KR20120097855A - Non-invasive and fractionational gamma knife immobilization system and mask fixed position correcting method thereof - Google Patents

Abstract

PURPOSE: A non-invasion division measurement knife fixing system and mask fixing location compensation method using the same are provided to control the fixing location of a mask installed on a gamma-knife frame using a compensation value. CONSTITUTION: A mask includes a marker for recognizing a plurality of locations formed at an outside surface. The mask fixes the head of a patient on a gamma-knife frame in a stereotactic radiation surgery. Two or more CCD(Charge Coupled Device) image devices(120) obtain images from two or more directions of a patient head. An image processing unit(130) stores the images obtained from the CCD image device from an initial surgery process. The image processing unit compares the marker coordinate of the initial image with the marker coordinate of the additional image in an additional surgery process. The image processing unit compensates errors for wearing the mask by computing the error of the marker coordinate between the additional image and the initial image. [Reference numerals] (131) Video encoder; (132) Image compression digital signal processor; (133) Video decoder; (134) Memory; (135) Image comparison microprocessor unit; (136) Adjacent apparatus controller; (140) Display unit; (151) Hard-disk drive; (152) Key input unit; (153) Communication module; (AA, BB, 120) Charge coupled device image device

Description

Non-invasive and Fractionational Gamma Knife Immobilization System and Mask fixed position correcting Method

The present invention relates to a non-invasive split irradiation gamma knife fixing system and a method for correcting the mask fixed position using the same, more specifically, the error of the fixed position that may occur in the process of re-fixing the mask on the head of the patient for the partial irradiation The present invention relates to a non-invasive split irradiation gamma knife fixing system and a mask fixing position correction method using the same.

Gamma Knife is a type of bloodless brain surgery device that performs radiosurgery without incision of the patient's head in intracranial lesions of humans. It was developed in 1968 by Swedish neurosurgeon Leksell. Using this gamma knife, non-invasive and precise radiation surgery can be performed by gamma rays on brain disease lesions such as arteriovenous malformations and various brain tumors in the human skull.

Gamma Knife has been recognized as the most accurate and safe equipment among the existing radiation surgery equipments and has been established as a synonym for radiation surgery since the 1990s. Currently, about 270 units are installed in 30 countries including Korea, and about 50,000 cases per year. A degree of radiation surgery is being done.

Looking at the process of radiosurgery, after installing a stereotactic wartle in the patient's brain, and through the process of accurately identifying the treatment site through CT, MRI and angiography device according to the tumor, make a treatment plan and gamma knife (Gamma Knife) The patient is placed on a radiosurgical device such as a back, and a stereotactic fixation is performed to irradiate a previously identified treatment site.

If you look at radiosurgery, it is a treatment that reduces the tumor or suppresses the growth by strongly radiating the radiation to the tumor area. By intensively supplying a large amount of radiation, intensive treatment of the tumor site is like collecting sun from the focal point with a magnifying glass and burning the paper. Identifying the exact location of treatment in the brain beforehand is absolutely critical.

Hereinafter, the structure of the gamma knife radiosurgery apparatus 1 will be described with reference to FIGS. 1A to 3.

FIG. 1A is a perspective view of a gamma knife radiation surgery apparatus 1 currently in use, and FIG. 1B is a side cross-sectional structural view of the gamma knife radiation surgery apparatus 1 of FIG. 1A.

Referring to FIGS. 1A and 1B, the gamma knife radiation surgical apparatus 1 is a cobalt-60 radiation source that is a radioisotope in an inner space obscured by the shield door 21 of the shielding radiation unit 20. And 201 are installed, and gamma rays emitted from the respective cobalt-60 sources 24 constantly provide collimating holes formed in the internal collimator, the beam channel 24a and the helmet 10. Pass through and gather at one point (focus). At this time, the focus of the radiation is always in the center of the sphere of the helmet 10 and is invariant.

Where the patient rests on the procedure bed 30, the stereotactic device automatic positioning device 33 is installed and the helmet 10 is mounted adjacent to the automatic positioning device 33.

The helmet 10 is a hemispherical shape in which 201 collimator holes are evenly distributed around it, also called a collimator, and a shielded radiation unit mounted inside the gamma knife equipment 1. unit, 20).

The surgical bed 30 is slidable back and forth, and when the surgical bed 30 slides into the shielded radiation unit 20, the helmet 10 moves to the helmet mounting position 26 shown in FIG. 1B. In this case, the collimator balls of the helmet 10 are respectively fitted to the beam channels 24a. Since the cobalt-60 crew members 24 of the gamma knife radiation surgical apparatus 1 always emit gamma rays, the helmet 10 moves to the helmet mounting position 26 so that the collimator balls of the helmet 10 are beamed. When matched with the channels 24a, gamma rays are irradiated to the head of the patient located in the helmet 10.

Protective panels 32 are installed at left and right sides of the procedure bed 30, and a bed release handle 31 is installed at the rear end of the bed 30.

FIG. 2 shows a collimator helmet 10 and a stereotactic device automatic positioning device 33 of the gamma knife radiation surgery apparatus of FIG. 1A.

Stereotactic device automatic positioning device 33 is a device that can automatically move the stereotactic device 40 fixed to the patient's head in the vertical direction of the helmet and the depth inward and outward. The automatic positioning device 33 can move the stereotactic mechanism in three directions: the x-axis (horizontal direction in the cross section of the helmet), the y-axis (vertical direction in the cross section of the helmet) and the z-axis (direction inward of the helmet). It is composed of an x-axis automatic positioning unit 331, a y-axis automatic positioning unit 332 and a z-axis automatic positioning unit 333. The angle adjustment curve bar 33a attached to the y-axis automatic position adjusting unit 332 is used to turn the head back and forth while the patient is lying straight up.

The helmet 10 is coupled to the patient's head end of the surgical bed (30). A pair of coupling supports 11 are formed at both edges of the helmet 10, and the coupling supports 11 are coupled to the treatment bed 30 by filling bolts 11a in the coupling holes 11b, respectively. do. Reference numeral 12 in FIG. 2 denotes a release handle for releasing the positioning device 40 (see FIG. 3) from the positioning device automatic positioning device 33, and 34 is a patient microphone and a connecting line.

3 shows a state in which four front and rear fixing posts 41 and 42 are fitted to the lexel frame 40.

Currently used gamma knife radiosurgery apparatus (see FIGS. 1A to 2) is a direction perpendicular to the quadrilateral frame 400 of the stereotactic mechanism 40, as shown in FIG. 10, the inner direction of the helmet 10 is set to the z axis, and a plane made of the tetragonal frame 400 of the positioning device 40, i.e., a legal plane with respect to the z axis, is set. Set the two coordinate axes that make up the x and y axes, respectively.

The zero point (0,0,0) of the stereotactic device 40 is set to the point that becomes the right corner of the back of the head when the patient puts the stereotactic device 40 on the head, and the helmet 10 The focal point where the beams of radiation irradiated through the collimator balls of are converged at the coordinate center point x, y, z = (100,100,100). And, the focus of the radiation beam during radiation surgery coincides with the position of the tumor in any of the coordinates of FIG.

However, the conventional gamma knife radiosurgery device is invasive because the fixation method of the stereotactic instrument is accompanied by pain and discomfort of the patient, so that the maximum radiation dose that can be irradiated once with one gamma knife operation is irradiated to the tumor site. In this operation, side effects may occur such as the patient is exposed to excessive radiation or the normal tissue is damaged.

Therefore, it is preferable to perform irradiation by dividing the radiation dose, but for the divided irradiation, invasive stereotactic instruments should be fixed at each operation. In addition to the inconvenience of having to take additional transmission pictures, there is a problem that the patient is further exposed to radiation, there was a difficulty in the divided irradiation.

Meanwhile, Gamma Knife Models B, C, 4C, and Perfexion enable non-invasive radiosurgery and allow patients to use it in a comfortable posture and accurately perform segmented irradiation. It is a device that is used only in the Gamma Knife of the Perfexion model, in which the patient bites the stereotactic instrument during surgery.

However, the gamma knife, which requires more than one hour of operation time per day, should be biting the stereotactic device with the mouth, so this process works as a pain, and because the structure of the patient's head is low enough to move the patient, the accuracy is low. Because of this, it is difficult to select a patient for actual use.

Accordingly, an object of the present invention is to solve such a conventional problem, and while the mask having the position recognition marker is fixed to the head of the patient, the coordinates and the mask of the state where the first mask is worn through the CCD image image are reconstructed. Analyze and compare the coordinates of the worn state to calculate the correction value, and adjust the fixed position of the mask installed on the gamma knife frame by using the corrected value according to the fixed position of the mask repeatedly worn / removed for the partial irradiation. A non-invasive split irradiation gamma knife fixing system capable of precise position correction and a mask fixing position correction method using the same are provided.

In addition, by fixing the mask to the head of the patient in a non-invasive manner, rather than using a fixing bolt directly to the skull as in the prior art not only to reduce the pain of the patient, but also to correct the position of the mask The present invention provides a non-invasive split irradiation gamma knife fixing system and a mask fixing position correction method using the same, which can be freely designed to provide an optimal treatment effect for the split irradiation in the treatment planning process.

In addition, since it is not necessary to take a radiographic photograph for accurate position measurement after wearing the fixing device using a bolt as in the prior art, non-invasive split irradiation gamma knife fixation that can reduce the cost and minimize the radiation exposure of the patient. A system and a method for correcting a mask fixed position using the same are provided.

In addition, by inserting the RFID tag in the mask, to provide a non-invasive split irradiation gamma knife fixing system for easy identification of the patient and a mask fixing position correction method using the same.

In addition, since the correction value is extracted by calculating the correction value at the front, left and right sides of the patient who is wearing the mask again, the roll, pitch, The present invention provides a non-invasive split irradiation gamma knife fixing system capable of correcting a rotational error on yaw and a mask fixing position correction method using the same.

In addition, by tailoring the mask to match the shape of the patient's skull to be detachably fixed to the gamma knife frame, it is possible to re-wear the mask, thereby enabling a partial irradiation of the radiation to the large dose exposure The present invention provides a non-invasive split irradiation gamma knife fixing system and a mask fixing position correction method using the same, which can reduce the risk and increase the resilience of radiation exposure to reduce side effects caused by radiation.

The above object, according to the present invention, a plurality of position recognition markers are formed on the outer surface, repeated wearing and removal every time the stereotactic radiosurgery, mask for fixing the head of the patient to the gamma knife frame; and, the patient head Two or more CCD imaging elements for acquiring an imaging image from at least two directions of the image; And storing the image image obtained from the CCD imager during the first operation, comparing the marker coordinates of the first image image with the marker coordinates of the additional image image during the additional surgery, and then marking the marker coordinates of the first image image and the markers of the additional image image. It is achieved by a non-invasive split irradiation gamma knife fixing system comprising a; image processing unit for calculating the error of the coordinates to correct the error for mask wearing.

Here, the CCD imaging device is preferably arranged to acquire an image image from at least two of the left side, the right side, and the front side of the patient.

In addition, the image processing unit preferably generates three-dimensional information by extracting the connection vector of the reference position of the body and the mask marker through the image image obtained from the CCD image device.

In addition, it is preferable that the image image of the left side sets the reference point of the body to the left and right ears, and the image image of the front side sets the reference point of the body to the front teeth.

In addition, the mask is preferably made to fit the head shape of the patient based on the radiographic image to fix the head of the patient non-invasive and is fixed in a form surrounding the head of the patient.

In addition, the position recognition markers are preferably formed at least three places so that they can be observed from the left, right, and front of the position between the brow, both eyes, under the cheekbones, and between the eyes and the ears.

In addition, the mask is preferably inserted with a Radio Frequency Identification (RFID) tag to distinguish the patient.

The display apparatus may further include a display unit configured to output an image image obtained from the CCD image device.

In addition, it is preferable that the communication module further comprises a wired / wireless connection to the network communication network.

Still another object of the present invention is a method for correcting a mask fixation position using a non-invasive split irradiation gamma knife fixing system, wherein a head of a patient is fixed to a gamma knife frame by using a mask having a position recognition marker formed on an outer surface thereof, and a CCD After using the imaging device to acquire the first image of the patient wearing the mask, to establish a treatment plan, to set the radiation dose according to the treatment plan to proceed the initial cerebral stereosurgery, and to remove the mask from the patient's head Initial surgical stage; And a vector value for fixing the head of the patient to the gamma knife frame using a mask, acquiring an additional image of the patient using a CCD imager, and connecting a body reference point and each marker in the initial image and the additional image. To generate three-dimensional information by comparing the coordinate values of the first image image and the coordinate values of the additional image image, and when there is a difference in the coordinate values, calculates a vector displacement value connecting the coordinates where the difference occurs. Using the vector displacement value, the correction value for the moving position of the body reference point is calculated, the position of the patient is corrected using the correction value, and then the divided cerebral radiosurgery procedure is performed by setting the divided irradiation dose according to the treatment plan. , And further surgical step of removing the mask from the head of the patient, wherein the additional surgical step is to be repeated according to the treatment plan Non-invasive investigation division is achieved by the mask holding position correcting method using a gamma knife fixing system according to claim.

Here, prior to the initial operation, the radiographs and magnetic resonance imaging (MRI) of the patient's head are taken before the operation to diagnose the quantity, location, and size of the tumor, and at the same time, determine the shape of the patient's skull, The method may further include preparing a mask in which a plurality of markers for position recognition are formed on the outer surface according to the shape.

In addition, in the initial image image acquisition step and the additional image image acquisition step, it is preferable to acquire image images from at least two surfaces of the left side, the right side, and the front face of the patient, respectively.

In addition, the front image is preferably set the body reference point to the front teeth of the patient, and in the left and right image image it is preferable to set the body reference point to the left and right ears, respectively.

According to the present invention, in the state where the position-sensitive marker is fixed to the head of the patient, the coordinates of the state of wearing the first mask and the coordinates of the state of wearing the mask is analyzed and compared through a CCD image to calculate a correction value. Non-invasive split irradiation gamma knives that can be precisely corrected according to the fixed position of the mask repeatedly worn / removed for divided irradiation by adjusting the fixed position of the mask installed in the gamma knife frame using these correction values. A fixing system and a mask fixing position correction method using the same are provided.

In addition, by fixing the mask to the head of the patient in a non-invasive manner, rather than using a fixing bolt directly to the skull as in the prior art not only to reduce the pain of the patient, but also to correct the position of the mask As a simple method, a non-invasive split irradiation gamma knife fixing system and a mask fixing position correction method using the same are provided.

In addition, since it is not necessary to take a radiographic photograph for accurate position measurement after wearing the fixing device using a bolt as in the prior art, non-invasive split irradiation gamma knife fixation that can reduce the cost and minimize the radiation exposure of the patient. A system and a method for correcting a mask fixed position using the same are provided.

In addition, by inserting the RFID tag in the mask, there is provided a non-invasive split irradiation gamma knife fixing system for easy identification of the patient and a mask fixing position correction method using the same.

In addition, since the correction value is extracted by calculating the correction value at the front, left and right sides of the patient who is wearing the mask again, the roll, pitch, Provided are a non-invasive split irradiation gamma knife fixing system capable of correcting rotational errors with respect to yaw and a mask fixing position correction method using the same.

In addition, by tailoring the mask to match the shape of the patient's skull to be detachably fixed to the gamma knife frame, it is possible to re-wear the mask, thereby enabling a partial irradiation of the radiation to the large dose exposure In addition to reducing the risk, there is provided a non-invasive split irradiation gamma knife fixing system and a mask fixing position correction method using the same to increase the resilience of radiation exposure to reduce the side effects caused by radiation.

1A is a perspective view of a gamma knife radiation surgery apparatus currently in use,
FIG. 1B is a side cross-sectional structural view of the gamma knife radiosurgery apparatus of FIG. 1A.
Figure 2 is a perspective view of the collimator helmet and stereotactic device automatic positioning device of the gamma knife radiation surgery apparatus of Figure 1a,
3 is a perspective view illustrating a state in which four front and rear fixing posts are fitted to a lexel frame (orthogonal mechanism);
4 is a block diagram of a non-invasive split irradiation gamma knife fixing system of the present invention,
Figure 5 is a schematic configuration diagram according to the mask of the present invention non-invasive split irradiation gamma knife fixing system,
Figure 6 is a flow chart of the mask fixing position correction method using the present invention non-invasive split irradiation gamma knife fixing system,
7 is a diagram illustrating a process of calculating a correction value from a front image image according to the present invention;
8 is a diagram illustrating a process of calculating a correction value from a left image image according to the present invention.

Prior to the description, in the various embodiments, components having the same configuration will be representatively described in the first embodiment using the same reference numerals, and in other embodiments, different configurations from the first embodiment will be described. do.

Hereinafter, a non-invasive split irradiation gamma knife fixing system according to a first embodiment of the present invention will be described in detail with reference to the accompanying drawings.

4 is a schematic diagram of a non-invasive split irradiation gamma knife fixing system of the present invention, Figure 5 is a schematic configuration of a mask of the non-invasive split irradiation gamma knife fixing system of the present invention.

The non-invasive split irradiation gamma knife fixing system of the present invention as shown in the drawings, the mask 110 for fixing the head of the patient to the gamma knife frame, the left side with respect to the head of the patient wearing the mask 110, An image that calculates a position correction value when the mask 110 is remounted by analyzing and comparing the CCD image device 120 that acquires the image image from the right side and the front surface, respectively, and the image image acquired from the CCD image device 120. The processor 130 includes a display unit 140 for outputting an image of the image processor 130, and peripheral devices connected to the image processor 130.

In the present embodiment, it was applied to the gamma knife surgical apparatus to correct the fixed position of the mask 110. However, the present invention is not limited thereto, and the mask 110 is repeatedly manufactured and worn / removed according to the shape of the patient's skeleton. It can also be applied to medical equipment that treats in a precise position.

The mask 110 performs a function of fixing the gamma knife frame in a state in which the area except the skull, eyes, ears, nose, and mouth of the mask is not moved, and the outer surface of the patient's forehead, both eyes, Under the cheekbones, a number of position recognition markers 111 are formed at positions corresponding to the eyes and the ears, and are repeatedly worn and removed on the head of the patient every time the stereotactic radiosurgery. The mask 110 may be made of plastic by a three-dimensional printing system (Rapid Prototyping System) after obtaining the skull shape information of the patient from radiographic images for diagnosing the quantity, location, size, etc. of the tumor before surgery, A radio frequency identification (RFID) tag is inserted to distinguish a patient, and a fixing means (not shown) for fixing to a couch of a gamma knife device is provided at a rear portion thereof.

On the other hand, the gamma knife surgical apparatus is provided with a reader for reading the information stored in the RFID tag in relation to the RFID tag of the mask 110, the fixing means of the mask (110) is in the couch of the gamma knife surgical apparatus (couch) A coupling means for detachably coupling is provided.

The CCD (Charge Coupled Device) imaging device is provided to acquire a plurality of image images from the left side, the right side, and the front side of the patient wearing the mask 110, the resolution is different depending on the proximity, but approximately per pixel Preferably, a 1920 × 1080 Full HD (High Definition) camera having a resolution of about 0.18 mm is applied.

The image processor 130 includes a video encoder 131 for converting an image image obtained from the CCD image device 120 into an encoded signal, an image compression DSP 132 (digital signal processor) for compressing the encoded image image, and A video decoder 133 for restoring the compressed video image and converting it into a decoded signal and providing it to the display unit 140; a memory 134 for temporarily storing video images read from the hard disk drive 151; And an image comparison MPU 135 (Micro Processor Unit) for matching and comparing the image images stored in the memory 134 and calculating a correction value, and a peripheral controller 136 for controlling the peripheral devices.

In particular, when the image comparison MPU 135 acquires the initial image image, the body reference points P1 and P2 of the original image image and the mask 110 as shown in FIGS. 7A and 8A. When the vector value connecting the markers 111 is extracted to generate three-dimensional information, and when the mask 110 is worn again for further surgery and an additional image is obtained, the (b) of FIG. 7 and the (8) of FIG. As shown in b), three-dimensional information is generated by extracting a vector value connecting the body reference points P1 and P2 of the additional image image and the marker 111 of the mask 110, and coordinates of the marker 111 of the first image image. Value and the coordinate value of the marker 111 of the additional image image, respectively, calculate the vector displacement value for the coordinate where the coordinate value difference, and then calculate the correction value for the moving position of the body reference point, In the process of fixing the mask 110 fixed to the gamma knife frame, Correct the error for the correct position. The process of calculating the correction value of the image comparison MPU 135 will be described in detail later.

Here, the initial image image and the additional image image is composed of the image image of the left side, the right side, and the front side obtained from the respective CCD image elements 120, and the image image of the left side and the right side sets the body reference point as the ear, respectively. The front image is set to the body reference point as the front teeth. On the other hand, it is preferable to set a plurality of body reference points for the accuracy improvement.

The display unit 140 outputs an image image obtained from the CCD image device 120, and may be provided in plural.

The peripheral device 140 may include a hard disk drive (HDD) 151 for storing an initial image image and an additional image image processed by the image processor 130, a key input unit 152 for inputting information, and a network communication network. It is composed of a wirelessly connectable communication module 153.

On the other hand, when connected to a communication network such as Ethernet through the communication module 153, in real time to transmit the data of the image processing unit 130 to the server, the wireless terminal communicating with the server in the image processing unit 130 provided to the server It is also possible to check the data of).

6 is a flowchart of a mask fixing position correction method using the non-invasive split irradiation gamma knife fixing system of the present invention.

Hereinafter, a method of correcting a mask 110 fixed position using the non-invasive split irradiation gamma knife fixing system of the present invention will be described with reference to FIG. 6.

First, look at the preparation step (S10) step is as follows.

Taking a radiographic picture of the head of the patient (S12) to diagnose the number, location, size, etc. of the tumor before surgery, to determine the shape of the patient's skull to produce a mask 110 suitable for the shape of the skull (S13). . In this case, the mask 110 is worn and removed every time the stereotactic radiosurgery, and performs a function of fixing a portion of the patient's skull, eyes, ears, nose and mouth to the gamma knife frame so as not to move. It is manufactured to have a position recognition marker 111 at a position corresponding to the patient's forehead, under both eyes, under the cheekbones, between the eyes and the ear, etc. of the outer surface.

Then look at the initial surgical step (S20) as follows.

In the state in which the mask 110 is fixed to the head of the patient (S21), when the first image of the left side, the right side, and the front side of the patient is acquired using the CCD imaging device 120, the image processor 130 The video is compressed through the video encoder 131 and the image compression DSP 132, stored in the memory 134, and then displayed on the display 140 through the video decoder 133.

Meanwhile, the image comparison MPU 135 receives the initial image image from the image compression DSP 132 and extracts the vector value between the body reference point and the coordinates (S23) to generate three-dimensional information, and through the peripheral controller 136. The first image image corresponding to the left side, the right side, and the front side, the 3D information of the body reference point and the markers are stored in the hard disk drive 151.

After generating the three-dimensional information by extracting the vector value from the initial image image as described above, the initial operation by setting the initial radiation dose according to the treatment plan, and when the operation is completed, remove the mask 110 from the head of the patient (S24).

On the other hand, before taking the radiographic picture to confirm whether or not the first operation stage (S11) to take the radiographic picture in the case of the initial surgical step (S12), if the additional surgical step is added The mask 110 of the surgical stage to be fixed (S31) to perform.

Subsequently, the additional surgical step (S30) is as follows.

The additional image image acquired through the CCD image device 120 is displayed on the display unit 140 through the video encoder 131, the image compression DSP 132, and the video decoder 133 of the image processor 130.

The image comparison MPU 135 extracts the vector values between the body reference point and the coordinates from the additional image image (S33) to generate three-dimensional information, and compares the coordinate values of the markers 111 of the first image image with the additional image image (S34). If there is no difference in the coordinates, additional surgery is performed as it is without performing the correction step. If there is a difference in the coordinate values, the vector displacement value between the corresponding coordinates with the difference is calculated (S35), and the correction value for the movement position of the body reference point is calculated through the vector displacement value (S36), and then fixed to the head of the patient. In the process of fixing the mask 110 to the gamma knife frame, the fixed value is corrected by applying the correction value to correct the fixed position of the mask 110 installed on the head of the patient.

Looking at the correction value calculation process as described above in more detail as follows.

7 is a diagram illustrating a comparison process of a front image image according to the present invention, and FIG. 8 is a diagram illustrating a comparison process of a left image image according to the present invention.

First, Figure 7 (a) is an image image showing the front of the first image obtained during the initial operation stage, the lower end of the central boundary of the front tooth of the patient is set as the body reference point, between the body reference point and the marker 111 3D information is generated by extracting a vector value connecting. In addition, (b) is an image image showing the front of the additional image image obtained by fixing the mask 110 in the additional surgical step, the lower end of the central boundary of the front tooth of the patient is set as the body reference point, and the body reference point and 3D information is generated by extracting a vector value connecting the markers 111, and then comparing the coordinates of the marker 111 in the first image image with the coordinates of the marker 111 in the additional image image. Calculate the vector displacement value of the coordinate.

That is, the marker 111 denoted by A in FIG. 7A is changed to the position B in FIG. 7B, which calculates the vector displacement values of A and B, and is indicated by A of the initial image image. When the vector displacement value is applied to the vector value connecting the marker 111 and the body reference point, the body reference point in the additional image image is positioned as shown in (b), and thus a correction value can be calculated.

Similarly, Figure 8 (a) is an image image showing the left side of the first image obtained during the initial operation stage, at least one or more specific positions of the curvature of the left ear of the patient is set as the body reference point, the body reference point 3D information is generated by extracting a vector value connecting between and the marker 111 displayed on the first image.

Subsequently, by comparing the coordinate values of the marker 111 with the body reference point designated as the end of the concave groove of the left ear of the patient from the image image showing the left side of the additional image image obtained in the additional surgical step as shown in (b) When the vector displacement value of the coordinate is calculated and the vector displacement values of A and B in the initial image image and the additional image image are applied to the body reference point of the additional image image, the distance shifted during the re-wearing of the mask 110 is corrected. do.

On the other hand, since the process of calculating the correction value from the right side image image obtained from the right side is made in the same way as the left side image image, a detailed description thereof will be omitted.

As described above, when the correction values are calculated from the front, left, and right sides of the patient who is wearing the mask 110 again, as well as the error of the positions of the X, Y, and Z axes, rolls, pitches, Since it is possible to correct the rotational error of the yaw (Yaw), it is possible to precisely correct the fixed position that may occur during the re-wear process of the mask (110).

The correction value may be provided to the automatic positioning device installed in the gamma knife frame so that the correction process may be automatically performed.

On the other hand, after correcting the fixed position of the mask 110 is re-installed in the head of the patient, the additional radiation dose according to the treatment plan is set to proceed with additional surgery, and when the operation is completed, remove the mask 110 from the head of the patient do.

If the additional surgical step according to the treatment plan needs to be additionally performed, the additional surgical step is repeated, and if the additional surgical step does not exist, the operation is terminated.

As described above, the present invention generates a correction value for correcting the fixed position of the mask 110 to be re-installed on the head of the patient compared with the initial fixed position, and using the correction value, the mask 110 installed in the gamma knife frame. By adjusting the fixed position of the position of the tumor present in the head of the patient can be precisely repeatedly positioned at the point where the radiation is concentrated.

In addition, since the fixing device using the fixing bolt as described above does not need to be fixed directly to the skull, the pain of the patient is not only reduced, and the position correction for the repositioning of the mask 110 is easy, so the divisional investigation in the process of establishing the treatment plan is performed. It is possible to design freely to provide the optimal therapeutic effect.

In addition, since it is not necessary to additionally take a radiographic photograph for accurate position measurement after wearing the fixing device using a bolt as in the related art, it is possible to minimize the radiation exposure of the patient as well as the cost.

The scope of the present invention is not limited to the above-described embodiments but may be implemented in various forms of embodiments within the appended claims. Without departing from the gist of the invention claimed in the claims, it is intended that any person skilled in the art to which the present invention pertains falls within the scope of the claims described in the present invention to various extents which can be modified.

110: mask, 111: marker, 120: CCD image element, 130: image processor,
131: video encoder, 132: video compression DSP, 133: video decoder, 134: memory,
135: video comparison MPU, 136: peripheral controller, 140: display unit,
151: hard disk drive, 152: key input, 153: communication module,
P1, P2: Body reference point

Claims (13)

Masks for forming a plurality of position recognition markers on the outer surface, repeated wearing and removal every time the stereotactic radiosurgery, and fixing the head of the patient to the gamma knife frame;
Two or more CCD imaging elements for acquiring an imaging image from at least two directions of the head of the patient; And,
In the first operation, the image image obtained from the CCD imager is stored, and in the additional operation, the marker coordinates of the first image image and the marker coordinates of the additional image image are compared, and then the marker coordinates of the initial image image and the marker coordinates of the additional image image are compared. The non-invasive split irradiation gamma knife fixing system comprising a; image processing unit for calculating the error to correct the error for mask wearing. The method of claim 1,
The CCD imaging device is a non-invasive segmentation irradiation gamma knife fixed system, characterized in that arranged to obtain the respective image images from at least two of the left side, right side, front face. The method of claim 2,
And the image processor extracts the connection vector of the reference position of the body and the mask marker from the image image obtained from the CCD imager to generate three-dimensional information. The method of claim 3, wherein
The image image of the left side sets the reference point of the body to the left, right ears, and the image image of the front set the reference point of the body to the front teeth non-invasive split irradiation gamma knife fixing system. The method of claim 1,
The mask is a non-invasive split irradiation gamma knife fixing system characterized in that the non-invasive fixation to the head of the patient is made to fit the shape of the head based on the radiographic image to fix the head of the patient. 6. The method of claim 5,
The position recognition marker is fixed to the non-invasive split irradiation gamma knife, characterized in that formed at least three places to be observed from the left, right, and front of the position between the glabella, both eyes, under the cheekbones, eyes and ears. system. The method according to claim 6,
The mask is a non-invasive split irradiation gamma knife fixing system that the RFID (Radio Frequency Identification) tag is inserted to distinguish the patient. The method of claim 1,
And a display unit for outputting an image image acquired from the CCD imager. The method of claim 1,
Non-invasive split investigation gamma knife fixed system further comprises a communication module capable of wired / wireless connection to the network communication network. In the mask fixing position correction method using a non-invasive split irradiation gamma knife fixing system,
The head of the patient is fixed to the gamma knife frame using a mask with a position recognition marker on the outer surface, the first image of the patient wearing the mask is acquired using a CCD imager, and then a treatment plan is established. Initial surgical stage by setting the radiation dose according to the plan, and performing the initial cerebral stereosurgery and removing the mask from the head of the patient; And,
Using a mask, fix the head of the patient to the gamma knife frame, acquire additional image of the patient using CCD imager, and connect vector reference values between the body reference point and each marker in the initial image and the additional image, respectively. 3D information is extracted and the coordinate value of the first image image is compared with the coordinate value of the additional image image, and when a difference occurs in the coordinate value, a vector displacement value connecting the coordinates in which the difference occurs is calculated, and the vector The displacement value is used to calculate the correction value for the moving position of the reference point of the body, the position of the patient is corrected using the correction value, and then the divided cerebral radiation dose is set according to the treatment plan to proceed with additional cerebral stereosurgery. Including; further surgical step of removing the mask from the head of,
The additional surgical step is a mask fixed position correction method using a non-invasive split irradiation gamma knife fixing system, characterized in that to perform repeatedly according to the treatment plan. The method of claim 10,
Prior to the initial stage of surgery, radiographs of the patient's head are taken before surgery to diagnose the number, location, and size of the tumor, identify the patient's skull shape, and identify markers on the outer surface according to the shape of the skull. Method for correcting the mask fixed position using a non-invasive split irradiation gamma knife fixing system, characterized in that it further comprises a preparatory step of manufacturing a plurality of masks formed. 12. The method of claim 11,
In the initial image acquisition step and the additional image acquisition step, a method for correcting a mask fixation position using a non-invasive split irradiation gamma knife fixing system, which acquires an image image from at least two of a left side, a right side, and a front side of the patient, respectively. . 13. The method of claim 12,
In the front image, the body reference point is set to the front teeth of the patient, and in the left and right image images, the reference point of the mask is fixed using a non-invasive split irradiation gamma knife fixing system. Way.

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