KR20120108042A - Jak 억제제로서의 아제티딘 및 시클로부탄 유도체 - Google Patents

Jak 억제제로서의 아제티딘 및 시클로부탄 유도체 Download PDF

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KR20120108042A
KR20120108042A KR1020127020848A KR20127020848A KR20120108042A KR 20120108042 A KR20120108042 A KR 20120108042A KR 1020127020848 A KR1020127020848 A KR 1020127020848A KR 20127020848 A KR20127020848 A KR 20127020848A KR 20120108042 A KR20120108042 A KR 20120108042A
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mol
mixture
reaction
formula
compound
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Korean (ko)
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제임스 디. 로저스
스테이시 셰퍼드
윤-롱 리
지아쳉 조우
핑리 리우
데이비드 멜로니
마이클 시아
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인사이트 코포레이션
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
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    • A61P17/00Drugs for dermatological disorders
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    • A61P17/06Antipsoriatics
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    • A61P19/00Drugs for skeletal disorders
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P35/00Antineoplastic agents
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B60VEHICLES IN GENERAL
    • B60QARRANGEMENT OF SIGNALLING OR LIGHTING DEVICES, THE MOUNTING OR SUPPORTING THEREOF OR CIRCUITS THEREFOR, FOR VEHICLES IN GENERAL
    • B60Q3/00Arrangement of lighting devices for vehicle interiors; Lighting devices specially adapted for vehicle interiors
    • B60Q3/70Arrangement of lighting devices for vehicle interiors; Lighting devices specially adapted for vehicle interiors characterised by the purpose
    • B60Q3/76Arrangement of lighting devices for vehicle interiors; Lighting devices specially adapted for vehicle interiors characterised by the purpose for spotlighting, e.g. reading lamps
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B60VEHICLES IN GENERAL
    • B60QARRANGEMENT OF SIGNALLING OR LIGHTING DEVICES, THE MOUNTING OR SUPPORTING THEREOF OR CIRCUITS THEREFOR, FOR VEHICLES IN GENERAL
    • B60Q3/00Arrangement of lighting devices for vehicle interiors; Lighting devices specially adapted for vehicle interiors
    • B60Q3/80Circuits; Control arrangements
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S362/00Illumination
    • Y10S362/80Light emitting diode
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S362/00Illumination
    • Y10S362/802Position or condition responsive switch

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020127020848A 2008-03-11 2009-03-10 Jak 억제제로서의 아제티딘 및 시클로부탄 유도체 Ceased KR20120108042A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3566208P 2008-03-11 2008-03-11
US61/035,662 2008-03-11
US14498209P 2009-01-15 2009-01-15
US61/144,982 2009-01-15

Related Parent Applications (1)

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KR1020107020309A Division KR101240882B1 (ko) 2008-03-11 2009-03-10 Jak 억제제로서의 아제티딘 및 시클로부탄 유도체

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KR20120108042A true KR20120108042A (ko) 2012-10-04

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KR1020107020309A Active KR101240882B1 (ko) 2008-03-11 2009-03-10 Jak 억제제로서의 아제티딘 및 시클로부탄 유도체

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KR1020107020309A Active KR101240882B1 (ko) 2008-03-11 2009-03-10 Jak 억제제로서의 아제티딘 및 시클로부탄 유도체

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US (3) US8158616B2 (enrdf_load_stackoverflow)
EP (1) EP2288610B8 (enrdf_load_stackoverflow)
JP (2) JP5275371B2 (enrdf_load_stackoverflow)
KR (2) KR20120108042A (enrdf_load_stackoverflow)
CN (2) CN102026999B (enrdf_load_stackoverflow)
AR (1) AR070828A1 (enrdf_load_stackoverflow)
AU (1) AU2009223640B2 (enrdf_load_stackoverflow)
BR (1) BRPI0909040B8 (enrdf_load_stackoverflow)
CA (1) CA2718271C (enrdf_load_stackoverflow)
CL (1) CL2009000576A1 (enrdf_load_stackoverflow)
CO (1) CO6290658A2 (enrdf_load_stackoverflow)
CY (2) CY1118176T1 (enrdf_load_stackoverflow)
DK (1) DK2288610T3 (enrdf_load_stackoverflow)
DO (2) DOP2010000270A (enrdf_load_stackoverflow)
EA (1) EA017218B1 (enrdf_load_stackoverflow)
EC (1) ECSP10010475A (enrdf_load_stackoverflow)
ES (1) ES2602577T3 (enrdf_load_stackoverflow)
HN (1) HN2010001761A (enrdf_load_stackoverflow)
HR (1) HRP20161390T1 (enrdf_load_stackoverflow)
HU (2) HUE029767T2 (enrdf_load_stackoverflow)
IL (1) IL208023A (enrdf_load_stackoverflow)
LT (2) LT2288610T (enrdf_load_stackoverflow)
LU (1) LUC00027I2 (enrdf_load_stackoverflow)
MA (1) MA32219B1 (enrdf_load_stackoverflow)
MX (1) MX2010010012A (enrdf_load_stackoverflow)
MY (1) MY165582A (enrdf_load_stackoverflow)
NL (1) NL300886I2 (enrdf_load_stackoverflow)
NO (1) NO2017033I2 (enrdf_load_stackoverflow)
NZ (1) NZ587928A (enrdf_load_stackoverflow)
PA (1) PA8819201A1 (enrdf_load_stackoverflow)
PE (2) PE20140099A1 (enrdf_load_stackoverflow)
PL (1) PL2288610T3 (enrdf_load_stackoverflow)
PT (1) PT2288610T (enrdf_load_stackoverflow)
RS (1) RS55263B1 (enrdf_load_stackoverflow)
SG (1) SG191660A1 (enrdf_load_stackoverflow)
SI (1) SI2288610T1 (enrdf_load_stackoverflow)
SV (1) SV2010003662A (enrdf_load_stackoverflow)
TN (1) TN2010000415A1 (enrdf_load_stackoverflow)
TW (1) TWI444382B (enrdf_load_stackoverflow)
UA (1) UA101493C2 (enrdf_load_stackoverflow)
UY (1) UY31705A1 (enrdf_load_stackoverflow)
WO (1) WO2009114512A1 (enrdf_load_stackoverflow)
ZA (1) ZA201006000B (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190111089A (ko) * 2017-01-23 2019-10-01 상하이 롱우드 바이오파마슈티칼스 컴퍼니 리미티드 Jak 효소 억제제 및 이의 제조 방법과 용도

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JP5480813B2 (ja) * 2007-11-16 2014-04-23 インサイト・コーポレイション Janusキナーゼ阻害剤としての置換複素環
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CN102458581B (zh) * 2009-05-22 2016-03-30 因塞特控股公司 作为JANUS激酶抑制剂的吡唑-4-基-吡咯并[2,3-d]嘧啶和吡咯-3-基-吡咯并[2,3-d]嘧啶的N-(杂)芳基-吡咯烷衍生物
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EA036970B1 (ru) * 2010-11-19 2021-01-21 Инсайт Холдингс Корпорейшн Применение {1-{1-[3-фтор-2-(трифтометил)изоникотиноил] пиперидин-4-ил}-3-[4-(7h-пирроло[2,3-d]пиримидин-4-ил)-1н-пиразол-1-ил]азетидин-3-ил}ацетонитрила для лечения заболеваний, связанных с активностью jak1
PH12013501103A1 (en) * 2010-12-01 2021-06-02 Nissan Chemical Ind Ltd Pyrazole compounds having therapeutic effect on multiple myeloma
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