KR20230033388A - Compositions for Improving Skin Wrinkles and Skin Whitening Using an Extract of Veratrum versicolor - Google Patents
Compositions for Improving Skin Wrinkles and Skin Whitening Using an Extract of Veratrum versicolor Download PDFInfo
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- KR20230033388A KR20230033388A KR1020210116297A KR20210116297A KR20230033388A KR 20230033388 A KR20230033388 A KR 20230033388A KR 1020210116297 A KR1020210116297 A KR 1020210116297A KR 20210116297 A KR20210116297 A KR 20210116297A KR 20230033388 A KR20230033388 A KR 20230033388A
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Abstract
Description
본 발명은 푸른여로(Veratrum versicolor) 추출물을 이용한 피부 주름 개선 및 피부 미백용 조성물에 관한 것이다.The present invention relates to a composition for improving skin wrinkles and skin whitening using an extract of Blue Yero ( Veratrum versicolor ).
피부는 인체의 약 16 %를 차지하고 있으며, 외부환경과 직접적으로 접해 있어 온도, 습도 및 자외선 등과 같은 외부 유해인자들로부터 인체를 보호하는 중요한 역할을 하고 있다. 피부는 각질 아래 표피, 진피, 피하조직으로 구성되어 있다. 표피는 주로 케라틴으로 되어 있는 케라티노사이트(keratinocytes), 멜라닌을 생성하고 분비하는 멜라닌 세포(melanocytes), 랑게르한스 세포(langerhans cells) 등의 면역세포 그리고 지각관련세포 (Merkel's copuscles)로 구성되는 얇은 보호층으로 외부자극과 병원균의 침입을 방지하고 체온조절, 수분과 지질 성분 유지 작용을 한다. 진피는 표피 아래에 있는 결합조직으로 대부분 세포외 간질(extracellular matrix)이라 불리는 거대 분자의 망상 구조로 구성되어 있다. 이 세포외 간질은 섬유아세포에서 만들어지며, 콜라겐, 엘라스틴 등의 섬유상 단백질과 히알루론산 등의 다당체로 이루어져 있다.The skin occupies about 16% of the human body and is in direct contact with the external environment, so it plays an important role in protecting the human body from external harmful factors such as temperature, humidity and ultraviolet rays. The skin is composed of epidermis, dermis, and subcutaneous tissue under the keratin. The epidermis is a thin protective layer composed mainly of keratinocytes, melanocytes that produce and secrete melanin, immune cells such as Langerhans cells, and Merkel's copuscles. It prevents the invasion of external stimuli and pathogens, regulates body temperature, and maintains moisture and lipid components. The dermis is a connective tissue beneath the epidermis and is mostly composed of a network structure of macromolecules called the extracellular matrix. This extracellular matrix is made from fibroblasts and is composed of fibrous proteins such as collagen and elastin and polysaccharides such as hyaluronic acid.
나이가 들어감에 따라 각종 오염물질, 강한 자외선, 스트레스 및 영양결핍 등으로 인해 피부 세포들이 손상을 입게 되고, 세포 증식이 원활하게 되지 않아 피부에 주름, 탄력 손실, 색소 침착 및 각질화 등이 발생한다(Gilchrest B.A., J. Am. Acad. Dermatol, 21, 610. 1989).As we age, skin cells are damaged due to various pollutants, strong ultraviolet rays, stress, and nutritional deficiency, and cell proliferation is not smooth, resulting in wrinkles, loss of elasticity, pigmentation, and keratinization of the skin ( Gilchrest B.A., J. Am. Acad. Dermatol, 21, 610. 1989).
콜라겐은 피부 수분을 유지하고 피부 유연성과 탄력을 유지하는 데 가장 중요한 단백질로 진피층의 90%를 차지하고 있으며(J Am Acad Dermatol, 17(4):610-613. 2001) 피부의 강도와 장력을 부여하여 외부의 자극으로부터 피부를 보호하는 역할을 한다. 또한 진피층의 엘라스틴은 2% 정도를 차지하고 있어 콜라겐보다는 적은 양이지만, 콜라겐 섬유를 지탱하는 역할을 하고 있으며 엘라스틴 섬유의 결핍과 응집, 소실이 피부 주름 형성 기전에서 중요한 역할을 하는 것으로 최근 많은 연구에서 보고되고 있다(Weihermann AC et al., Int J Cosmet Sci. 2017 Jun;39(3):241-247; Mora Huertas AC et al., Biochimie. 2016 Sep-Oct;128-129:163-73). Collagen is the most important protein for maintaining skin moisture and maintaining skin flexibility and elasticity. It accounts for 90% of the dermal layer (J Am Acad Dermatol, 17(4):610-613. 2001) and provides strength and tension to the skin. It serves to protect the skin from external stimuli. In addition, elastin in the dermis layer accounts for about 2%, which is less than collagen, but plays a role in supporting collagen fibers, and many recent studies have reported that the deficiency, aggregation, and loss of elastin fibers play an important role in the mechanism of skin wrinkle formation. (Weihermann AC et al., Int J Cosmet Sci. 2017 Jun; 39(3): 241-247; Mora Huertas AC et al., Biochimie. 2016 Sep-Oct; 128-129: 163-73).
콜라겐과 엘라스틴은 섬유아세포에서 합성되며 콜라겐나아제(collagenase) 또는 엘라스타아제(elastase)에 의해 분해된다. 나이가 들거나 자외선 등에 노출되면 섬유아세포의 작용과 세포 수가 감소하여 콜라겐 또는 엘라스틴의 합성량이 줄어들고 이들을 분해하는 콜라겐나아제 또는 엘라스타아제의 작용이 증가하게 된다. 콜라겐과 엘라스틴에 의한 피부의 탄력성은 한번 감소하고 난 후 회복하기가 매우 어렵다. 이에 따라 나이가 들수록 증가하는 엘라스타아제 활성을 억제하여 피부 주름을 개선하기 위한 연구가 활발하게 진행되고 있다.Collagen and elastin are synthesized in fibroblasts and degraded by collagenase or elastase. As people age or are exposed to ultraviolet light, the activity and cell number of fibroblasts decrease, the amount of synthesis of collagen or elastin decreases, and the activity of collagenase or elastase that decomposes them increases. Once the elasticity of the skin by collagen and elastin is reduced, it is very difficult to recover. Accordingly, studies to improve skin wrinkles by inhibiting elastase activity, which increases with age, are being actively conducted.
현재 피부 주름형성을 억제하는 물질로는 레티노익산과 레티놀(Simon C et al., J Invest Dermatol 98: 248-260. 1992; Elaine S et al., J Invest Dermatol 96: 975-978. 1991)의 효과가 입증되어 있고, dehydroepiandrosterone(Shin MH et al., J Invest Dermatol 124: 315-323.2005), 인삼에서 추출한 ginsenoside Rg3(Kim SW et al., J Soc Cosmet Scientists Korea 30: 221-225.2004), 플라보노이드(Francesco B et al., Int J Pharm 145: 87-94.1996), 팥배나무 추출물(한국등록특허 제 101008833호), 연교 추출물(한국등록특허 제 100825450호)등 다양한 물질의 주름 개선 및 피부 보호효과가 탐색되었다. 그러나 일부 물질들은 안정성이 낮거나 피부 자극을 일으켜 안전성에 문제가 있기 때문에 사용에 제한이 있다. 이에 따라 우수한 주름개선 활성 효과와 안전성 및 안정성을 지닌 물질의 탐색이 지속되고 있다.Currently, substances that inhibit skin wrinkle formation include retinoic acid and retinol (Simon C et al., J Invest Dermatol 98: 248-260. 1992; Elaine S et al., J Invest Dermatol 96: 975-978. 1991). The effect has been proven, dehydroepiandrosterone (Shin MH et al., J Invest Dermatol 124: 315-323.2005), ginsenoside Rg3 extracted from ginseng (Kim SW et al., J Soc Cosmet Scientists Korea 30: 221-225.2004), flavonoids ( Francesco B et al., Int J Pharm 145: 87-94.1996), Sorrel pear extract (Korean Patent No. 101008833), Yeongyo extract (Korean Patent No. 100825450), etc., wrinkle improvement and skin protection effects are explored It became. However, some materials are limited in use because they have low stability or cause skin irritation and safety problems. Accordingly, the search for substances having excellent anti-wrinkle activity and safety and stability is continuing.
멜라닌은 피부(표피)내 기저층에 존재하는 색세포인 멜라노사이트(melanocyte)에서 합성되며 주변 각질세포(keratinocyte)로 전이되어 사람의 피부색을 나타내는 것으로 알려져 있다. 피부가 햇빛을 받으면 색소 형성 세포인 멜라노사이트에서 화학반응이 일어나 멜라닌이 만들어진다. 멜라닌의 주요한 역할을 피부에서 발생하는 활성산소가 프리라디칼(free radical)을 제거하고, 자외선의 투과를 막아 피부의 내부를 보호하는 것이다(Brain Research Bulletin 10 (6): 847 851, 1983; Mutation Research 571 (1): 121-2, 2005; Nature. 22;445(7130):843-50. 2007). 그러나 멜라닌이 과발현하면 피부 흑화, 색소침착, 기미, 주근깨, 피부암 등 피부 건강 뿐만 아니라 미적 측면에서도 크게 영향을 주게 된다(Pigment Cell Res 10, 127-138. 1997;Vet Dermatol. 2003 Apr;14(2):57-65.).It is known that melanin is synthesized in melanocytes, which are color cells present in the basal layer of the skin (epidermis), and is transferred to surrounding keratinocytes to represent human skin color. When the skin is exposed to sunlight, a chemical reaction occurs in melanocytes, which are pigment-forming cells, and melanin is produced. The main role of melanin is to protect the inside of the skin by removing free radicals from active oxygen generated in the skin and blocking the transmission of ultraviolet rays (Brain Research Bulletin 10 (6): 847 851, 1983; Mutation Research 571 (1): 121-2, 2005; Nature. 22;445(7130):843-50. 2007). However, when melanin is overexpressed, it greatly affects not only skin health such as skin darkening, pigmentation, melasma, freckles, and skin cancer, but also aesthetic aspects (Pigment Cell Res 10, 127-138. 1997; Vet Dermatol. 2003 Apr; 14(2 ):57-65.).
멜라닌을 만드는 출발물질은 인체에 정상적으로 존재하는 아미노산의 일종인 티로신(tyrosine)이다. 티로신은 멜라닌세포 내에서 티로시나제(tyrosinase)라는 효소에 의해 산화되어 도파(dihydroxy phenylalanine, DOPA)로 변하고, 도파는 더욱 산화하여 도파퀴논(DOPA-Quinone)을 만들어 낸다. 그리고 도파퀴논이 시스테인(cysteine)을 만나게 되면 시스테이닐도파(cysteinyldopa)가 만들어지고, 그 결과 적갈색의 페오멜라닌(pheomelanin)이 만들어 진다. 이후 생성된 멜라닌은 멜라노소체(melanosome)에 실려 각질 형성 세포로 전달된다(Pigment Cell Res.12(1):4-12.1999.;Cell Mol Biol (Noisy-le-grand).45(7):981-90.1999; An Bras Dermatol.88(1): 76-3. 2013). The starting material for making melanin is tyrosine, a type of amino acid normally present in the human body. Tyrosine is oxidized by an enzyme called tyrosinase in melanocytes and converted into dihydroxy phenylalanine (DOPA), and DOPA is further oxidized to produce DOPA-Quinone. When dopaquinone meets cysteine, cysteineyldopa is produced, resulting in reddish-brown pheomelanin. Afterwards, the produced melanin is loaded onto melanosomes and transferred to keratinocytes (Pigment Cell Res.12(1):4-12.1999.; Cell Mol Biol (Noisy-le-grand). 45(7):981 -90.1999;An Bras Dermatol.88(1):76-3.2013).
이에 따라 색소 침착의 예방 또는 완화를 목적으로 미백 화장품에 배합되는 약제의 기본적인 메커니즘은 티로시나아제 작용 억제, 티로시나아제 생성 억제, 멜라닌 생성 미디에이터의 억제, 기존 멜라닌의 환원 및 강산화 억제, 멜라닌 배설의 촉진, 자외선 차단 등이 있다. 티로시나아제의 활성을 억제하는 대표적인 물질로는, 알부틴(arbutin), 코직산(kojic acid) 등이 있다. 직접적으로 멜라닌을 파괴하는 물질로는 하이드로퀴논, 수은 등이 있으나 수은은 독성물질로 사용이 금지되어 있다. 생성된 멜라닌을 환원시키는 미백제로는 비타민C, 글루타티온(glutathione), 아스크로빈산 인산 에스테르 마그네슘 등이 있다(J Cosmet Sci.65(6):365-75. 2014; Int J Cosmet Sci.37(6):567-73. 2015; Yakugaku Zasshi. 128(8):1203-7. 2008; Int J Cosmet Sci.27(3):147-53. 2005; Acta Derm Venereol.63(3):209-14.1983; Skin Pharmacol Appl Skin Physiol.13(3-4):143-9. 2000; J Cosmet Laser Ther.15(2):107-13. 2013.). Accordingly, the basic mechanisms of agents formulated in whitening cosmetics for the purpose of preventing or alleviating pigmentation include inhibition of tyrosinase action, inhibition of tyrosinase production, inhibition of melanin production mediators, inhibition of existing melanin reduction and strong oxidation, and melanin excretion. promotion, UV protection, etc. Representative substances that inhibit the activity of tyrosinase include arbutin, kojic acid, and the like. Substances that directly destroy melanin include hydroquinone and mercury, but mercury is prohibited as a toxic substance. Whitening agents that reduce the produced melanin include vitamin C, glutathione, magnesium ascorbic acid phosphate ester (J Cosmet Sci.65(6):365-75. 2014; Int J Cosmet Sci.37( 6):567-73.2015;Yakugaku Zasshi.128(8):1203-7.2008;Int J Cosmet Sci.27(3):147-53.2005;Acta Derm Venereol.63(3):209- 14.1983; Skin Pharmacol Appl Skin Physiol.13(3-4):143-9.2000;J Cosmet Laser Ther.15(2):107-13.2013.).
이처럼 미백에 대한 관심이 고조됨에 따라 기존의 잘 알려진 물질 이외에 더욱 우수한 효과를 지닌 미백 화장품 개발이 활발하게 이루어지고 있으나 합성미백원료들은 사용 중 분해나 착색, 이취, 안정성 및 안전성 등의 문제가 대두되고 있다. 따라서 최근에는 세포에 영향을 끼치지 않으며 멜라닌 합성을 감소시키는 천연 미백제에 대한 연구가 활발히 진행되고 있다.As interest in whitening increases, the development of whitening cosmetics with more excellent effects in addition to the existing well-known substances is being actively conducted. there is. Therefore, recently, studies on natural whitening agents that do not affect cells and reduce melanin synthesis have been actively conducted.
본 발명은 푸른여로 추출물의 피부 주름 개선 활성과 피부 미백 활성을 개시한다.The present invention discloses the skin-wrinkle-improving activity and skin-whitening activity of the blue yarrow extract.
본 발명의 목적은 푸른여로 추출물을 이용한 피부 주름 개선 및 피부 미백용 조성물을 제공하는 데 있다.An object of the present invention is to provide a composition for improving skin wrinkles and skin whitening using blue yero extract.
본 발명의 다른 목적이나 구체적인 목적은 이하에서 제시될 것이다.Other objects or specific objects of the present invention will be presented below.
본 발명은 아래의 실시예 및 실험예에서 확인되는 바와 같이, 푸른여로 추출물이 엘라스타아제 저해 활성을 보이고 또한 티로시나아제 저해 활성을 보임을 확인함으로써 완성된 것이다.The present invention was completed by confirming that, as confirmed in the Examples and Experimental Examples below, the blue yero extract showed elastase inhibitory activity and also showed tyrosinase inhibitory activity.
전술한 바를 고려할 때, 본 발명은 일 측면에 있어서 푸른여로 추출물을 유효성분으로 포함하는 피부 주름 개선용 조성물로 파악할 수 있고, 다른 측면에 있어서는 푸른여로 추출물을 유효성분으로 포함하는 피부 미백용 조성물로 파악할 수 있다.Considering the above, the present invention can be identified as a composition for improving skin wrinkles containing blue yero extract as an active ingredient in one aspect, and a skin whitening composition containing blue yero extract as an active ingredient in another aspect. can figure it out
본 명세서에서, "푸른여로 추출물"이란 추출 대상인 푸른여로 전초, 잎, 줄기, 지상부, 뿌리, 근경, 지하부, 종자 또는 이들의 혼합물을 물, 탄소수 1 내지 4의 저급 알콜(메탄올, 에탄올, 부탄올 등), 메틸렌클로라이드, 에틸렌, 아세톤, 헥산, 에테르, 클로로포름, 에틸아세테이트, 부틸아세테이트, N,N-디메틸포름아미드(DMF), 디메틸설폭사이드(DMSO), 1,3-부틸렌글리콜, 프로필렌글리콜 또는 이들의 혼합 용매를 사용하여 침출하여 얻어진 추출물, 이산화탄소, 펜탄 등 초임계 추출 용매를 사용하여 얻어진 추출물 또는 그 추출물을 분획하여 얻어진 분획물을 의미하며, 추출 방법은 활성물질의 극성, 추출 정도, 보존 정도를 고려하여 냉침, 환류, 가온, 초음파 방사, 초임계 추출 등 임의의 방법을 적용할 수 있다. 분획된 추출물의 경우 추출물을 특정 용매에 현탁시킨 후 극성이 다른 용매와 혼합·정치시켜 얻은 분획물, 상기 조추출물을 실리카겔 등이 충진된 칼럼에 흡착시킨 후 소수성 용매, 친수성 용매 또는 이들의 혼합 용매를 이동상으로 하여 얻은 분획물을 포함하는 의미이다. 또한 상기 추출물의 의미에는 동결건조, 진공건조, 열풍건조, 분무건조 등의 방식으로 추출 용매가 제거된 농축된 액상의 추출물 또는 고형상의 추출물이 포함된다. 바람직하게는 추출용매로서 물, 탄소수 1 내지 4의 저급 알콜(메탄올, 에탄올, 부탄올 등) 또는 이들의 혼합 용매를 사용하여 얻어진 추출물을 의미한다. In the present specification, "purunyarrow extract" refers to the extraction target of blue yarrow whole plant, leaves, stems, aerial parts, roots, rhizomes, underground parts, seeds, or mixtures thereof in water, lower alcohols having 1 to 4 carbon atoms (methanol, ethanol, butanol, etc. ), methylene chloride, ethylene, acetone, hexane, ether, chloroform, ethyl acetate, butyl acetate, N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), 1,3-butylene glycol, propylene glycol or It refers to an extract obtained by leaching using a mixture of these solvents, an extract obtained using a supercritical extraction solvent such as carbon dioxide or pentane, or a fraction obtained by fractionating the extract, and the extraction method is the polarity of the active substance, the degree of extraction, and the degree of preservation. Any method such as cooling, reflux, heating, ultrasonic radiation, and supercritical extraction can be applied in consideration of In the case of the fractionated extract, after suspending the extract in a specific solvent, the fraction obtained by mixing and standing with a solvent of different polarity, and the crude extract are adsorbed on a column filled with silica gel, etc., and then a hydrophobic solvent, a hydrophilic solvent, or a mixed solvent thereof It is meant to include fractions obtained as a mobile phase. In addition, the meaning of the extract includes a concentrated liquid extract or solid extract from which the extraction solvent is removed by lyophilization, vacuum drying, hot air drying, spray drying, or the like. Preferably, it refers to an extract obtained by using water, a lower alcohol having 1 to 4 carbon atoms (methanol, ethanol, butanol, etc.) or a mixed solvent thereof as an extraction solvent.
또 본 명세서에서 "유효성분"이란 단독으로 목적하는 활성을 나타내거나 또는 그 자체는 활성이 없는 담체와 함께 활성을 나타낼 수 있는 성분을 의미한다.In addition, in the present specification, "active ingredient" means a component that exhibits the desired activity alone or can exhibit activity in combination with a carrier having no activity itself.
본 발명의 조성물은 유효성분 이외에, 피부 주름 개선 효과 또는 피부 미백 효과의 상승·보강 등을 위하여 또는 피부 과민 반응 억제 활성, 피부 보호 활성(자외선에 의한 피부 손상 억제, 피부 보습 등) 등 유사활성의 부가를 통한 복용이나 섭취, 사용의 편리성 증진을 위하여, 당업계에서 이미 안전성이 검증되고 해당 활성을 갖는 것으로 공지된 임의의 화합물이나 천연 추출물을 추가로 포함할 수 있다. In addition to active ingredients, the composition of the present invention has similar activities such as skin hypersensitivity reaction inhibition activity, skin protection activity (suppression of skin damage by ultraviolet rays, skin moisturizing, etc.) In order to enhance the convenience of intake, intake, and use through addition, any compound or natural extract known to have a corresponding activity and whose safety has already been verified in the art may be further included.
이러한 화합물 또는 추출물에는 각국 약전(한국에서는 「대한민국약전」), 각국 건강기능식품공전(한국에서는 식약처 고시인 「건강기능식품 기준 및 규격」임), 각국 기능성화장품공전(한국에서는 식약처 고시인 「기능성화장품 기준 및 시험방법」) 등의 공정서에 실려 있는 화합물 또는 추출물, 의약품의 제조·판매를 규율하는 각국의 법률(한국에서는 「약사법」임)에 따라 품목 허가를 받은 화합물 또는 추출물, 건강기능식품의 제조·판매를 규율하는 각국 법률(한국에서는 「건강기능식품에관한법률」임)에 따라 기능성이 인정된 화합물 또는 추출물, 기능성 화장품의 제조·판매를 규율하는 각국 법률(한국에서는 「화장품법」임)에 따라 기능성이 인정된 화합물 또는 추출물이 포함된다. These compounds or extracts include each country's Pharmacopoeia (Korean Pharmacopoeia), each country's Health Functional Food Codex (in Korea, it is the Ministry of Food and Drug Safety's notification, "Health Functional Food Standards and Specifications"), each country's Functional Cosmetics Codex (in Korea, the Ministry of Food and Drug Safety notification Compounds or extracts listed in compendial documents such as 「Functional Cosmetics Standards and Test Methods」), compounds or extracts that have been approved as items under the laws of each country governing the manufacture and sale of pharmaceuticals (in Korea, it is the 「Pharmaceutical Affairs Act」), health In accordance with the laws of each country regulating the manufacture and sale of functional foods (in Korea, it is the 「Health Functional Food Act」), the laws of each country regulating the manufacture and sale of compounds or extracts with recognized functionality, and the manufacture and sale of functional cosmetics (in Korea, the 「Cosmetics Act」 ”), compounds or extracts whose functionality has been recognized are included.
이러한 성분들로서는 예컨대 한국 화장품법에 따른 화장품공전(한국 식약처 고시, 「기능성화장품의 기준 및 규격」)에서 피부 미백 성분으로 인정된 알부틴, 나이아신아마이드, 아스코빌글루코사이드, 알파-비사보롤, 유용성 감초 추출물(Oil Soluble Licorice(Glycyrrhiza) Extract) 등과, 또 같은 한국 화장품공전에서 피부 주름 개선 성분으로 인정된 레티놀, 레티닐팔미테이트, 아데노신, 폴리에톡실레이티드아마이드 등과, 또 같은 한국 화장품공전에서 자외선 보호 성분으로 인정된 드로메트리졸, 드로메트리졸트리실록산, 디갈로일트리올리에이트, 디메치코디에칠벤잘말로네이트, 디에칠헥실부타미도트리아존, 소나무 껍질 추출물 등의 복합물, 포스파티딜세린, 핑거루트 추출 분말, 홍삼과 산수유 등의 복합 추출물 등을 들 수 있고, 또한 한국 건강기능식품에관한법률에 따라 '과민피부상태 개선' 기능성 성분으로서는 L. sakei Probio 65, 감마리놀렌산 함유 유지, 과채 유래 유산균인 L.plantarum CJLP133, 프로바이오틱스 ATP 등을 들 수 있다. 이러한 화합물 또는 천연 추출물은 본 발명의 조성물에 그 유효성분과 함께 하나 이상 포함될 수 있다.These ingredients include, for example, arbutin, niacinamide, ascorbyl glucoside, alpha-bisabolol, and oil-soluble licorice, which are recognized as skin whitening ingredients in the Cosmetics Codex (Korean Ministry of Food and Drug Safety notification, 「Standards and Specifications for Functional Cosmetics」) according to the Korean Cosmetics Act. extract (Oil Soluble Licorice (Glycyrrhiza) Extract), retinol, retinyl palmitate, adenosine, polyethoxylated amide, etc. recognized as skin wrinkle improvement ingredients in the same Korea Cosmetics Code, and UV protection in the same Korea Cosmetics Code Drometrizol, drometrizoltrisiloxane, digaloyltrioleate, dimethicodiethylbenzalmalonate, diethylhexylbutamidotriazone, pine bark extract, phosphatidylserine, and fingerroot recognized as ingredients extract powder, complex extracts such as red ginseng and cornus officinalis, etc., and functional ingredients for 'improving sensitive skin condition' according to the Korean Health Functional Food Act include L. sakei Probio 65, gamma-linolenic acid-containing oil, and fruit and vegetable-derived lactic acid bacteria L.plantarum CJLP133, probiotics ATP, etc. are mentioned. One or more of these compounds or natural extracts may be included in the composition of the present invention together with the active ingredient.
본 발명의 조성물은 그 유효성분을 용도, 제형, 배합 목적 등에 따라 치료를 의도하는 주름 개선 활성, 피부 미백 활성을 나타낼 수 있는 한 임의의 양(유효량)으로 포함할 수 있는데, 통상적인 유효량은 조성물 전체 중량을 기준으로 할 때 0.001 중량 % 내지 15 중량 % 범위 내에서 결정될 것이다. 여기서 "유효량"이란 그 적용 대상인 포유동물 바람직하게는 사람에게 의료 또는 피부 전문가 등의 제언에 의한 투여 기간 동안 본 발명의 조성물이 투여될 때, 주름 개선 효과, 피부 미백 효과 등 의도한 피부학적·의료학적 효과를 나타낼 수 있는, 본 발명의 조성물에 포함되는 유효성분의 양을 말한다. 이러한 유효량은 당업자의 통상의 능력 범위 내에서 실험적으로 결정될 수 있다.The composition of the present invention may contain the active ingredient in any amount (effective amount) as long as it can exhibit the anti-wrinkle activity and skin whitening activity intended for treatment depending on the use, formulation, blending purpose, etc. It will be determined within the range of 0.001% to 15% by weight based on the total weight. Here, "effective amount" means when the composition of the present invention is administered to a mammal, preferably a human, for a period of administration according to the advice of a medical or skin expert, etc. It refers to the amount of the active ingredient included in the composition of the present invention that can exhibit a scientific effect. Such an effective amount can be determined empirically within the ordinary ability of one skilled in the art.
본 발명의 조성물은 구체적인 양태에 있어서, 식품 조성물로서 파악할 수 있다. In a specific aspect, the composition of the present invention can be regarded as a food composition.
본 발명의 식품 조성물은 어떠한 형태로도 제조될 수 있으며, 예컨대 차, 쥬스, 탄산음료, 이온음료 등의 음료류, 우유, 요구르트 등의 가공 유류, 껌류, 떡, 한과, 빵, 과자, 면 등의 식품류, 정제, 캡슐, 환, 과립, 액상, 분말, 편상, 페이스트상, 시럽, 겔, 젤리, 바 등의 건강기능식품 제제류 등으로 제조될 수 있다. The food composition of the present invention can be prepared in any form, for example, beverages such as tea, juice, carbonated beverages, and ionic beverages, processed oils such as milk and yogurt, chewing gum, rice cakes, traditional Korean snacks, bread, snacks, noodles, etc. It can be manufactured into health functional food formulations such as foods, tablets, capsules, pills, granules, liquid, powder, flakes, pastes, syrups, gels, jellies, and bars.
또 본 발명의 식품 조성물은 법률상·기능상의 구분에 있어서 제조·유통 시점의 시행 법규에 부합하는 한 임의의 제품 구분을 띨 수 있다. 예컨대 건강기능식품의 제조·판매를 규율하는 제외국의 법률(한국에서는 「건강기능식품에관한법률」임)에 따른 건강기능식품이거나, 식품의 제조·판매를 규율하는 제외국의 법률(한국에서는 「식품위생법」임)의 식품공전(한국에서는 한국 식약처 고시 「식품의 기준 및 규격」임)상 각 식품유형에 따른 과자류, 두류, 두유류, 발효음료류, 특수용도식품 등일 수 있다.In addition, the food composition of the present invention may take any product classification as long as it conforms to the enforcement regulations at the time of manufacture and distribution in legal and functional classification. For example, it is a health functional food in accordance with the laws of a foreign country regulating the manufacture and sale of health functional foods (in Korea, the 「Health Functional Food Act」), or the laws of a foreign country regulating the manufacture and sale of food (in Korea, It can be confectionery, bean, soy milk, fermented beverage, special purpose food, etc. according to each food type according to the Food Codex (in Korea, the Korean Ministry of Food and Drug Safety notice, 「Standards and Specifications for Food」) of the 「Food Sanitation Act」.
본 발명의 식품 조성물에는 그 유효성분 이외에 식품첨가물이 포함될 수 있다. 식품첨가물은 일반적으로 식품을 제조, 가공 또는 보존함에 있어 식품에 첨가되어 혼합되거나 침윤되는 물질로서 이해될 수 있는데, 식품과 함께 매일 그리고 장기간 섭취되므로 그 안전성이 보장되어야 한다. 식품의 제조·유통을 규율하는 각국 법률(한국에서는 「식품위생법」임)에 따른 식품첨가물공전에는 안전성이 보장된 식품첨가물이 성분 면에서 또는 기능 면에서 한정적으로 규정되어 있다. 한국 식품첨가물공전(식약처 고시 「식품첨가물 기준 및 규격」)에서는 식품첨가물이 성분 면에서 화학적 합성품, 천연 첨가물 및 혼합 제제류로 구분되어 규정되어 있는데, 이러한 식품첨가물은 기능 면에 있어서는 감미제, 풍미제, 보존제, 유화제, 산미료, 점증제 등으로 구분된다. The food composition of the present invention may include food additives in addition to the active ingredient. Food additives may generally be understood as substances that are added to, mixed with, or infiltrated into food in manufacturing, processing, or preserving food. Since food is consumed daily and for a long period of time, its safety must be guaranteed. According to the Food Additives Code under the laws of each country governing the manufacture and distribution of food (in Korea, it is the 「Food Sanitation Act」), safety-guaranteed food additives are limitedly regulated in terms of ingredients or functions. In the Korean Food Additives Codex (MFDS notification 「Standards and Specifications for Food Additives」), food additives are classified into chemical synthetic products, natural additives and mixed preparations in terms of ingredients and are regulated. It is divided into additives, preservatives, emulsifiers, acidulants, and thickeners.
감미제는 식품에 적당한 단맛을 부여하기 위하여 사용되는 것으로, 천연의 것이거나 합성된 것 모두 본 발명의 조성물에 사용할 수 있다. 바람직하게는 천연 감미제를 사용하는 경우인데, 천연 감미제로서는 옥수수 시럽 고형물, 꿀, 수크로오스, 프룩토오스, 락토오스, 말토오스 등의 당 감미제를 들 수 있다. Sweeteners are used to impart appropriate sweetness to foods, and both natural and synthetic sweeteners can be used in the composition of the present invention. Preferably, a natural sweetener is used, and examples of the natural sweetener include sugar sweeteners such as corn syrup solids, honey, sucrose, fructose, lactose, and maltose.
풍미제는 맛이나 향을 좋게 하기 위하여 사용될 수 있는데, 천연의 것과 합성된 것 모두 사용될 수 있다. 바람직하게는 천연의 것을 사용하는 경우이다. 천연의 것을 사용할 경우에 풍미 이외에 영양 강화의 목적도 병행할 수 있다. 천연 풍미제로서는 사과, 레몬, 감귤, 포도, 딸기, 복숭아 등에서 얻어진 것이거나 녹차잎, 둥굴레, 대잎, 계피, 국화 잎, 자스민 등에서 얻어진 것일 수 있다. 또 인삼(홍삼), 죽순, 알로에 베라, 은행 등에서 얻어진 것을 사용할 수 있다. 천연 풍미제는 액상의 농축액이나 고형상의 추출물일 수 있다. 경우에 따라서 합성 풍미제가 사용될 수 있는데, 합성 풍미제는 에스테르, 알콜, 알데하이드, 테르펜 등이 이용될 수 있다. Flavors may be used to improve taste or aroma, and both natural and synthetic flavors may be used. Preferably, it is the case of using a natural one. In case of using natural ones, in addition to flavor, the purpose of enhancing nutrition can also be combined. As a natural flavoring agent, it may be obtained from apples, lemons, tangerines, grapes, strawberries, peaches, etc., or obtained from green tea leaves, roundworms, bamboo leaves, cinnamon, chrysanthemum leaves, jasmine, and the like. In addition, those obtained from ginseng (red ginseng), bamboo shoots, aloe vera, ginkgo, etc. can be used. Natural flavors can be liquid concentrates or solid extracts. In some cases, synthetic flavors may be used, and synthetic flavors may include esters, alcohols, aldehydes, terpenes, and the like.
보존제로서는 소듐 소르브산칼슘, 소르브산나트륨, 소르브산칼륨, 벤조산칼슘, 벤조산나트륨, 벤조산칼륨, EDTA(에틸렌디아민테트라아세트산) 등이 사용될 수 있고, 또 유화제로서는 아카시아검, 카르복시메틸셀룰로스, 잔탄검, 펙틴 등을 들 수 있으며, 산미료로서는 연산, 말산, 푸마르산, 아디프산, 인산, 글루콘산, 타르타르산, 아스코르브산, 아세트산, 인산 등이 사용될 수 있다. 산미료는 맛을 증진시키는 목적 이외에 미생물의 증식을 억제할 목적으로 식품 조성물이 적정 산도로 되도록 첨가될 수 있다.As preservatives, sodium sorbate, sodium sorbate, potassium sorbate, calcium benzoate, sodium benzoate, potassium benzoate, EDTA (ethylenediaminetetraacetic acid), etc. may be used, and as emulsifiers, acacia gum, carboxymethylcellulose, xanthan gum, pectin and the like, and examples of the acidulant include acid salt, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, phosphoric acid, and the like. Acidulants may be added to the food composition to have an appropriate acidity for the purpose of inhibiting the growth of microorganisms in addition to improving taste.
점증제로서는 현탁화 구현제, 침강제, 겔형성제, 팽화제 등이 사용될 수 있다.As the thickening agent, a suspending agent, a sedimentation agent, a gel forming agent, a swelling agent, and the like may be used.
본 발명의 식품 조성물은 전술한 바의 식품첨가물 이외에, 기능성과 영양성을 보충, 보강할 목적으로 당업계에 공지되고 식품첨가물로서 안정성이 보장된 생리활성 물질이나 미네랄류를 포함할 수 있다.In addition to the food additives described above, the food composition of the present invention may include physiologically active substances or minerals known in the art and whose stability is guaranteed as food additives for the purpose of supplementing or reinforcing functionality and nutrition.
그러한 생리활성 물질로서는 녹차 등에 포함된 카테킨류, 비타민 B1, 비타민 C, 비타민 E, 비타민 B12 등의 비타민류, 토코페롤, 디벤조일티아민 등을 들 수 있으며, 미네랄류로서는 구연산 칼슘 등의 칼슘 제제, 스테아린산마그네슘 등의 마그네슘 제제, 구연산철 등의 철 제제, 염화 크롬, 요오드칼륨, 셀레늄, 게르마늄, 바나듐, 아연 등을 들 수 있다. Examples of such physiologically active substances include catechins contained in green tea, vitamins such as vitamin B1, vitamin C, vitamin E, and vitamin B12, tocopherol, dibenzoylthiamine, and the like. Examples of minerals include calcium preparations such as calcium citrate and magnesium stearate. magnesium preparations such as the like, iron preparations such as iron citrate, chromium chloride, potassium iodine, selenium, germanium, vanadium, zinc, and the like.
본 발명의 식품 조성물에는 전술한 바의 식품첨가물이 제품 유형에 따라 그 첨가 목적을 달성할 수 있는 적량으로 포함될 수 있다.The food composition of the present invention may include the above-mentioned food additives in an appropriate amount to achieve the purpose of addition according to the type of product.
본 발명의 식품 조성물에 포함될 수 있는 기타의 식품첨가물과 관련하여서는 각국 식품공전이나 식품첨가물 공전을 참조할 수 있다.Regarding other food additives that may be included in the food composition of the present invention, reference may be made to national food codes or food additive codes.
본 발명의 조성물은 다른 구체적인 양태에 있어서는 약제학적 조성물로 파악될 수 있다. The composition of the present invention can be understood as a pharmaceutical composition in another specific aspect.
특히 본 발명의 피부 미백용 조성물이 약제학적 조성물로 파악될 경우 그 용도는 피부 과색소침착증 예방 또는 치료로 이해될 수 있으며, 그러한 과색소침작증의 구체적인 예로서는 주근깨, 노인성 반점, 간반, 기미, 갈색 또는 흑점, 일광 색소반, 푸른 흑피증(cyanic melasma), 칼슘 길항제와 같은 약물 사용 후의 과다색소침착, 조직경화치료법(sclerotherapy)에 따른 후유증, 임신성 갈색반(gravidic chloasma), 경구 피임약을 복용한 여성에서의 흑피증, 찰상 및 화상을 비롯한 상처 또는 피부염으로 인한 염증 후 과다 색소 침착, 광독성 반응 또는 다른 유사한 소형의 고정 색소성 병변 등이 포함될 수 있으나, 이에 제한되는 것은 아니다.In particular, when the skin whitening composition of the present invention is understood as a pharmaceutical composition, its use can be understood as prevention or treatment of skin hyperpigmentation, and specific examples of such hyperpigmentation include freckles, senile spots, liver spots, melasma, brown or Melasma, solar pigment, cyanic melasma, hyperpigmentation after use of drugs such as calcium antagonists, sequelae of sclerotherapy, gravidic chloasma, in women taking oral contraceptives post-inflammatory hyperpigmentation due to wounds or dermatitis, including but not limited to melasma, abrasions and burns, phototoxic reactions, or other similar small, fixed pigmented lesions.
본 발명의 약제학적 조성물은 유효성분 이외에 약제학적으로 허용되는 담체를 포함하여 당업계에 공지된 통상의 방법으로 투여 경로에 따라 경구용 제형 또는 비경구용 제형으로 제조될 수 있다. 여기서 투여 경로는 국소 경로, 경구 경로, 정맥 내 경로, 근육 내 경로, 및 점막 조직을 통한 직접 흡수를 포함하는 임의의 적절한 경로일 수 있으며, 두 가지 이상의 경로를 조합하여 사용할 수도 있다. 두 가지 이상 경로의 조합의 예는 투여 경로에 따른 두 가지 이상의 제형의 약물이 조합된 경우로서 예컨대 1차로 어느 한 약물은 정맥 내 경로로 투여하고 2차로 다른 약물은 국소 경로로 투여하는 경우이다. The pharmaceutical composition of the present invention may be formulated into an oral formulation or a parenteral formulation according to the route of administration by a conventional method known in the art, including a pharmaceutically acceptable carrier in addition to the active ingredient. The route of administration herein may be any appropriate route including topical route, oral route, intravenous route, intramuscular route, and direct absorption through mucosal tissue, and two or more routes may be used in combination. An example of a combination of two or more routes is a case in which two or more formulations of drugs are combined according to the route of administration, for example, one drug is firstly administered intravenously and the other drug is secondly administered through a topical route.
약학적으로 허용되는 담체는 투여 경로나 제형에 따라 당업계에 주지되어 있으며, 구체적으로는 "대한민국약전"을 포함한 각국의 약전을 참조할 수 있다. Pharmaceutically acceptable carriers are well known in the art depending on the route of administration or dosage form, and specifically, reference may be made to the pharmacopoeia of each country including the "Korean Pharmacopoeia".
본 발명의 약제학적 조성물이 경구용 제형으로 제조될 경우, 적합한 담체와 함께 당업계에 공지된 방법에 따라 분말, 과립, 정제, 환제, 당의정제, 캡슐제, 액제, 겔제, 시럽제, 현탁액, 웨이퍼 등의 제형으로 제조될 수 있다. 이때 적합한 담체의 예로서는 락토스, 글루코스, 슈크로스, 덱스트로스, 솔비톨, 만니톨, 자일리톨 등의 당류, 옥수수 전분, 감자 전분, 밀 전분 등의 전분류, 셀룰로오스, 메틸셀룰로오스, 에틸셀룰로오스, 나트륨 카르복시메틸셀룰로오스, 하이드록시프로필메틸셀룰로오스 등의 셀룰로오스류, 폴리비닐 피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 마그네슘 스테아레이트, 광물유, 맥아, 젤라틴, 탈크, 폴리올, 식물성유, 에탄올, 그리세롤 등을 들 수 있다. 제제화활 경우 필요에 따라적절한 결합제, 윤활제, 붕해제, 착색제, 희석제 등을 포함시킬 수 있다. 적절한 결합제로서는 전분, 마그네슘 알루미늄 실리케이트, 전분페리스트, 젤라틴, 메틸셀룰로스, 소듐 카복시메틸셀룰로스, 폴리비닐피롤리돈, 글루코스, 옥수수 감미제, 소듐 알지네이트, 폴리에틸렌 글리콜, 왁스 등을 들 수 있고, 윤활제로서는 올레산나트륨, 스테아르산나트륨, 스테아르산마그네슘, 벤조산나트륨, 초산나트륨, 염화나트륨, 실리카, 탈쿰, 스테아르산, 그것의 마그네슘염과 칼슘염, 폴리데틸렌글리콜 등을 들 수 있으며, 붕해제로서는 전분, 메틸 셀룰로스, 아가(agar), 벤토나이트, 잔탄 검, 전분, 알긴산 또는 그것의 소듐 염 등을 들 수 있다. 또 희석제로서는 락토즈, 덱스트로즈, 수크로즈, 만니톨, 소비톨, 셀룰로스, 글라이신 등을 들 수 있다. When the pharmaceutical composition of the present invention is prepared as an oral dosage form, powder, granule, tablet, pill, dragee, capsule, liquid, gel, syrup, suspension, wafer according to a method known in the art together with a suitable carrier. It can be prepared in formulations such as Examples of suitable carriers include sugars such as lactose, glucose, sucrose, dextrose, sorbitol, mannitol, and xylitol, starches such as corn starch, potato starch, and wheat starch, cellulose, methylcellulose, ethylcellulose, sodium carboxymethylcellulose, Celluloses such as hydroxypropylmethylcellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, magnesium stearate, mineral oil, malt, gelatin, talc, polyol, vegetable oil, ethanol, Serol etc. are mentioned. In the case of formulation, appropriate binders, lubricants, disintegrants, coloring agents, diluents, etc. may be included as needed. Suitable binders include starch, magnesium aluminum silicate, starch ferrite, gelatin, methylcellulose, sodium carboxymethylcellulose, polyvinylpyrrolidone, glucose, corn sweetener, sodium alginate, polyethylene glycol, wax, and the like, and oleic acid as a lubricant Sodium, sodium stearate, magnesium stearate, sodium benzoate, sodium acetate, sodium chloride, silica, talcum, stearic acid, magnesium salts and calcium salts thereof, polyethylene glycol, etc. may be mentioned. As disintegrants, starch, methyl cellulose , agar, bentonite, xanthan gum, starch, alginic acid or its sodium salt, and the like. Examples of the diluent include lactose, dextrose, sucrose, mannitol, sorbitol, cellulose, and glycine.
본 발명의 약제학적 조성물이 비경구용 제형으로 제조될 경우, 적합한 담체와 함께 당업계에 공지된 방법에 따라 주사제, 경피 투여제, 비강 흡입제 및 좌제의 형태로 제제화될 수 있다. 주사제로 제제화할 경우 적합한 담체로서는 수성 등장 용액 또는 현탁액을 사용할 수 있으며, 구체적으로는 트리에탄올 아민이 함유된 PBS(phosphate buffered saline)나 주사용 멸균수, 5% 덱스트로스 같은 등장 용액 등을 사용할 수 있다. 경피 투여제로 제제화할 경우 연고제, 크림제, 로션제, 겔제, 외용액제, 파스타제, 리니멘트제, 에어롤제 등의 형태로 제제화할 수 있다. 비강 흡입제의 경우 디클로로플루오로메탄, 트리클로로플루오로메탄, 디클로로테트라플루오로에탄, 이산화탄소 등의 적합한 추진제를 사용하여 에어로졸 스프레이 형태로 제제화할 수 있으며, 좌제로 제제화할 경우 그 담체로는 위텝솔(witepsol), 트윈(tween) 61, 폴리에틸렌글리콜류, 카카오지, 라우린지, 폴리옥시에틸렌 소르비탄 지방산 에스테르류, 폴리옥시에틸렌 스테아레이트류, 소르비탄 지방산 에스테르류 등을 사용할 수 있다.When the pharmaceutical composition of the present invention is prepared as a parenteral formulation, it may be formulated in the form of an injection, transdermal administration, nasal inhalation, and suppository along with a suitable carrier according to a method known in the art. When formulated as an injection, an aqueous isotonic solution or suspension may be used as a suitable carrier, and specifically, an isotonic solution such as phosphate buffered saline (PBS) containing triethanolamine, sterile water for injection, or 5% dextrose may be used. . When formulated as a transdermal formulation, it may be formulated in the form of ointments, creams, lotions, gels, external solutions, pastas, liniments, air rolls, and the like. In the case of nasal inhalation, it can be formulated in the form of an aerosol spray using a suitable propellant such as dichlorofluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide, etc., and when formulated as a suppository, the carrier is Witepsol ( witepsol), tween 61, polyethylene glycols, cacao fat, laurin fat, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene stearates, sorbitan fatty acid esters, and the like can be used.
약제학적 조성물의 구체적인 제제화와 관련하여서는 당업계에 공지되어 있으며, 예컨대 문헌[Remington's Pharmaceutical Sciences(19th ed., 1995)] 등을 참조할 수 있다. 상기 문헌은 본 명세서의 일부로서 간주 된다.Regarding the specific formulation of the pharmaceutical composition, it is known in the art, and for example, reference may be made to Remington's Pharmaceutical Sciences (19th ed., 1995) and the like. These documents are considered as part of this specification.
본 발명의 약제학적 조성물의 바람직한 투여량은 환자의 상태, 체중, 성별, 연령, 환자의 중증도, 투여 경로에 따라 1일 0.001mg/kg ~ 10g/kg 범위, 바람직하게는 0.001mg/kg ~ 1g/kg 범위일 수 있다. 투여는 1일 1회 또는 수회로 나누어 이루어질 수 있다. 이러한 투여량은 어떠한 측면으로든 본 발명의 범위를 제한하는 것으로 해석되어서는 아니 된다. The preferred dosage of the pharmaceutical composition of the present invention is in the range of 0.001 mg/kg to 10 g/kg per day, preferably 0.001 mg/kg to 1 g, depending on the patient's condition, weight, sex, age, severity of the patient, and route of administration. /kg range. Administration can be done once a day or divided into several times. These dosages should not be construed as limiting the scope of the present invention in any respect.
본 발명의 조성물은 또 다른 구체적인 양태에 있어서, 화장료 조성물로 파악할 수 있다. In another specific aspect, the composition of the present invention can be identified as a cosmetic composition.
본 발명의 조성물이 화장료 조성물로 파악될 경우에도 그 화장료 조성물은 그 용도상, 법률상 임의의 제품 구분을 띨 수 있으며, 구체적으로 피부 트러블 개선, 피부 미백 증진, 아토피 피부염 개선 등의 용도를 가진 기능성 화장품, 비기능성 일반 화장품 등일 수 있다. 제품 형태에 있어서도 임의의 제품 형태를 띨 수 있는데, 구체적으로 용액, 현탁액, 유탁액, 페이스트, 젤, 크림, 로션, 파우더, 비누, 계면활성제-함유 클렌징, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션, 스프레이 등의 제품 형태를 띨 수 있다. 구체적인 제품 형태에 있어서는 유연 화장수, 영양 화장수, 영양 크림, 마사지 크림, 에센스, 아이 크림, 클렌징 크림, 클렌징 포옴, 클렌징 워터, 팩, 스프레이 또는 파우더의 제형 등일 수 있다.Even when the composition of the present invention is identified as a cosmetic composition, the cosmetic composition may be classified as an arbitrary product in terms of its use and law, and specifically, functional with uses such as improvement of skin trouble, promotion of skin whitening, improvement of atopic dermatitis, etc. It may be cosmetics, non-functional general cosmetics, and the like. In product form, it may take any product form, specifically, solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax It may take the form of a product such as foundation or spray. In a specific product form, it may be a softening lotion, nutrient lotion, nutrient cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder formulation.
본 발명의 화장료 조성물은 그 유효성분 이외에 화장료 조성물에 통상적으로 이용되는 성분들, 예컨대, 안정화제, 용해화제, 계면활성제, 비타민, 색소 및 항료와 같은 통상적인 보조제, 및 담체를 포함할 수 있다. The cosmetic composition of the present invention may include, in addition to the active ingredient, ingredients commonly used in cosmetic compositions, for example, stabilizers, solubilizers, surfactants, vitamins, conventional adjuvants such as pigments and fragrances, and carriers.
본 발명의 제형이 페이스트, 크림 또는 젤인 경우에는 담체 성분으로서 동물성유, 식물성유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등이 이용될 수 있다.When the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component. can
본 발명의 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진체를 포함할 수 있다.When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additional chlorofluorohydrocarbon, propane / May contain a propellant such as butane or dimethyl ether.
본 발명의 제형이 용액 또는 유탁액인 경우에는 담체 성분으로서 용매, 용해화제 또는 유탁화제가 이용되는데, 구체적으로 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌 글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜, 소르비탄의 지방산 에스테르 등이 이용될 수 있다.When the formulation of the present invention is a solution or emulsion, a solvent, solubilizing agent or emulsifying agent is used as a carrier component, specifically water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol oil, glycerol aliphatic esters, polyethylene glycol, fatty acid esters of sorbitan, and the like may be used.
본 발명의 제형이 현탁액인 경우에는 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상의 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르, 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 등이 이용될 수 있다.When the formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, or polyoxyethylene sorbitan ester, microcrystals Star cellulose, aluminum metahydroxide, bentonite, agar, and the like can be used.
본 발명의 제형이 계면-활성제 함유 클렌징인 경우에는 담체 성분으로서 지방족 알코올 설페이트, 지방족 알코올 에테르 설페이트, 설포숙신산 모노에스테르, 이세티오네이트, 이미다졸리늄 유도체, 메틸타우레이트, 사르코시네이트, 지방산 아미드 에테르 설페이트, 알킬아미도베타인, 지방족 알코올, 지방산 글리세리드, 지방산 디에탄올아미드, 식물성 유, 라놀린 유도체 또는 에톡실화 글리세롤 지방산 에스테르 등이 이용될 수 있다.When the formulation of the present invention is surfactant-containing cleansing, as carrier components, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.
본 발명의 화장료 조성물은 피부 주름 개선 활성, 피부 미백 활성을 나타내는 그 유효성분을 포함하는 것을 제외하고는 당업계에 통상적으로 행하여지는 화장료 조성물의 제조방법에 따라 제조할 수 있다.The cosmetic composition of the present invention may be prepared according to a method for preparing a cosmetic composition conventionally performed in the art, except for including an active ingredient exhibiting skin wrinkle improvement activity and skin whitening activity.
전술한 바와 같이, 본 발명에 따르면 푸른여로 추출물을 이용한 피부 주름 개선용 조성물과 피부 미백용 조성물을 제공할 수 있다.As described above, according to the present invention, it is possible to provide a composition for improving skin wrinkles and a composition for skin whitening using a blue yarrow extract.
본 발명의 이러한 조성물은 식품, 화장품, 약품 등으로 제품화될 수 있다.These compositions of the present invention can be commercialized as foods, cosmetics, pharmaceuticals, and the like.
도 1은 엘라스타아제 저해 활성 실험 결과이다.
도 2는 티로시나아제 저해 활성 실험 결과이다.1 is an experimental result of elastase inhibitory activity.
2 is a test result of tyrosinase inhibitory activity.
이하 본 발명을 실시예 및 실험예를 참조하여 설명한다. 그러나 본 발명의 범위가 이러한 실시예 및 실험예에 한정되는 것은 아니다.Hereinafter, the present invention will be described with reference to Examples and Experimental Examples. However, the scope of the present invention is not limited to these Examples and Experimental Examples.
<실시예> 푸른여로 추출물의 제조<Example> Preparation of blue yarrow extract
푸른여로(추출부위, 지상부) 건조 분말에 10배 중량의 70% 에탄올을 첨가하여 실온에서 24시간 침출한 뒤 와트만(whatman paper) 여과지 No.2로 여과한 후, 상기 여과액을 감압농축하고 동결 건조하여 고형상의 추출물을 제조하였다.After adding 10 times the weight of 70% ethanol to the blue filter (extracted part, aerial part) dried powder, leaching at room temperature for 24 hours, filtering with whatman paper filter paper No. 2, and concentrating the filtrate under reduced pressure A solid phase extract was prepared by freeze-drying.
<실험예> 엘라스타아제 저해 활성 실험 및 티로시나아제 저해 활성 실험<Experimental Example> Elastase inhibitory activity test and tyrosinase inhibitory activity test
<실험예 1> 엘라스타아제 저해 활성 실험<Experimental Example 1> Elastase inhibitory activity test
50 mM Tris-Cl buffer (pH 8.5)에 농도 별로 희석한 시료를 첨가한 후 50mM Tris-Cl buffer (pH 8.5) 에 기질 1mg/ml N-succinyl-(Ala)3-p-nitroanilide를 첨가하였다. 0.6U/ml PPE(porcine pancreas elastase)를 첨가하여 잘 섞은 후 25℃에서 반응 시켜 405nm에서 ELISA reader를 이용하여 흡광도를 측정하였다. 시료 무처리군인 대조군 대비 엘라스타아제 저해능을 측정하여 도 1에 나타내었다. 결과는 각 농도별 3회 반복 실험에 따른 결과이다. 양성대조군으로 ursolic acid를 사용하였다. After adding samples diluted by concentration in 50 mM Tris-Cl buffer (pH 8.5), 1 mg/ml N-succinyl-(Ala) 3 -p-nitroanilide as a substrate was added to 50 mM Tris-Cl buffer (pH 8.5). 0.6 U/ml PPE (porcine pancreas elastase) was added, mixed well, reacted at 25° C., and absorbance was measured using an ELISA reader at 405 nm. The elastase inhibitory ability compared to the control group, which is a sample untreated group, was measured and shown in FIG. 1. The results are the results of three repeated experiments for each concentration. As a positive control, ursolic acid was used.
도 1을 참조하여 보면 실시예의 추출물은 농도 의존적으로 엘라스타아제 저해 활성을 보였다. 양성 대조군인 ursolic acid는 그 IC50(엘라스타아제 50% 저해 농도)는 37.37 ㎍/ml로 나타났다. Referring to Figure 1, the extracts of Examples showed elastase inhibitory activity in a concentration-dependent manner. The IC 50 (50% inhibitory concentration of elastase) of ursolic acid, a positive control group, was 37.37 μg/ml.
<실험예 2> 티로시나아제 저해 활성 실험<Experimental Example 2> Tyrosinase inhibitory activity test
0.1 M potassium phosphate buffer (pH 6.5)에 농도별로 희석한 시료와 1250 unit/ml 버섯 유래 티로시나아제를 첨가한 후 기질 1.5 mM L-tyrosine을 첨가하여 잘 섞은 후 37℃에서 20분 반응 후 490 nm에서 ELISA reader를 이용하여 흡광도를 측정하였다. 시료 무처리군인 대조군 대비 티로시나아제 저해능을 측정하여 도 2에 나타내었다. 결과는 각 농도별 3회 반복 실험에 따른 결과이다.After adding samples diluted by concentration in 0.1 M potassium phosphate buffer (pH 6.5) and 1250 unit/ml mushroom-derived tyrosinase, add substrate 1.5 mM L-tyrosine, mix well, and react at 37°C for 20 minutes, then 490 nm Absorbance was measured using an ELISA reader. The tyrosinase inhibitory ability compared to the control group, which is the sample untreated group, was measured and shown in FIG. 2. The results are the results of three repeated experiments for each concentration.
도 2에서 확인되듯이, 실시예의 추출물은 모든 처리 농도에서 90% 정도의 티로시나아제 저해 활성을 보였다. As confirmed in Figure 2, the extracts of the examples showed tyrosinase inhibitory activity of about 90% at all treatment concentrations.
Claims (9)
A composition for improving skin wrinkles comprising blue yero extract as an active ingredient.
푸른여로 지상부의 물, 에탄올 또는 이들의 혼합용매 추출물인 것을 특징으로 하는 조성물
According to claim 1,
A composition characterized in that the extract of water, ethanol or a mixed solvent thereof
상기 조성물은 식품 조성물인 것을 특징으로 하는 조성물.
According to claim 1 or 2,
The composition is a composition, characterized in that the food composition.
상기 조성물은 화장료 조성물인 것을 특징으로 하는 조성물.
According to claim 1 or 2,
The composition is a composition, characterized in that the cosmetic composition.
A composition for skin whitening comprising blue yero extract as an active ingredient.
푸른여로 지상부의 물, 에탄올 또는 이들의 혼합용매 추출물인 것을 특징으로 하는 조성물
According to claim 5,
A composition characterized in that the extract of water, ethanol or a mixed solvent thereof
상기 조성물은 식품 조성물인 것을 특징으로 하는 조성물.
According to claim 5 or 6,
The composition is a composition, characterized in that the food composition.
상기 조성물은 화장료 조성물인 것을 특징으로 하는 조성물.
According to claim 5 or 6,
The composition is a composition, characterized in that the cosmetic composition.
상기 조성물은 약제학적 조성물인 것을 특징으로 하는 조성물.
According to claim 5 or 6,
The composition, characterized in that the composition is a pharmaceutical composition.
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