KR890001508A - 종양에 대한 높은 친화성을 지닌 비히클의 용도 - Google Patents

종양에 대한 높은 친화성을 지닌 비히클의 용도 Download PDF

Info

Publication number
KR890001508A
KR890001508A KR1019880008468A KR880008468A KR890001508A KR 890001508 A KR890001508 A KR 890001508A KR 1019880008468 A KR1019880008468 A KR 1019880008468A KR 880008468 A KR880008468 A KR 880008468A KR 890001508 A KR890001508 A KR 890001508A
Authority
KR
South Korea
Prior art keywords
tpa
fragment
formulation
derivative
contained
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019880008468A
Other languages
English (en)
Korean (ko)
Inventor
카로넨 시르카-리사
린드그렌 쟌
아로넨 한누
Original Assignee
디터 라우디엔,루돌프 호프만
베링거 인겔하임 인터내셔날 지엠에이치
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 디터 라우디엔,루돌프 호프만, 베링거 인겔하임 인터내셔날 지엠에이치 filed Critical 디터 라우디엔,루돌프 호프만
Publication of KR890001508A publication Critical patent/KR890001508A/ko
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Motorcycle And Bicycle Frame (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019880008468A 1987-07-08 1988-07-08 종양에 대한 높은 친화성을 지닌 비히클의 용도 Ceased KR890001508A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3722522.7 1987-07-08
DE19873722522 DE3722522A1 (de) 1987-07-08 1987-07-08 Verwendung eines vehikels mit hoher affinitaet zu tumoren

Publications (1)

Publication Number Publication Date
KR890001508A true KR890001508A (ko) 1989-03-27

Family

ID=6331118

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880008468A Ceased KR890001508A (ko) 1987-07-08 1988-07-08 종양에 대한 높은 친화성을 지닌 비히클의 용도

Country Status (13)

Country Link
EP (1) EP0298436B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH01125331A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR890001508A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE81473T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU623080B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE3722522A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK167561B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2046244T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI883177L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3006404T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO883040L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ225350A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA884870B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA831399B (en) * 1982-03-05 1984-02-29 Health Lab Service Board New fibrinolytic enzymes and methods for their production and pharmaceutical compositions containing them
US4663146A (en) * 1983-07-29 1987-05-05 Codon Genetic Engineering Laboratories Methods and compositions for the diagnosis of bloodclots using plasminogen activator

Also Published As

Publication number Publication date
FI883177A7 (fi) 1989-01-09
ES2046244T3 (es) 1994-02-01
JPH01125331A (ja) 1989-05-17
DE3875290D1 (de) 1992-11-19
EP0298436A3 (en) 1990-01-17
FI883177A0 (fi) 1988-07-04
ATE81473T1 (de) 1992-10-15
AU1889588A (en) 1989-01-12
DE3722522A1 (de) 1989-01-19
NZ225350A (en) 1991-07-26
EP0298436A2 (de) 1989-01-11
FI883177L (fi) 1989-01-09
DK377588A (da) 1989-01-09
DK167561B1 (da) 1993-11-22
NO883040L (no) 1989-01-09
NO883040D0 (no) 1988-07-07
ZA884870B (en) 1989-04-26
DK377588D0 (da) 1988-07-07
AU623080B2 (en) 1992-05-07
GR3006404T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-06-21
EP0298436B1 (de) 1992-10-14

Similar Documents

Publication Publication Date Title
Zhang et al. Fatty acid-conjugated radiopharmaceuticals for fibroblast activation protein-targeted radiotherapy
US4652440A (en) Method of stably radiolabeling antibodies with technetium and rhenium
Ege et al. Lymphoscintigraphy: a comparison of 99Tcm antimony sulphide colloid and 99Tcm stannous phytate
US6409987B1 (en) Targeted agents useful for diagnostic and therapeutic applications
JP3853354B2 (ja) 放射性標識ペプチドおよびタンパク質の自己放射線分解を防止する安定剤
JPH04503945A (ja) 血管透過性抱合体
Khaw et al. Gamma imaging with negatively charge-modified monoclonal antibody: modification with synthetic polymers
Halliday et al. Iron absorption in the rat: the search for possible intestinal mucosal carriers
IL97776A (en) Composition comprising a conjugate of a ZME antibody and a biological response modifier
KR100437507B1 (ko) 신규의콜라겐제제
JP2000515847A (ja) ペプチド放射性医薬品用途
KR890001508A (ko) 종양에 대한 높은 친화성을 지닌 비히클의 용도
JPS61155324A (ja) 癌治療薬剤
Dixit et al. Studies on rats with islet beta cell tumors induced by nicotinamide and streptozotocin
JP2725777B2 (ja) ウロキナーゼ阻害剤
EP0494247B1 (en) Reducing non-target retention of immunoconjugates and metabolites thereof
Endresen et al. Protective function of metallothionein against certain anticancer agents
Anghileri et al. 57Co-hematoporphyrin accumulation by experimental tumors
Smith et al. 99mTc-labelled human serum transferrin for tumour imaging: an in vitro and in vivo study of the complex
JP3522798B2 (ja) 糖修飾蛋白質の製造法
Catherwood et al. Generation of a carboxyl-terminal fragment of bovine parathyroid hormone by canine renal plasma membranes
Behnke et al. In vivo localisation of radiolabeled monoclonal antibody in human gliomas
WO1991004057A1 (en) Stable therapeutic radionuclide compositions and methods for preparation thereof
Billinghurst et al. An investigation of the effect of the quantity of stannous ion on the quality of technetium‐99m labelled albumin
Horvath et al. Leydig-like cells in the adrenals of a woman with ectopic ACTH syndrome

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19880708

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19930617

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19880708

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19960720

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 19961017

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 19960720

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I