KR20250099473A - Cosmetic composition for improving skin itching comprising the complex extract of sophora japonica fruits, dried ginger and akebiae quinata caulis, and manufacturing method thereof - Google Patents

Abstract

The present invention relates to a cosmetic composition for improving itching comprising a composite extract of Phellodendron amurense, Ginseng and Gosling stems as active ingredients, and a method for producing the same. The nano liposome (SOPHONLC) comprising a composite extract of Phellodendron amurense, Ginseng and Gosling stems as active ingredients provided by the present invention is superior in anti-itching and skin moisturizing efficacy compared to the use of a composite extract of Phellodendron amurense, Ginseng and Gosling stems, and therefore can be usefully utilized as a cosmetic composition or the like using the same as an active ingredient.

Description

Cosmetic composition for improving itching comprising the complex extract of sophora japonica fruit, dried ginger and akebiae quinata vine stem as effective ingredients and a manufacturing method thereof {COSMETIC COMPOSITION FOR IMPROVING SKIN ITCHING COMPRISING THE COMPLEX EXTRACT OF sophora japonica fruit, dried ginger and akebiae quinata caulis, and a manufacturing method thereof}

The present invention relates to a cosmetic composition for improving itching or a method for producing the same, and more specifically, to a cosmetic composition having skin moisturizing and itching alleviating effects and a method for producing the same, which comprises a composite extract of the fruit of the locust tree, health, and the stem of the quince, manufactured as a nanoliposome using a nanostructured lipid carrier method, as an effective ingredient.

Fine dust is at a very serious level worldwide, and this fine dust causes serious damage to modern people, such as respiratory diseases as well as various skin diseases such as contact dermatitis and eczema.

Accordingly, the market size of products for calming and relieving sensitive skin-related troubles is growing steadily by more than 15% every year along with the steady growth of the cosmetics industry.

In addition, many cosmetics using natural materials are being developed recently to reduce skin irritation caused by various chemicals. Natural materials not only have fewer side effects on the skin, but as consumers' response to cosmetics using natural materials has increased recently, their development value as cosmetic raw materials is increasing even more.

Sophora japonica fruit is the fruit of Sophora japonica, a deciduous broad-leaved tree in the legume family. The flowers and fruit of Sophora japonica are used as herbal medicine in oriental medicine. It contains apigenin, a flavonoid compound isolated from soybean leaves, and isoflavones, and has been reported to have anti-inflammation, hemostatic, hypertension, hemorrhoids, and eczema treatment effects. It has also been reported to be used for intestinal bleeding, uterine bleeding, gum inflammation, and skin cosmetics (Song Haeng-seon et al., The Society of Cosmetic Scientists of Korea, 2016, 42(4), p351-358).

In addition, methanol or ethanol reflux extraction methods were used to determine the efficacy and effect of the extracts of the flowers, fruits, and branches of the Prunella vulgaris. The polyphenol content of the methanol Prunella vulgaris flower extract was 38.9 mg/g, while the polyphenol content of the Prunella vulgaris flower extract extracted by the 75% ethanol reflux extraction method was 261.38±7.02 mg/g on average, showing a better result. These results suggest that the solvent and extraction method affect the effect of the ingredients. (Study on the skin improvement effect of the extracts of the flowers, fruits, and branches of the Prunella vulgaris. Authors: Song Haeng-seon, Jang Hye-in. The Society of Cosmetic Scientists of Korea, November 10, 2016)

In addition, as stated in Patent Publication No. 10-2011-0004603, since it was discovered that the extract of the fruit of the Chinese juniper tree has better estrogen secretion activity than estradiol, which is known to be the most effective among estrogens, research on compositions containing the extract of the Chinese juniper tree as an active ingredient is actively being conducted.

However, the extract of the Chinese juniper tree, which has been used in the past for its anti-aging and wrinkle-improving effects, has been used as a method of improving wrinkles and preventing aging by mixing it with cosmetics or medicines as a simple substance that inhibits ascorbic acid, retinol, and collagenase activity. However, there was a problem that it was difficult to obtain a practical effect because the stability was poor when mixed or the skin did not absorb it easily, so the effect was minimal.

Dried ginger is known to have physiological activities such as antibacterial and antioxidant effects.

Akebia quinata, also called Akebia or Akebia quinata, grows in mountains and fields and grows to about 5 m in length. In oriental medicine, the roots and stems are used as medicine because they are effective in anti-inflammatory, diuretic, and laxative effects. Akebia extract can be obtained by extracting various organs or parts of Akebia (e.g., leaves, roots, stems, branches, twigs, bark, and seeds).

Republic of Korea Patent No. 10-2232341 Republic of Korea Patent No. 10-2579345 Republic of Korea Patent No. 10-2121457 Republic of Korea Publication Patent No. 10-2014-0071716

The purpose of the present invention is to provide a cosmetic composition that has an effect of helping to improve skin itchiness, has few side effects on the human body, and has a high skin absorption rate, and a method for producing the same.

In addition, the purpose of the present invention is to provide a cosmetic composition that helps improve skin moisturization and skin itchiness by using a nanostructured lipid carrier method and a method for manufacturing the same, which contains a composite extract of the fruit of the locust tree, health, and the stem of the quince, as an effective ingredient.

In order to achieve the above purpose, the cosmetic composition for improving itching according to the present invention,

A compound extract comprising a mixture of the fruits of the conversation tree, health and the stem of the vine, wherein the compound extract is manufactured and contained in the form of a nano liposome.

Here, the compound extract of the conversation tree fruit, health, and mugwort stem is characterized in that it is mixed in a weight ratio of 5 to 10: 0.5 to 1: 0.5 to 1.

In addition, in the cosmetic composition for improving itching of the present invention,

The above complex extract is characterized by containing sophoricoside.

In addition, the method for producing a cosmetic composition for improving itching according to the present invention,

Step 1: Making a mixture by mixing the fruits of the conversation tree, health and the vine;

A second step of extracting the mixture of the first step with ethanol;

A third step of obtaining a complex extract through cooling and depressurization concentration after the extraction in the second step; and

A fourth step of maturing the complex extract obtained in the third step; containing the manufactured complex extract,

The invention is characterized in that the above-mentioned manufactured complex extract is passed through a high-pressure microemulsifier together with solid lipids, liquid lipids, and an emulsifying agent to produce nano liposomes.

At this time, the conversation tree fruit, health and mugwort stem of the compound extract of the first step can be mixed in a weight ratio of 5 to 10: 0.5 to 1: 0.5 to 1.

Additionally, the first step includes a moisturizer and a preservative,

The above moisturizer may include dipropylene glycol, and the above preservative may include 1,2-hexanediol.

In addition, in the method for manufacturing a cosmetic composition for improving itching according to the present invention,

The above-mentioned manufactured complex extract is characterized in that it contains sophoricoside.

In addition, the solid lipid is at least one selected from the group consisting of hydrogenated lecithin and cetyl palmitate, and the liquid lipid is macadamia seed oil.

The above emulsifying agent is characterized by being polyglyceryl-3 methyl glucose distearate.

In addition, in the method for manufacturing a cosmetic composition for improving itching according to the present invention,

The above complex extract is characterized in that it is contained in an amount of 30 to 35 wt% based on the total weight of the cosmetic composition.

The cosmetic composition provided by the present invention has the effect of improving stability and dispersibility and increasing skin absorption rate by using a nano-liposome method using a nanostructured lipid carrier containing a composite extract of the fruit of the Chinese juniper tree, health, and the stem of the Chinese juniper tree as effective ingredients.

Additionally, a cosmetic composition including nano liposomes can be manufactured into a cosmetic composition or skin external application that helps protect the skin and improve skin itchiness.

Figure 1 is a diagram according to the present invention. The particle diameter size of nano liposomes of a complex extract containing sophoricoside was measured using Photal ELS-Z.
Figure 2 shows the results of measuring the zeta potential using Photal and ELS-Z to measure the stability of nano liposomes of a complex extract containing Sophoricoside according to the present invention.
Figure 3 shows the results of measuring the temperature-dependent stability of nano liposomes of a complex extract containing Sophoricoside according to the present invention.
Figure 4 shows the results of Filaggrin protein analysis according to the present invention.
Figure 5 shows the results of Loricrin (LOR) protein analysis according to the present invention.
Figure 6 shows the results of TRPV-1 protein analysis according to the present invention.
Figure 7 shows the results of moisturizing power and sustained moisturizing power evaluation for Manufacturing Examples 1 and 2 according to the present invention.
Figure 8 shows the results of evaluating the improvement in transepidermal water loss for Manufacturing Examples 1 and 2 according to the present invention.
Figure 9 is a drawing comparing the composition of a nanolipid carrier (NLC) according to the present invention and a conventional liposome.

Hereinafter, the cosmetic composition according to the present invention will be described in detail with reference to test examples and examples, but the present invention is not limited to these manufacturing examples, test examples and examples. These examples are provided to explain the present invention in more detail to a person having ordinary knowledge in the technical field to which the present invention belongs.

The complex extract according to the present invention is characterized in that it is manufactured and contained as a nano liposome, and the nano lipid carrier (NLC) is composed of a solid lipid component (hydrogenated lecithin) and a liquid lipid component (vegetable oil), as shown in (b) of FIG. 9, and has a single membrane structure.

The nano lipid carrier (NLC) according to the present invention has both solid lipid and liquid lipid components, so it is adsorbed to the skin surface to form a thin film and has a skin shielding effect. In other words, it can physically block evaporation of moisture from the skin and maintain moisture in the skin.

In addition, as shown in comparison in (a) and (b) of FIG. 9, the nanolipid carrier (NLC) has the advantage of superior physical stability compared to liposomes because it is composed of solid lipid components.

In particular, nanolipid carriers (NLCs) can capture large amounts of active ingredients as a structure in which structurally very different lipids are mixed.

[Comparative Example] Manufacturing of Conversation Tree Fruit Extract, Health Extract, and Mugwort Stem Extract

[Comparative Example 1: Extraction step of the fruit extract of the Chinese juniper tree]

The fruit of the conversation tree was extracted with 50% ethanol at 70℃ for 6 hours, cooled to room temperature, and concentrated under reduced pressure to obtain an extract. The obtained extract was stored in a cool place at 20℃ for 2 days to mature, and then used in the experiment.

[Comparative Example 2: Health Extract Extraction Step]

Health was extracted using 50% ethanol at 70℃ for 6 hours, cooled to room temperature, and concentrated under reduced pressure to obtain an extract. The obtained extract was stored in a cool place at 20℃ for 2 days to mature, and then used in the experiment.

[Comparative Example 3: Extraction step of the extract of the stem of the vine]

The stem of the vine was extracted with 50% ethanol at 70℃ for 6 hours, cooled to room temperature, and concentrated under reduced pressure to obtain an extract. The obtained extract was stored in a cool place at 20℃ for 2 days to mature before use.

[Decompression Concentration Stage]

The extracts of the fruit of the Chinese juniper tree, the health extracts, and the extracts of the stem of the Chinese juniper tree, which were extracted independently in each extraction step of Comparative Examples 1, 2, and 3, were cooled and concentrated under reduced pressure.

More specifically, in the reduced pressure concentration step, it is preferable to cool the single extract of the extraction step to room temperature of 15 to 35°C and concentrate it under reduced pressure.

[Example 1] Manufacturing steps of a composite extract (Pine tree fruit, health, and quince stem)

A mixture of the fruits of the conversation tree, health, and vine stems in a weight ratio of 5–10: 0.5–1: 0.5–1 was extracted with 50% ethanol at 70°C for 6 hours. After extraction, the extract was mixed with dipropylene glycol as a moisturizer and 1,2-hexanediol as a preservative, then cooled to room temperature and concentrated under reduced pressure to secure a complex extract. The obtained extract was stored in a cool place at 20°C for 2 days to mature, and then used in the experiment.

ingredient weight(%) Sophora Japonica Fruit Extract 38.40 Health Extract (Zingiber Officinale (Ginger) Root Extract) 4.80 Akebia Quinata Stem Extract 4.80 Dipropylene Glycol 50.00 1,2-Hexanediol 2.00

[Example 2] Preparation of nano liposomes from a complex extract (Prunella vulgaris fruit, health, and vine stem) containing sophoricoside

Nano liposomes were manufactured using a high-pressure emulsifier, including 30 wt% of the complex extract of Example 1. The liposome was passed through the high-pressure microemulsifier at a pressure of 1000 bar three times in succession, and the liposome composition was as shown in Table 2 below. Hydrogenated lecithin and Cutina®CP (cetyl palmitate) were used as solid lipid components, macadamia seed oil was used as a liquid lipid (liquid lipid) vegetable oil, and TEGO®Care 450 (polyglyceryl-3 methyl glucose distearate) was used as an emulsifying aid.

Here, hydrogenated lecithin, a solid lipid component, is one of the phospholipid components and contributes to the formation of the vesicle membrane during liposome manufacturing.

ingredient weight(%) Hydrogenated Lecithin 5.00 Cetyl Palmitate 15.00 Polyglyceryl-3 methyl glucose distearate
(Polyglyceryl-3 Methylglucose Distearate) 3.00 Purified water 42.00 Macadamia Ternifolia Seed Oil 5.00 Compound extract 30.00

[Experimental Example 1] Measurement of particle distribution

The particle distribution of nano liposomes containing the composite extracts (Prunella vulgaris fruit, health, and quince stem) prepared in Example 1 was measured using Photal ELS-Z, and is shown in Figure 1.

As shown in Figure 1, the measurement results showed that the average particle size of the nano liposomes containing the composite extracts (Prunella vulgaris fruit, health, and quince stem) was 139.2 nm, respectively.

[Experimental Example 2] Measurement of zeta potential

In order to measure the stability of nano liposomes of the complex extract (Prunella vulgaris fruit, health, and quince stem) containing sophoricoside prepared in Example 2, the zeta potential was measured using Photal and ELS-Z, and the results are shown in Fig. 2.

As shown in Fig. 2, the measurement result showed that the potential was stable at -16.87 mV.

[Experimental Example 3] Stability Measurement Using Turbiscan

In order to measure the stability of the complex extract (Prunella vulgaris fruit, health, and quince stem) containing Sophoricoside manufactured in Example 2, near-infrared rays were irradiated 50 times under two conditions of 45℃ and 25℃ for 4 hours from the top to the bottom of the liposome raw sample using Turbiscan (TurbiscanLAB, Formulation, France). The dispersion stability and particle size of the formed nanoliposomes were confirmed, and the results are shown in Fig. 3.

As shown in Figure 3, the measurement results graph showed no significant change and was constant, confirming that it was a stable material property.

[Experimental Example 4] Measurement of the percutaneous absorption rate of nanoliposomes containing composite extracts (Prunella vulgaris fruit, health, and quince stem) as active ingredients

The skin penetration rate of Sophoricoside of the raw materials manufactured in Examples 1 and 2 was compared and evaluated. The experiment was conducted by mounting it on a Franz-type diffusion cell (Transdermal Semi-Auto Diffusion Cell, LOGAN Instruments, USA) using an artificial skin, Strat-M®Membrane (Transdermal Diffusion Test Model).

After adding 50 mM phosphate buffer (pH 7.4, 0.1 M NaCl) to the receptor container (5 mL) of the Franz-type diffusion cell, the diffusion cell was mixed and dispersed at 32°C and 600 rpm, and the samples of Example 1 and Example 2 were placed in the donor container.

After placing and fixing the artificial skin between the Franz diffusion cell and the media, the absorption process was observed for 48 hours, and then all of the media solution was recovered using a fixed syringe.

The content of Sophoricoside contained in the recovered media solution was quantitatively evaluated through HPLC analysis.

[Experimental Example 4-1] Sophoricoside HPLC content analysis

To measure the content of Sophoricoside contained in the nano liposomes manufactured in Examples 1 and 2, an HPLC (Model 510 Waters USA) analysis method was used under the conditions in Table 3 below.

The measurement results are shown in Fig. 4, and as illustrated in Fig. 4, Example 1 was detected from about 1.15% in the initial content analysis value (0 hr) to about 0.00014% after percutaneous absorption (24 hrs), and the absorption amount was confirmed to be about 0.012%.

Example 2 was detected at about 0.313% in the initial content analysis value (0 hr) and about 0.00093% after percutaneous absorption (24 hrs), and the absorption amount was confirmed to be about 0.30%.

The nano liposome of Example 2 showed a skin absorption rate that was approximately 20 times higher than the percutaneous absorption rate.

[Experimental Example 5] Test for Itching Improvement Efficacy by Histamine Stimulation in Artificial Skin

We conducted a test on the effects of histamine-induced itching-related proteins, Filaggrin, Loricrin, and Transient receptor potential vanilloid type 1 (TRPV-1), in reconstructed skin tissue. The experimental method is to treat the reconstructed skin tissue with samples and irritants (histamine) every 48 hours, harvest the tissue after 5 days, and fix it in 10% Neutral Buffered formalin for 24 hours. Embed it with OCT Compound, make 12 μm sections, and then fix it on slides.

After performing H&E (Hematoxylin and eosin) staining, observe General Morphology under a microscope. After performing immunofluorescence staining, observe under a fluorescence microscope.

(1) Results of Filaggrin (FLG) protein analysis

Filaggrin (FLG) is a protein that plays an important role in the formation of the stratum corneum in the epidermis. An increase in filaggrin means that a normal skin barrier is formed, preventing skin moisture evaporation. Filaggrin was stained with red fluorescence from the granular layer of the epidermis to the stratum corneum. The blue light is the staining of the cell nucleus.

As a result of the measurement, there was a statistically significant change in the Example 1 treatment group compared to the Histamine 10 μM treatment group, and the increase rate was 321.93%.

Compared to the histamine 10 μM treatment group, there was a statistically significant change in the Example 2 treatment, and the increase rate was 442.58%.

This indicates that the amount of FLG was increased by the test sample.

(2) Results of Loricrin (LOR) protein analysis

Loricrin (LOR) is a protein expressed during the terminal differentiation of keratinocytes. It is necessary for keratinocytes to differentiate and form stable keratin and accounts for 70-85% of keratin mass. It has a domain rich in glutamine and lysine that can participate in cross-linking between peptides catalyzed by transglutaminase, and plays an important role in keratinogenesis by helping cross-linking between keratinogenic proteins. The expression of this protein is reduced in skin continuously exposed to histamine.

The measurement results showed that there was a statistically significant change in the Example 1 treatment group compared to the Histamine 10 μM treatment group, and the increase rate was 154.74%.

Compared to the histamine 10 μM treatment group, there was a statistically significant change in the Example 2 treatment, and the increase rate was 188.14%.

This indicates that the amount of LOR was increased by the test sample.

(3) Results of TRPV-1 protein analysis

Among the TRP channels, TRPV-1 (transient receptor potential vanilloid type 1), known as the capsaicin receptor, plays a role in protecting oneself by responding to external stimuli in addition to causing a burning sensation of heat. When TRPV1 is excessively activated, it increases the sensation of heat and itchiness, causing skin sensitivity. This is excessively activated by histamine.

The measurement results showed that there was a statistically significant change in the Example 1 treatment group compared to the Histamine 10 μM treatment group, and the increase rate was 56.17%.

Compared to the histamine 10 μM treatment group, there was a statistically significant change in the Example 2 treatment, and the increase rate was 69.74%.

This indicates that the amount of TRPV-1 was increased by the test sample.

[Experimental Example 6] Primary skin irritation test for skin irritation

The complex extracts manufactured in Examples 1 and 2 above were used to prepare a cream according to the contents of Manufacturing Examples 1 and 2 below, and the following test was conducted on the skin irritation effect of 30 healthy adult men and women.

[Manufacturing Example 1] Manufacturing of a cream using the combined extracts of the fruit of the Chinese juniper tree, health, and the stem of the Chinese juniper tree of Example 1

A transparent emulsifying system was prepared by dissolving cetearyl olivate, sorbitan olivate, cetearyl alcohol, hydrogenated polydecene, and squalane at 75°C to 80°C. Disodium EDTA, glycerin, panthenol, and carbomer were dispersed in purified water, and the emulsifying system dissolved in the water phase heated to 70°C to 75°C was added, and emulsified for 5 minutes under the conditions of 3,500 to 4,000 rpm with a homomixer. Tromethamine was added at 60°C to 65°C, and the mixture was stirred for 3 minutes under the conditions of 3,000 to 3,500 rpm with a homomixer to neutralize. 1,2-hexanediol and ethylhexylglycerin were added at 45°C, stirred for 3 minutes, and then cooled to 30°C. After that, CSP-811 was added and stirred and defoamed for 3 minutes to prepare a cream formulation.

[Manufacturing Example 2] Manufacturing of a cream using nano liposomes of the combined extracts of the fruit of the Chinese juniper tree, health, and the stem of the Chinese juniper tree of Example 2

A transparent emulsifying system was prepared by dissolving cetearyl olivate, sorbitan olivate, cetearyl alcohol, hydrogenated polydecene, and squalane at 75°C to 80°C. Disodium EDTA, glycerin, panthenol, and carbomer were dispersed in purified water, and the emulsifying system dissolved in the water phase heated to 70°C to 75°C was added, and emulsified for 5 minutes under the conditions of 3,500 to 4,000 rpm with a homomixer. Tromethamine was added at 60°C to 65°C, and the mixture was stirred for 3 minutes under the conditions of 3,000 to 3,500 rpm with a homomixer to neutralize. 1,2-hexanediol and ethylhexylglycerin were added at 45°C, stirred for 3 minutes, and then cooled to 30°C. After that, CSP-811 nano liposomes were added and stirred and defoamed for 3 minutes to prepare a cream formulation.

Ingredients Manufacturing example 1 Manufacturing example 2 Example 1 2 - Example 2 - 2 Purified water to 100 to 100 Glycerin 15 15 Hydrogenated polydecene 5 5 Panthenol 5 5 Cetearyl Olivate 3 3 Solbitan Olivate 2 2 Cetearyl alcohol 1 1 Tromethamine 0.12 0.12 Disodium EDTA 0.02 0.02 Total 100 100

The test area was the subject's back, and to ensure the same measurement conditions, the test area was kept clean and dry. The test was performed after allowing the skin to rest in a place with constant temperature and humidity (22±2℃, R.H. 40-60%) for at least 30 minutes.

Manufacturing Examples 1 and 2 were applied to the skin as patches for 24 hours, and after the patches were removed, skin reactions appearing at the test site were classified into the degree of irritation according to the criteria of the International Contact Dermatitis Research Group (ICDRG), and the average skin reaction score was calculated according to the skin patch test result assessment table.

As a result of the experiment, as shown in Fig. 5, no irritation was observed for Manufacturing Examples 1 and 2 for 24 hours and 48 hours. The average skin reactivity was 0.00, which was judged as non-irritating.

[Experimental Example 7] Evaluation of moisturizing power and continuous moisturizing power

In the preparation stage, the test area was kept clean and dry to ensure the same measurement conditions for the subjects, and the skin was allowed to rest in a place with constant temperature and humidity (22±2℃ RH 40~60%) for at least 30 minutes before testing. In the measurement stage, the products of Manufacturing Examples 1 and 2 were applied to the selected test area (5 cm X 4 cm) of the forearm using a micro pipette in an amount of 2 mg/ ^cm2 . The measurements were taken four times in total, before, after, 3 hours later, and 6 hours later, and the average value was calculated using the three values. Skin moisture was measured using an aphrodite moisture checker MC-1000.

As a result of evaluating moisturizing and moisturizing durability, Manufacturing Example 1 showed an increase and maintenance of moisturizing power of 52.5% after application, 49.5% after 3 hours of application, and 44.8% after 6 hours of application. Manufacturing Example 2 showed an increase and maintenance of moisturizing power of 58.0% after application, 55.8% after 3 hours of application, and 48.4% after 6 hours of application.

[Experimental Example 8] Evaluation of improvement in skin moisture loss

In the preparation stage, the test area was kept clean and dry to ensure the same measurement conditions for the subjects, and the skin was allowed to rest in a place with constant temperature and humidity (22±2℃ RH 40~60%) for at least 30 minutes before the test. In the measurement stage, the products of Manufacturing Examples 1 and 2 were applied to the selected test area (5 cm X 4 cm) on the forearm using a micro pipette at an amount of 2 mg/ ^cm2 . Measurements were taken twice in total, before and after 3 hours of product use, and the average value was calculated using the three values. The transepidermal water loss was measured using a Tewameter®TM 300 device.

As a result of evaluating the improvement in transepidermal water loss, Manufacturing Example 1 showed a 58.1% improvement after application, a 48.7% improvement after 3 hours, and a 41.3% improvement after 6 hours, demonstrating a continuous effect. Manufacturing Example 2 showed a 31.8% improvement after application, a 32.3% improvement after 3 hours, and a 46.4% improvement after 6 hours, demonstrating a continuous effect of improvement.

The embodiments of the present invention described above should not be construed as limiting the technical idea of the present invention. The protection scope of the present invention is limited only by the matters described in the claims, and those with ordinary knowledge in the technical field of the present invention can improve and change the technical idea of the present invention in various forms. Accordingly, such improvements and changes will fall within the protection scope of the present invention as long as they are obvious to those with ordinary knowledge.

Claims (9)

Contains a complex extract extracted by mixing the fruits of the conversation tree, health and the stem of the vine,
A cosmetic composition for improving itching, characterized in that the above complex extract is manufactured and contained in the form of nano liposomes.
In paragraph 1,
A cosmetic composition for improving itching, characterized in that the fruits of the above-mentioned compound extract, the health extract, and the stem of the mugwort are mixed in a weight ratio of 5 to 10: 0.5 to 1: 0.5 to 1.
In paragraph 1 or 2,
A cosmetic composition for improving itching, characterized in that the above complex extract contains sophoricoside.
Step 1: Making a mixture by mixing the fruits of the conversation tree, health and the vine;
A second step of extracting the mixture of the first step with ethanol;
A third step of obtaining a complex extract through cooling and depressurization concentration after the extraction in the second step; and
A fourth step of maturing the complex extract obtained in the third step; containing the manufactured complex extract,
A method for producing a cosmetic composition for improving itching, characterized in that the above-mentioned manufactured complex extract is passed through a high-pressure microemulsifier together with a solid lipid, a liquid lipid, and an emulsifying agent to produce nano liposomes.
In paragraph 4,
A method for producing a cosmetic composition for improving itching, characterized in that the first step conversation tree fruit, health and mugwort vine are mixed in a weight ratio of 5 to 10: 0.5 to 1: 0.5 to 1.
In paragraph 4,
The first step above includes moisturizers and preservatives,
A method for producing a cosmetic composition for improving itching, characterized in that the moisturizer is dipropylene glycol and the preservative is 1,2-hexanediol.
In paragraph 4,
A method for producing a cosmetic composition for improving itching, characterized in that the above-mentioned manufactured complex extract contains sophoricoside.
In paragraph 4,
The above solid lipid is at least one selected from the group consisting of hydrogenated lecithin and cetyl palmitate,
The above liquid lipid is macadamia seed oil.
A method for producing a cosmetic composition for improving itching, characterized in that the emulsifying agent is polyglyceryl-3 methyl glucose distearate.
In paragraph 4,
A method for producing a cosmetic composition for improving itching, characterized in that the above complex extract is contained in an amount of 30 to 35 wt% based on the total weight of the cosmetic composition.