KR20130005456A - Injection syringe for separating platelet rich plasma - Google Patents

Abstract

PURPOSE: A syringe for separating platelet rich plasma is provided to facilitate a separation and exhaust work and to obtain pure platelet rich plasma. CONSTITUTION: A syringe for separating platelet rich plasma comprises a cylinder(10) which is formed with a joint for coupling a injection needle or a cap to the front, a piston(20) which is inserted into inner space of the cylinder, and a pusher(30) for moving the piston. The piston is made of a rubber material and is formed with a stepped groove unit. The injection needle of the syringe is formed with an injection needle insertion penetration unit.

Description

Therapeutic platelet enriched plasma separation syringe {INJECTION SYRINGE FOR SEPARATING Platelet Rich Plasma}

In the present invention, the blood is sieved with a syringe, the first centrifuged to separate the lower precipitated red blood cells by pushing the push rod, and then the second centrifuged to separate the upper and lower layers of PPP (Platelet Poor Plasma) and PRP. (Platelet Rich Plasma: Platelet-enriched plasma) to separate and discharge the upper layer of PPP to obtain PRP used as a therapeutic injection, but the separation and discharge of the PPP is simple, excellent workability and precisely separated and discharged A therapeutic platelet-concentrated plasma separation syringe that provides to obtain pure PRP.

As is well known, blood is largely divided into blood cells and plasma.

The blood cells are composed of red blood cells, white blood cells and platelets, and the plasma is mainly composed of water, but also includes a blood coagulation factor, an electrolyte and the like.

This blood is used to separate and extract each component of the blood for various medical purposes, and the most commonly used method of separating and extracting each component of the blood is centrifugal separation of the blood by the specific gravity of the blood components It is to separate each component.

When the blood is centrifuged in this way, due to the specific gravity of the blood, the heaviest red blood cells form a lower layer, from which white blood cells and platelets are formed, and plasma or serum is formed thereon.

In this case, platelet-rich plasma, called PRP (Platelet Rich Plasma), is located at the lower part of the plasma and contains growth factors such as cytokines, PDGF, TGF-BETA1, and VEGP. It is found in the literature that it has been found to have good effects in wound healing such as disease, degenerative arthritis, chondrosis, cartilage damage, fifty shoulders, ligament damage, and joint damage.

In addition, a platelet-free plasma called PPP (Platelet Poor Plasma) is used as an autologous blood filler or autologous plasma-derived cosmetic that injects PPP into the gel form by heating and injecting it into the skin.

As described above, various techniques for separating and extracting each component by centrifugation of blood have been proposed. The syringe was mainly used as in Patent Registration No. 10-988221.

In more detail, after the anticoagulant is put into the syringe and the body is bleeded, the needles are separated, the caps are combined and sealed, and the centrifuge is performed by mounting the centrifuge and separating the needles.

At this time, the blood inside the syringe is separated and formed by forming a layer of red blood cells, PRP (Platelet Rich Plasma), and PPP (Platelet Poor Plasma: lean platelets) due to specific gravity.

As such, when the blood is separated by each component, the cap of the syringe is separated and a separate storage container (or syringe) is sequentially connected to the syringe by the connector to separate and discharge each component of the blood.

That is, the push rod of the syringe to separate and discharge the blood cells located in the lower part of each component of the blood, platelet rich plasma (PRP), platelet enriched plasma (PPP) and platelet poor plasma (platelet lean plasma) will be.

However, in the conventional method, the operator separates and discharges the push rod of the syringe while visually confirming the separated state of each component of the blood by the operator visually. There was a problem in that it is not possible to precisely proceed to separate discharge operation to ensure excellent purity of each component discharged separately.

In addition, since the negative pressure is applied to the blood during the process of separating and discharging the pushing rod of the syringe, the density is generated due to the density difference in the blood, so that the components of the blood separated up and down are mixed again, and the red blood cells of the syringe cylinder are extracted. Residual red blood cells may remain on the wall, making it difficult to separate pure PRP.

Therefore, in the related art, since the PRP separated as described above requires a separate process to increase the purity by removing blood cells by the separator, workability is cumbersome.

The present invention has been invented to solve all the problems of the prior art as described above, by bleeding the blood with a syringe, the first centrifuged to separate the lower precipitated red blood cells by pushing the push rod and then centrifuged again to the upper and lower layers Separate PPP (Platelet Poor Plasma) and PRP (Platelet Rich Plasma) from Platelet Rich Plasma (Platelet Rich Plasma) to separate and discharge PPP to be used as a therapeutic injection. Its purpose is to provide pure PRP with excellent workability and precise separation and discharge.

In particular, the present invention does not push and separate the push rod as in the conventional platelet poor plasma (PPP) and platelet rich plasma (PRP) platelet enriched plasma (PRP) to separate the injection needle of the syringe for storage in the piston It separates and discharges PPP by penetrating through the storage syringe or discharges PPP through the resin pipe inserted into the lower part of the syringe, so that the PPP is separated and discharged more precisely, thus obtaining pure PRP and providing excellent therapeutic effect. There is a purpose.

The present invention provides a needle or a needle at the tip to separate and discharge the platelet poor plasma (PPP) and platelet rich plasma (PRP), which are separated into the upper and lower layers by centrifugation, and red blood cells. A cylinder forming a coupling part capable of engaging a cap, a piston inserted into the cylinder inner space, and a push rod for moving the piston;

The piston is formed of a stepped groove that forms a step at the bottom of the screw coupling hole for screwing the push rod to the upper portion of the rubber material to insert the needle of the storage syringe for separating and discharging blood into the inner space of the cylinder. Or to form a needle insert through-hole forming a thin thickness,

A vertical hole is formed in the lower portion of the cylinder to penetrate into the inner space, a hard resin pipe inserted into the inner space in the hole inside the packing, and a cap for opening and closing the resin pipe. However, the resin pipe is characterized in that it is configured to separate and discharge the blood while adjusting the moving up and down in the inner space of the cylinder.

The packing of the present invention is characterized in that it protrudes the locking jaw in the upper and lower portions to prevent the vertical deviation from the hole of the cylinder.

In the present invention, the blood is sieved with a syringe, the first centrifuged to separate the lower precipitated red blood cells by pushing the push rod, and then the second centrifuged to separate the upper and lower layers of PPP (Platelet Poor Plasma). PRP (Platelet Rich Plasma) is separated and discharged from the upper layer to obtain PRP to be used as a therapeutic injection, but the PPP and PRP are stored separately in the piston rather than pushing out the push rod as in the prior art. PPP is inhaled and discharged through the needle of the syringe for storage, or PPP is separated and discharged through the resin pipe inserted under the syringe, so it is easy to separate and discharge the PPP. It is possible to have the effect of providing you to get pure PRP.

1 is a cross-sectional view of a syringe showing an embodiment of the present invention.
2 is an enlarged view illustrating main parts of FIG. 1;
3 is a cross-sectional view of a syringe showing another embodiment of the present invention.
4 is an enlarged exploded view of the main part of FIG. 3;
5 is a work flow chart according to FIG. 1.
6 is a work flow chart according to FIG. 3.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

The present invention separates and discharges the red precipitated red blood cells after the first centrifugation, and the second centrifugation to separate the platelet Poor Plasma (platelet lean plasma) and PRP (Platelet Rich Plasma). The purpose of the present invention is to provide a dedicated syringe that separates and discharges the upper layer of PPP from platelet-concentrated plasma to obtain PRP for therapeutic use.

That is, the therapeutic platelet-concentrated plasma separation syringe of the present invention has a cylinder 10 and the cylinder forming a coupling portion 12 capable of coupling an injection needle or a cap at the tip, as shown in FIGS. 1 to 6. It consists of a piston 20 inserted into the inner space and a push rod 30 for moving the piston.

In this case, the present invention provides two types of embodiments to separate and discharge the PPP of the upper layer in the PPP and PRP separated into the upper and lower layers inside the cylinder.

First, as shown in FIGS. 1 and 2, the piston 20 is formed of a rubber material, but the step groove 22 forms a step below the screw coupling hole 21 for screwing the push rod 30 to the upper portion. In order to insert the needle (3) of the storage syringe (2) for the separate discharge of the blood into the cylinder inner space portion 13 to form a needle thickness through-hole 25 forming a thin thickness with the piston bottom Configured to form.

Secondly, as shown in FIGS. 3 to 4, a vertical hole 14 penetrating through the inner space 13 is formed in the lower portion of the cylinder 10, and the packing 40 and the elastic material are formed in the hole. A rigid resin pipe 45 inserted into the through-hole 42 inside the packing and a cap 46 for opening and closing the bottom of the resin pipe, wherein the resin pipe 45 is lifted from the cylinder inner space. It is configured to separate and discharge blood, while controlling downward movement.

At this time, the packing 40 is formed by protruding the locking step (41, 41 ') in the upper and lower portions to prevent the vertical deviation from the hole 14 of the cylinder (10).

Hereinafter, the operation and operation of the present invention will be described.

First, the anticoagulant is put into the syringe of the present invention, and the injection needle 3 'is connected to perform the body blood.

After the injection needle is separated, the cap 5 is coupled and sealed, and the push rod 30 of the syringe is separated from the screw coupling hole 21 of the piston 20.

In this state, the syringe is mounted in a centrifuge (not shown) to undergo a first centrifugation process.

When the first centrifugation process as described above, the blood inside the cylinder 10 of the syringe is separated so that the red blood cells are located at the bottom by the specific gravity difference of each component.

After removing the cap 5 coupled to the coupling portion 12 of the syringe in such a state, the push rod 30 is coupled to the piston 20 and slowly pushed in the lowermost of the components of the blood by conventionally. The red blood cells are located and discharged separately.

In such a state, the cap 5 is coupled to the coupling part 12 of the syringe and sealed, and the separator 30 is separated and then mounted on a centrifuge (not shown) to undergo a second centrifugal separation process.

As a result of the second centrifugation process, the blood inside the cylinder 10 of the syringe passes the upper and lower layers of PPP (Platelet Poor Plasma) and PRP (Platelet Rich Plasma). Separated to achieve.

In such a state, in addition to PRP (Platelet Rich Plasma: Platelet Concentrated Plasma) to be used for treatment in the cylinder 10 of the syringe, unnecessary PPP (Platelet Poor Plasma: platelet lean plasma) is to be discharged.

1 and 2 and 5, the needle 3 of the separate small syringe 2 is inserted through the piston 20 of the cylinder 10 from the top of the piston 20 into the inner space 13. .

At this time, the upper center of the piston 20 is the injection needle insertion through which forms a thin thickness with the bottom of the piston by the step groove 22 forming a step below the screw coupling hole 21 to which the push rod 30 is screwed Since the 25 is formed, the needle 3 of the small syringe can be easily inserted.

By pulling the push rod of the small syringe 2 in such a state, the PPP located in the upper part of the cylinder is sucked and discharged.

That is, since the PPP inside the cylinder is sucked through the needle 3 of the small syringe and separated and discharged, the PPP can be separated and separated from the PRP so that the PPP can be discharged precisely, so that only pure PRP remains in the cylinder 10 of the syringe. Will be discharged.

In this manner, only pure PRP remains inside the cylinder 10, which is used to connect the injection needle 3 ′ to the coupling portion 12 of the cylinder to inject for various therapeutic purposes.

3 to 4 and 6, the cap 46 at the bottom of the hard resin pipe 45 inserted together with the packing 40 in the vertical hole 14 in the lower part of the cylinder is separated and opened. Let's do it.

When the lower end of the resin pipe 45 is opened in this way, the PPP located in the upper layer inside the cylinder through the resin pipe is separated and discharged downward through the resin pipe 45.

At this time, since the resin pipe 45 is inserted into the through hole 42 of the packing material 40 of the elastic material, the resin pipe 45 is moved upward and downward to adjust the position of the upper end of the resin pipe to separate the discharge water level of the PPP. Will be controlled.

That is, while separating and discharging the PPP located in the upper layer inside the cylinder to the bottom through the resin pipe 45, by adjusting the height of the resin pipe to move up and down to control the separation discharge level of the PPP, PRP in the cylinder Only the PPP layer on the top of the layer can be separated and precisely discharged so that only pure PRP will be separated and discharged to remain in the cylinder 10 of the syringe.

In this manner, only pure PRP remains inside the cylinder 10, which is used to connect the injection needle 3 ′ to the coupling portion 12 of the cylinder to inject for various therapeutic purposes.

10: cylinder 12: coupling part
20: piston 30: push rod
21: screw coupling hole 22: step groove
25: insertion hole 14: hole
40: Packing 41,41 ': Hanging jaw
42: through hole 45: vertical pipe
46: cap

Claims (3)

Combine needle or cap at the tip to separate and discharge platelet poor plasma (PPP), platelet rich plasma (PRP) and red blood cells, which are separated into the upper and lower layers by circulating blood. In the syringe consisting of a cylinder 10 forming a coupling portion 12, a piston 20 inserted into the inner space of the cylinder and a push rod 30 for moving the piston,
The piston 20 is formed of a rubber material, a storage syringe for separating and discharging blood by forming a step groove 22 to form a step below the screw coupling hole 21 for screwing the push rod 30 to the upper portion Injecting the needle into the cylinder space portion 13, the platelet-concentrated plasma separation syringe for treatment, characterized in that formed to form a needle insertion through-hole 25 to form a thin thickness with the bottom of the piston.
Combine needle or cap at the tip to separate and discharge platelet poor plasma (PPP), platelet rich plasma (PRP) and red blood cells, which are separated into the upper and lower layers by circulating blood. In the syringe consisting of a cylinder 10 forming a coupling portion 12, a piston 20 inserted into the inner space of the cylinder and a push rod 30 for moving the piston,
A vertical hole 14 penetrating into the inner space part 13 is formed in the lower part of the cylinder 10, and the hole is inserted into the packing 40 made of an elastic material and the through-hole 42 inside the packing. It consists of a rigid resin pipe 45 and the cap 46 for opening and closing the resin pipe lower portion, characterized in that the resin pipe 45 is configured to separate and discharge the blood while adjusting the movement, up and down in the inner space of the cylinder A therapeutic platelet-concentrated plasma separation syringe.
The method of claim 2,
The packing 40 is a therapeutic platelet-concentrated plasma separation syringe, characterized in that formed by protruding the locking jaw (41, 41 ') in the upper and lower portions to prevent the upper and lower deviation from the hole (14) of the cylinder (10).

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