KR20170109527A - N-아세틸시스테인 아미드를 사용한 색소성 망막염의 치료 - Google Patents

N-아세틸시스테인 아미드를 사용한 색소성 망막염의 치료 Download PDF

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Publication number
KR20170109527A
KR20170109527A KR1020177015227A KR20177015227A KR20170109527A KR 20170109527 A KR20170109527 A KR 20170109527A KR 1020177015227 A KR1020177015227 A KR 1020177015227A KR 20177015227 A KR20177015227 A KR 20177015227A KR 20170109527 A KR20170109527 A KR 20170109527A
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KR
South Korea
Prior art keywords
naca
administered
acid
months
intramuscularly
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Ceased
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KR1020177015227A
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English (en)
Korean (ko)
Inventor
피터 에이 캄포치아로
다니엘 하트만
Original Assignee
더 존스 홉킨스 유니버시티
나쿠이티 파마슈티컬스, 인코포레이티드
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Priority to KR1020227009489A priority Critical patent/KR20220039853A/ko
Publication of KR20170109527A publication Critical patent/KR20170109527A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y10S514/912—

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
KR1020177015227A 2014-11-07 2015-11-06 N-아세틸시스테인 아미드를 사용한 색소성 망막염의 치료 Ceased KR20170109527A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227009489A KR20220039853A (ko) 2014-11-07 2015-11-06 N-아세틸시스테인 아미드를 사용한 색소성 망막염의 치료

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462076594P 2014-11-07 2014-11-07
US62/076,594 2014-11-07
PCT/US2015/059589 WO2016073931A1 (en) 2014-11-07 2015-11-06 Treatment of retinitis pigmentosa with n-acetylcysteine amide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020227009489A Division KR20220039853A (ko) 2014-11-07 2015-11-06 N-아세틸시스테인 아미드를 사용한 색소성 망막염의 치료

Publications (1)

Publication Number Publication Date
KR20170109527A true KR20170109527A (ko) 2017-09-29

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KR1020177015227A Ceased KR20170109527A (ko) 2014-11-07 2015-11-06 N-아세틸시스테인 아미드를 사용한 색소성 망막염의 치료
KR1020227009489A Ceased KR20220039853A (ko) 2014-11-07 2015-11-06 N-아세틸시스테인 아미드를 사용한 색소성 망막염의 치료
KR1020237036499A Ceased KR20230152177A (ko) 2014-11-07 2015-11-06 N-아세틸시스테인 아미드를 사용한 색소성 망막염의 치료

Family Applications After (2)

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KR1020227009489A Ceased KR20220039853A (ko) 2014-11-07 2015-11-06 N-아세틸시스테인 아미드를 사용한 색소성 망막염의 치료
KR1020237036499A Ceased KR20230152177A (ko) 2014-11-07 2015-11-06 N-아세틸시스테인 아미드를 사용한 색소성 망막염의 치료

Country Status (11)

Country Link
US (2) US12472157B2 (https=)
EP (2) EP3214934A4 (https=)
JP (5) JP2017533969A (https=)
KR (3) KR20170109527A (https=)
CN (2) CN108498495A (https=)
AU (5) AU2015342831B2 (https=)
BR (1) BR112017009584A2 (https=)
CA (1) CA2967327C (https=)
HK (1) HK1252822A1 (https=)
RU (1) RU2711913C2 (https=)
WO (2) WO2016073931A1 (https=)

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US12472157B2 (en) 2014-11-07 2025-11-18 Nacuity Pharmaceuticals, Inc. Treatment of retinitis pigmentosa with n-acetylcysteine amide
WO2016077467A1 (en) 2014-11-11 2016-05-19 The Johns Hopkins University Biomarkers useful in the treatment of subjects having diseases of the eye
US11091433B2 (en) 2017-09-20 2021-08-17 Nacuity Pharmaceutials, Inc. Method for preparation of N-acetyl cysteine amide and derivatives thereof
EP3684756A4 (en) 2017-09-20 2020-10-28 NaCuity Pharmaceuticals, Inc. SYNTHESIS OF N-ACETYLCYSTEIN AMIDE AND ITS DERIVATIVES
US11548851B2 (en) 2017-09-20 2023-01-10 Nacuity Pharmaceuticals, Inc. Method for preparation of n-acetyl cysteine amide and derivatives thereof
US20190135741A1 (en) 2017-11-09 2019-05-09 Nacuity Pharmaceuticals, Inc. Methods of Making Deuterium-Enriched N-acetylcysteine Amide (D-NACA) and (2R, 2R')-3,3'-Disulfanediyl BIS(2-Acetamidopropanamide) (DINACA) and Using D-NACA and DINACA to Treat Diseases Involving Oxidative Stress
US20190151271A1 (en) * 2017-11-21 2019-05-23 The Johns Hopkins University Compositions and methods for treatment of eye diseases
CA3104209A1 (en) * 2018-07-09 2020-01-16 Fondation Asile Des Aveugles Inhibition of prc2 subunits to treat eye disorders
CN109096161B (zh) * 2018-08-24 2020-10-27 武汉远大弘元股份有限公司 一种n-乙酰半胱氨酸的制备方法
US10807973B2 (en) 2018-12-28 2020-10-20 Endogena Therapeutics, Inc. Compounds for use as therapeutically active substances in the treatment of retinal diseases
WO2020146660A1 (en) 2019-01-11 2020-07-16 Nacuity Pharmaceuticals, Inc. N-acetylcysteine amide (naca) and (2r,2r')-3-3'-disulfanediyl bis (2-acetamidopropanamide) (dinaca) for prevention and treatment of radiation pneumonitis and treatment of pulmonary function in cystic fibrosis
EP3908341A4 (en) 2019-01-11 2022-03-02 NaCuity Pharmaceuticals, Inc. TREATMENT OF AGE-RELATED MACULAR DEGENERATION, GLAUCOMA AND DIABETIC RETINOPATHY WITH N-ACETYLCYSTEINE AMIDE (NACA) OR (2R,2R')-3,3'-BIS(2-ACETAMIDOPROPANAMIDE) DISULFANEDIYL (DINACA)
EP3908271A4 (en) 2019-01-11 2022-10-26 NaCuity Pharmaceuticals, Inc. N-ACETYLCYSTEINE AMIDE (NACA) AND (2R,2R')-3,3'-DISULFANDIYL BIS-(2-ACETAMIDOPROPANAMIDE) (DINACA) FOR THE PREVENTION AND TREATMENT OF RADIATION DERMATITIS AND SKIN LIGHTENING AND IMPROVEMENT
AU2021209953B2 (en) * 2020-01-24 2024-08-22 Nacuity Pharmaceuticals, Inc. Prodrug for the treatment of disease and injury of oxidative stress

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Publication number Publication date
JP2023145734A (ja) 2023-10-11
RU2017119230A (ru) 2018-12-10
AU2024200436A1 (en) 2024-02-08
KR20220039853A (ko) 2022-03-29
WO2016073829A9 (en) 2016-06-23
AU2015342831B2 (en) 2019-09-12
JP2017533969A (ja) 2017-11-16
JP2025160381A (ja) 2025-10-22
CN107426997A (zh) 2017-12-01
CA2967327C (en) 2020-04-28
AU2019261762A1 (en) 2019-11-28
HK1252822A1 (zh) 2019-06-06
US20180296503A1 (en) 2018-10-18
EP3214934A1 (en) 2017-09-13
BR112017009584A2 (pt) 2017-12-26
EP3214934A4 (en) 2018-06-20
RU2711913C2 (ru) 2020-01-24
EP4000612A1 (en) 2022-05-25
AU2026200033A1 (en) 2026-01-22
CA2967327A1 (en) 2016-05-12
KR20230152177A (ko) 2023-11-02
AU2021225263B2 (en) 2023-11-02
WO2016073829A2 (en) 2016-05-12
JP2021193119A (ja) 2021-12-23
US12472157B2 (en) 2025-11-18
RU2017119230A3 (https=) 2018-12-10
JP2020023549A (ja) 2020-02-13
WO2016073931A1 (en) 2016-05-12
US20170333375A1 (en) 2017-11-23
AU2021225263A1 (en) 2021-09-30
CN108498495A (zh) 2018-09-07
AU2019261762B2 (en) 2021-06-10
AU2015342831A1 (en) 2017-05-25

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