KR20260040656A - 2차원 lc-ms/ms 시스템 - Google Patents

2차원 lc-ms/ms 시스템

Info

Publication number
KR20260040656A
KR20260040656A KR1020267006791A KR20267006791A KR20260040656A KR 20260040656 A KR20260040656 A KR 20260040656A KR 1020267006791 A KR1020267006791 A KR 1020267006791A KR 20267006791 A KR20267006791 A KR 20267006791A KR 20260040656 A KR20260040656 A KR 20260040656A
Authority
KR
South Korea
Prior art keywords
column
solvent
liquid chromatography
sample
analytes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020267006791A
Other languages
English (en)
Korean (ko)
Inventor
웨이-리엔 추앙
펠리페 가조스 로페즈
조슈아 파체코
게라드 샌더링크
Original Assignee
젠자임 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 젠자임 코포레이션 filed Critical 젠자임 코포레이션
Publication of KR20260040656A publication Critical patent/KR20260040656A/ko
Pending legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
    • B01D15/1878—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series for multi-dimensional chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/322—Normal bonded phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N30/14—Preparation by elimination of some components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G01N30/463—Flow patterns using more than one column with serial coupling of separation columns for multidimensional chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/89—Inverse chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/08—Sphingolipids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Endocrinology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1020267006791A 2019-05-31 2020-05-29 2차원 lc-ms/ms 시스템 Pending KR20260040656A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962855636P 2019-05-31 2019-05-31
US62/855,636 2019-05-31
KR1020217040904A KR102936574B1 (ko) 2019-05-31 2020-05-29 2차원 lc-ms/ms 시스템
PCT/US2020/035231 WO2020243502A1 (en) 2019-05-31 2020-05-29 Two-dimensional lc-ms/ms systems

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020217040904A Division KR102936574B1 (ko) 2019-05-31 2020-05-29 2차원 lc-ms/ms 시스템

Publications (1)

Publication Number Publication Date
KR20260040656A true KR20260040656A (ko) 2026-03-25

Family

ID=72193559

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020267006791A Pending KR20260040656A (ko) 2019-05-31 2020-05-29 2차원 lc-ms/ms 시스템
KR1020217040904A Active KR102936574B1 (ko) 2019-05-31 2020-05-29 2차원 lc-ms/ms 시스템

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020217040904A Active KR102936574B1 (ko) 2019-05-31 2020-05-29 2차원 lc-ms/ms 시스템

Country Status (14)

Country Link
US (2) US12292424B2 (https=)
EP (2) EP3976218B1 (https=)
JP (3) JP7568648B2 (https=)
KR (2) KR20260040656A (https=)
CN (2) CN119861166A (https=)
AU (1) AU2020282831B2 (https=)
CA (1) CA3140183A1 (https=)
DK (1) DK3976218T3 (https=)
ES (1) ES3026686T3 (https=)
HU (1) HUE071194T2 (https=)
IL (2) IL288497B1 (https=)
PL (1) PL3976218T3 (https=)
TW (1) TWI862597B (https=)
WO (1) WO2020243502A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120254137B (zh) * 2025-06-05 2026-04-14 科诺美(北京)科技有限公司 辅酶q10的检测方法及其应用
CN120820662B (zh) * 2025-09-17 2025-11-18 岛津企业管理（中国）有限公司 一种同步分析检测水产品中代谢物和脂质的方法

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WO2000045929A1 (en) * 1999-02-08 2000-08-10 Admetric Biochem Inc. Chromatographic system with pre-detector eluent switching
JP2003028849A (ja) 2001-07-10 2003-01-29 Hiromasa Tojo 自動化脂質組成一斉分析装置
JP2004184215A (ja) 2002-12-03 2004-07-02 Shimadzu Corp アクリルアミドの分析方法及び装置
EP1635174A1 (en) 2003-02-28 2006-03-15 Japan Science and Technology Agency Method of separating sugar from compound having glycoside bond, sugar separation system, sugar separation agent kit, standardized sample for sugar separation and assessment system
KR100614099B1 (ko) 2005-11-25 2006-08-22 한국과학기술연구원 뇨 또는 플라즈마 시료 중의 디에이치이에이 설페이트의검출방법
JP4790435B2 (ja) * 2006-02-03 2011-10-12 株式会社日立ハイテクノロジーズ ３次元液体クロマトグラフィ
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JP5054439B2 (ja) 2007-06-15 2012-10-24 株式会社日立ハイテクノロジーズ イオン交換および順相カラムによる２次元液体クロマトグラフ
DE102008013500A1 (de) * 2008-03-10 2009-09-17 Evonik Degussa Gmbh Neue chirale Selektoren und stationäre Phasen zur Trennung von Enantiomerengemischen
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TWI613445B (zh) 2016-04-01 2018-02-01 行政院農業委員會農業藥物毒物試驗所 搭配質譜影像分析檢驗農藥殘留之方法及其系統
US20180306797A1 (en) 2017-04-24 2018-10-25 Washington University Methods of detecting ceramide
HUE057483T2 (hu) 2017-06-02 2022-05-28 Genzyme Corp Eljárások kis gyakoriságú polipeptidek abszolút kvantifikálására tömeg-spektrometria alkalmazásával
KR20250025051A (ko) * 2017-08-24 2025-02-20 사노피 산성 스핑고미엘린분해효소 결핍증 환자에서의 비정상적 골병태의 치료
CN109187822A (zh) 2018-11-22 2019-01-11 上海烟草集团有限责任公司 一种中心切割二维色谱质谱联用分析烟草中农残的方法

Also Published As

Publication number Publication date
JP7804023B2 (ja) 2026-01-21
PL3976218T3 (pl) 2025-06-09
CA3140183A1 (en) 2020-12-03
AU2020282831B2 (en) 2026-03-05
JP2026062952A (ja) 2026-04-10
ES3026686T3 (en) 2025-06-11
EP3976218B1 (en) 2025-02-19
AU2020282831A1 (en) 2021-12-16
IL288497B1 (en) 2026-04-01
EP4560320A3 (en) 2025-08-13
JP7568648B2 (ja) 2024-10-16
IL326850A (en) 2026-04-01
IL288497A (en) 2022-01-01
JP2025000908A (ja) 2025-01-07
EP4560320A2 (en) 2025-05-28
CN119861166A (zh) 2025-04-22
KR20220016103A (ko) 2022-02-08
US20220252559A1 (en) 2022-08-11
DK3976218T3 (da) 2025-05-05
JP2022534363A (ja) 2022-07-29
CN114364980B (zh) 2024-12-27
KR102936574B1 (ko) 2026-03-09
WO2020243502A1 (en) 2020-12-03
CN114364980A (zh) 2022-04-15
TW202111322A (zh) 2021-03-16
TWI862597B (zh) 2024-11-21
US12292424B2 (en) 2025-05-06
US20250327780A1 (en) 2025-10-23
HUE071194T2 (hu) 2025-08-28
EP3976218A1 (en) 2022-04-06

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