KR20210154176A - 표적화된 생체내 후성유전학적 억제에 의한 장기지속성 진통 - Google Patents

표적화된 생체내 후성유전학적 억제에 의한 장기지속성 진통 Download PDF

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KR20210154176A
KR20210154176A KR1020217036307A KR20217036307A KR20210154176A KR 20210154176 A KR20210154176 A KR 20210154176A KR 1020217036307 A KR1020217036307 A KR 1020217036307A KR 20217036307 A KR20217036307 A KR 20217036307A KR 20210154176 A KR20210154176 A KR 20210154176A
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프라샨트 말리
아나 모레노
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더 리젠츠 오브 더 유니버시티 오브 캘리포니아
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/40—Systems of functionally co-operating vectors

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  • Genetics & Genomics (AREA)
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  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020217036307A 2019-04-09 2020-04-09 표적화된 생체내 후성유전학적 억제에 의한 장기지속성 진통 Pending KR20210154176A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962831706P 2019-04-09 2019-04-09
US62/831,706 2019-04-09
US201962877810P 2019-07-23 2019-07-23
US62/877,810 2019-07-23
PCT/US2020/027541 WO2020210542A1 (en) 2019-04-09 2020-04-09 Long-lasting analgesia via targeted in vivo epigenetic repression

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KR20210154176A true KR20210154176A (ko) 2021-12-20

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US (1) US20220202957A1 (https=)
EP (2) EP4335925A3 (https=)
JP (2) JP2022526398A (https=)
KR (1) KR20210154176A (https=)
CN (1) CN113950526B (https=)
CA (1) CA3131759A1 (https=)
WO (1) WO2020210542A1 (https=)

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WO2024049179A1 (ko) * 2022-08-31 2024-03-07 주식회사 아이엔테라퓨틱스 인비보 세포외 신경다발절 기록법을 이용한 전기생리학적 약효평가법

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US20220202957A1 (en) 2022-06-30
EP3953461A1 (en) 2022-02-16
CN113950526B (zh) 2025-03-21
JP2025084803A (ja) 2025-06-03
CA3131759A1 (en) 2020-10-15
EP3953461A4 (en) 2023-05-31
JP2022526398A (ja) 2022-05-24
WO2020210542A1 (en) 2020-10-15
EP4335925A3 (en) 2024-08-28
CN113950526A (zh) 2022-01-18

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