KR20170000432A

KR20170000432A - Safety filter and syringe having the same

Info

Publication number: KR20170000432A
Application number: KR1020150088987A
Authority: KR
Inventors: 이재영; 임현철; 황원철
Original assignee: 주식회사 아모라이프사이언스
Priority date: 2015-06-23
Filing date: 2015-06-23
Publication date: 2017-01-03
Also published as: KR101765786B1

Abstract

The safety filter of the present invention includes a housing detachably connected between a needle and a cylinder, and a filter unit installed inside the housing to filter foreign substances contained in the injection liquid, wherein the filter unit is installed in the housing, And a filter member for filtering the foreign substances contained in the injection liquid, the filter member being disposed in the inflow passage, wherein the filter member comprises a porous support, And a membrane formed in the form of a nanofiber web having micropores to be laminated on the porous support and electrospinning the polymer material, thereby reducing the injection pressure and facilitating injection of the injection solution into the patient.

Description

[0001] SAFETY FILTER AND SYRINGE HAVING THE SAME [0002]

TECHNICAL FIELD The present invention relates to a safety filter and a syringe having the same, which can prevent foreign substances such as glass fragments and rubber fragments from being injected into a patient.

Generally, a syringe includes a cylinder in which an injection solution is stored, a needle, which is mounted in front of the cylinder, and a plunger, which is inserted linearly in the cylinder and sucks the injection fluid into the cylinder or discharges the injection fluid stored in the cylinder to the outside .

In such a syringe, the upper part of the ampule glass bottle containing the injection solution is cut to open the ampule glass bottle, and the injection needle is inserted through the opened space to store the injection solution into the cylinder.

In the case of a vial container in which a syringe is sealed and sealed with a rubber seal, a syringe is injected into the cylinder by inserting an injection needle with a rubber seal.

However, when the ampule glass bottle is cut, the glass sludge is introduced into the ampule glass bottle and mixed with the injection solution. Then, when the injection needle is inserted into the vial container through the rubber stopper, the rubber debris penetrates into the injection needle or the inside of the vial container

When glass fragments or rubber fragments are mixed with the injection solution and injected into the patient's body, various diseases such as phlebitis and sepsis are caused. In order to solve the problem of such a syringe, a syringe having a filter in a needle has been developed.

Conventional filter needles consist of a needle and a fixation member for fixing the needle to the syringe cylinder, as disclosed in Japanese Patent Application No. 10-1222881 (Jan. 10, 2013), in which a filter is built-in A filter structure is built in the fixing member, and the filter structure has a suction port at the rim portion of the circular body and a discharge port at the central portion, respectively, so that the suction path and the discharge path And the inlet and outlet of each of the inlets and outlets can be opened only in different directions by the check valve structure. Therefore, when the chemical liquid is filled, the foreign substances introduced into the syringe cylinder are not discharged to the outside through the injection needle, And a rear portion of the tube portion formed in the form of a circular pipe is provided on the discharge port side, And a cross section of the filter contacting the chemical solution is formed to be wider than a cross sectional area of the discharge port so that the pressure is dispersed when the chemical solution is discharged.

However, in the conventional filter needle as described above, when the chemical liquid is filled in the syringe cylinder, the foreign substance contained in the chemical liquid is filled into the syringe cylinder like the chemical liquid, and the chemical liquid is discharged through the filter when the chemical liquid is discharged from the syringe cylinder. There is a problem that it is difficult to inject the drug solution into the patient.

In particular, the syringe is mainly used by nurses. Since nurses have a lot of women, when injecting injection by pressing the plunger of the syringe after inserting the needle into the patient, it is difficult to inject the chemical solution when the discharge pressure of the chemical increases. There is a problem.

Patent Document 1: JP-A-10-1222881 (Jan. 10, 2013)

Therefore, it is an object of the present invention to provide a collecting chamber for collecting foreign matter, thereby preventing foreign matter from entering the cylinder, and preventing the injection liquid from passing through the filter member when the injection liquid is discharged from the cylinder, A safety filter for injecting an injection solution into a patient, and a syringe having the same.

Another object of the present invention is to provide a safety filter capable of preventing the injection liquid from returning to the collection chamber when discharging the injection liquid filled in the cylinder and preventing the waste of the injection liquid, .

It is a further object of the present invention to provide a method for manufacturing a membrane filter, which can greatly increase porosity by using a nanofiber web membrane having fine pores formed by electrospinning as a filter member, And a syringe having the safety filter.

It is still another object of the present invention to provide a safety filter having excellent compatibility and a syringe having the safety filter, which can be used by attaching a safety filter between a needle and a cylinder of an existing disposable syringe.

In order to attain the above object, the safety filter of the present invention comprises: a housing detachably connected between a needle and a cylinder; an inflow passage provided in the housing and into which the infusion fluid flows; And a filter member for filtering the foreign substance contained in the injection liquid to the passage member, wherein the filter member comprises: a porous support; and a microstructure layer laminated on the porous support, And a membrane formed in the form of a nanofiber web having pores.

The housing may include a first housing having a first inserting portion to be fitted to the needle and a second housing having a second inserting portion which is hermetically coupled to the first housing and into which the cylinder is fitted, .

The membrane may be formed by preparing a nanofiber by electrospinning a spinning solution obtained by mixing an electrospun polymer material and a solvent at a predetermined ratio, and accumulating the nanofiber on a porous support to a predetermined thickness.

The diameter of the nanofibers may be 0.1 to 3.0 mu m.

The porosity of the membrane may be 70-80% of the total area of the membrane.

The porous support may be formed of a nonwoven fabric or a mesh made of metal or resin.

A first check valve is formed at a center of the central member to form a collecting chamber connected to the inflow passage and collecting foreign substances contained in the injection liquid, and a first check valve is opened in front of the collecting chamber to open only a one- And a filter member may be provided at the back thereof.

A cover member to which the filter member is fixed is hermetically coupled to an open rear side of the collection chamber, and a second check valve is provided in the cover member to block return of the injection solution introduced into the collection chamber to the collection chamber .

The discharge passages may be formed at a plurality of intervals in the circumferential direction on the outer side of the collecting chamber, and a third check valve may be formed to open only the one-way flow through which the injected liquid is discharged from the cylinder.

The discharge passage may be equipped with an auxiliary filter member for filtering the foreign substances contained in the injection liquid discharged from the cylinder.

1 is an exploded perspective view of a syringe according to an embodiment of the present invention.
2 is a cross-sectional view of a safety filter according to an embodiment of the present invention.
3 is a cross-sectional view of a safety filter according to another embodiment of the present invention.
4 is a cross-sectional view of a filter member according to an embodiment of the present invention.
5 and 6 are operational views of a safety filter according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. The sizes and shapes of the components shown in the drawings may be exaggerated for clarity and convenience. In addition, terms defined in consideration of the configuration and operation of the present invention may be changed according to the intention or custom of the user, the operator. Definitions of these terms should be based on the content of this specification.

Referring to FIGS. 1 and 2, a syringe according to an embodiment of the present invention includes a cylinder 10 filled with an injection liquid, a cylinder 10 installed to be linearly movable in the cylinder 10, A safety needle 20 removably installed between the injection needle 20 and the cylinder 10 to remove foreign substances contained in the injection liquid, a plunger 12 for injecting the injection liquid into the cylinder 10, a needle 20 mounted in front of the cylinder 10, (30).

The needle 20 includes a needle 22 and a first connection 24 to which the needle 22 is secured and which is releasably connected to the safety filter 30. A second connection part 14 detachably connected to the safety filter 30 is formed in front of the cylinder 10.

The safety filter 30 includes housings 80 and 82 connected at one end to the needles 20 and connected at the other end to the cylinder 10 and a cylinder 10 A passage member 70 formed with an inlet passage 32 through which the injection liquid flows into the inside of the cylinder 10 and a discharge passage 34 through which the injection liquid stored in the cylinder 10 is discharged, And a filter member 44 installed to filter the foreign substances contained in the injection liquid.

The housings 80 and 82 include a first housing 80 formed with a first insertion portion 84 into which the first connection portion 24 is fitted and a second housing 80 which is hermetically coupled to the first housing 80, And a second housing 82 formed with a second insertion portion 86 into which the second housing 14 is fitted.

The passage member 70 may be formed of a resin material, silicone, or rubber material which is fixedly attached to the inner surface of the housings 80 and 82 and is elastically deformable.

The passage member 70 is formed at its center with an inflow passageway 32 through which the injection liquid is injected into the cylinder and the inflow passageway 32 is provided with a filter member 44 for filtering the injection liquid flowing into the cylinder 10, A discharge passage 34 for discharging the injection liquid stored in the cylinder 10 in the circumferential direction is formed outside the inflow passage 32.

A one-way flow (40) is formed at the center of the passage member (70) in which a collection chamber (40) for collecting foreign substances contained in the injection liquid flowing into the inflow passage (32) The first check valve 50 is opened.

The first check valve 50 includes an elastic rib 52 protruding in a convex spherical shape in the cylinder direction and a cutout hole 54 formed in the center of the elastic rib 52 and opened when pressure is applied from the inside, .

When the pressure is applied in the direction of the convex portion from the concave portion, the first check valve 50 opens the flow through the incision hole 54. When the convex portion is pressed by the concave portion, the incision hole 54 is closed To block the flow.

A cover member (42) is sealably fixed to the rear of the collection chamber (40). The cover member 42 is fitted to the open rear side of the collection chamber 40, and the filter member 44 is fixed to the inner surface thereof.

As described above, since the safety filter 30 of the present invention is provided with the collecting chamber 40, only foreign substances contained in the injecting solution are collected in the collecting chamber 40 and only the clean injecting solution filtered by the filter member 44 ).

The cover member 42 is formed with a second check valve 46 for preventing the injection liquid stored in the cylinder 10 from returning to the collection chamber 40. The second check valve 46 is the same as that of the first check valve 50 described above and is integrally formed with the cover member 42.

If the second check valve 46 is not provided, the injection liquid stored in the cylinder 10 is returned to the collection chamber 40 when the injection liquid is discharged from the cylinder 10, and the injection liquid is stored in the collection chamber 40 . In this way, since the injection liquid stored in the collection chamber 40 can not be discharged to the outside, the injection liquid may be wasted by the injection liquid stored in the collection chamber 40.

However, in the present invention, the second check valve 46 is formed on the cover member 42 to prevent the injection liquid stored in the cylinder 10 from returning to the collection chamber 40, thereby preventing the injection liquid from being wasted.

The discharge passages (34) are formed on the outer side of the collection passage (40) in plural in the circumferential direction at regular intervals. The third check valve 48 is formed in the discharge passage 34 to close the discharge passage 34 when the injection liquid is introduced into the cylinder 10 and to discharge the discharge passage 34 when the injection liquid is discharged from the cylinder 10. [ Lt; / RTI >

The third check valve 48 has the same structure as that of the first check valve 50, but only in the opposite direction.

As another example of the safety filter, the auxiliary filter member 72 is disposed in the discharge passage 34, as shown in Fig. The auxiliary filter member 72 is formed in a disk shape and is mounted at an inlet of the discharge passage 34 to filter foreign substances contained in the injection liquid when the injection liquid stored in the cylinder 10 is discharged into the discharge passage 34.

That is, the foreign substances contained in the injection liquid introduced into the cylinder 10 are first filtered by the filter member 44 and stored in the cylinder 10, and when the injection liquid stored in the cylinder 10 is discharged, In order to improve the filtering performance of the injection liquid.

4, the filter member 44 includes a porous support 60, a membrane 62 laminated to the porous support 60 and formed into a nanofiber web having micropores by electrospinning the polymeric material, .

Here, the membrane 62 may be laminated on one side of the porous support 60, laminated on both sides of the porous support 60, and the porous support 60 may be laminated on both sides of the membrane 62 have. The porous support 60 and the membrane 62 may be stacked in two or more layers when it is necessary to improve the filtering ability according to the purpose of use.

The membrane 62 is prepared by preparing a spinning solution in which an electrospun polymer material and a solvent are mixed at a predetermined ratio, and spinning the spinning solution to produce nanofibers. When the nanofibers are accumulated in the porous support 60 to a predetermined thickness And is formed into a nanofiber web shape having fine pores capable of filtering foreign matters.

The diameter of the nanofiber is preferably in the range of 0.1 to 3.0 mu m.

The thickness of the membrane 62 can be freely adjusted according to the time period of emission from the electrospinning device, and the pore size and porosity are determined according to the thickness of the nanofiber web.

Therefore, in this embodiment, the pore size and porosity of the membrane 62 can be freely adjusted, and the pore size can be variously produced according to the kind of the filtration.

In the conventional filter, the porosity of the membrane is about 40 to 50% of the total membrane area. In this case, the flow resistance of the injecting liquid passing through the membrane is increased, and there is a problem that the injecting liquid is injected into the cylinder and the use thereof is inconvenient.

Particularly, due to the characteristics of a syringe, a female nurse who is weaker in strength than men usually uses a lot of syringes. When injecting an injection, it is difficult to use a syringe.

In the present invention, the membrane 62 can be formed into a nanofiber web by accumulating nanofibers by electrospinning, so that the porosity of the membrane 62 can be 70 to 80% of the total area of the membrane 62 The flow resistance of the injection liquid passing through the membrane 62 can be minimized.

The porous support 60 may be formed of a nonwoven fabric or a net made of metal or resin. Any porous support may be used as long as it has pores through which the injectable solution can pass and can support the membrane 62.

The polymeric material used in the present invention is capable of electrospinning, for example, a hydrophilic polymer and a hydrophobic polymer, and one or more of these polymers may be used in combination.

The polymer material usable in the present invention is not particularly limited as long as it is soluble in an organic solvent for electrospinning and is capable of forming nanofibers by electrospinning. For example, polyvinylidene fluoride (PVdF), poly (vinylidene fluoride-co-hexafluoropropylene), perfluoropolymers, polyvinyl chloride, polyvinylidene chloride or copolymers thereof, polyethylene glycol di Polyoxyethylene-polyoxypropylene oxide, polyethylene glycol derivatives including alkyl ethers and polyethylene glycol dialkyl esters, polyoxides including poly (oxymethylene-oligo-oxyethylene), polyethylene oxide and polypropylene oxide, polyvinyl acetate, poly (vinylpyrrolidone- Vinyl acetate), polystyrene and polystyrene acrylonitrile copolymers, polyacrylonitrile (PAN), polyacrylonitrile copolymers including polyacrylonitrile methyl methacrylate copolymers, polymethyl methacrylate, polymethyl methacrylate Acrylate copolymer or a mixture thereof.

Examples of usable polymer materials include polyamide, polyimide, polyamideimide, poly (meta-phenylene isophthalamide), polysulfone, polyetherketone, polyetherimide, polyethylene terephthalate, , Aromatic polyesters such as polyethylene naphthalate, polyphosphazenes such as polytetrafluoroethylene, polydiphenoxaphospazene, poly {bis [2- (2-methoxyethoxy) Polyurethane copolymers including polyether urethanes, cellulose acetate, cellulose acetate butyrate, and cellulose acetate propionate.

Of the above polymer materials, PAN, polyvinylidene fluoride (PVdF), polyester sulfone (PES) and polystyrene (PS) may be used alone or polyvinylidene fluoride PVdF) and polyacrylonitrile (PAN), PVDF, PES, PVdF and thermoplastic polyurethane (TPU) may be mixed and used.

The operation of the safety filter installed in the syringe thus constructed will be described below.

The upper part of the ampule glass bottle containing the injection solution is cut to open the ampule glass bottle, and the injection needle is inserted through the opened space. In the case of a vial container sealed with a rubber seal, the injection needle is inserted into the vial container by inserting the injection needle into the rubber vial.

As shown in FIG. 5, when the plunger 12 is pulled, a negative pressure is generated in the cylinder, and the injection liquid is injected into the injection needle 20. Then, the first check valve 50 is opened by the pressure of the injection liquid, and the injection liquid flows into the collection chamber 40. The injected liquid which has flowed into the collecting chamber 40 is filtered while passing through the filter member 44 and foreign substances such as glass fragments and rubber fragments are collected in the collecting chamber 40.

The second check valve 46 is opened by the pressure of the injection liquid that has passed through the filter member 44, and the injection liquid is stored into the cylinder 10.

In this way, the injected solution stored in the cylinder 10 is filtered while passing through the filter member 44, and the injected solution is stored.

6, when the injection needle 20 is inserted into the patient and then the plunger 12 is pushed, the injection liquid is discharged to the discharge passage 34 and the third check valve 48 is opened by the pressure of the injection liquid And the injection is injected into the patient. At this time, it is possible to prevent the injection liquid stored in the cylinder 10 from being returned to the collection chamber 40 by the second check valve 46, thereby preventing the injection liquid from being wasted.

Since the safety filter 30 of the present invention is detachably connected between the injection needle 20 and the cylinder 30, the safety filter 30 can be installed in the existing syringe, It is also possible to separate the safety filter 30 and mount the injection needle 20 directly on the cylinder 10 and use it.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is clearly understood that the same is by way of illustration and example only and is not to be construed as limited to the embodiments set forth herein. Various changes and modifications may be made by those skilled in the art.

10: cylinder 12: plunger
20: Needle 30: Safety filter
32: injection passage 34:
40: collection chamber 42: cover member
44; Filter member 46: second check valve
48: third check valve 50: first check valve
60: Porous support 62: Membrane
70: passage member 80, 82: housing

Claims

A housing detachably connected between the needle and the cylinder;
A passage member formed in the housing and having an inlet passage through which the injection liquid flows into the cylinder and a discharge passage through which the injection liquid stored in the cylinder is discharged; And
And a filter member provided on the passage member for filtering the foreign substances contained in the injection liquid,
Wherein the filter member comprises a porous support and a membrane laminated to the porous support and formed in the form of a nanofiber web having micropores by electrospinning a polymeric material.

The method according to claim 1,
The housing includes a first housing formed with a first insertion portion to be fitted into a needle, and a second housing formed with a second insertion portion which is hermetically coupled to the first housing and into which the cylinder is fitted. As a safety filter.

The method according to claim 1,
Wherein the membrane is formed by preparing a nanofiber by electrospinning a spinning solution comprising a mixture of an electrospun polymer material and a solvent at a predetermined ratio, and accumulating the nanofiber on the porous support to a predetermined thickness.

The method of claim 3,
Wherein the diameter of the nanofibers is 0.1 to 3.0 mu m.

The method according to claim 1,
Wherein the porosity of the membrane is 70-80% of the total area of the membrane.

The method according to claim 1,
Wherein the porous support is formed of a nonwoven fabric or a mesh of metal or resin.

The method according to claim 1,
A collecting chamber is formed at the center of the passage member, the collecting chamber being connected to the inflow passage to collect foreign substances contained in the injection liquid,
Wherein a first check valve that opens only a one-way flow through which the injection liquid flows into the cylinder is formed in front of the collection chamber, and a filter member is provided behind the first check valve.

8. The method of claim 7,
A cover member to which the filter member is fixed is sealably coupled to an open rear side of the collection chamber,
Wherein the cover member is provided with a second check valve for blocking return of the injection liquid introduced into the cylinder to the collection chamber.

8. The method of claim 7,
Wherein a plurality of discharge passages are formed at a predetermined interval in the circumferential direction on the outer side of the collecting chamber and a third check valve is formed to open only one directional flow through which the injected liquid is discharged from the cylinder.

The method according to claim 1,
Wherein the discharge passage is equipped with an auxiliary filter member for filtering the foreign substances contained in the injection liquid discharged from the cylinder.

A cylinder in which an injection liquid is stored; and a safety filter detachably mounted between the injection needle and the cylinder to remove foreign matter contained in the injection liquid,
Wherein the safety filter is a safety filter according to any one of claims 1 to 10.