC(C)OC(C)C1 PTGQYZXUURFBKB-UHFFFAOYSA-N 0.000 claims 1
- HNVIQLPOGUDBSU-UHFFFAOYSA-N 2,6-dimethylmorpholine Chemical compound CC1CNCC(C)O1 HNVIQLPOGUDBSU-UHFFFAOYSA-N 0.000 claims 1
- SDGKUVSVPIIUCF-UHFFFAOYSA-N 2,6-dimethylpiperidine Chemical compound CC1CCCC(C)N1 SDGKUVSVPIIUCF-UHFFFAOYSA-N 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- YRNWIMMHPVTBHI-UHFFFAOYSA-N CC(OC=1C=C(C=CC1)C(C(O)C)N1CC(OC(C1)C)C)([SiH2]C1=CC=CC=C1)C Chemical compound CC(OC=1C=C(C=CC1)C(C(O)C)N1CC(OC(C1)C)C)([SiH2]C1=CC=CC=C1)C YRNWIMMHPVTBHI-UHFFFAOYSA-N 0.000 claims 1
- 241000221787 Erysiphe Species 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical group C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 239000000010 aprotic solvent Substances 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 150000001728 carbonyl compounds Chemical class 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 238000007796 conventional method Methods 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000003586 protic polar solvent Substances 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 claims 1
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical group C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 claims 1
- 229930192474 thiophene Chemical group 0.000 claims 1
- 244000045561 useful plants Species 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C07D213/643—2-Phenoxypyridines; Derivatives thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N39/00—Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or, e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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- C07C2601/00—Systems containing only non-condensed rings
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- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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Abstract
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Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (18)
- 하기 일반식을 갖는 화합물, 그의 거울상 이성질체, 부분입체 이성질체 및 상응하는 금속염 및 착화물,[상기 식중 : R1및R2는 서로 동일하거나 다르고, H 원자, 직쇄 또는 측쇄(C1~C6)-알킬기, 또는 Ar-B기(상기 식중, Ar은(C6~C10)-아릴 또는 (C6~C10)-할로-아릴기이고, B는 (C1~C4)-알킬렌 또는 (C1~C2)-알킬-(C1~C4)-알킬렌기이거나, Ar및 B는 서로 및 N원자와 함께 결합하여, O및 S로 부터 선택된 제 2헤테로 원자를 포함하는 (C2~C7)-헤테로 환기 또는 (C3~C8) 헤테로 환기를 나타내며, 상기 헤테로환기는 임의로 치완된 것이다.)를 나타내며: R3및 R5는 서로 동일하거나 다르고, H원자, (C2~C3)-알킬기를 나타내거나 연결되어 직쇄 또는 측쇄(C1~C7)알킬렌기를 형성하며: m는 0내지 4의 정수이고: R4는 m이 1보다 클때, 서로 다르거나 동일할 수 있으며, 할로겐 원자, (C1~C3)-알킬기 또는 (C2~C3)-할로-알킬기를 나타내고: R',R″,는 서로 동일하거나 다를수 있으며, H,(C1~C3)-알킬기 또는 할로겐 원자를 나타내고: n은 0내지 3 범위 내에 포함된 정수이며 Y 는 -CH=CH2기, (C3~C6)-시클로알킬기, (C6~C10)-아릴기, 5- 또는 6- 원 헤테로환기를 나타내거나; 하기식의 기를 나타낸다.(상기 식중 C,D,E는 서로 동일하거나 다르며, H원자, (C1~C4)알킬기, (C1~C4)-할로알킬기, (C1~C4)-알콕시기, (C1~C4)-할로알콕시기, (C6~C10)-아릴기, 및 (C6~C10)-할로아릴기를 나타낸다.)].
- 제1항에 있어서, 상기의(C3~C6)-또는 (C2~C7)-헤테로 환기가, 치닐환체를 임의로 포함하는 모르폴린, 2,6-디메틸-모르폴린, 피페리딘, 2,6-디메틸-피페리딘, 티오모르폴린기 중에서 선택되는 화합물.
- 제 1또는 제2항에 있어서, Y가 피리딘, 피리미딘, 티오펜, 티아졸, 옥사졸, 이소옥사졸기, 및, 그들의 융합벤젠 고리 함유 유도체, 시클로헥실, 시클로프로필, 시클로펜틸, 시클로부틸, 1-메틸-2,2,-디클로로-시크로프로필, 트림메틸실릴, t-부틸-디메틸-실릴 및 디메틸-페닐-실라닐기를 나타내는 화합물.
- 제1항 내지 3항중 어느 한 항에 있어서, 상기 Ar-B기가 벤질기 및 3-페닐-이소프로필기에서 선택된 화합물.
- 제1항 내지 4항중 어느 한항에 있어서, 상기의 (C3~C8)-또는 (C2~C7)-헤테로환기가, (C1~C4)-알킬, (C6~C10)-아릴, Ar-B기(기호는 상기 정의와 동일한 의미를 가진다.), 및 할로겐 원자 중에서 선택한 적어도 하나의 기에 의해 치환된 화합물.
- 제1항 내지 5항 중 어느 한 항에 있어서, 에테닐, (C3~C8)-시클로알킬, 또는 헤테로환기인 상기 Y기가 할로겐 원자, (C1~C4)-알킬기, (C1~C2)-할로알케닐기, (C1~C3)-알콕시기, (C1~C3)-할로알콕시기에서 선택된 적어도 하나의 기로 치환된 화합물.
- 제1항에 있어서, 4-{3-[4-(트리메틸실릴메특시)페닐]-2-메틸-3-옥사프로필]-2,6-디메틸-모르폴린인 화합물.
- 제1항에 있어서, 4-{3-[3-(2-(4,6-디클로로)-피리딜옥시)페닐]- ]-2,6-디메틸-모르폴린인 화합물.
- 제1항에 있어서, 4-{3-[3-(2,2-디클로로-1-메틸-시크로프로필메톡시)페닐]-]-2-메틸-3-옥사프로필}-2,6-디메틸-모르폴린인 화합물.
- 제1항에 있어서, 4-[3-(5-트리플루오로메틸피리딜옥시-2-일)페닐-2-메메틸-3-옥사프로필]-2,6-디메틸모르폴린인 화합물.
- 제1항에 있어서, 4-[3-(3-클로로-5-트리플루오로메틸피리딜옥시-2-일)페닐-2-메틸-3-옥사프로필]-2,6-디메틸모르폴린인 화합물.
- 제1항에 있어서, 4-[4-(디메틸페닐실릴메톡시)-페닐-2-메틸-3-옥사프로필]-2,6-디메틸모르폴린인 화합물.
- 제1항에 있어서, 4-[3-(디메틸페닐실릴메톡시)-페닐-2-메틸-3-옥사프로필]-2,6-디메틸모르폴린인 화합물.
- 제1항에 있어서, 4-[3-[1-(트리메틸실릴)에톡시)페닐-2-메틸-3-옥사프로필]-2,6-디메틸모르폴린인 화합물.
- 제1항에 있어서, 4-[4-[1-(트리메틸실릴)- 에톡시)페닐-2-메틸-3-옥사프로필]-2,6-디메틸모르폴린인 화합물.
- 제1항에 있어서, 4-[3-[1-(트리메틸실릴)에톡시)페닐-2-메틸-3-옥사프로필]-2,6-디메틸모르폴린인 화합물.
- 하기 일반식(Ⅱ)의 카르보닐 화합물을, 하기 일반식(Ⅲ)의 아민 첨가후에, 수소화 촉매의 존재하에, 0℃내지 60℃ 범위내에 포함되는 온도에서, 1내지 10기압의 범위 내에 포함되는 수소압으로 수소화하여 하기 일반식(Ⅳ)의 아민을 수득하고, 아민(Ⅳ)를 염기 존재하에, 쌍극성 양성자성 또는 비양성자성 용매 중에서, 25℃ 내지 반응 혼합물의 비등 온도까지의 범위 내에 포함되는 온도에서 하기 일반식(Ⅴ)의 화합물과 반응시켜 화합물(Ⅰ)을 수득하고, 상기 화합물(Ⅰ)로 부터 그의 상응하는 금속염 및 착물을 통상적인 방법에 따라 제조할 수 있음을 특징으로 하는, 제 1항 내지 16항중 어느 한항에서 정의된 화합물의 제조방법.G-(CR'R″)-Y (V)[상기 식들중, G는 GI,Br, I메탄-슬포네이트 에스테르, p-톨루엔-슬포네이트 에스테르이며, 나머지 기호는 제 1항에서 정의한 의미를 가진다.]
- 유용식물의 경작시에 병원체 균의 성장을 억제하는, 특히 에리시페(Erysiphe)및 헬민토스포리움(Helminthosprium)속에 속하는 균을 퇴치하기 위한 억제제로서, 제1항 내지 9항중 어느 한 항에 따른 아릴-프로필-아민 화합물의 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19653A/90 | 1990-03-13 | ||
| IT19653A IT1240598B (it) | 1990-03-13 | 1990-03-13 | Derivati amminici ad azione antifungina |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR910016729A true KR910016729A (ko) | 1991-11-05 |
| KR100193159B1 KR100193159B1 (ko) | 1999-06-15 |
Family
ID=11160100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019910004009A KR100193159B1 (ko) | 1990-03-13 | 1991-03-13 | 살균 활성을 나타내는 아민 유도체 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5385892A (ko) |
| EP (1) | EP0446873B1 (ko) |
| JP (1) | JPH05310652A (ko) |
| KR (1) | KR100193159B1 (ko) |
| AT (1) | ATE128963T1 (ko) |
| AU (1) | AU637204B2 (ko) |
| BR (1) | BR9100971A (ko) |
| CA (1) | CA2038076A1 (ko) |
| DE (1) | DE69113659T2 (ko) |
| DK (1) | DK0446873T3 (ko) |
| ES (1) | ES2078369T3 (ko) |
| GR (1) | GR3017838T3 (ko) |
| HU (1) | HU212751B (ko) |
| IL (1) | IL97499A (ko) |
| IT (1) | IT1240598B (ko) |
| NO (1) | NO179835C (ko) |
| RU (1) | RU2038353C1 (ko) |
| ZA (1) | ZA911850B (ko) |
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| CN100591679C (zh) * | 2003-07-28 | 2010-02-24 | 詹森药业有限公司 | 苯并咪唑、苯并噻唑和苯并唑衍生物及其作为lta4h调节剂的应用 |
| TW200906396A (en) * | 2007-02-14 | 2009-02-16 | Janssen Pharmaceutica Nv | LTA4H modulators and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE167035C (ko) * | ||||
| DE1670635A1 (de) * | 1967-09-06 | 1970-08-06 | Eisai Co Ltd | o-(ss-Morpholinoaethoxy) diphenylaether |
| US3988475A (en) * | 1974-02-05 | 1976-10-26 | Istituto Luso Farmaco D'italia S.R.L. | Phenoxyalkylamines |
| CA1086733A (en) * | 1976-12-06 | 1980-09-30 | Ryoji Kikumoto | Pharmaceutically active 2-substituted-1-(omega- aminoalkoxy) benzenes |
| GB2078217B (en) * | 1980-06-14 | 1984-01-11 | Beecham Group Ltd | Phenolic ethers their preparation and use |
| US4393061A (en) * | 1982-06-21 | 1983-07-12 | Stiefel Laboratories, Inc. | Anesthetic-antipruritic morpholine compounds, compositions and use |
| DE3410070A1 (de) * | 1984-03-20 | 1985-10-03 | Hoechst Ag, 6230 Frankfurt | 1-(2-aryl-1,3-dioxolan-2-ylmethyl)-azole, ihre salze, verfahren zu ihrer herstellung, sie enthaltende zubereitungen und ihre verwendung |
| DK368687A (da) * | 1986-11-21 | 1988-05-22 | Cheminova As | Aminoalkylerede hydroxyforbindelser og deres anvendelse som fungicider |
-
1990
- 1990-03-13 IT IT19653A patent/IT1240598B/it active IP Right Grant
-
1991
- 1991-03-11 IL IL9749991A patent/IL97499A/en not_active IP Right Cessation
- 1991-03-11 AU AU72794/91A patent/AU637204B2/en not_active Ceased
- 1991-03-12 DE DE69113659T patent/DE69113659T2/de not_active Expired - Fee Related
- 1991-03-12 ES ES91103764T patent/ES2078369T3/es not_active Expired - Lifetime
- 1991-03-12 BR BR919100971A patent/BR9100971A/pt not_active Application Discontinuation
- 1991-03-12 RU SU914894899A patent/RU2038353C1/ru active
- 1991-03-12 NO NO910965A patent/NO179835C/no unknown
- 1991-03-12 EP EP91103764A patent/EP0446873B1/en not_active Expired - Lifetime
- 1991-03-12 CA CA002038076A patent/CA2038076A1/en not_active Abandoned
- 1991-03-12 AT AT91103764T patent/ATE128963T1/de not_active IP Right Cessation
- 1991-03-12 DK DK91103764.6T patent/DK0446873T3/da active
- 1991-03-13 KR KR1019910004009A patent/KR100193159B1/ko not_active IP Right Cessation
- 1991-03-13 HU HU91822A patent/HU212751B/hu not_active IP Right Cessation
- 1991-03-13 JP JP3073837A patent/JPH05310652A/ja active Pending
- 1991-03-13 ZA ZA911850A patent/ZA911850B/xx unknown
-
1993
- 1993-01-04 US US08/001,919 patent/US5385892A/en not_active Expired - Fee Related
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1995
- 1995-10-24 GR GR950402936T patent/GR3017838T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3017838T3 (en) | 1996-01-31 |
| DE69113659T2 (de) | 1996-04-04 |
| DK0446873T3 (da) | 1996-02-19 |
| DE69113659D1 (de) | 1995-11-16 |
| IT9019653A1 (it) | 1991-09-13 |
| JPH05310652A (ja) | 1993-11-22 |
| CA2038076A1 (en) | 1991-09-14 |
| IT9019653A0 (it) | 1990-03-13 |
| ZA911850B (en) | 1991-12-24 |
| ATE128963T1 (de) | 1995-10-15 |
| AU637204B2 (en) | 1993-05-20 |
| NO179835C (no) | 1996-12-27 |
| US5385892A (en) | 1995-01-31 |
| RU2038353C1 (ru) | 1995-06-27 |
| IL97499A0 (en) | 1992-06-21 |
| NO910965L (no) | 1991-09-16 |
| EP0446873A1 (en) | 1991-09-18 |
| NO910965D0 (no) | 1991-03-12 |
| AU7279491A (en) | 1991-09-19 |
| BR9100971A (pt) | 1991-11-05 |
| EP0446873B1 (en) | 1995-10-11 |
| HUT56482A (en) | 1991-09-30 |
| NO179835B (no) | 1996-09-16 |
| ES2078369T3 (es) | 1995-12-16 |
| HU212751B (en) | 1996-10-28 |
| IT1240598B (it) | 1993-12-17 |
| IL97499A (en) | 1994-11-11 |
| KR100193159B1 (ko) | 1999-06-15 |
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