KR20250005145A - 감마-하이드록시부티레이트 전달 화합물 및 이를 제조 및 사용하는 방법 - Google Patents

감마-하이드록시부티레이트 전달 화합물 및 이를 제조 및 사용하는 방법 Download PDF

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KR20250005145A
KR20250005145A KR1020247034900A KR20247034900A KR20250005145A KR 20250005145 A KR20250005145 A KR 20250005145A KR 1020247034900 A KR1020247034900 A KR 1020247034900A KR 20247034900 A KR20247034900 A KR 20247034900A KR 20250005145 A KR20250005145 A KR 20250005145A
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ghb
compound
tablet
mmol
oral
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스벤 귄터
산집 베라
아담 스미스
트래비스 믹클
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제브라 테라퓨틱스, 인코포레이티드
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    • C07F9/2479Compounds containing the structure P(=X)n-N-acyl, P(=X)n-N-heteroatom, P(=X)n-N-CN (X = O, S, Se; n = 0, 1)
    • C07F9/2487Compounds containing the structure P(=X)n-N-acyl, P(=X)n-N-heteroatom, P(=X)n-N-CN (X = O, S, Se; n = 0, 1) containing the structure P(=X)n-N-C(=X) (X = O, S, Se; n = 0, 1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears

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JP4576737B2 (ja) 2000-06-09 2010-11-10 Jsr株式会社 感放射線性樹脂組成物
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ES2383673T3 (es) * 2000-09-22 2012-06-25 Jpi Commercial, Llc Composiciones de gamma-hidroxibutirato que contienen portadores de hidrato de carbonos
US20040229943A1 (en) * 2003-05-16 2004-11-18 Cephalon Inc Analeptic and drug combinations
JP4973304B2 (ja) * 2007-04-27 2012-07-11 日油株式会社 1,2,3,4−シクロブタンテトラカルボン酸の製造方法
WO2011057199A1 (en) * 2009-11-06 2011-05-12 Adenios, Inc. Compositions for treating cns disorders
JP5531034B2 (ja) * 2012-01-31 2014-06-25 富士フイルム株式会社 感光性樹脂組成物、硬化膜の形成方法、硬化膜、有機el表示装置及び液晶表示装置
US8591922B1 (en) * 2012-12-14 2013-11-26 Jazz Pharmacuticals, Inc. Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
ITMI20132041A1 (it) * 2013-12-06 2015-06-07 Ct Lab Farm Srl Derivati dell'acido gamma-idrossibutirrico, loro preparazione e loro uso medico.
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US20200114015A1 (en) * 2017-04-11 2020-04-16 John K. Thottathil Novel Alpha-Hydroxy Carboxylic Acid And Derivatives And Other GRAS- Based Prodrugs Of Gamma-Hydroxybutyrate (GHB) And Uses Thereof
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