KR20060015507A - 연조직 질환의 방사선 치료에 사용하기 위한 토륨-227 - Google Patents

연조직 질환의 방사선 치료에 사용하기 위한 토륨-227 Download PDF

Info

Publication number
KR20060015507A
KR20060015507A KR1020057019497A KR20057019497A KR20060015507A KR 20060015507 A KR20060015507 A KR 20060015507A KR 1020057019497 A KR1020057019497 A KR 1020057019497A KR 20057019497 A KR20057019497 A KR 20057019497A KR 20060015507 A KR20060015507 A KR 20060015507A
Authority
KR
South Korea
Prior art keywords
thorium
complex
soft tissue
kbq
radium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020057019497A
Other languages
English (en)
Korean (ko)
Inventor
로이 라르센
외이빈드 브루란트
Original Assignee
알게타 에이에스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0308731.9A external-priority patent/GB0308731D0/en
Application filed by 알게타 에이에스 filed Critical 알게타 에이에스
Publication of KR20060015507A publication Critical patent/KR20060015507A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A61K51/1096Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Radiology & Medical Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medicinal Preparation (AREA)
KR1020057019497A 2003-04-15 2004-04-15 연조직 질환의 방사선 치료에 사용하기 위한 토륨-227 Ceased KR20060015507A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0308731.9 2003-04-15
GBGB0308731.9A GB0308731D0 (en) 2003-04-15 2003-04-15 Method of radiotherapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020117003862A Division KR101274867B1 (ko) 2003-04-15 2004-04-15 연조직 질환의 방사선 치료에 사용하기 위한 토륨-227

Publications (1)

Publication Number Publication Date
KR20060015507A true KR20060015507A (ko) 2006-02-17

Family

ID=35385222

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020057019497A Ceased KR20060015507A (ko) 2003-04-15 2004-04-15 연조직 질환의 방사선 치료에 사용하기 위한 토륨-227
KR1020117003862A Expired - Lifetime KR101274867B1 (ko) 2003-04-15 2004-04-15 연조직 질환의 방사선 치료에 사용하기 위한 토륨-227

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020117003862A Expired - Lifetime KR101274867B1 (ko) 2003-04-15 2004-04-15 연조직 질환의 방사선 치료에 사용하기 위한 토륨-227

Country Status (18)

Country Link
EP (1) EP1617876B1 (https=)
JP (2) JP5006032B2 (https=)
KR (2) KR20060015507A (https=)
CN (1) CN100586484C (https=)
AU (1) AU2004229218B2 (https=)
BR (1) BRPI0409387B8 (https=)
CA (1) CA2522148C (https=)
CY (1) CY1115407T1 (https=)
DK (1) DK1617876T3 (https=)
EA (1) EA008195B1 (https=)
ES (1) ES2486845T3 (https=)
IL (1) IL171148A (https=)
MX (1) MXPA05010804A (https=)
NO (1) NO332931B1 (https=)
NZ (3) NZ606996A (https=)
PL (1) PL1617876T3 (https=)
PT (1) PT1617876E (https=)
ZA (1) ZA200507983B (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2522148C (en) * 2003-04-15 2010-07-13 Algeta As Thorium-227 for use in radiotherapy of soft tissue disease
GB201002508D0 (en) * 2010-02-12 2010-03-31 Algeta As Product
GB201007354D0 (en) * 2010-04-30 2010-06-16 Algeta Asa Method
GB201105298D0 (en) * 2011-03-29 2011-05-11 Algeta Asa Pharmaceutical preparation
GB201600153D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope preparation method
GB201600154D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope preparation method
ES2952744T3 (es) 2016-12-15 2023-11-03 Nestle Sa Composiciones y procedimientos que modulan los glóbulos blancos o los neutrófilos en un animal de compañía
FR3088769B1 (fr) * 2018-11-15 2020-12-25 Orano Med Procede de preparation d'au moins un generateur a haute teneur en radium-228
RU2767567C1 (ru) * 2020-10-27 2022-03-17 Станислав Анатольевич Дороватовский Комплексные соединения, содержащие в своем составе радионуклид 227Th, а также бисфосфонатный фрагмент, способы их получения, а также потенциальное применение в качестве действующего вещества в составе остеотропного радиофармацевтического лекарственного препарата
CN119912489B (zh) * 2024-12-23 2026-02-03 中国科学院近代物理研究所 一种膦酸钍框架材料及其制备方法和在钍镭发生器中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69007430T2 (de) * 1989-06-19 1994-07-07 Akzo Nobel N.V., Arnheim/Arnhem Radioimmuntherapie unter alphapartikelausstrahlung.
SG52470A1 (en) * 1992-04-13 1998-09-28 Dow Chemical Co Process for preparing macrocyclic chelating agents and formation of chelates and conjugates thereof
CN1073860C (zh) * 1998-08-20 2001-10-31 中国核动力研究设计院 用于骨肿瘤治疗或诊断的放射性药物药盒的制备方法
MY133346A (en) * 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
NO314537B1 (no) 1999-12-06 2003-04-07 Anticancer Therapeutic Inv Sa Reseptorbindende konjugater
NO312708B1 (no) * 2000-02-21 2002-06-24 Anticancer Therapeutic Inv Sa Radioaktive liposomer til terapi
WO2001066155A2 (en) * 2000-02-25 2001-09-13 Dangshe Ma Actinium-225 complexes and conjugates for radioimmunotherapy
NO313180B1 (no) * 2000-07-04 2002-08-26 Anticancer Therapeutic Inv Sa Bensökende alfapartikkel emitterende radiofarmasöytika
ITMI20022411A1 (it) * 2002-11-14 2004-05-15 Bracco Imaging Spa Agenti per la diagnosi e la terapia di tumori che espongono sulla superficie delle cellule proteine alterate.
CA2522148C (en) * 2003-04-15 2010-07-13 Algeta As Thorium-227 for use in radiotherapy of soft tissue disease

Also Published As

Publication number Publication date
NZ606996A (en) 2014-08-29
HK1094150A1 (zh) 2007-03-23
KR101274867B1 (ko) 2013-06-13
PL1617876T3 (pl) 2015-03-31
JP2006523664A (ja) 2006-10-19
EA200501456A1 (ru) 2006-06-30
CY1115407T1 (el) 2017-01-04
EA008195B1 (ru) 2007-04-27
EP1617876A1 (en) 2006-01-25
PT1617876E (pt) 2014-08-04
NZ543044A (en) 2010-04-30
ES2486845T3 (es) 2014-08-19
DK1617876T3 (da) 2014-07-21
BRPI0409387A (pt) 2006-04-18
KR20110022743A (ko) 2011-03-07
JP5006032B2 (ja) 2012-08-22
CN100586484C (zh) 2010-02-03
MXPA05010804A (es) 2006-03-09
EP1617876B1 (en) 2014-05-14
JP5468597B2 (ja) 2014-04-09
BRPI0409387B1 (pt) 2021-05-11
AU2004229218B2 (en) 2009-05-07
NZ595758A (en) 2013-02-22
JP2012051942A (ja) 2012-03-15
NO20055390D0 (no) 2005-11-15
NO332931B1 (no) 2013-02-04
BRPI0409387B8 (pt) 2021-05-25
CN1805760A (zh) 2006-07-19
ZA200507983B (en) 2007-03-28
CA2522148A1 (en) 2004-10-28
IL171148A (en) 2013-12-31
AU2004229218A1 (en) 2004-10-28
CA2522148C (en) 2010-07-13
NO20055390L (no) 2006-01-16

Similar Documents

Publication Publication Date Title
US20140235924A1 (en) Method of radiotherapy
JP5468597B2 (ja) 軟組織疾患の放射線治療におけるトリウム−227を用いた医薬組成物、複合体及びその調製方法、並びにキット
AU2005259258B2 (en) Radionuclides for medical use
CZ299087B6 (cs) Farmaceutický prostredek
JP6442072B2 (ja) 有利な特性を有する放射性医薬溶液
KR100304155B1 (ko) 표적화성분과비스무스방사성동위원소의결합체,그의제조방법및그를사용한치료방법
US20060228297A1 (en) Thorium-227 for use in radiotherapy of soft tissue disease
US7794691B2 (en) Radionuclides for medical use
US20100047167A1 (en) Combination therapy in the treatment of cancer
US7374936B2 (en) Method and means for site directed therapy
Vallabhajosula Radiopharmaceuticals for therapy
HK1094150B (en) Thorium-227 for use in radiotherapy of soft tissue disease

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20051014

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
AMND Amendment
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20070726

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20081124

Patent event code: PE09021S01D

AMND Amendment
E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20090828

Patent event code: PE09021S01D

AMND Amendment
E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20101021

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20090828

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

Patent event date: 20081124

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

J201 Request for trial against refusal decision
PJ0201 Trial against decision of rejection

Patent event date: 20110120

Comment text: Request for Trial against Decision on Refusal

Patent event code: PJ02012R01D

Patent event date: 20101021

Comment text: Decision to Refuse Application

Patent event code: PJ02011S01I

Appeal kind category: Appeal against decision to decline refusal

Decision date: 20120322

Appeal identifier: 2011101000380

Request date: 20110120

A107 Divisional application of patent
AMND Amendment
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20110218

PB0901 Examination by re-examination before a trial

Comment text: Amendment to Specification, etc.

Patent event date: 20110218

Patent event code: PB09011R02I

Comment text: Request for Trial against Decision on Refusal

Patent event date: 20110120

Patent event code: PB09011R01I

Comment text: Amendment to Specification, etc.

Patent event date: 20100225

Patent event code: PB09011R02I

Comment text: Amendment to Specification, etc.

Patent event date: 20090423

Patent event code: PB09011R02I

Comment text: Amendment to Specification, etc.

Patent event date: 20070726

Patent event code: PB09011R02I

B601 Maintenance of original decision after re-examination before a trial
PB0601 Maintenance of original decision after re-examination before a trial

Comment text: Report of Result of Re-examination before a Trial

Patent event code: PB06011S01D

Patent event date: 20110317

J301 Trial decision

Free format text: TRIAL DECISION FOR APPEAL AGAINST DECISION TO DECLINE REFUSAL REQUESTED 20110120

Effective date: 20120322

PJ1301 Trial decision

Patent event code: PJ13011S01D

Patent event date: 20120322

Comment text: Trial Decision on Objection to Decision on Refusal

Appeal kind category: Appeal against decision to decline refusal

Request date: 20110120

Decision date: 20120322

Appeal identifier: 2011101000380

J121 Written withdrawal of request for trial
PC1202 Submission of document of withdrawal before decision of registration

Comment text: [Withdrawal of Procedure relating to Patent, etc.] Withdrawal (Abandonment)

Patent event code: PC12021R01D

Patent event date: 20120521

PJ1201 Withdrawal of trial

Patent event code: PJ12011R01D

Patent event date: 20120521

Comment text: Written Withdrawal of Request for Trial

Appeal identifier: 2011101000380

Request date: 20110120

Appeal kind category: Appeal against decision to decline refusal

Decision date: 20120322

WITB Written withdrawal of application