KR880009904A - 도부타민염 및 이의 제조방법 - Google Patents

도부타민염 및 이의 제조방법 Download PDF

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Publication number
KR880009904A
KR880009904A KR1019880001856A KR880001856A KR880009904A KR 880009904 A KR880009904 A KR 880009904A KR 1019880001856 A KR1019880001856 A KR 1019880001856A KR 880001856 A KR880001856 A KR 880001856A KR 880009904 A KR880009904 A KR 880009904A
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KR
South Korea
Prior art keywords
salt
dobutamine
monobasic
phosphoric acid
phosphate
Prior art date
Application number
KR1019880001856A
Other languages
English (en)
Inventor
스코트 헤이스 제임스
롤스키 스태니슬로
Original Assignee
메리 앤 터커
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 메리 앤 터커, 일라이 릴리 앤드 캄파니 filed Critical 메리 앤 터커
Publication of KR880009904A publication Critical patent/KR880009904A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음.

Description

도부타민염 및 이의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. N-〔3-(4-하이드록시페닐)-1-메틸프로필〕-2-(3,4-디하이드록시페닐)에틸아민의 인산과의 (1:1)염.
  2. 제1항에 있어서, 상기 염이 라세미 일염기성 도부타민 인산염인 염.
  3. 제1항에 있어서, 상기 염이 일염기성(-)-도부타민 인산염인 염.
  4. 제1항에 있어서, 상기 염이 일염기성(+)-도부타민 인산염인 염.
  5. 산화방지제와 연합된 제1 내지 4항중 어느 한항에서 청구된 도부타민과 인산과의 염 용액을 포함하는 약제학적 제형.
  6. 제5항에 있어서, 용액이 수용액인 약제학적 제형.
  7. 라세미 일염기성 도부타민 인산염 및 중아횡산 나트륨의 수용액을 포함하는 약제학적 제형.
  8. 일염기성(-)-도부타민 인산염 및 중아황산 나트륨의 수용액을 포함하는 약제학적 제형.
  9. a)유리염기로서의 도부타민을 인산으로 중화시키거나: 또는 b) 도부타민의 산부가염을 인산으로 치환반응시키는 것을 포함하는 제1 내지 4항중 어느 한 항에서 청구된 도부타민과 인산과의 염을 제조하는 방법.
  10. 제9항에 따른 방법으로 제조된 도부타민의 염.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880001856A 1987-02-24 1988-02-23 도부타민염 및 이의 제조방법 KR880009904A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1826487A 1987-02-24 1987-02-24
US018264 1987-02-24

Publications (1)

Publication Number Publication Date
KR880009904A true KR880009904A (ko) 1988-10-05

Family

ID=21787060

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880001856A KR880009904A (ko) 1987-02-24 1988-02-23 도부타민염 및 이의 제조방법

Country Status (11)

Country Link
EP (1) EP0280461A3 (ko)
JP (1) JPS63225343A (ko)
KR (1) KR880009904A (ko)
CN (1) CN88100990A (ko)
AU (1) AU1202088A (ko)
DK (1) DK86488A (ko)
HU (1) HUT50101A (ko)
IL (1) IL85438A0 (ko)
PH (1) PH24791A (ko)
PT (1) PT86774B (ko)
ZA (1) ZA881076B (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104860833A (zh) * 2015-04-30 2015-08-26 上海紫源制药有限公司 一种盐酸多巴酚丁胺的纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA732136B (en) * 1972-04-12 1974-03-27 Lilly Co Eli Dopamine derivatives
FR2333499A1 (fr) * 1975-12-01 1977-07-01 Roussel Uclaf Nouveau derive de la phenethylamine et ses sels, procede de preparation et application a titre de medicament
RO93391B (ro) * 1984-12-20 1988-03-31 Eli Lilly And Company Procedeu pentru prepararea unor saruri de dobutamina

Also Published As

Publication number Publication date
DK86488A (da) 1988-08-25
AU1202088A (en) 1988-08-25
PT86774A (pt) 1988-03-01
HUT50101A (en) 1989-12-28
PH24791A (en) 1990-10-30
DK86488D0 (da) 1988-02-19
EP0280461A3 (en) 1989-09-20
IL85438A0 (en) 1988-07-31
EP0280461A2 (en) 1988-08-31
CN88100990A (zh) 1988-09-07
PT86774B (pt) 1992-05-29
ZA881076B (en) 1989-10-25
JPS63225343A (ja) 1988-09-20

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