KR20210068092A - 핵산 전달을 위한 3차 아미노 지질화 양이온성 펩타이드 - Google Patents

핵산 전달을 위한 3차 아미노 지질화 양이온성 펩타이드 Download PDF

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KR20210068092A
KR20210068092A KR1020217012768A KR20217012768A KR20210068092A KR 20210068092 A KR20210068092 A KR 20210068092A KR 1020217012768 A KR1020217012768 A KR 1020217012768A KR 20217012768 A KR20217012768 A KR 20217012768A KR 20210068092 A KR20210068092 A KR 20210068092A
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tertiary amino
cationic peptide
lipidated
integer
independently
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콜린 제임스 맥킨레이
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넛크래커 테라퓨틱스 인코포레이티드
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
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    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • B—PERFORMING OPERATIONS; TRANSPORTING
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KR1020217012768A 2018-09-28 2019-09-27 핵산 전달을 위한 3차 아미노 지질화 양이온성 펩타이드 Ceased KR20210068092A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862738717P 2018-09-28 2018-09-28
US62/738,717 2018-09-28
US201962885036P 2019-08-09 2019-08-09
US62/885,036 2019-08-09
PCT/US2019/053655 WO2020069442A1 (en) 2018-09-28 2019-09-27 Tertiary amino lipidated cationic peptides for nucleic acid delivery

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KR20210068092A true KR20210068092A (ko) 2021-06-08

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KR1020217012768A Ceased KR20210068092A (ko) 2018-09-28 2019-09-27 핵산 전달을 위한 3차 아미노 지질화 양이온성 펩타이드
KR1020217012769A Ceased KR20210068093A (ko) 2018-09-28 2019-09-27 핵산 전달을 위한 지질화 양이온성 펩타이드 화합물을 포함하는 지질 나노입자 제형

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KR1020217012769A Ceased KR20210068093A (ko) 2018-09-28 2019-09-27 핵산 전달을 위한 지질화 양이온성 펩타이드 화합물을 포함하는 지질 나노입자 제형

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US (4) US20210322575A1 (https=)
EP (2) EP3856757A4 (https=)
JP (2) JP7430713B2 (https=)
KR (2) KR20210068092A (https=)
CN (2) CN112789031B (https=)
AU (2) AU2019347774A1 (https=)
BR (2) BR112021005815A2 (https=)
CA (2) CA3110914A1 (https=)
IL (2) IL281135B2 (https=)
MX (2) MX2021003420A (https=)
MY (1) MY204458A (https=)
SG (2) SG11202102164PA (https=)
WO (2) WO2020069442A1 (https=)
ZA (2) ZA202101376B (https=)

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