KR20180067915A - Health functional foods and compositions thereof for activating immune function - Google Patents
Health functional foods and compositions thereof for activating immune function Download PDFInfo
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- KR20180067915A KR20180067915A KR1020160169349A KR20160169349A KR20180067915A KR 20180067915 A KR20180067915 A KR 20180067915A KR 1020160169349 A KR1020160169349 A KR 1020160169349A KR 20160169349 A KR20160169349 A KR 20160169349A KR 20180067915 A KR20180067915 A KR 20180067915A
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
- 229960000314 zinc acetate Drugs 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
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- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
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- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/324—Foods, ingredients or supplements having a functional effect on health having an effect on the immune system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/15—Inorganic Compounds
- A23V2250/156—Mineral combination
- A23V2250/1642—Zinc
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
본 발명은 면역 기능 활성화를 위한 건강기능 식품 및 그 조성물에 관한 것으로, 더욱 상세하게는 적정량의 아연 성분 함유를 통하여 면역 기능을 활성화시킨 건강기능 식품 및 그 조성물에 관한 것이다.The present invention relates to a health functional food and its composition for activating an immune function, and more particularly, to a health functional food and a composition thereof that activate an immune function through the proper amount of a zinc ingredient.
아연 이온은 일반적으로 세포 배양과 관련하여 항산화 작용(설프히드릴기 방어 및 하이드록실 라디칼 생성 억제, 항산화 단백질 메탈로티오인 생성 유도), 인슐린 유사 효과, 항염증, 면역 반응 조절 또는 세포 사멸 억제(MAP 키나아제 경로를 통한 세포 분열 촉진, 카스파아제-3 활성 억제, Bcl-2/Bax 비율 증가) 등과 관련되어 있다. Zinc ions are commonly associated with cell culture in response to antioxidant effects (inhibition of sulfhydryl groups and hydroxyl radical formation, induction of antioxidant protein metallothionein production), insulin-like effects, anti-inflammation, modulation of immune responses or inhibition of cell death Promoting cell division through MAP kinase pathway, inhibiting caspase-3 activity, and increasing the Bcl-2 / Bax ratio).
또한, 아연은 DNA 합성, 단백질 합성, 세포 분열, 세포 증식, 세포 사멸, 에너지 생산 등에 관여하는 300개 이상의 생물학적 작용을 조절하는 조효소로 알려져 있고, 우리 몸의 주요 장기 예를 들어 전립선, 신장, 간장, 심장, 췌장, 대동맥, 난소, 고환, 비장, 폐, 뇌, 백혈구 등에 소정 범위로 함유되어 있는 것으로 알려져 있다. Zinc is also known as a coenzyme that regulates more than 300 biological functions involved in DNA synthesis, protein synthesis, cell division, cell proliferation, apoptosis, and energy production. The main organs of our body are the prostate, kidney, liver , Heart, pancreas, aorta, ovary, testis, spleen, lung, brain, white blood cell, and the like.
그러나, 이러한 체내의 아연은 다른 미네랄 성분에 비해 체내 보유량 대비 다량이 체외로 배출되는 것으로 알려져 있다. 따라서, 체내에 충분한 양의 아연 성분을 갖기 위해서는 배출되는 양을 초과하여 보충될 필요가 있다.However, zinc in this body is known to be excreted in vitro to a greater extent than other mineral components in the body. Therefore, in order to have a sufficient amount of zinc component in the body, it needs to be replenished in excess of the discharged amount.
종래에는 식물 추출물 중 자운영속 멤브라나시어스(Astragulas Membranaceous)가 마우스에서 인터페론 및 면역 글로불린 A와 면역 글로불린 G(IgA와 IgG)의 생성을 자극할 수 있는 것으로 알려져 있다(문헌[Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi Jiehe Zazhi, "Clinical study on effect of Astragalus in efficacy enhancing and toxicity reducing of chemotherapy in patients of malignant tumor", Chinese Journal of Integrated Traditional and Western Medicine, 2002, 22(7):515-517] 참조).It has been known in the past that Astragulas Membranaceous in plant extracts can stimulate the production of interferon and immunoglobulin A and immunoglobulin G (IgA and IgG) in mice (Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi Jiehe Zazhi, " Clinical study on effect of Astragalus in efficacy enhancing and toxicity reducing of chemotherapy in patients of malignant tumor", Chinese Journal of Integrated Traditional and Western Medicine, 2002, 22 (7): 515-517] , see ).
그러나 인체에서 실질적인 면역 기능 활성화를 제공할 수 있는 식물 추출물은 현재까지 많이 알려져 있지 않다. 이에 세포 분열을 자극하여 면역 기능을 강화시키는 데 기여하는 식물 추출물이 함유된 건강기능 식품의 제공이 요구된다.However, plant extracts that can provide substantial immune function activation in the human body are not known to date. Therefore, it is required to provide a health functional food containing a plant extract that stimulates cell division to enhance immune function.
따라서, 본 발명의 목적은 적정량의 아연 성분 함유를 통하여 면역 기능을 활성화시킨 건강기능 식품 및 그 조성물을 제공하는 것이다.Accordingly, an object of the present invention is to provide a health functional food and a composition thereof which have activated immune function through the proper amount of zinc ingredient.
본 발명의 하나의 양태는 산화 아연을 주원료로 포함하고, L-아르기닌 유리 염기, 인삼 추출물, 새삼씨 추출물, 쏘팔메토 열매 추출물, 마늘 추출물, 구기자 추출물, 하수오 추출물, 호손베리 추출물, 다미아나 잎 추출물, 남가새 열매 추출물 및 흑후추 추출물 중 적어도 1종을 부원료로 포함하는 면역 기능 활성화를 위한 건강기능 식품 조성물에 관한 것이다.One aspect of the present invention relates to a method for producing a Chinese cabbage comprising zinc oxide as an main raw material and containing L-arginine free base, ginseng extract, ginseng seed extract, Saw palmetto fruit extract, garlic extract, Gugija extract, Which comprises at least one member selected from the group consisting of extracts of Sambrook, fruit of S. sinensis, and extract of black pepper as minor ingredients.
본 발명의 하나의 실시양태에 따르면, 식품 조성물의 100 중량부를 기준으로, 산화 아연 0.5 내지 1.0 중량부, L-아르기닌 유리 염기 20 내지 25 중량부, 인삼 추출물 5 내지 10 중량부, 새삼씨 추출물 1.0 내지 5 중량부, 쏘팔메토 열매 추출물 5 내지 10 중량부, 마늘 추출물 1.0 내지 5 중량부, 구기자 추출물 1.0 내지 5 중량부, 하수오 추출물 1.0 내지 5 중량부, 호손베리 추출물 5 내지 10 중량부, 다미아나 잎 추출물 1.0 내지 5 중량부, 남가새 열매 추출물 8 내지 15 중량부, 및 흑후추 추출물 0.1 내지 1.0 중량부, 및 나머지 보조제를 포함하는 면역 기능 활성화를 위한 건강기능 식품 조성물을 제공한다.According to one embodiment of the present invention there is provided a food composition comprising 0.5 to 1.0 part by weight of zinc oxide, 20 to 25 parts by weight of L-arginine free base, 5 to 10 parts by weight of ginseng extract, 1.0 to 10 parts by weight of ginseng seed extract 5 to 10 parts by weight of the extract of Hawthorne fruit, 5 to 10 parts by weight of the extract of Saw Palmetto, 1.0 to 5 parts by weight of the garlic extract, 1.0 to 5 parts by weight of the extract of Gujija, 1.0 to 5 parts by weight of the Sasao extract, 1.0 to 5 parts by weight of an ala leaf extract, 8 to 15 parts by weight of S. scutellariae fruit extract, and 0.1 to 1.0 part by weight of blackhout extract, and the remaining adjuvant.
또한, 본 발명의 다른 양태는 이러한 건강기능 식품 조성물을 타원형 정제에 포장하여 경구 복용할 수 있도록 된 면역 기능 활성화를 위한 건강기능 식품에 관한 것이다.Further, another aspect of the present invention relates to a health functional food for immunological function activation, which can be taken orally by packing such a health functional food composition into an oval tablet.
본 발명의 건강기능 식품은 면역 강화제로서 사용될 수 있다.The health functional food of the present invention can be used as an immunity enhancer.
본 발명의 건강기능 식품은 항산화제로서 사용될 수 있다.The health functional food of the present invention can be used as an antioxidant.
본 발명에 따른 건강기능 식품은 아연 성분이 적정량 함유됨으로써 장기간 섭취시 면역 기능을 활성화시키고 체질 개선, 피로회복 등 항산화 효과를 제공할 수 있다.The health functional food according to the present invention can provide an antioxidative effect such as improving the constitution and fatigue by activating the immune function upon long-term ingestion by containing an appropriate amount of zinc component.
이하 본 발명을 더욱 상세히 설명한다.Hereinafter, the present invention will be described in more detail.
본 발명의 하나의 양태는 산화 아연을 주원료로 포함하고, L-아르기닌 유리 염기, 인삼 추출물, 새삼씨 추출물, 쏘팔메토 열매 추출물, 마늘 추출물, 구기자 추출물, 하수오 추출물, 호손베리 추출물, 다미아나 잎 추출물, 남가새 열매 추출물 및 흑후추 추출물 중 적어도 1종을 부원료로 포함하는 아연 보충을 통해 면역 기능을 활성화하기 위한 건강기능 식품 조성물을 제공한다. 이러한 식품 조성물은 예를 들어 적정 용량의 타원형 정제에 포장하여 경구 복용할 수 있도록 함으로써 건강기능 식품으로 이용할 수 있다.One aspect of the present invention relates to a method for producing a Chinese cabbage comprising zinc oxide as an main raw material and containing L-arginine free base, ginseng extract, ginseng seed extract, Saw palmetto fruit extract, garlic extract, Gugija extract, The present invention provides a health functional food composition for activating immune function through supplementation of zinc containing at least one of extract, S. clodavirus fruit extract and black pepper extract as an additive. Such a food composition can be used, for example, as a health functional food by allowing it to be taken orally in an oval tablet packed in an appropriate volume.
일반적으로, 아연은 100g당 채소류에 100 내지 150㎍, 과일류에 10 내지 200㎍ 함유되어 있고, 소, 돼지 등의 고기(2 내지 4mg) 및 내장(3 내지 7mg); 조개류(1 내지 3mg); 새우 또는 게류(1 내지 5mg); 해조류(2 내지 5mg); 어류의 알(2 내지 4mg); 종실류(1 내지 7mg); 콩류(2 내지 5mg) 등에 함유되어 있으며, 특히 굴(약 40mg)에 다량 함유되어 있으므로, 자연에서 쉽게 입수할 수 있다.Generally, zinc is contained in 100 to 150 mu g of fruits per 100 g of fruit and 10 to 200 mu g in fruits, and meat (2 to 4 mg) and viscera (3 to 7 mg) such as cow, pig, etc .; Shellfish (1-3 mg); Shrimp or crab (1-5 mg); Algae (2 to 5 mg); Fish eggs (2 to 4 mg); Seedling (1 to 7 mg); It is contained in legumes (2 to 5 mg) and especially in oysters (about 40 mg), so it can be easily obtained from nature.
본 발명에 사용된 "아연"은 글루콘산 아연, 산화 아연, 황산 아연, 염화 아연 및 아세트산 아연 중 1종 이상의 아연 화합물의 형태일 수 있고, 바람직하게는 산화 아연이다.As used herein, "zinc" may be in the form of one or more zinc compounds, such as zinc gluconate, zinc oxide, zinc sulfate, zinc chloride and zinc acetate, preferably zinc oxide.
본 발명의 아연 성분은 조성물의 100 중량부를 기준으로 0.5 내지 1.0 중량부 범위의 효과적인 양으로 함유된다. 아연 성분이 조성물의 0.5 중량부 미만이면 그 효과가 미미하고, 1.0 중량부를 초과하면 식물 추출물과의 시너지 효능이 반감된다.The zinc component of the present invention is contained in an effective amount ranging from 0.5 to 1.0 part by weight based on 100 parts by weight of the composition. If the zinc component is less than 0.5 part by weight of the composition, the effect is insignificant. If the zinc component is more than 1.0 part by weight, the synergistic effect with the plant extract is reduced.
아연 성분과의 면역 기능 및 세포 분열에 대한 시너지 효능을 위해, 본 발명은, L-아르기닌 유리 염기, 인삼 추출 분말, 새삼씨 추출물, 쏘팔메토 열매 추출물, 마늘 추출 분말, 구기자 추출 분말, 하수오 추출물, 호손베리 추출 분말, 다미아나 잎 분말, 남가새 열매 추출물 및 흑후추 추출 분말 중 적어도 1종을 포함하는 식물 추출물을 포함한다.For the synergistic effect on the immune function and cell division with the zinc component, the present invention relates to a method for producing the extract of L-arginine free base, ginseng extract powder, ginseng seed extract, saw palmetto fruit extract, garlic extract powder, , Hawthorn berries extract powder, Damiana leaf powder, Namulgathae fruit extract, and black pepper extract powder.
이들 식물은 일반적으로 당해 분야에서 상업적으로 용이하게 입수 가능하다.These plants are generally commercially available in the art.
본 발명에 사용된 L-아르기닌(유리 염기)은 구아니딘기(-NHC(=N)NH2)를 가진 염기성이 높은 아미노산으로서, 자연계에 널리 존재하며, 특히 어류 등의 정자 단백질 내에 비교적 많이 함유되어 있는 천연 L-아미노산이다. 식물 종자 및 마늘 중에는 유리 상태로 함유되어 있다. 그 수용액은 알칼리성을 띤다.The L-arginine (free base) used in the present invention is a highly basic amino acid having a guanidine group (-NHC (= N) NH 2 ) and widely exists in the natural world, and is relatively highly contained in sperm proteins such as fish Lt; / RTI > amino acids. Plant seeds and garlic are contained in glassy state. The aqueous solution is alkaline.
본 발명에 사용된 인삼은 다양한 형태로 가공된 임의의 인삼, 예를 들어, 수삼, 미삼, 백삼, 태극삼, 흑삼, 호정화 인삼, 효소처리 인삼, 발효 인삼, 홍삼 및 발효 홍삼을 포함하며, 이에 한정되지 않는다. 또한, 본 발명에 사용된 인삼은 고려삼, 회기삼, 전칠삼, 죽절삼, 삼엽삼, 히말라야삼, 베트남삼 및 미국삼을 포함하나, 이에 한정되지 않는다. 바람직하게는, 본 발명에 사용된 인삼은 고려삼이다.The ginseng used in the present invention includes any ginseng processed in various forms such as ginseng, misham, white ginseng, taegeuk ginseng, black ginseng, enzyme purified ginseng, enzyme treated ginseng, fermented ginseng, red ginseng and fermented red ginseng It is not limited. In addition, the ginseng used in the present invention includes, but is not limited to, Korean ginseng, Sajisan, Jeonjil, Gamjang, Gamma, Himalaya, Vietnamese and American ginseng. Preferably, the ginseng used in the present invention is Korean ginseng.
본 발명에 사용된 새삼(custcuta)은 갯실새삼(Cuscuta chinensis Lam.), 미국실새삼(Cuscuta pentagona Engelm.), 새삼(Cuscuta japonica Choisy), 실새삼(Cuscuta australis R. Br.) 등을 포함하나, 이들에 한정되지 않는다.The custcuta used in the present invention includes Cuscuta chinensis Lam., Cuscuta pentagona Engelm., Cuscuta japonica Choisy and Cuscuta australis R. Br. .
본 발명에 사용된 쏘팔메토(saw palmetto)는 톱야자 나무의 열매에서 추출한 것으로서 전립선 비대증에 가장 흔히 사용되는 대표적인 천연 유래 기능성 식품이다. 쏘팔메토의 주성분은 TG형의 여러 지방산과 피토스테롤으로서, 5-알파 환원효소 억제제 작용을 한다.The saw palmetto used in the present invention is extracted from the fruit of saw palmetto and is a typical natural-derived functional food most commonly used for the enlargement of the prostate. The main component of soap palmetto is TG type of fatty acid and phytosterol, which acts as a 5-alpha reductase inhibitor.
본 발명에 사용된 마늘은 식품의 향신료, 의약품의 원료, 기능성 식품으로서 이용되며, 항균작용을 비롯하여 항암작용, 면역증진작용, 항산화작용이 있다. The garlic used in the present invention is used as food spices, raw materials for pharmaceuticals, and functional foods, and has anticancer activity, anticancer activity, immunity enhancing activity, and antioxidative activity.
본 발명에 사용된 구기자(lycium chinense)는 근골을 튼튼하게 하고 장내 칼슘 흡수 방해 요소로 인한 골다공증을 예방할 수 있다.The lycium chinense used in the present invention can strengthen the muscles and prevent osteoporosis due to intestinal calcium absorption inhibiting factors.
본 발명에 사용된 하수오(pleuropterus multiflorus)는 다년생 박주가리과의 넝쿨성 초본식물로서, 특히 이에 함유된 성분들 중 강심 배당체인 트라이테르펜계 사포닌은 인슐린 유사 성장 인자(IGF-1) 분비능 증강 및 뼈 골격 성장 촉진 효능이 있다.The pleiropterus multiflorus used in the present invention is a perennial herbaceous herbaceous plant. Especially, among the components contained therein, tridentate saponin, which is a cardiac glycoside, is an insulin-like growth factor (IGF-1) There is an accelerating effect.
본 발명에 사용된 호손베리(hawthornemerry)는 혈관을 확장시켜 혈액의 흐름을 좋게 하고 굳은 피를 없애주며 혈중 지질을 떨어뜨리는 효과가 있어 콜레스테롤의 수치를 줄이고 혈압을 조절해 주며, 동맥경화, 심장질환의 예방에 도움이 된다.The hawthornemerry used in the present invention has the effect of expanding the blood vessels to improve the flow of blood, eliminating the hard blood, lowering the lipid of the blood, reducing the cholesterol level and controlling the blood pressure, .
본 발명에 사용된 다미아나 잎(damiana leaf)은 천연 약초로 화학적으로 합성된 비타민과 달리 인체에 100% 흡수되고, 다미아나에 다량 함유되어 있는 천연 성분인 베타-시토스테롤 및 베타-카로텐은 간과 신장 및 인체 호르몬 균형에 탁월한 효능을 갖는다.The damiana leaf used in the present invention is 100% absorbed into the human body unlike the chemically synthesized vitamin, which is a natural herb. Beta-sitosterol and beta-carotene, which are largely contained in Damiana, And human hormone balance.
본 발명에 사용된 남가새(tribulus terrestris) 열매는 맛은 쓰고 맵고, 간경에 들어가며, 혈압을 낮출 뿐만 아니라 혈관을 부드럽게 하고 콜레스테롤을 용해시켜 혈액순환이 잘 되게 한다.The tribulus terrestris fruit used in the present invention tastes spicy, spicy, enters the liver, lowers blood pressure, smoothes blood vessels, and dissolves cholesterol, thereby improving blood circulation.
본 발명에 사용된 흑후추(black pepper)는 피페린을 함유하는 것으로, 내부적으로 섭취했을 때 영양소, 식물 약품 및 약물의 흡수를 현저하게 증가시킨다. 또한, 흑후추는 장벽의 침투성을 변경하고, 장의 운동성을 늦추고, 장내 효소를 자극함으로써 장의 흡수를 증가시킬 수 있다(ex. 문헌[Srinivasan, L. “Black pepper and its pungent principle-piperine: a review of diverse physiological effects,” Critical Reviews of Food Science and Nutrition, 2007] 참조).The black pepper used in the present invention contains piperine, which significantly increases the uptake of nutrients, plant drugs and drugs when ingested internally. Also, black pepper can increase intestinal absorption by modifying barrier permeability, slowing intestinal motility and stimulating intestinal enzymes (eg, Srinivasan, L. "Black pepper and its pungent principle-piperine: a review of diverse physiological effects, " Critical Reviews of Food Science and Nutrition, 2007).
본 발명의 상기 열거된 식물 추출물들은 당업계의 통상적인 방법에 의해 추출될 수 있으며, 그 방법은 특별히 한정되지 않는다. 예를 들어, 초고압 추출될 경우 상기 열거된 식물 특유의 생리 활성 성분을 더욱 효율적으로 추출할 수 있는 이점이 있다.The above-mentioned plant extracts of the present invention can be extracted by a conventional method in the art, and the method is not particularly limited. For example, when the extract is subjected to ultra-high pressure extraction, there is an advantage that the physiologically active component peculiar to the plant enumerated above can be extracted more efficiently.
본 발명의 일 실시양태에 따르면, 상기 열거된 식물 추출물들은 세척 단계, 냉풍 건조 단계, 및 100 내지 400 MPa의 압력 및 30초 내지 90분 동안 0 내지 25℃의 온도 등의 처리 조건하에서 수행되는 저온 초고압 처리 공정에 의해 추출함으로써 얻을 수 있다. According to one embodiment of the present invention, the plant extracts enumerated above are subjected to a washing step, a cold air drying step and a low temperature treatment which is carried out under processing conditions such as a pressure of 100 to 400 MPa and a temperature of 0 to 25 DEG C for 30 seconds to 90 minutes And can be obtained by extraction by an ultra-high pressure treatment process.
얻어진 추출물들은 각각, 식품 조성물의 100 중량부를 기준으로, L-아르기닌 유리 염기 20 내지 25 중량부, 인삼 추출물 5 내지 10 중량부, 새삼씨 추출물 1.0 내지 5 중량부, 쏘팔메토 열매 추출물 5 내지 10 중량부, 마늘 추출물 1.0 내지 5 중량부, 구기자 추출물 1.0 내지 5 중량부, 하수오 추출물 1.0 내지 5 중량부, 호손베리 추출물 5 내지 10 중량부, 다미아나 잎 추출물 1.0 내지 5 중량부, 남가새 열매 추출물 8 내지 15 중량부, 및 흑후추 추출물 0.1 내지 1.0 중량부를 포함할 수 있다. 이들 추출물들의 상기한 유효 함량의 범위에서, 위에 열거된 효능을 갖는 아연 성분과의 시너지 효능이 발휘된다.The obtained extracts each contain 20 to 25 parts by weight of L-arginine free base, 5 to 10 parts by weight of ginseng extract, 1.0 to 5 parts by weight of ginseng seed extract, 5 to 10 parts by weight of Saw palmetto fruit extract, 1.0 to 5 parts by weight of garlic extract, 1.0 to 5 parts by weight of garlic extract, 1.0 to 5 parts by weight of a sulfoisophthalic acid extract, 5 to 10 parts by weight of a hawthornberry extract, 1.0 to 5 parts by weight of a Damiana leaf extract, To 15 parts by weight, and black pepper extract, 0.1 to 1.0 part by weight. Within the above range of effective contents of these extracts, the synergistic efficacy with the zinc ingredient having the above-listed potency is exerted.
본 발명의 조성물은 본 발명에 상술된 추출물들 외에 보조제를 추가로 포함할 수 있다. 보조제의 예는 셀룰로오스, 변형 셀룰로오스, 나트륨 카복시메틸 셀룰로오스, 에틸 셀룰로오스, 하이드록시메틸 셀룰로오스, 하이드록시프로필 셀룰로오스, 셀루로오스 아세테이트, 미세결정성 셀룰로오스, 이염기성 칼슘 포스페이트, 수크로오스, 락토오스, 옥수수 전분, 감자 전분 또는 이들의 임의의 조합일 수 있으나, 이들에 한정되지 않는다. 이들은 주요 유효 성분에 영향을 주지 않는 양으로 첨가될 수 있다.The composition of the present invention may further comprise adjuvants in addition to the extracts described in the present invention. Examples of adjuvants include cellulose, modified cellulose, sodium carboxymethylcellulose, ethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, cellulose acetate, microcrystalline cellulose, dibasic calcium phosphate, sucrose, lactose, corn starch, potatoes Starch, or any combination thereof. They may be added in amounts that do not affect the main active ingredients.
또한, 본 발명은 일 실시양태에 따른 건강기능 식품 조성물(혹은 식품)의 제조 방법을 제공한다.The present invention also provides a method for producing a health functional food composition (or food) according to one embodiment.
상기 방법은, 식품 조성물의 100 중량부를 기준으로, 0.5 내지 1.0 중량부의 산화 아연, L-아르기닌 유리 염기 20 내지 25 중량부, 인삼 추출물 5 내지 10 중량부, 새삼씨 추출물 1.0 내지 5 중량부, 쏘팔메토 열매 추출물 5 내지 10 중량부, 마늘 추출물 1.0 내지 5 중량부, 구기자 추출물 1.0 내지 5 중량부, 하수오 추출물 1.0 내지 5 중량부, 호손베리 추출물 5 내지 10 중량부, 다미아나 잎 추출물 1.0 내지 5 중량부, 남가새 열매 추출물 8 내지 15 중량부, 및 흑후추 추출물 0.1 내지 1.0 중량부를 포함하는 조성물이 되도록 하기에 충분한 양으로 혼합하는 단계; 혼합물을 물에서 교반하는 단계; 및 임의적으로 희석하는 단계를 포함한다.The method comprises the steps of: 0.5 to 1.0 parts by weight of zinc oxide; 20 to 25 parts by weight of the L-arginine free base; 5 to 10 parts by weight of the ginseng extract; 1.0 to 5 parts by weight of the ginseng seed extract; 5 to 10 parts by weight of palmetto fruit extract, 1.0 to 5 parts by weight of garlic extract, 1.0 to 5 parts by weight of Gugija extract, 1.0 to 5 parts by weight of Sasao extract, 5 to 10 parts by weight of Hawthorne berry extract, 8 to 15 parts by weight of S. sinensis fruit extract, and 0.1 to 1.0 part by weight of black pepper extract; Stirring the mixture in water; And optionally diluting.
식품 조성물의 제조 방법은 본 발명이 속하는 기술 분야의 통상의 숙련자에게 자명하며, 그 상세한 설명은 생략한다.The method of manufacturing the food composition is obvious to those skilled in the art, and a detailed description thereof will be omitted.
인체에는 체내의 아연 농도에 따라서 아연의 흡수를 조절하는 네거티브 피드백 시스템이 갖춰져 있어, 대량으로 경구 섭취하여도 혈청 내 아연농도는 일정 값을 초과하지 않는다. 즉, 건강한 사람의 경우 혈청 내 아연농도는 80 내지 140 ppm의 범위 내에 있으며, 장기간 대량 섭취할 경우에도 혈청 내 아연농도는 200 ppm 이상으로 나타나지 않는 것으로 보고되어 있다.The body has a negative feedback system that controls the absorption of zinc according to the concentration of zinc in the body. Even if ingested in large quantities, the zinc concentration in the serum does not exceed a certain value. That is, in a healthy person, the zinc concentration in the serum is in the range of 80 to 140 ppm, and the zinc concentration in the serum is not more than 200 ppm even in the case of long-term high-dose ingestion.
본 발명의 일 실시양태에 따른 건강기능 식품 조성물은 면역 기능 강화제 및 항산화제의 용도로 경구 적용될 수 있으며, 적용 형태는 특별히 제한되지 않는다. 예를 들어, 경구 투여되는 경우, 하루 섭취량은 5000 mg 이하인 것이 바람직하고, 하루 섭취량이 2000 mg 이하인 것이 보다 바람직하며, 하루 섭취량이 500 내지 1500 mg, 또는 1450 mg인 것이 가장 바람직하다.The health functional food composition according to one embodiment of the present invention can be orally applied for the use of an immune function enhancer and an antioxidant, and the application form thereof is not particularly limited. For example, when administered orally, the daily intake amount is preferably 5000 mg or less, more preferably 2000 mg or less, and most preferably 500 to 1500 mg or 1450 mg per day.
본 발명의 식품 조성물은 약제학적으로 허용가능한 담체와 함께 경구적으로 수용가능한 복용 형태인 캡슐제, 정제, 산제, 액제, 시럽제 등으로 제조될 수 있다.The food composition of the present invention may be prepared in the form of capsules, tablets, powders, solutions, syrups or the like, which are orally administrable dosage forms together with a pharmaceutically acceptable carrier.
약제학적으로 허용가능한 담체는 이에 제한되는 것은 아니나, 전분, 락토스, 말토스, 자당, 과당, 덱스트로스, 말토덱스트린, 설탕, 구연산, 사과산, 기타 음료용 향료 등의 감미료, 만니톨, 솔비톨, 자일리톨 등의 당알콜, 또는 다이칼슘 포스페이트, 칼슘 설페이트, 칼슘 카보네이트, 마이크로결정 셀룰로스 등을 포함할 수 있다.Pharmaceutically acceptable carriers include, but are not limited to, sweeteners such as starch, lactose, maltose, sucrose, fructose, dextrose, maltodextrin, sugar, citric acid, malic acid and other beverage flavorings, mannitol, sorbitol, xylitol Of calcium carbonate, calcium carbonate, microcrystalline cellulose and the like.
본 발명의 식품 조성물을 캡슐제로 제제화하는 경우, 연질 캡슐 또는 경질 캡슐 형태로 희석제가 있거나 또는 없이 제제화할 수 있으며, 희석제로는 락토스 또는 건조된 옥수수 전분 등을 사용할 수 있다.When the food composition of the present invention is formulated into a capsule, it may be formulated in the form of a soft capsule or a hard capsule with or without a diluent. As the diluent, lactose or dried corn starch may be used.
또한, 본 발명의 식품 조성물을 정제로 제제화하는 경우에는 마그네슘 스테아레이트, 소듐 라우릴 설페이트, 탈크 등의 활택제를 추가로 포함할 수 있다.When the food composition of the present invention is formulated into tablets, it may further comprise a lubricant such as magnesium stearate, sodium lauryl sulfate, and talc.
본 발명에 따른 식품 조성물을 캡슐제, 정제 등으로 제제화할 경우, 1일 1회 1정을 물과 함께 투여할 수 있다.When the food composition according to the present invention is formulated into capsules, tablets or the like, one tablet may be administered once a day together with water.
이와 같은 본 발명에 따른 식품 조성물은 체내에 투여되는 경우 신체의 신진대사에 도움을 주어 면역력 향상, 체질 개선, 피로 회복 등 항산화 작용에 효과적이다. 특히, 본 발명의 조성물은 장 기능, 위장병, 변비, 위궤양, 위염 및 위암 증상 중 적어도 하나를 개선하기 위한 면역 기능 강화제로서 사용될 수 있다.Such a food composition according to the present invention is effective for antioxidative action such as improvement of immunity, improvement of body constitution, fatigue recovery by helping the metabolism of the body when administered into the body. In particular, the composition of the present invention can be used as an immune function-enhancing agent for improving at least one of intestinal function, gastrointestinal diseases, constipation, gastric ulcer, gastritis and gastric cancer symptoms.
본 발명에 관한 보다 상세한 내용은 다음의 구체적인 실시예에 의해 설명된다. 하기 실시예는 본 발명을 예시하기 위한 것일 뿐 어떠한 의미로도 이에 의해 본 발명이 제한되는 것은 아니다. 다만, 여기에 기재되지 않은 내용은 당해 기술 분야에서 숙련된 자가 충분히 기술적으로 유추할 수 있는 것이므로 상세한 설명을 생략하도록 한다.Further details concerning the present invention are explained by the following specific examples. The following examples are for illustrative purposes only and are not intended to limit the scope of the invention in any way. However, the contents not described here are sufficiently technically inferior to those skilled in the art, so a detailed description will be omitted.
이하, 본 발명의 실시예에 따른 식품 조성물의 제조에 대하여 살펴본다.Hereinafter, preparation of a food composition according to an embodiment of the present invention will be described.
각각 준비된 인삼 분말, 새삼씨, 쏘팔메토 열매, 마늘 분말, 구기자 분말, 하수오, 호손베리, 다미아나 잎, 남가새 열매 및 흑후추 분말을 100 내지 400 MPa의 압력에서 30초 내지 90분 동안 0 내지 25℃의 온도하에서 초고압 처리하여 추출함으로써 각각의 추출물을 제조하고 여과하고 배합한 후, 여기에 L-아르기닌 유리 염기 및 산화 아연을 투입하고 교반하면서 혼합하였다. 이후, 이 혼합물에 하기 <표 1>에 기재된 바와 같은 비활성 성분들을 첨가하고 균일하게 혼합하였다. 이들을 충분히 용해시키고 여과한 후, 약제학적으로 허용되는 적절한 담체를 첨가하여 교반시킨 후, 실온에서 냉각시킨 다음 타원형 정제에 충전하고 밀봉하였다.The powdered ginseng powder, the ginseng seed, the saw palmetto fruit, the garlic powder, the ginger powder, the sage, the hawthorn berry, the damiana leaf, the sunflower seeds and the blackhawk powder are mixed at a pressure of 100 to 400 MPa for 30 seconds to 90 minutes for 0 to 25 And the extracts were prepared, filtered and mixed. Then, L-arginine free base and zinc oxide were added thereto and mixed with stirring. Then, the inert ingredients as shown in Table 1 below were added to this mixture and mixed uniformly. After sufficiently dissolving and filtering the mixture, an appropriate pharmaceutically acceptable carrier was added and stirred, then cooled at room temperature, filled in an elliptical tablet and sealed.
본 발명의 실시예 1에 따라 제조된 정제의 조성은 <표 1>과 같다.Table 1 shows the composition of tablets prepared according to Example 1 of the present invention.
실시예 1에 따라 제조된 타원형 정제를 화학적/물리적으로 분석하였고, 그 결과는 <표 2>와 같다.The elliptical tablets prepared according to Example 1 were analyzed chemically / physically and the results are shown in Table 2 below.
너비: 9.70 mm±10%
두께: 8.15 mm±10%Length: 19.30 mm ± 10%
Width: 9.70 mm ± 10%
Thickness: 8.15 mm ± 10%
실시예 1에 따라 제조된 타원형 정제의 미생물 분석을 수행하였으며, 그 결과는 <표 3>과 같다.The microbial analysis of the elliptical tablets prepared according to Example 1 was performed, and the results are shown in Table 3.
실시예 1에 따라 제조된 타원형 정제 1회 분량, 즉 1정(1,461mg) 당 영양소를 분석하였으며, 그 결과는 <표 4>와 같다.The nutrients per 1 tablet (1,461 mg) of the elliptical tablet prepared according to Example 1 were analyzed, and the results are shown in Table 4.
위의 표에서 알 수 있는 바와 같이, 본 발명의 식품 조성물은 아연 성분을 체내에 충분히 보충할 수 있음을 알 수 있다.As can be seen from the above table, it can be seen that the food composition of the present invention can sufficiently supplement the zinc component in the body.
본 발명의 실시예에 따라, 사용자들은 아연 성분이 함유된 건강기능 식품을 섭취함으로써 면역 강화, 체질 개선 및 피로회복의 효과를 볼 수 있을 것이다.In accordance with an embodiment of the present invention, users will be able to see the effects of immune enhancement, constitutional improvement and fatigue recovery by ingesting health functional foods containing zinc.
Claims (5)
식품 조성물의 100 중량부를 기준으로, 산화 아연 0.5 내지 1.0 중량부, L-아르기닌 유리 염기 20 내지 25 중량부, 인삼 추출물 5 내지 10 중량부, 새삼씨 추출물 1.0 내지 5 중량부, 쏘팔메토 열매 추출물 5 내지 10 중량부, 마늘 추출물 1.0 내지 5 중량부, 구기자 추출물 1.0 내지 5 중량부, 하수오 추출물 1.0 내지 5 중량부, 호손베리 추출물 5 내지 10 중량부, 다미아나 잎 추출물 1.0 내지 5 중량부, 남가새 열매 추출물 8 내지 15 중량부, 및 흑후추 추출물 0.1 내지 1.0 중량부, 및 나머지 보조제를 포함하는 면역 기능 활성화를 위한 건강기능 식품 조성물.The method according to claim 1,
0.5 to 1.0 part by weight of zinc oxide, 20 to 25 parts by weight of L-arginine free base, 5 to 10 parts by weight of ginseng extract, 1.0 to 5 parts by weight of ginseng seed extract, 5 to 10 parts by weight of garlic extract, 1.0 to 5 parts by weight of garlic extract, 1.0 to 5 parts by weight of Guji extract, 1.0 to 5 parts by weight of Sasao extract, 5 to 10 parts by weight of Hawthorne extract, 1.0 to 5 parts by weight of Damiana leaf extract, 8 to 15 parts by weight of a fruit extract, and 0.1 to 1.0 part by weight of a black pepper extract, and the remaining adjuvant.
항산화제로서 사용하기 위한 면역 기능 활성화를 위한 건강기능 식품.The method of claim 3,
A health functional food for immune function activation for use as an antioxidant.
장 기능, 위장병, 변비, 위궤양, 위염 및 위암 증상 중 적어도 하나를 개선하기 위한 면역 강화제로서 사용하기 위한 면역 기능 활성화를 위한 건강기능 식품.The method of claim 3,
A health functional food for use as an immunity enhancer for improving at least one of intestinal function, gastrointestinal disease, constipation, gastric ulcer, gastritis and gastric cancer.
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| KR20220000029A (en) | 2020-06-24 | 2022-01-03 | 주식회사 해피마스타 | Health functional foods and compositions thereof for activating immune function |
| CN115919929A (en) * | 2022-12-01 | 2023-04-07 | 金华寿仙谷药业有限公司 | Antioxidant traditional Chinese medicine composition and application thereof |
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| CN115919929A (en) * | 2022-12-01 | 2023-04-07 | 金华寿仙谷药业有限公司 | Antioxidant traditional Chinese medicine composition and application thereof |
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