KR20080005926A - 항고혈압제로서 알리스키렌의 효능에 대한 바이오마커 - Google Patents

항고혈압제로서 알리스키렌의 효능에 대한 바이오마커 Download PDF

Info

Publication number
KR20080005926A
KR20080005926A KR1020077024124A KR20077024124A KR20080005926A KR 20080005926 A KR20080005926 A KR 20080005926A KR 1020077024124 A KR1020077024124 A KR 1020077024124A KR 20077024124 A KR20077024124 A KR 20077024124A KR 20080005926 A KR20080005926 A KR 20080005926A
Authority
KR
South Korea
Prior art keywords
gene
snp
aliskiren
individual
angiotensin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020077024124A
Other languages
English (en)
Korean (ko)
Inventor
제시 구
조안 마이어
Original Assignee
노파르티스 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20080005926A publication Critical patent/KR20080005926A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020077024124A 2005-03-22 2006-03-20 항고혈압제로서 알리스키렌의 효능에 대한 바이오마커 Ceased KR20080005926A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66424805P 2005-03-22 2005-03-22
US60/664,248 2005-03-22
US74240106P 2006-02-06 2006-02-06
US60/742,401 2006-02-06

Publications (1)

Publication Number Publication Date
KR20080005926A true KR20080005926A (ko) 2008-01-15

Family

ID=37024459

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077024124A Ceased KR20080005926A (ko) 2005-03-22 2006-03-20 항고혈압제로서 알리스키렌의 효능에 대한 바이오마커

Country Status (8)

Country Link
US (1) US20100240760A1 (https=)
JP (1) JP2008538549A (https=)
KR (1) KR20080005926A (https=)
AU (1) AU2006227283B2 (https=)
BR (1) BRPI0609702A2 (https=)
CA (1) CA2600525A1 (https=)
MX (1) MX2007011697A (https=)
WO (1) WO2006102177A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100240760A1 (en) * 2005-03-22 2010-09-23 Jessie Gu Biomarkers for Efficacy of Aliskiren as a Hypertensive Agent
EP2205279B1 (en) * 2007-09-28 2011-04-13 Novartis AG Pharmaceutical combination of aliskiren and valsartan
CN108660205A (zh) * 2018-07-04 2018-10-16 刘城 一种糖尿病遗传风险评估试剂盒及其运用
CN111024960B (zh) * 2019-12-27 2023-02-17 广州阳普医疗科技股份有限公司 用于高血压血样检测的添加剂、试剂盒和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988008457A1 (en) * 1987-04-30 1988-11-03 Biotechnology Research Partners, Ltd. Hypertension-related blood tests useful as genetic markers
WO2000022166A2 (en) * 1998-10-14 2000-04-20 Pyrosequencing Ab Genes for assessing cardiovascular status and compositions for use thereof
DK1507558T3 (da) * 2002-05-17 2011-12-05 Novartis Pharma Ag Farmaceutisk sammensætning omfattende en renininhibitor, en calciumkanalblokker og et diuretikum
WO2006082570A1 (en) * 2005-02-02 2006-08-10 Royal College Of Surgeons In Ireland Pharmacogenomics of blood pressure lowering agents
US20100240760A1 (en) * 2005-03-22 2010-09-23 Jessie Gu Biomarkers for Efficacy of Aliskiren as a Hypertensive Agent

Also Published As

Publication number Publication date
MX2007011697A (es) 2007-11-16
BRPI0609702A2 (pt) 2010-04-20
WO2006102177A3 (en) 2007-05-10
WO2006102177A2 (en) 2006-09-28
AU2006227283A1 (en) 2006-09-28
US20100240760A1 (en) 2010-09-23
CA2600525A1 (en) 2006-09-28
AU2006227283B2 (en) 2010-07-01
JP2008538549A (ja) 2008-10-30

Similar Documents

Publication Publication Date Title
US20100035251A1 (en) BioMarkers for the Progression of Alzheimer's Disease
EP1673473B1 (en) Use of genetic polymorphisms that associate with efficacy of treatment of inflammatory disease
US20100249107A1 (en) Biomarkers for Alzheimer's Disease Progression
US20070065821A1 (en) Methods for the prediction of suicidality during treatment
EP1869214A2 (en) Biomarkers for pharmacogenetic diagnosis of type 2 diabetes
US20090118350A1 (en) Biomarkers for Identifying Efficacy of Tegaserod in Patients with Chronic Constipation
WO2006060429A2 (en) Identification of variants in histone deacetylase 1 (hdac1) to predict drug response
AU2006227283B2 (en) Biomarkers for efficacy of aliskiren as a hypertensive agent
RU2408363C2 (ru) Биомаркеры для оценки эффективности алискирена в качестве гипертензивного агента
JP4979382B2 (ja) 薬剤誘発肝細胞毒性を予測するための遺伝子多型の使用
CN1973051A (zh) 用于预测对氯氮平治疗的应答性的生物标记
WO2007109183A2 (en) Mutations and polymorphisms of fms-related tyrosine kinase 1
WO2007002217A2 (en) Mutations and polymorphisms of bcl-2
CN101146915A (zh) 高血压药阿利克仑功效的生物标志物
KR20070022710A (ko) 클로자핀 치료에 대한 반응성을 예측하기 위한 바이오마커
WO2007121017A2 (en) Mutations and polymorphisms of fms-like tyrosine kinase 4

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20071019

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20110318

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20130128

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20130718

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20130128

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I