KR20230079405A - Snca-관련 신경퇴행성 질환의 치료 또는 예방을 위한 snca irna 조성물 및 그 사용 방법 - Google Patents

Snca-관련 신경퇴행성 질환의 치료 또는 예방을 위한 snca irna 조성물 및 그 사용 방법 Download PDF

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KR20230079405A
KR20230079405A KR1020237014415A KR20237014415A KR20230079405A KR 20230079405 A KR20230079405 A KR 20230079405A KR 1020237014415 A KR1020237014415 A KR 1020237014415A KR 20237014415 A KR20237014415 A KR 20237014415A KR 20230079405 A KR20230079405 A KR 20230079405A
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nucleotides
strand
nucleotide
antisense strand
dsrna
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만갈라 미낙시 사운다라판디안
란 티 호앙 당
제임스 디. 매킨취
마크 케이. 슐레겔
아담 카스토레노
차랄람보스 카이타니스
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알닐람 파마슈티칼스 인코포레이티드
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KR1020237014415A 2020-10-01 2021-09-29 Snca-관련 신경퇴행성 질환의 치료 또는 예방을 위한 snca irna 조성물 및 그 사용 방법 Pending KR20230079405A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063086495P 2020-10-01 2020-10-01
US63/086,495 2020-10-01
PCT/US2021/052580 WO2022072447A1 (en) 2020-10-01 2021-09-29 Snca irna compositions and methods of use thereof for treating or preventing snca-associated neurodegenerative diseases

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KR20230079405A true KR20230079405A (ko) 2023-06-07

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KR1020237014415A Pending KR20230079405A (ko) 2020-10-01 2021-09-29 Snca-관련 신경퇴행성 질환의 치료 또는 예방을 위한 snca irna 조성물 및 그 사용 방법

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US (1) US20240011032A1 (https=)
EP (1) EP4221838A4 (https=)
JP (1) JP2023544385A (https=)
KR (1) KR20230079405A (https=)
CN (1) CN116710107A (https=)
AR (1) AR123679A1 (https=)
AU (1) AU2021353935A1 (https=)
CA (1) CA3193830A1 (https=)
IL (1) IL301712A (https=)
MX (1) MX2023003810A (https=)
TW (1) TW202229551A (https=)
WO (1) WO2022072447A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119630791A (zh) * 2022-05-13 2025-03-14 迪克纳制药公司 用于抑制snca表达的组合物和方法
US20260103703A1 (en) * 2022-09-29 2026-04-16 Atalanta Therapeutics, Inc. siRNA COMPOSITIONS AND METHODS TARGETING ALPHA-SYNUCLEIN NUCLEIC ACIDS
WO2024166019A1 (en) * 2023-02-08 2024-08-15 Biorchestra Co., Ltd. Sirna targeting alpha-synuclein and uses thereof
AU2024335806A1 (en) * 2023-09-07 2026-04-23 Janssen Pharmaceutica Nv SNCA siRNA AND USES THEREOF
WO2025162214A1 (en) * 2024-01-30 2025-08-07 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of synuclein alpha (snca) gene
TW202547527A (zh) * 2024-02-08 2025-12-16 日商泰爾茂股份有限公司 寡核苷酸

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006006948A2 (en) * 2002-11-14 2006-01-19 Dharmacon, Inc. METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
EP2508608A1 (en) * 2003-06-09 2012-10-10 Alnylam Pharmaceuticals Inc. Method of treating neurodegenerative disease
WO2005045034A2 (en) * 2003-10-23 2005-05-19 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED TREATMENT OF PARKINSON DISEASE USING SHORT INTERERING NUCLEIC ACID (siNA)
US20080003570A1 (en) * 2004-12-22 2008-01-03 The General Hospital Corporation Translation enhancer elements of genes encoding human Tau protein and human alpha-synuclein protein
US20100105134A1 (en) * 2007-03-02 2010-04-29 Mdrna, Inc. Nucleic acid compounds for inhibiting gene expression and uses thereof
WO2009079399A2 (en) * 2007-12-14 2009-06-25 Alnylam Pharmaceuticals, Inc. Method of treating neurodegenerative disease
WO2012027713A2 (en) * 2010-08-26 2012-03-01 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibition of snca
CA3077910A1 (en) * 2010-11-17 2012-05-24 Ionis Pharmaceuticals, Inc. Modulation of alpha synuclein expression
CN108728533B (zh) * 2017-04-20 2022-06-14 常青 用于髓母细胞瘤分子分型的基因群以及snca基因作为4型髓母细胞瘤的生物标志物的用途
AU2019207859A1 (en) * 2018-01-12 2020-07-02 Roche Innovation Center Copenhagen A/S Alpha-synuclein antisense oligonucleotides and uses thereof
WO2019217459A1 (en) * 2018-05-07 2019-11-14 Alnylam Pharmaceuticals, Inc. Extrahepatic delivery
EP3830265A1 (en) * 2018-08-03 2021-06-09 Genzyme Corporation Variant rnai against alpha-synuclein

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JP2023544385A (ja) 2023-10-23
TW202229551A (zh) 2022-08-01
CA3193830A1 (en) 2022-04-07
CN116710107A (zh) 2023-09-05
AU2021353935A1 (en) 2023-05-25
WO2022072447A1 (en) 2022-04-07
AR123679A1 (es) 2023-01-04
EP4221838A1 (en) 2023-08-09
MX2023003810A (es) 2023-06-12
US20240011032A1 (en) 2024-01-11
EP4221838A4 (en) 2025-04-16
IL301712A (en) 2023-05-01

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