KR20210046525A - a composite for dermatitis treatment and improvement using Wild Cultivated Ginseng vinegar - Google Patents

Abstract

The present invention relates to a composition for alleviating atopic dermatitis, and more specifically, to a composition for alleviating atopic dermatitis comprising vinegar using wild cultivated ginseng. The present invention provides a composition for alleviating atopic dermatitis prepared by mixing wild cultivated ginseng vinegar, dandelion enzyme vinegar, brown rice vinegar, honey, and water. In addition, the present invention provides a composition for alleviating atopic dermatitis, prepared by mixing 80 to 120 parts by weight of dandelion enzyme vinegar, 50 to 80 parts by weight of brown rice vinegar, 500 to 800 parts by weight of honey, and 4000 to 7000 parts by weight of water in 100 parts by weight of wild cultivated ginseng vinegar. Furthermore, the present invention provides a pharmaceutical composition for alleviating atopic dermatitis comprising the composition for alleviating atopic dermatitis.

Description

A composite for dermatitis treatment and improvement using Wild Cultivated Ginseng vinegar}

The present invention relates to a composition for improving skin, and more specifically, to a composition for skin treatment and improvement using wild ginseng vinegar.

Since the skin is in direct contact with the external environment and serves as an important protective film protecting the human body from physical, chemical, and biological irritants, cells are damaged by various external environmental stresses, resulting in aging.

Human skin undergoes various physical and chemical changes during the aging process. The causes are largely divided into intrinsic aging and photo-aging, and research on this has been actively conducted. UV rays, stress, disease states, environmental factors, wounds, and aging can be caused by activating free radicals, and if these conditions intensify, it destroys the antioxidant defenses existing in the living body and damages cells and tissues, leading to adult diseases. And accelerates aging. Lipids, proteins, polysaccharides, and nucleic acids, which are major components of the skin, are oxidized to destroy skin cells and tissues, resulting in skin aging.

In particular, the oxidation of proteins cuts the connective tissues of the skin, such as collagen, hyaluronic acid, elastin, proteoglycan, and fibronectin, which causes severe excessive inflammatory reactions and disrupts skin elasticity. If this gets worse, mutations in DNA lead to mutations, cancer, and immune function decline.

In particular, when the skin is exposed to ultraviolet rays, free radicals and reactive oxygen species (ROS), which are the main causes of skin cell damage, are generated. They cause DNA damage, attack the cell membrane structure, generate aging spots, and promote aging by attacking collagen and fibers that keep the skin moist, soft and supple.

Therefore, research is actively underway for the development of cosmetics for protecting skin cells from external environments such as ultraviolet rays, activating cell proliferation ability, and activating cell functions. Recently, the number of cases of developing substances having excellent skin cosmetic effects by searching for skin physiological activity for various herbal ingredients and using them in functional cosmetics such as anti-aging has been increasing rapidly.

However, most of the herbal ingredients have a stability problem, so when applied as a cosmetic, storage stability is poor, and there is a limit to the skin delivery power of active ingredients, so it is difficult to expect the practical efficacy of the herbal medicine.

As a related technology, Registration Patent No. 10-1754643 (hereinafter referred to as prior art) is "a cosmetic composition for skin improvement comprising an extract of wild ginseng cultured root captured in liposomes and a method for manufacturing the same" as "cultivating wild ginseng adventitious roots in a medium containing stevia extract. And extracting the cultured wild ginseng adventitious root to prepare a wild ginseng adventitious root extract; And after placing a bead in a lipid membrane obtained by drying the lipid mixed with phospholipids and cholesterol, adding the wild ginseng adventitious root extract to hydrate and ultrasonically decompose liposomes A method for producing a cosmetic composition comprising the wild ginseng adventitious root extract captured in the liposome as an active ingredient, comprising the step of preparing a wild ginseng adventitious root extract captured in the "

Has been presented.

In addition, the inventor of the present invention proposes “atopic dermatitis improvement composition including vinegar using apples” as “atopic dermatitis improvement composition using apples” as “Registration Patent No. 10-1923343 (hereinafter prior art 2) Compared to the prior art, a composition for improving atopic dermatitis, which has no side effects at all and has a remarkable effect in the improvement of atopic dermatitis, has been proposed.

The above-described prior art is an atopic dermatitis composition using apple cider vinegar, which is effective in treating atopic dermatitis, but is insufficient in improving skin burns, wounds, and dryness.

Accordingly, the present invention is an improvement of the prior art, and an object of the present invention is to provide a composition comprising vinegar using natural ingredients such as wild ginseng and dandelion, which are natural materials, and having a remarkable effect on the treatment and improvement of the skin.

In addition, the present invention is to provide a composition for skin treatment and improvement using wild ginseng vinegar that does not have any side effects because it is not irritating to the skin.

The present invention in order to solve the above objects and needs,

It provides a composition for skin treatment and improvement formed by mixing wild wild ginseng vinegar, dandelion enzyme vinegar, brown rice vinegar, honey, and water.

In addition, the present invention is a composition for skin treatment and improvement comprising 80 to 120 parts by weight of dandelion enzyme vinegar, 50 to 80 parts by weight of brown rice vinegar, 500 to 800 parts by weight of honey, and 4000 to 7000 parts by weight of water to 100 parts by weight of goat wild ginseng vinegar Provides.

In addition, the present invention provides a pharmaceutical composition for skin treatment and improvement comprising the composition for skin treatment and improvement.

The composition for skin treatment and improvement using wild mountain ginseng vinegar according to the present invention has a remarkable effect on skin treatment and improvement compared to the prior art and prior art.

In addition, while the prior art and the prior art have side effects, the composition for skin treatment and improvement using wild ginseng vinegar according to the present invention has no side effects at all.

The composition for skin treatment and improvement using wild mountain ginseng vinegar according to the present invention has a concentration of about 3 to 5 times higher based on the same mass of the added wild mountain ginseng and ginseng with respect to the composition prepared with conventional ginseng in the saponin component. Remarkably high efficacy appears in treatment and improvement.

Figure 1 is a view showing a process of manufacturing a wild ginseng vinegar sanyang according to the present invention.

Hereinafter, the present invention will be described in detail with reference to the drawings.

The present invention provides a composition for skin treatment and improvement formulated by mixing wild wild ginseng vinegar, dandelion enzyme vinegar, brown rice vinegar, honey, and water.

The present invention is a skin treatment formulated by mixing 80 to 120 parts by weight of dandelion enzyme vinegar, 50 to 80 parts by weight of brown rice vinegar, 500 to 800 parts by weight of honey, and 4000 to 7000 parts by weight of water to 100 parts by weight of the above-described goat wild ginseng vinegar or/and It provides an improvement composition.

The present invention provides a pharmaceutical composition for skin treatment and improvement comprising the composition for skin treatment and improvement described above.

The technical feature of the present invention is to provide a composition for skin treatment and improvement, including the above-described mountain-yang wild ginseng vinegar, and in addition to the preparation of the mountain-yang wild ginseng vinegar.

The sanyang wild ginseng vinegar of the present invention is characterized in that it is prepared by mixing finely crushed wild wild ginseng with honey and fermenting it for 5 to 9 days.

Sanyang wild ginseng vinegar stock solution is obtained by the following process.

First, the process of pulverizing wild wild ginseng with a grinder is performed (S-1).

Then, 100 to 2,000 parts by weight of honey is mixed with 100 parts by weight of the pulverized wild mountain ginseng and fermented while maintaining a temperature of 20 to 38 degrees Celsius for 5 to 9 days, thereby preparing a wild mountain ginseng vinegar undiluted solution. (S-2)

The sanyang wild ginseng vinegar of the present invention is prepared by mixing 200 to 700 parts by weight of purified water to 1 part by weight of the wild ginseng vinegar undiluted solution described above to prepare wild ginseng vinegar. (S-3)

The above-described sanyang wild ginseng vinegar of the present invention has a remarkable function in skin treatment and improvement.

That is, the technical feature of the present invention is that it exerts a remarkable function in skin treatment and improvement as the composition contains the wild ginseng vinegar prepared by the above method.

The above-described dandelion enzyme vinegar of the present invention means that the collected dandelion is washed, and 80 to 120 parts by weight of sugar are mixed with 100 parts by weight of dandelion, and fermented and aged for 2 to 3 years.

Preferably, the dandelion enzyme vinegar of the present invention is fermented and aged for 2 to 3 years by mixing 100 parts by weight of sugar with 100 parts by weight of dandelion and fermenting and aging for 2 to 3 years at 15 to 25 degrees Celsius, preferably 20 degrees Celsius. Good for treatment and improvement.

In particular, in the present invention, it is very effective to use dandelions from Mt.

The dandelion of the present invention is a plant belonging to the dicotyledons of the genus plant family and grows in the field in the sunny place. There is no stem, and leaves clump at the root and spread sideways. The leaves are inverted lanceolate, 6-15cm long, 1.2-5cm wide, and deeply dug into a pinnate shape, with serrated edges and some hairs.

The flower blooms yellow in April-May, and one head-shaped flower is attached to the end of the stalk, which is similar in length to the leaf. There are white hairs on the flower stalk, but gradually disappears and hairs remain only under the head flower. The gun gun is 17-20mm long when the flower blooms, and the outer gun gun piece is narrow egg-shaped or wide lanceolate, standing upright and has a horn-shaped protrusion at the end.

The fruit is a fruit. It is a long oval shape of 3~3.5mm in length, is brown, and has a spiny protrusion on the upper part. The root is 7-8.5mm long, and the tube hair is 6mm long, and the light white color turns. Young leaves are eaten as herbs in spring.

In oriental medicine, the plant before flowering is used as a medicinal herb called Pogongyeong (蒲公英). It is effective for swelling, mastitis, sore throat, appendicitis, peritonitis, acute hepatitis, jaundice due to heat, and is also used for symptoms of inability to urinate due to heat. In the private sector, it is also used as a medicinal material that makes milk quickly secreted. It is distributed in Korea, China, and Japan.

The technical feature of the present invention is that it exhibits a remarkable function in skin treatment and improvement as the composition contains vinegar fermented and aged for 2 to 3 years by mixing such dandelion with sugar.

The brown rice vinegar of the present invention may be vinegar prepared by fermentation using conventional brown rice.

As an example, the brown rice vinegar of the present invention is acetic acid fermentation by adding 4-15% by weight of seed seeds to the step (1) of performing alcohol fermentation using brown rice, yeast and yeast, and the result of step (1). Brown rice vinegar prepared by the method of preparing vinegar including the step (2) is used.

Step (1) of performing the alcohol fermentation is as follows.

5 to 20 parts by weight of pulverized yeast is mixed with 100 parts by weight of washed brown rice, and 300 to 600 parts by weight of water is mixed, and saccharification is performed at 50 to 60 degrees Celsius for 8 to 18 hours.

And, based on 100 parts by weight of brown rice, 3 to 10 parts by weight of yeast are mixed, and alcohol fermentation is performed for 4 to 6 days while intermittently stirring at 23 to 28 degrees C to obtain the result of alcohol fermentation.

In addition, the step (2) of fermenting acetic acid is as follows.

The seeds prepared above may be prepared in the following manner.

The acetic acid bacterium of the present invention can be used as a conventional acetic acid bacterium, and it is efficient to use KFRI 895 Acetobacter aceti.

A liquid medium (10 to 20 parts by weight of yeast extract, 10 to 20 parts by weight of peptone, 110 to 200 parts by weight of alcohol (95%, v/v) and 2000 to 4000 parts by weight of distilled water are mixed in a liquid medium (100 parts by weight of glucose). Inoculation) and shaking cultured acetic acid bacteria in a 30° C. shaking incubator (JSSI-100T, JSR, Korea) were prepared.

Next, the acetic acid bacteria cultured with shaking above are cultured in a seed culture medium and used as seed plants.

The composition of the seed medium is 100 parts by weight of yeast extract, 80 to 120 parts by weight of glucose, 15 to 40 parts by weight of glycerin, 0.05 to 0.3 parts by weight of magnesium sulfate, 100 to 200 parts by weight of alcohol (95%, v/v), acetic acid 20 to 80 parts by weight, 20 to 80 parts by weight of brewed vinegar, and 150 to 300 parts by weight of purified water are mixed and formulated.

Inoculate acetic acid bacteria cultured in a liquid medium prior to the agitated medium, and cultured with shaking in a 30°C shaking incubator (JSSI-100T, JSR, Korea), and used as a seed when the acidity reaches 5 or higher.

Brown rice vinegar is obtained by adding the seed vinegar to 4-15% by weight of the alcohol fermentation result from step (1) of performing alcohol fermentation and performing acetic acid fermentation at 23 to 28 degrees Celsius for 4 to 6 days.

In the present invention, the brown rice vinegar prepared by further mixing a natural additive composition in step (1) of performing alcohol fermentation using the brown rice, yeast and yeast described above can be more effective in skin treatment and improvement.

The above-described natural additive composition of the present invention is ephedra 100 parts by weight, 50 to 80 parts by weight of green tea, 10 to 40 parts by weight of Nabokja, 10 to 40 parts by weight of Maekmundong, 10 to 40 parts by weight of Gilkyung, 50 to 80 parts by weight of Jibuja, Baekchul Extracted by mixing 100-150 parts by weight, 80-120 parts by weight of the memorial ship, 80-120 parts by weight of Cheonodu, 80-120 parts by weight of Siho, 80-120 parts by weight of Jeokbokryong, 80-120 parts by weight of crust, 80-120 parts by weight of Chunma Means composition.

As a method of extracting the natural additive composition, water may be mixed and heated, alcohol may be used, or reflux extraction may be used.

In the natural additive composition extraction method, the mixing ratio of water is usually 3 to 20 times the total weight of the raw material, and it is recommended to extract by heating, and even when using alcohol, the alcohol is 1 to 20 times the total weight of the raw material. It is better to do reflux extraction.

In the present invention, when 1 to 10 parts by weight of the natural additive composition is mixed with 100 parts by weight of the brown rice, and the mixture is subjected to alcohol fermentation to produce brown rice vinegar, higher efficacy is exhibited in skin treatment and improvement.

In the present invention, when the brown rice vinegar prepared by further mixing natural improved additives in step (1) of performing alcohol fermentation using the brown rice, yeast and yeast described above is included, the antibacterial effect is exhibited.

The natural improvement additive of the present invention refers to a composition extracted by mixing Samcho, Hwangbaek, Hwanggi, Banggi, Cheonodu, Eoseongcho, Geumeunhwa, Baekji, Gyomaek, and Baekseonpi.

The above-mentioned natural improvement additives are 100 parts by weight of three seconds, 80 to 120 parts by weight of Hwangbaek, 80 to 120 parts by weight of Astragalus, 80 to 120 parts by weight of Banggi, 80 to 120 parts by weight of Cheonodu, 80 to 120 parts by weight of Eoseongcho, 80 to 120 parts by weight of gold and silver flowers. It refers to a composition extracted by mixing parts by weight, 80 to 120 parts by weight of white paper, 80 to 120 parts by weight of interlacing, and 80 to 120 parts by weight of tinea bark.

The method of extracting the natural improved additive may be performed in the same manner as the method of extracting the natural additive composition.

In the present invention, when producing brown rice vinegar by mixing 2 to 5 parts by weight of the above-described natural improvement additive to 100 parts by weight of brown rice and performing alcohol fermentation of the mixture as described above, higher antimicrobial efficacy is exhibited.

As the honey of the present invention, ordinary honey can be used.

More preferably, honey is highly effective against atopic dermatitis by using native honey from Jirisan.

As the water of the present invention, ordinary water may be used, preferably purified water.

In the present invention, it can be seen that the composition for skin treatment and improvement prepared by mixing goat wild ginseng vinegar, dandelion enzyme vinegar, brown rice vinegar, honey and water prepared according to the following examples has a remarkable effect on skin treatment and improvement.

<Example>

1. Sample preparation and method

(1) Preparation of sample

The preparation of the composition for skin treatment and improvement using the wild mountain ginseng used in the experiment is as follows.

Grind 11 g of wild mountain ginseng with a grinder, mix it with 200 g of honey, mix uniformly in a fermenter, and ferment at a temperature of 28 to 30 degrees C for 7 days to prepare a wild ginseng vinegar undiluted solution.

Take 2 g of the above prepared wild ginseng vinegar undiluted solution and mix 998 g of purified water to prepare 1000 g of wild ginseng vinegar (1000 ml, specific gravity 1).

Dandelion enzyme vinegar is prepared by mixing 100g of dandelion with 100g of sugar, fermenting and aging for 2 years and 6 months at 15-25 degrees.

Brown rice vinegar is prepared as follows.

1) brown rice vinegar 1

Brown rice vinegar was prepared by fermentation using general brown rice, and this is called brown rice vinegar 1.

2) Brown rice vinegar 2

Acetic acid bacteria (KFRI 895 Acetobacter aceti) was inoculated into a liquid medium (glucose 3g, yeast extract 0.5g, peptone 0.5g, alcohol (95%, v/v) 5g and distilled water 100g) inoculated into a 30°C shaking incubator (JSSI- 100T, JSR, Korea) to prepare acetic acid bacteria by shaking culture.

Yeast extract 125 g, glucose 125 g, glycerin 25 g, magnesium sulfate 0.125 g, alcohol (95%, v/v) 175 g, acetic acid 50 g, brewed vinegar 50 g, and purified water 250 g were mixed in a medium for seed plant in a Banpol flask and mixed After stirring, inoculate the above acetic acid bacteria, and shake culture in a 30°C shaking incubator (JSSI-100T, JSR, Korea), and use the one having an acidity of 5 or higher as the seed.

A mixture for brown rice vinegar is prepared by mixing 1000 g of brown rice, 100 g of koji, 30 g of a natural additive composition, 25 g of a natural improvement additive, and 4000 g of water.

The above natural additive composition is water in a mixture of 100 g of ephedra, green tea 60g, nabokja 30g, maekmundong 30g, Gilkyung 30g, Jibuja 60g, Baekchul 120g, Wiryeongseon 100g, Cheonodu 100g, Siho 100g, Jeokbokryong 100g, crust 100g, and Cheonma 100g. Mix 3000g, heat for 12 hours, and filter the cooled one to prepare.

The above-described natural improvement additives were mixed with 3000 g of water in a mixture of 100 g of Samcho, 100 g of Hwangbaek, 100 g of Astragalus, 100 g of Banggi, 100 g of Cheonodu, 100 g of Eoseongcho, 100 g of Geumeunhwa, 100 g of white paper, 100 g of Gyomaek, and 100 g of Baekseonpi. Prepare by filtering the cooled ones.

The above-described brown rice vinegar mixture was saccharified at 55°C for 12 hours, and then 50 g of pulverized yeast was added thereto, followed by alcohol fermentation for 5 days to obtain an alcohol fermentation product.

Brown rice vinegar is obtained by adding 450 g of seed vinegar to the above-described alcohol fermentation result and fermenting with acetic acid for 25 days at 25°C.

Such brown rice vinegar is called brown rice vinegar 2.

3) Preparation of a composition for skin treatment and improvement using wild ginseng vinegar

① A composition for skin treatment and improvement using wild mountain ginseng vinegar was prepared and used by mixing the above prepared goat wild ginseng vinegar 30g, dandelion enzyme vinegar 30g, brown rice vinegar 1 20g, Jirisan native honey 150g, and water 1500g (Sample 1).

① A composition for skin treatment and improvement using wild mountain ginseng vinegar was prepared and used by mixing the above prepared goat wild ginseng vinegar 30g, dandelion enzyme vinegar 30g, brown rice vinegar 2 20g, Jirisan native honey 150g, and water 1500g. (Sample 2)

(2) Direct test on the human body

1) Results of use on patients in their 50s with face burns

After applying the composition for skin treatment and improvement using the Sanyang wild ginseng vinegar (Sample 1) of the present invention to a patient in their 50s who suffered a burn around the nose of the face, three times a day for 7 days, the burn marks were remarkably lightened and no indication was displayed. The skin recovery effect was shown.

In addition, as a result of applying the composition for skin treatment and improvement using the sanyang wild ginseng vinegar (Sample 2) of the present invention for 5 days 3 times a day to patients in their 40s who suffered a hand burn, the burn marks were remarkably lightened to recover the skin that did not show signs. The effect appeared.

According to the above experiment, in the composition for skin treatment and improvement using wild ginseng vinegar, the treatment time of sample 2 (using brown rice vinegar including natural improvement additives and natural additive composition) was shorter than that of sample 1 (using normal brown rice vinegar). It can be seen that sample 2 has a more remarkable effect on skin treatment.

2) Results of using it on a woman in her late 50s with severe dryness of the leg skin

Skin recovery effect as a result of applying the composition for skin treatment and improvement using the sanyangsansam vinegar (Sample 1) of the present invention 3 times a day for 3 days to a female patient in their late 50s with severe dryness of the leg skin. Was markedly high.

In addition, as a result of applying the composition for skin treatment and improvement using the sanyangsansam vinegar (Sample 2) of the present invention three times a day for 20 days to a male patient in his late 30s with psoriasis on the leg skin, the pain caused by psoriasis disappears and psoriasis psoriasis It was shown that the disappearance of the skin showed remarkably high skin recovery effect.

According to the above experiment, sample 2 (using brown rice vinegar including natural improvement additives and natural additive composition) is more effective against malignant skin than sample 1 (using normal brown rice vinegar) in the composition for skin treatment and improvement using wild ginseng vinegar. It can be seen that the effect of skin treatment and improvement is more remarkable.

The present invention provides a composition for skin treatment and improvement using goat ginseng vinegar having the above-described configuration and function.

The present invention is very useful in industries that produce, manufacture, sell, distribute, and research a composition for skin treatment and improvement.

In particular, the present invention is very useful in the industry to produce, manufacture, sell, distribute, and research a composition for improving atopic dermatitis using wild ginseng vinegar.

Claims (2)

A composition for skin treatment and improvement formulated by mixing wild wild ginseng vinegar, dandelion enzyme vinegar, brown rice vinegar, honey, and water.
The method of claim 1,
A composition for skin treatment and improvement prepared by mixing 80 to 120 parts by weight of dandelion enzyme vinegar, 50 to 80 parts by weight of brown rice vinegar, 500 to 800 parts by weight of honey, and 4000 to 7000 parts by weight of water.

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