KR20030067050A - Cosmetic Compositions Comprising Lactate and Ramulus Mori Extracts for Skin Whitening - Google Patents

Abstract

PURPOSE: A cosmetic composition containing as an effective ingredient lactate and Ramulus mori extracts in a specified ratio is provided. Therefore, it is improved in skin stability while showing synergistic skin-whitening effect as compared to the cosmetic composition containing lactate or Ramulus mori extracts alone. CONSTITUTION: The skin-whitening cosmetic composition comprises: 1 to 20% by weight of 60%(w/w) of lactate such as sodium lactate; 0.0001 to 10% by weight of Ramulus mori extracts and conventional components such as an antioxidant, a stabilizer, a solubilizing agent, vitamins, a pigment, a fragrance material and a carrier. The composition has very low dermal irritation properties.

Description

Cosmetic Composition Comprising Lactate and Ramulus Mori Extracts for Skin Whitening

The present invention relates to a cosmetic composition, and more particularly to a whitening cosmetic composition comprising lactate and upper limb extract (Ramulus mori extracts) as an active ingredient.

Human skin color is generally determined by the quinone complex called melanin, which is synthesized by melanin forming cells present in the basal cell layer of the epidermis. The unit that forms melanin is the amino acid tyrosine, which is converted to dopa by a tyrosinase enzyme, oxidized and converted back to dopa quinone. The synthesized melanin is collected in a cell organelle called melanosomes and transferred to keratinocytes through dendritic processes. Numerous factors influence melanin production, and the ultraviolet rays irradiated to the skin play the most important role in melanin formation. Melanin removes free radicals and free radicals that occur naturally in the human skin, or plays a beneficial role in preventing the transmission of ultraviolet rays that cause much harm to the skin. However, since tyrosinase is more activated by ultraviolet light, it is well known that the skin turns black when exposed to a lot of ultraviolet light.

One of the areas of greatest interest in East Asian women, especially in Korea, Japan, and China, is the skin whitening. As used herein, the term "skin whitening" may be referred to as a concept of arranging a change in skin color caused by excessive generation of pigment in the skin due to external environmental changes such as ultraviolet rays, stress, hormone secretion abnormalities, and pregnancy.

For skin whitening, a method mainly used in combination with cosmetics, etc., which is effective for whitening is used. As a representative substance, ascorbic acid, kojic acid, arbutin, hydroquinone, etc. are used as a tyrosinase inhibitor. However, the amount of the raw materials is limited due to safety and the like when formulated to prepare a cosmetic composition.

In order to improve the above problems of the conventional whitening cosmetics, the development of a whitening raw material that improves the safety using natural products has been attempted. For example, extracts such as Broussonetia kazinoki Sieb , Koji ( Broussonetia papyrigera Vent ) and Mulberry ( Morus alba, Ramulus Mori , US Pat. No. 5,872,254) are known as whitening cosmetics with improved stability. Moreover, a number of papers and patents have been published on the active ingredients contained in mulberry and upper limbs, representative of which is oxyresbaretrol ( Biochem & Biophys Res. Com. , 243: 801-803 (1998)).

The mulberry is a temperate, subtropical country of origin and the leaves are used as food for silkworms, the fruit is called udi used to soak food or alcohol, root bark is used for the treatment of fever, Chinhae, diuretics and small species in Chinese medicine Wood is used for furniture. On the other hand, it is known that the upper limbs of the mulberry tree is excellent in skin beauty effect.

Meanwhile, sodium lactate, which is used as another whitening cosmetic, has an advantage of easily penetrating into the skin because of its small molecular weight, but has a problem of causing skin irritation such as erythema and itching when used continuously.

Republic of Korea Patent Application No. 253842 discloses a whitening cosmetics containing mulberine extracted from the upper limbs of the mulberry branch of the mulberry plant, Korean Patent Application No. 230130 discloses a whitening cosmetics containing the extract of the upper limbs, Korean Patent No. 260510 discloses a whitening cosmetic containing a dispensing extract of a limb extract.

In addition, Korean Patent Application No. 1999-17810 discloses a whitening cosmetic composition comprising both the upper limb extract and vitamin C having an excellent antioxidant effect, and Korean Patent Application No. 2000-16923 discloses phytosphingosine and A skin improvement cosmetic composition containing an upper limb extract is disclosed, and Korean Patent Application No. 2000-27000 discloses a whitening cosmetic composition including an upper limb extract and glutathione.

Throughout this specification, many papers and patent documents are referred to and their citations are indicated. The disclosures of cited papers and patent documents are incorporated herein by reference in their entirety, and the level of the technical field to which the present invention belongs and the contents of the present invention are more clearly explained.

The present inventors have diligently researched to develop a cosmetic composition having higher skin safety and excellent whitening effect. As a result, when the lactate and upper limb extract are used as active ingredients and the composition ratio is properly adjusted, the skin is synergistically exerted. The present invention was completed by confirming that the stability was greatly improved.

Accordingly, it is an object of the present invention to provide a cosmetic composition with improved whitening effect.

The present invention provides a whitening cosmetic composition comprising 1-20% by weight of lactate and 0.0001-10% by weight of the upper limb extract as an active ingredient.

Lactate used as an active ingredient in the present invention is a component that inhibits the production of tyrosinase and exhibits a whitening effect, and has already been used in various kinds of cosmetics. In addition, lactate is a component that shows the effect of increasing the level of moisturizing effect and natural ceramide in the skin in addition to the whitening effect in the cosmetic composition.

The present inventors have conducted various studies to remove the side effects (e.g. skin irritation such as erythema, itching, etc.) caused by lactate used as a raw material for whitening and to improve the whitening effect. In addition to synergic whitening effects, skin irritation was also significantly reduced.

The lactate and the upper limb extract used as active ingredients in the present invention are included in an amount of 1-20% by weight of lactate and 0.0001-10% by weight of the upper limb extract, based on the total cosmetic composition, preferably the amount of lactate is 10- 18 wt%.

If the content of lactate in the cosmetic composition of the present invention is less than 10% by weight, there is a problem that can not expect more synergistic effect, when it exceeds 18% by weight does not have a clear effect of increasing the content and the viscosity of the formulation There is a problem that can not fall off. In addition, when the content of the upper limb extract in the cosmetic composition of the present invention is less than 0.0001% by weight, there is a problem that can not be expected synergistic effect, when it exceeds 10% by weight there is no obvious increase with the increase in content of the formulation stability There is a problem.

According to the most preferred embodiment of the present invention, the amount of lactate is 15% by weight, and the amount of the upper limb extract is 4.5-5% by weight.

According to a preferred embodiment of the present invention, the lactate included in the composition of the present invention is 60% (w / w) lactate.

The lactates of the present invention can take the form of salts in combination with various cations, most preferably sodium lactate.

In addition, the upper limb extract used as an active ingredient in the cosmetic composition of the present invention refers to a substance extracted from the upper limbs, which is a young branch of mulberry, and the extraction method is not particularly limited, but by adding an aqueous or organic solvent to the upper limbs The method of obtaining the extract, specifically, a method of obtaining the extract by adding water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, butyl acetate, chloroform, 1,3-butylene glycol, or the like is used. It is apparent to those of ordinary skill in the art that the preferred and other treatment methods using the upper limb can also be used. In addition, the range of "upper limb extract" includes "melbourne" and other processed products of upper limbs extracted and processed from upper limbs.

The components included in the cosmetic composition of the present invention include components commonly used in cosmetic compositions in addition to lactate and upper limb extract as active ingredients, and include, for example, conventional agents such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavorings. Adjuvants, and carriers.

The whitening composition of the present invention may be prepared in any formulation conventionally prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing It may be formulated as cleansing, oil, powder foundation, emulsion foundation, wax foundation, spray, and the like, but is not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. Can be.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Soluble cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it is to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. Will be self-evident.

Preparation Example 1 Preparation of Cosmetic Composition

In order to identify a suitable mixing ratio of sodium lactate and upper limb extract in the whitening cosmetic composition, a flexible lotion (skin), milk lotion and nourishing cream containing sodium lactate and upper limb extract mixed in various mixing ratios was prepared.

Preparation Example 1-1 Preparation of Flexible Lotion

To the flexible cosmetic lotion of Example 1 and Comparative Examples 1-3 was prepared in the composition of Table 1.

ingredient Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Upper limb extract 5.0 - - 5.0 60% Sodium Lactate 15.0 - 15.0 - Tocopherol Acetate 5.2 5.2 5.2 5.2 Oleyl alcohol 1.5 1.5 1.5 1.5 ethanol 3.2 3.2 3.2 3.2 Benzophenone-9 2.0 2.0 2.0 2.0 Carboxyl Vinyl Polymer 1.0 1.0 1.0 1.0 Cellulose gum 3.5 3.5 3.5 3.5 incense a very small amount a very small amount a very small amount a very small amount antiseptic a very small amount a very small amount a very small amount a very small amount Purified water Remaining amount Remaining amount Remaining amount Remaining amount Total weight 100 100 100 100

Preparation Example 1-2 Preparation of Milk Lotion

To the milk lotion of Example 2 and Comparative Examples 4-6 to the composition of Table 2.

ingredient Example 2 Comparative Example 4 Comparative Example 5 Comparative Example 6 Upper limb extract 5.0 5.0 5.0 5.0 60% sodium lactate 15.0 5.0 10.0 20.0 glycerin 5.1 5.1 5.1 5.1 Propylene glycol 4.2 4.2 4.2 4.2 Tocopherol Acetate 3.0 3.0 3.0 3.0 Liquid paraffin 4.6 4.6 4.6 4.6 Triethanolamine 1.0 1.0 1.0 1.0 Squalane 3.1 3.1 3.1 3.1 Macadamia Nut Oil 2.5 2.5 2.5 2.5 Polysorbate 60 1.6 1.6 1.6 1.6 Sorbitan sesquirrolate 1.6 1.6 1.6 1.6 Propylparaben 0.6 0.6 0.6 0.6 Carboxyl Vinyl Polymer 1.5 1.5 1.5 1.5 incense a very small amount a very small amount a very small amount a very small amount antiseptic a very small amount a very small amount a very small amount a very small amount Purified water Remaining amount Remaining amount Remaining amount Remaining amount Total weight 100 100 100 100

Preparation Example 1-3: Preparation of Nutritional Cream

The nutrition cream of Example 3 and Comparative Example 7-9 was prepared in the composition shown in Table 3.

ingredient Example 3 Comparative Example 7 Comparative Example 8 Comparative Example 9 Upper limb extract 4.5 0.0001 10.0 15.0 60% Sodium Lactate 15.0 15.0 15.0 15.0 glycerin 4.0 4.0 4.0 4.0 vaseline 3.5 3.5 3.5 3.5 Triethanolamine 2.1 2.1 2.1 2.1 Liquid paraffin 5.3 5.3 5.3 5.3 Squalane 3.0 3.0 3.0 3.0 Beeswax 2.6 2.6 2.6 2.6 Tocopherol Acetate 5.4 5.4 5.4 5.4 Polysorbate 60 3.2 3.2 3.2 3.2 Carboxyl Vinyl Polymer 1.0 1.0 1.0 1.0 Sorbitan sesquirrolate 3.1 3.1 3.1 3.1 incense a very small amount a very small amount a very small amount a very small amount antiseptic a very small amount a very small amount a very small amount a very small amount Purified water Remaining amount Remaining amount Remaining amount Remaining amount Total weight 100 100 100 100

Experimental Example 1: Skin irritation test

In order to examine the skin irritation of each cosmetic prepared in the above preparation, 0.1 g of each sample was patched for 24 hours at 5 × 20 cm in the lower part of both arms for 50 healthy adults male and female. After elapsed and after 24 hours, the skin condition change was read visually, and the stimulation rate was calculated by the following equation. The results are shown in Table 4.

Prescription Number of test subjects Judgment result Stimulus% ++ + +-- Example 1 50 - - 4 46 2.6 Example 2 50 - One 3 46 3.3 Example 3 50 - - 2 48 1.3 Comparative Example 1 50 - - 2 48 1.3 Comparative Example 2 50 - 3 6 41 8.0 Comparative Example 3 50 - - 3 47 2.0 Comparative Example 4 50 - - 3 47 2.0 Comparative Example 5 50 - 3 4 43 6.6 Comparative Example 6 50 - - 3 47 4.6 Comparative Example 7 50 - - 4 46 2.0 Comparative Example 8 50 - 2 6 42 6.7 Comparative Example 9 50 - - 3 47 2.0

Criteria

-: No erythema or unusual symptoms

+-: Slightly redder than the surroundings

+: Significantly redder than the surroundings

++: Reddens and swells more heavily than the surroundings

As can be seen in Table 4, the cosmetic composition of Examples 1-3 of the present invention shows almost similar skin irritation compared to Comparative Examples 1, 3, 4, 7 and 9 without sodium lactate, only lactate The added upper extremity extract showed very low irritation compared to Comparative Examples 2, 5 and 8, which were not contained. That is, it can be seen that the upper limb extract in the cosmetic composition of the present invention significantly lowers the skin irritation caused by lactate.

Experimental Example 2: Measurement of the whitening effect

The whitening effect of the formulations of each Example and Comparative Example prepared in Preparation Examples was measured in 30 women aged 19-40 with dark skin as follows. Nine places of the test subject's arms were displayed by 1 cm in width and length, and the cosmetics of Example 2-3 and Comparative Example 4-9 were applied to eight places, respectively, and the other one was used as a control. Subsequently, the whitening degree (ΔL value) was measured at 2 weeks intervals for 2 months using the Minolta CR 300 measuring instrument. The results are shown in Table 5 below.

Example 2 Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Comparative Example 8 Comparative Example 9 Control ΔL value 3.75 4.00 0.50 2.00 1.25 0.75 2.25 1.75 0

As shown in Table 5, the ΔL value of Example 2-3 is 4-9 times higher than the comparative example, it can be seen that the whitening effect is greatly increased, Comparative Example 5 containing only lactate known to have excellent whitening effect Compared with 8 and the whitening effect was confirmed to be greatly increased, it can be seen that the synergistically increased whitening effect when the upper limb extract and lactate as in the composition of the present invention at the same time.

As described in detail above, the present invention provides a whitening cosmetic composition comprising lactate and upper limb extract. The cosmetic composition of the present invention exhibits an improved whitening effect with very low skin irritation.

Claims (7)

A whitening cosmetic composition comprising 1-20% by weight of lactate and 0.0001-10% by weight of the upper extremity extract as active ingredients. The whitening cosmetic composition of claim 1, wherein the amount of lactate is 10-18% by weight. The whitening cosmetic composition according to claim 2, wherein the amount of lactate is 15% by weight. The whitening cosmetic composition according to any one of claims 1 to 3, wherein the amount of the upper limb extract is 4.5-5% by weight. The whitening cosmetic composition according to any one of claims 1 to 3, wherein the lactate is 60% (w / w) lactate. The whitening cosmetic composition according to any one of claims 1 to 3, wherein the lactate is sodium lactate. 4. The whitening cosmetic composition according to any one of claims 1 to 3, wherein the whitening cosmetic composition is a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion A whitening cosmetic composition, characterized in that it has a formulation selected from the group consisting of liquid foundation, wax foundation and spray.