KR20150063374A - 자연 살해 세포 및 그의 용도 - Google Patents

자연 살해 세포 및 그의 용도 Download PDF

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KR20150063374A
KR20150063374A KR1020157006395A KR20157006395A KR20150063374A KR 20150063374 A KR20150063374 A KR 20150063374A KR 1020157006395 A KR1020157006395 A KR 1020157006395A KR 20157006395 A KR20157006395 A KR 20157006395A KR 20150063374 A KR20150063374 A KR 20150063374A
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cells
cell
population
medium
progenitor
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Korean (ko)
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에릭 로
린 캉
블라디미르 얀코빅
시아오쿠이 장
스튜어트 애봇
로버트 제이 하리리
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안트로제네시스 코포레이션
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Priority to KR1020217017107A priority Critical patent/KR20210076150A/ko
Publication of KR20150063374A publication Critical patent/KR20150063374A/ko
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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KR1020157006395A 2012-08-13 2013-08-13 자연 살해 세포 및 그의 용도 Ceased KR20150063374A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020217017107A KR20210076150A (ko) 2012-08-13 2013-08-13 자연 살해 세포 및 그의 용도

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261682706P 2012-08-13 2012-08-13
US61/682,706 2012-08-13
US201361799211P 2013-03-15 2013-03-15
US61/799,211 2013-03-15
PCT/US2013/054677 WO2014028453A2 (en) 2012-08-13 2013-08-13 Natural killer cells and uses thereof

Related Child Applications (1)

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KR1020217017107A Division KR20210076150A (ko) 2012-08-13 2013-08-13 자연 살해 세포 및 그의 용도

Publications (1)

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KR20150063374A true KR20150063374A (ko) 2015-06-09

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KR1020157006395A Ceased KR20150063374A (ko) 2012-08-13 2013-08-13 자연 살해 세포 및 그의 용도
KR1020227042037A Ceased KR20220166873A (ko) 2012-08-13 2013-08-13 자연 살해 세포 및 그의 용도
KR1020217017107A Ceased KR20210076150A (ko) 2012-08-13 2013-08-13 자연 살해 세포 및 그의 용도

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KR1020227042037A Ceased KR20220166873A (ko) 2012-08-13 2013-08-13 자연 살해 세포 및 그의 용도
KR1020217017107A Ceased KR20210076150A (ko) 2012-08-13 2013-08-13 자연 살해 세포 및 그의 용도

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Country Link
US (1) US20150225697A1 (https=)
EP (2) EP3722416A1 (https=)
JP (4) JP2015526088A (https=)
KR (3) KR20150063374A (https=)
CN (2) CN114134113A (https=)
AU (3) AU2013302853A1 (https=)
BR (1) BR112015003149A2 (https=)
CA (1) CA2881792C (https=)
HK (1) HK1211620A1 (https=)
MX (1) MX2015001871A (https=)
RU (2) RU2015108761A (https=)
WO (1) WO2014028453A2 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020180065A1 (ko) * 2019-03-05 2020-09-10 주식회사 온코인사이트 제대혈 단핵세포에서의 자연살해세포의 제조 방법
KR20200132722A (ko) * 2019-05-15 2020-11-25 (주)포에버엔케이 효율적 자연살해세포 배양방법 및 이의 배지첨가 키트
US11278569B2 (en) 2016-11-14 2022-03-22 Paean Biotechnology Inc. Natural killer cell containing exogenous mitochondrium and pharmaceutical composition comprising same
WO2024101863A1 (ko) * 2022-11-07 2024-05-16 마루테라퓨틱스 주식회사 줄기세포 기원 및 발현 마커에 따른 nk 세포 분화 효율 증진 방법

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013204922B2 (en) 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
AU2014240083C1 (en) 2013-03-15 2019-10-24 Celgene Corporation Modified T lymphocytes
KR20160098244A (ko) * 2013-11-15 2016-08-18 안트로제네시스 코포레이션 사람 태반 관류액 세포를 포함하는 조성물, 상기 세포의 부분모집단 및 이의 용도
US20180021378A1 (en) * 2014-12-31 2018-01-25 Anthrogenesis Corporation Methods of treating hematological disorders, solid tumors, or infectious diseases using natural killer cells
NZ733213A (en) * 2014-12-31 2022-10-28 Celularity Inc Natural killer cells and uses thereof
WO2016162827A1 (en) * 2015-04-09 2016-10-13 Universita' Degli Studi Di Genova Population of human lymphoid precursors, method for their identification and uses thereof
JP6073417B2 (ja) * 2015-06-26 2017-02-01 チャ バイオテック カンパニー リミテッド 自然殺害細胞増殖方法、及び自然殺害細胞増殖用の組成物
CA2998292A1 (en) * 2015-09-11 2017-03-16 Emercell Sas Pooled nk cells from umbilical cord blood associated with antibodies and their uses for the treatment of disease
ES2980794T3 (es) 2015-09-15 2024-10-03 Acerta Pharma Bv Combinaciones terapéuticas de un inhibidor de CD19 y un inhibidor de BTK
MY201637A (en) * 2015-10-15 2024-03-06 Celularity Inc Natural killer cells and ilc3 cells and uses thereof
CA3003923A1 (en) * 2015-11-05 2017-05-11 Glycostem Therapeutics B.V. Composition for use in immunotherapy
CN106701677A (zh) * 2015-11-18 2017-05-24 深圳爱生再生医学科技有限公司 Nk细胞的体外扩增培养方法
AU2017215955B2 (en) * 2016-02-01 2020-01-23 GC Cell Corporation Medium composition for cryopreservation of cell and use thereof
CN109843304A (zh) * 2016-05-07 2019-06-04 细胞结构公司 使用自然杀伤细胞治疗急性髓性白血病和多发性骨髓瘤的方法
KR101926166B1 (ko) * 2016-05-24 2018-12-06 재단법인 아산사회복지재단 수용체 시너지 활성을 이용한 nk 세포의 활성도 검사 방법 및 이를 이용한 nk 세포의 활성도가 관련된 질환의 진단 방법
KR101866827B1 (ko) * 2016-09-28 2018-07-19 한국원자력의학원 방사선 조사된 말초혈액단핵구를 이용한 고효율 자연살상세포의 제조방법 및 이를 이용한 항암 면역 세포치료제 조성물
AU2017377309B9 (en) * 2016-12-14 2021-06-03 Otsuka Pharmaceutical Factory, Inc. Mammalian cell cryopreservation liquid
JP2020503043A (ja) * 2016-12-30 2020-01-30 セルラリティ インコーポレイテッド 遺伝子改変されたナチュラルキラー細胞
WO2018160673A1 (en) * 2017-02-28 2018-09-07 University Of Central Florida Research Foundation, Inc. Pm21 particles to improve bone marrow homing of nk cells
US12129487B2 (en) * 2017-03-27 2024-10-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Method to obtain lymphoid progenitors
CN113061577A (zh) * 2017-09-05 2021-07-02 四川新生命干细胞科技股份有限公司 一种高纯度nk细胞的分离培养方法
CA3077325A1 (en) * 2017-09-28 2019-04-04 Celularity Inc. Tumor suppression using human placenta-derived intermediate natural killer (pink) cells in combination with an antibody
IL273757B2 (en) 2017-10-02 2025-01-01 Gamida Cell Ltd Growing and using NK cell populations
CN107904175B (zh) * 2017-12-29 2018-09-25 广州沙艾生物科技有限公司 用于免疫细胞的诱导扩增的培养箱
JP2021525066A (ja) * 2018-05-30 2021-09-24 グリコステム セラピューティクス ベスローテン フェンノートシャップ Ｃａｒ ｎｋ細胞
AU2019300782B2 (en) 2018-07-10 2023-12-21 Immunitybio, Inc. Generating CIK NKT cells from cord blood
CN109337870B (zh) * 2018-12-24 2020-07-03 广东暨德康民生物科技有限责任公司 人Vγ9Vδ2T细胞扩增方法与培养基
KR102216710B1 (ko) * 2019-03-27 2021-02-17 신지섭 Nk세포배양배지용 첨가조성물, 상기 첨가조성물을 이용한 nk세포배양방법 및 상기 배양방법으로 얻어진 피부트러블개선용 화장료조성물
KR20200122261A (ko) * 2019-04-17 2020-10-27 (주)차바이오텍 항암 활성이 증가된 자연살해세포 및 그의 면역 치료 용도
IT201900023922A1 (it) * 2019-12-13 2021-06-13 Univ Degli Studi Genova Popolazione cellulare progenitrice CD56-CD16+PerfnegCD7- e progenie cellulare NK CD94/NKG2C+KIR+CD57+ originata da detta popolazione cellulare CD56-CD16+PerfnegCD7-, loro ottenimento e loro usi
EP4114415A1 (en) 2020-03-06 2023-01-11 Sorrento Therapeutics, Inc. Innate immunity killer cells targeting psma positive tumor cells
CN112029721A (zh) * 2020-09-09 2020-12-04 广东昭泰体内生物医药科技有限公司 一种活性增强型nk细胞的制备方法
CN112029722A (zh) * 2020-09-09 2020-12-04 广东昭泰体内生物医药科技有限公司 一种nk细胞培养基及其应用
CN112266900A (zh) * 2020-10-30 2021-01-26 广东康盾生物工程技术有限公司 一种car-nk细胞的培养方法
CN112708675A (zh) * 2020-12-25 2021-04-27 中山大学肿瘤防治中心 骨髓nk细胞联合mcl1抑制剂在抗白血病中的应用
CN113416701B (zh) * 2021-07-28 2023-05-09 新疆西部赛澳生物科技有限责任公司 一种nk细胞培养基及培养方法
EP4389877A4 (en) * 2021-08-06 2025-09-03 Inst Zoology Cas RIC CELL AND ITS PREPARATION METHOD AND USE
KR20240063899A (ko) * 2021-09-08 2024-05-10 가부시키가이샤 가이아바이오메디신 세포의 처리 방법
CN113801846B (zh) * 2021-09-22 2024-06-04 南京艾尔普再生医学科技有限公司 一种从人诱导多能干细胞分化为自然杀伤细胞的方法
CN114891856B (zh) * 2022-05-16 2025-08-15 武汉科技大学 大队列样本单细胞富集和混样建库测序方法
CN114736859B (zh) * 2022-06-13 2022-08-19 广东先康达生物科技有限公司 一种脐带血nk细胞的培养液及培养方法
US20240279607A1 (en) * 2023-02-17 2024-08-22 FullHope Biomedical Co., Ltd. Pharmaceutical composition comprising modified natural killer cells and antigen-specific t cells, manufacturing method thereof, and method of using the same
CN117603809A (zh) * 2023-12-06 2024-02-27 威海紫光科技园有限公司 一种应用于nk细胞制备过程中复苏的温度控制方法及系统
CN117946971B (zh) * 2023-12-14 2025-07-15 深圳泽医细胞治疗集团有限公司 一种用于诱导C1型iNKT细胞的培养基、培养方法及其应用
WO2025160465A1 (en) 2024-01-26 2025-07-31 Celularity Inc. A method of treating signs or symptoms of the aging process
CN118370308B (zh) * 2024-04-18 2025-11-11 维赛(佛山)生物科技有限公司 一种临床用犬自然杀伤细胞冷藏保存液及其制备方法和应用
WO2025225667A1 (ja) * 2024-04-26 2025-10-30 日機装株式会社 凍結された腎細胞凝集体を含むプレート、それを用いた薬物動態検査用キット、毒性検査用キット及び創薬開発用キット
CN120005821B (zh) * 2025-04-21 2025-07-25 上海华颜医药科技有限公司 一种免疫细胞的培养方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4798824A (en) 1985-10-03 1989-01-17 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
US5190556A (en) 1991-03-19 1993-03-02 O.B. Tech, Inc. Cord cutter sampler
US5552267A (en) 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5372581A (en) 1993-07-21 1994-12-13 Minneapolis Children's Services Corporation Method and apparatus for placental blood collection
EP2305795B1 (en) 2000-12-06 2019-07-03 Celularity, Inc. Method of collecting placental stem cells
EP2316918B1 (en) 2001-02-14 2015-07-01 Anthrogenesis Corporation Post-partum mammalian placenta, its use and placental stem cells therefrom
US20030124091A1 (en) * 2001-10-26 2003-07-03 Large Scale Biology Corporation Endothelial cell derived hematopoietic growth factor
US20030187515A1 (en) 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
US7498171B2 (en) 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
US7147626B2 (en) 2004-09-23 2006-12-12 Celgene Corporation Cord blood and placenta collection kit
ZA200804717B (en) 2005-12-29 2010-02-24 Anthrogenesis Corp Improved composition for collecting and preserving a placental stem cells and methods of using the composition
PL2471907T3 (pl) 2005-12-29 2019-07-31 Celularity, Inc. Populacje komórek macierzystych łożyska
ES2638435T3 (es) * 2007-03-27 2017-10-20 Ipd-Therapeutics B.V. Métodos y medios para proliferación de células madre y posterior generación y expansión de células progenitoras, así como también producción de células efectoras como terapéuticos clínicos
MX342995B (es) * 2010-07-13 2016-10-21 Anthrogenesis Corp Métodos de generar células asesinas naturales.
US9476029B2 (en) * 2010-11-13 2016-10-25 Lung-Ji Chang Ex vivo development, expansion and in vivo analysis of a novel lineage of dendritic cells
ES2856825T3 (es) * 2011-03-18 2021-09-28 Glycostem Therapeutics B V Generación de células NK y progenitores de células NK

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11278569B2 (en) 2016-11-14 2022-03-22 Paean Biotechnology Inc. Natural killer cell containing exogenous mitochondrium and pharmaceutical composition comprising same
US12128070B2 (en) 2016-11-14 2024-10-29 Paean Biotechnology Inc. Natural killer cell containing exogenous mitochondrium and pharmaceutical composition comprising same
WO2020180065A1 (ko) * 2019-03-05 2020-09-10 주식회사 온코인사이트 제대혈 단핵세포에서의 자연살해세포의 제조 방법
KR20200132722A (ko) * 2019-05-15 2020-11-25 (주)포에버엔케이 효율적 자연살해세포 배양방법 및 이의 배지첨가 키트
WO2024101863A1 (ko) * 2022-11-07 2024-05-16 마루테라퓨틱스 주식회사 줄기세포 기원 및 발현 마커에 따른 nk 세포 분화 효율 증진 방법

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