KR20120050492A - 테트라-치환된 헤테로아릴 화합물 및 mdm2 및/또는 mdm4 조절제로서의 그의 용도 - Google Patents
테트라-치환된 헤테로아릴 화합물 및 mdm2 및/또는 mdm4 조절제로서의 그의 용도 Download PDFInfo
- Publication number
- KR20120050492A KR20120050492A KR1020127007522A KR20127007522A KR20120050492A KR 20120050492 A KR20120050492 A KR 20120050492A KR 1020127007522 A KR1020127007522 A KR 1020127007522A KR 20127007522 A KR20127007522 A KR 20127007522A KR 20120050492 A KR20120050492 A KR 20120050492A
- Authority
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- South Korea
- Prior art keywords
- alkyl
- amino
- carbonyl
- phenyl
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 0 CC*c1nc(C2=NC(C)NO2)c(C2=CCCC=C2)[n]1-c1ccccc1 Chemical compound CC*c1nc(C2=NC(C)NO2)c(C2=CCCC=C2)[n]1-c1ccccc1 0.000 description 7
- TVVDNCXEYBKLFY-UHFFFAOYSA-N CCOC(C(C=C(C12C3C1)c(cccc1)c1-c1c2cccc1Cl)=C3c1cccc(Cl)c1)O Chemical compound CCOC(C(C=C(C12C3C1)c(cccc1)c1-c1c2cccc1Cl)=C3c1cccc(Cl)c1)O TVVDNCXEYBKLFY-UHFFFAOYSA-N 0.000 description 1
- MIRVUDAEUJVARS-UHFFFAOYSA-N C[Si](C)#Cc(ccc(Cl)c1F)c1-[n]1c(C2CCCCCC2)nc(C(OCc2ccccc2)=O)c1 Chemical compound C[Si](C)#Cc(ccc(Cl)c1F)c1-[n]1c(C2CCCCCC2)nc(C(OCc2ccccc2)=O)c1 MIRVUDAEUJVARS-UHFFFAOYSA-N 0.000 description 1
- GKGFTZKYPMWJBI-UHFFFAOYSA-N Cc(c(C)c1)ccc1-c1nc(C#N)c(c2c3)[n]1c1cc(Cl)ccc1c2ccc3Cl Chemical compound Cc(c(C)c1)ccc1-c1nc(C#N)c(c2c3)[n]1c1cc(Cl)ccc1c2ccc3Cl GKGFTZKYPMWJBI-UHFFFAOYSA-N 0.000 description 1
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23710709P | 2009-08-26 | 2009-08-26 | |
| US61/237,107 | 2009-08-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20120050492A true KR20120050492A (ko) | 2012-05-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127007522A Withdrawn KR20120050492A (ko) | 2009-08-26 | 2010-08-24 | 테트라-치환된 헤테로아릴 화합물 및 mdm2 및/또는 mdm4 조절제로서의 그의 용도 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20120149661A1 (OSRAM) |
| EP (1) | EP2470502A1 (OSRAM) |
| JP (1) | JP2013503129A (OSRAM) |
| KR (1) | KR20120050492A (OSRAM) |
| CN (1) | CN102574785A (OSRAM) |
| AU (1) | AU2010288534A1 (OSRAM) |
| BR (1) | BR112012008075A2 (OSRAM) |
| CA (1) | CA2771936A1 (OSRAM) |
| EA (1) | EA201200321A1 (OSRAM) |
| IN (1) | IN2012DN01693A (OSRAM) |
| MX (1) | MX2012002420A (OSRAM) |
| WO (1) | WO2011023677A1 (OSRAM) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2677045C (en) | 2007-01-31 | 2016-10-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| US8592377B2 (en) | 2007-03-28 | 2013-11-26 | President And Fellows Of Harvard College | Stitched polypeptides |
| NZ599343A (en) | 2009-10-14 | 2014-05-30 | Merck Sharp & Dohme | Substituted piperidines that increase p53 activity and the uses thereof |
| JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
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-
2010
- 2010-08-24 CA CA2771936A patent/CA2771936A1/en not_active Abandoned
- 2010-08-24 IN IN1693DEN2012 patent/IN2012DN01693A/en unknown
- 2010-08-24 KR KR1020127007522A patent/KR20120050492A/ko not_active Withdrawn
- 2010-08-24 EP EP10745635A patent/EP2470502A1/en not_active Withdrawn
- 2010-08-24 CN CN2010800482502A patent/CN102574785A/zh active Pending
- 2010-08-24 WO PCT/EP2010/062300 patent/WO2011023677A1/en active Application Filing
- 2010-08-24 JP JP2012526033A patent/JP2013503129A/ja active Pending
- 2010-08-24 EA EA201200321A patent/EA201200321A1/ru unknown
- 2010-08-24 MX MX2012002420A patent/MX2012002420A/es not_active Application Discontinuation
- 2010-08-24 BR BR112012008075A patent/BR112012008075A2/pt not_active Application Discontinuation
- 2010-08-24 AU AU2010288534A patent/AU2010288534A1/en not_active Abandoned
- 2010-08-24 US US13/392,231 patent/US20120149661A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013503129A (ja) | 2013-01-31 |
| CA2771936A1 (en) | 2011-03-03 |
| WO2011023677A1 (en) | 2011-03-03 |
| IN2012DN01693A (OSRAM) | 2015-06-05 |
| US20120149661A1 (en) | 2012-06-14 |
| CN102574785A (zh) | 2012-07-11 |
| EP2470502A1 (en) | 2012-07-04 |
| BR112012008075A2 (pt) | 2016-03-01 |
| AU2010288534A1 (en) | 2012-03-15 |
| EA201200321A1 (ru) | 2012-09-28 |
| MX2012002420A (es) | 2012-06-27 |
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