KR20000059680A - Heparin coating way of mac stent for a blood vessel - Google Patents

Heparin coating way of mac stent for a blood vessel Download PDF

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KR20000059680A
KR20000059680A KR1019990007470A KR19990007470A KR20000059680A KR 20000059680 A KR20000059680 A KR 20000059680A KR 1019990007470 A KR1019990007470 A KR 1019990007470A KR 19990007470 A KR19990007470 A KR 19990007470A KR 20000059680 A KR20000059680 A KR 20000059680A
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stent
heparin
blood vessel
mac
plasma
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KR1019990007470A
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KR100336508B1 (en
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정명호
장양수
조동련
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정명호
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Surgery (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Materials For Medical Uses (AREA)

Abstract

PURPOSE: A method for coating Mac stent for heparin for blood vessel is provided for inhibiting thrombosis on Mac stent for blood vessel during and after operation. CONSTITUTION: The method for coating Mac stent with heparin for blood vessel comprises the steps of: washing stent with oxygen or argon plasma with rotation under 0.01 or less mtorr vacuum condition to remove particles on the surface of stent, in which the stent is placed on plate within R.F. plasma vessel, oxygen or argon gas is introduced into the vessel at 0.05 to 5 atmospheric pressure, R.F. discharge power is 5 to 100 watts, and the stent is exposed to gas for 5 to 20 minutes; reducing the pressure to 0.01 or less atmospheric pressure; introducing diaminocyclohexane vapor into the R.F. plasma vessel at 0.01 to 0.5 atmospheric pressure, in which R.F. discharge power is 5 to 100 watts and the stent is exposed to gas for 5 to 20 minutes; aminating the surface of stent; soaking the stent in heparin solution at 25 to 30 deg. C for 5 to 80 minutes; and removing weak-attached heparins from the stent by washing with deionized water to coat the surface of stent with heparin.

Description

혈관용 맥 스텐트의 헤타린 코팅방법{HEPARIN COATING WAY OF MAC STENT FOR A BLOOD VESSEL}Hetalin coating method of vein stent for blood vessels {HEPARIN COATING WAY OF MAC STENT FOR A BLOOD VESSEL}

본 발명은 혈관내의 협착부에 삽입하여 차단물을 압착하도록 한 스텐트(stent)에 관한 것으로, 특히 혈관용 맥 스텐트(Mac stent)에 혈액의 응고를 방지하는 헤파린(heparin)을 코팅처리함으로써, 시술시 맥 스텐트의 헤파린 코팅막에 혈전이 응고되는 것을 방지하기 때문에, 시술후 재협착율도 현저히 낮추는 효과가 있도록 한 혈관용 맥 스텐트(Mac stent)의 헤파린(heparin) 코팅방법에 관한 것이다.The present invention relates to a stent inserted into a constriction in a blood vessel to compress a block, and in particular, by coating a heparin to prevent blood coagulation on a blood vessel mac stent. The present invention relates to a heparin coating method of a blood vessel Mac stent (Mac stent) that prevents blood clot from clotting the heparin coating film of the Mac stent, thereby significantly reducing the restenosis rate after the procedure.

일반적으로 동맥차단과 같은 인체내의 통로의 차단은 동맥절개술과 특정차단물질을 용해시키는 약물을 이용하여 치료되어 왔지만, 근래에는 발룬 카테터(balloon catheter)를 사용하여 관상 동맥의 혈관 협착을 제거하는 시술이 보편화되고 있다.In general, blockage in the human body, such as arterial blockage, has been treated with arteriotomy and drugs that dissolve specific blockers, but recently, a procedure is used to remove vascular stenosis of the coronary artery by using a balloon catheter. It is becoming commonplace.

상기한 혈관 형성 시술은, 우선 인체에 셀징가법 등에 의하여 혈관의 유입부를 확보한 후, 안내 카테터(guide catheter)를 혈관내에 삽입하여 진행시켜, 혈관내의 협착부에 근접시킨고, 협착부에 근접된 안내 카테터내에 가이드 와이어(guide catheter)를 삽입하게 되면, 가이드 와이어는 안내 카테터에 안내되어 굴곡진 혈관내의 협착부에 위치하게 된다.In the above-described blood vessel formation procedure, the inlet of blood vessels is first secured to the human body, and then a guide catheter is inserted into the blood vessel to advance the blood vessel to the stenosis in the blood vessel, and the guide is close to the stenosis. When a guide wire is inserted into the catheter, the guide wire is guided to the guide catheter and placed in the constriction in the curved blood vessel.

그리고, 풍선 카테터에 가이드 와이어를 삽입하여 혈관내의 협착된 부위까지 도달시킨 후, 풍선 카테터의 풍선부를 협착부에 위치시키고, 풍선 카테터의 결합부에 별도의 가압수단을 체결하여 공기를 가압함에 따라, 풍선부가 팽창하게 되고 혈관내의 차단물이 압착되면서, 협착부가 확대되어 혈류가 원활해질 수 있는 것이다.Then, the guide wire is inserted into the balloon catheter to reach the constricted portion in the blood vessel, and then the balloon portion of the balloon catheter is positioned in the constriction portion, and a separate pressurizing means is coupled to the engaging portion of the balloon catheter to pressurize the air. As the part expands and the blockage in the blood vessel is squeezed, the constriction is enlarged and blood flow can be smoothed.

그러나, 상기한 시술 방법은, 나이론 재질의 유연성이 있는 풍선부의 팽창으로 협착부의 차단물질을 압착하는데 한계가 있기 때문에, 시술후에 확대된 협착부가 재협착되는 경우가 빈번히 발생하게 되었다.However, the above-described method has a limitation in compressing the blocking material of the constriction part due to the expansion of the flexible balloon part of the nylon material, so that the enlarged constriction part is frequently restrained after the procedure.

따라서 종래에는, 상기 풍선 카테터의 풍선부에 스테인레스재의 그물망 모양으로 형성된 스텐트(stent)를 장착하여, 스텐트가 장착된 풍선부가 혈관내의 협착부에 도달하여, 상기 풍선부가 팽창함에 따라, 스텐트가 탄성적으로 확장되어 혈관내의 차단물을 압착하기 때문에, 혈관의 재협착을 방지하는데 높은 효과를 나타내었다.Therefore, in the related art, a stent formed in a mesh shape of a stainless steel is mounted on a balloon portion of the balloon catheter, and the stent-mounted balloon portion reaches a constriction portion in a blood vessel, and the stent is elastically expanded as the balloon portion expands. Since it expands and compresses the blockage in the blood vessel, it shows a high effect in preventing the restenosis of the blood vessel.

그러나 상기한 종래의 혈관용 맥 스텐트(Mac stent)는, 그물망 모양의 스테인레스 스틸 소재로서, 혈관내의 차단물을 압착할 경우에 혈관내의 혈전이 스텐트표면이 응고되기 때문에, 혈관이 재협착되는 경우가 많은 문제점이 발생하였다.However, the above-described conventional vein for blood vessels (Mac stent) is a mesh-shaped stainless steel material, and when blood vessels are squeezed into the blood vessels, the blood clots in the vessels solidify the stent surface. Many problems have arisen.

따라서, 본 발명은 혈관용 스텐트에 혈액의 응고를 방지하는 헤파린(heparin)을 코팅처리함으로써, 시술시 스텐트 표면의 헤파린 코팅막이 혈전의 응고를 방지하기 때문에, 시술후 재협착율을 현저히 낮추는 효과가 있도록 하는데 그 목적이 있는 것이다.Therefore, the present invention by coating a heparin (heparin) to prevent blood coagulation in the blood vessel stent, because the heparin coating film on the surface of the stent to prevent clotting of the thrombus during the procedure, to significantly reduce the restenosis rate after the procedure The purpose is.

도 1은 본 발명의 제조공정을 보인 간략도.1 is a simplified view showing a manufacturing process of the present invention.

도 2는 본 발명의 혈관용 스텐트(stent)를 보인 사시도.Figure 2 is a perspective view showing a blood vessel stent (stent) of the present invention.

도 3은 본 발명의 체결상태를 보인 측면도.Figure 3 is a side view showing a fastening state of the present invention.

도 4는 본 발명의 사용상태를 보인 측면도.Figure 4 is a side view showing a state of use of the present invention.

도면의 주요부분에 대한 부호의 설명Explanation of symbols for main parts of the drawings

11 : 반응기. 12 : 샘플 홀딩 플레이트.11: reactor. 12: sample holding plate.

13 : R.F. 전원 공급원. 14 : 연결망.13: R.F. Power source. 14: network.

15 : 정지밸브. 16 : 집단류 흐름 조절망.15: Stop valve. 16: mass flow control network.

17 : 가스, 또는 액체 저장고. 18 : 압력계.17: gas, or liquid reservoir. 18: pressure gauge.

19 : 문 밸브. 20 : 진공밸브.19: door valve. 20: vacuum valve.

21 : 전극. 22 : 맥 스텐트.21: electrode. 22: Mac stent.

도 1은 본 발명의 제조공정을 보인 간략도이고, 도 2는 본 발명의 혈관용 스텐트를 보인 사시도이고, 도 3은 본 발명의 체결상태를 보인 측면도이고, 도 4는 본 발명의 사용상태를 보인 측면도이다.1 is a simplified view showing a manufacturing process of the present invention, Figure 2 is a perspective view showing a stenting for blood vessels of the present invention, Figure 3 is a side view showing a fastening state of the present invention, Figure 4 is a use state of the present invention The side view shown.

이하, 첨부된 도면에 의하여 본 발명 스텐트의 구성과 코팅방법을 상세히 설명하면 다음과 같다.Hereinafter, the configuration and coating method of the stent of the present invention according to the accompanying drawings in detail as follows.

도 1을 참조하여 본 발명의 코팅방법을 각 공정별로 설명하면 다음과 같다.Referring to Figure 1, the coating method of the present invention will be described for each process as follows.

세척 공정.Washing process.

스텐트를 표면처리 전에 스텐트의 표면에 붙은 물질을 산소, 또는 아르곤 플라즈마(plasma)를 이용하여 제거한다.Before the surface treatment of the stent, the substance attached to the surface of the stent is removed by using oxygen or argon plasma.

세척 과정은 통 형태의 R.F. 플라즈마(plasma)에서 시행하고, 스텐트를 플레이트(plate)에 위치시키고, 밸브를 개방한 후에, 반응 챔버를 0.01 mtorr 이하에서 회전식 진공펌프를 이용하여 소제한다.The cleaning process is carried out in the form of a barrel R.F. After the plasma is carried out, the stent is placed on a plate, and the valve is opened, the reaction chamber is cleaned using a rotary vacuum pump at 0.01 mtorr or less.

산소, 또는 아르곤 플라즈마 세척을 위해서 정지 밸브를 개방한 후에, 가스 저장고를 개방하여 산소, 또는 아르곤 가스가 유입되게 하고, 가스압을 0.05∼5 기압으로 한다.After the stop valve is opened for oxygen or argon plasma cleaning, the gas reservoir is opened to allow oxygen or argon gas to flow in, and the gas pressure is set to 0.05 to 5 atmospheres.

R.F. 방전 전력(discharge power)은 5∼100 와트로 하고, 전극에서 공급받으며, R.F. 전원에서 저온 플라즈마를 생성하고, 스텐트를 5∼20분간 노출시킨다.R.F. The discharge power (discharge power) is 5 to 100 watts, supplied from an electrode, and R.F. A low temperature plasma is generated at the power source and the stent is exposed for 5-20 minutes.

표면 변조 공정.Surface modulation process.

세척과정후 0.01 기압이하에서 재 진공상태를 만들며, 표면 변조 과정 중 디아미노시클로핵산 증기(diaminocyclohexane vapor)가 액체 저장고로 유입되고, 가스압력이 0.01 내지 0.5기압에 도달할 때까지 흐름속도를 맞춘다.After washing, re-vacuum is made under 0.01 atm, and diaminocyclohexane vapor is introduced into the liquid reservoir during the surface modulation process, and the flow rate is adjusted until the gas pressure reaches 0.01 to 0.5 atm.

R.F. 방전 전력(discharge power)은 5∼100와트로 R.F. 전원을 이용하여 저온하에서 공급하고, 스탠트는 5분∼20분간 노출시켜 스탠트 표면에 얇은 막을 형성하도록 한다.R.F. The discharge power is 5 to 100 watts and the R.F. It is supplied under low temperature using a power source, and the stent is exposed for 5 to 20 minutes to form a thin film on the surface of the stent.

표면 변조후, 정지 판막을 폐쇄하고, 0.01 기압이하에서 재 배출하고, 변조된 스텐트는 진공에서 공기속으로 유출시킨다.After surface modulation, the stationary valve is closed, re-ejected below 0.01 atm, and the modulated stent is evacuated to air.

완제품 제조공정.Finished product manufacturing process.

상기한 표면 변조 공정을 거친 스텐트의 표면을 디아미노시클로핵산(diaminocyclohexane) 플라즈마에 아민(amine)군을 갖도록 한후, 헤파린 용액에 25∼50도에 5∼80분간 담근 후, 약하게 결합된 헤파린을 제거하기 위해서 탈이온화 용액(deionized water)에서 1분간 세척하면, 스텐트의 표면에 헤파린이 코팅된다.After the surface of the stent undergoing the surface modulation process to have an amine group in a diaminocyclohexane plasma, immerse in heparin solution at 25-50 degrees for 5 to 80 minutes, then remove the weakly bound heparin In order to wash in deionized water for 1 minute, heparin is coated on the surface of the stent.

도 2에 도시된 바와 같이, 상기한 스텐트는 스테인레스 스틸 소재로서, 표면이 헤파린으로 코팅처리되며, 그물망 모양으로 성형한다.As shown in Figure 2, the stent is a stainless steel material, the surface is coated with heparin, and formed into a mesh shape.

상기한 스텐트는 혈관의 협착부를 용이하게 통과하도록 표면을 매끄럽게 가공하며, 절첩시 크기를 최소화하도록 형성하고, 확장시 혈관벽에 둥근모양으로 견고하게 지탱되도록 형성한고, 스텐트의 양측부위에 탄성적으로 절첩, 확대되도록 한 절첩부를 형성한다.The stent smoothly processes the surface to easily pass through the constriction of the blood vessel, is formed to minimize the size when folded, and is formed to be firmly supported in a round shape on the vessel wall when expanded, elastically folded on both sides of the stent And forming a folded portion to be enlarged.

이상에서 설명된 본 발명의 작용 및 효과를 살펴보면 다음과 같다.Looking at the operation and effects of the present invention described above are as follows.

도 3에 도시된 바와 같이, 인체에 셀징가법 등에 의하여 혈관의 유입부를 확보한 후, 안내 카테터를 혈관내에 삽입하여 진행시켜, 혈관내의 협착부에 근접시키고, 협착부에 근접된 안내 카테터내에 가이드 와이어를 삽입하게 되면, 가이드 와이어는 안내 카테터에 안내되어 굴곡진 혈관내의 협착부에 위치하게 된다.As shown in FIG. 3, after the inlet of blood vessels is secured to the human body by a smelting method or the like, the guide catheter is inserted into the blood vessel to proceed, and the guide wire is inserted into the guide catheter close to the stenosis. When inserted, the guide wire is guided to the guide catheter and positioned at the constriction in the curved vessel.

도 4에 도시된 바와 같이, 풍선부에 절첩된 스텐트가 체결된 풍선 카테터에 가이드 와이어를 삽입하여 혈관내의 협착된 부위까지 도달시킨 후, 풍선 카테터의 풍선부를 협착부에 위치시키고, 풍선 카테터의 결합부에 별도의 가압수단을 체결하여 공기를 가압함에 따라, 풍선부가 팽창하게 되고, 풍선부에 체결된 스텐트도 탄성적으로 확장하게 되면서 혈관내의 차단물이 압착되면서, 협착부가 확대되어 혈류가 원활해질 수 있는 것이다.As shown in FIG. 4, after the guide wire is inserted into the balloon catheter in which the stent folded to the balloon is fastened to reach the constricted portion in the blood vessel, the balloon portion of the balloon catheter is positioned in the constriction portion, and the coupling portion of the balloon catheter As a separate pressurizing means to pressurize the air, the balloon is expanded, the stent is fastened to the balloon portion elastically expands while the blockage in the blood vessel is compressed, the constriction is enlarged can be smooth blood flow It is.

상기한 스텐트가 둥근모양으로 확장되어 차단물의 압착하는 동안, 스텐트의 표면에 코팅처리된 헤파린이 혈액의 응고를 방지하는 효과를 얻을 수 있기 때문에, 혈관의 재협착율도 현저히 낮출수 있는 것이다.While the stent is expanded in a round shape and the blocker is pressed, the heparin coated on the surface of the stent can obtain the effect of preventing the coagulation of blood, thereby significantly lowering the stenosis of blood vessels.

따라서, 본 발명은 혈관용 스텐트에 혈액의 응고를 방지하는 헤파린을 코팅처리함으로써, 시술시 헤파린 코팅막이 스텐트 표면에서의 혈전의 응고를 방지하기 때문에, 시술후 재협착율도 현저히 낮추는 효과를 얻을 수 있도록 한 유익한 발명인 것이다.Therefore, the present invention is coated with heparin to prevent blood coagulation to the blood vessel stent, the heparin coating film during the procedure prevents the clotting of the thrombus on the surface of the stent, it is possible to obtain a significantly lower effect of restenosis after the procedure It is a beneficial invention.

Claims (1)

스텐트의 표면에 붙은 물질을 산소, 또는 아르곤 플라즈마를 이용하여 제거시키는 세척공정과:The cleaning process removes the substance on the surface of the stent by using oxygen or argon plasma: 세척과정후 0.01 기압이하에서 재 진공상태를 만들며, 표면 변조 과정 중 디아미노시클로핵산 증기(diaminocyclohexane vapor)가 액체 저장고로 유입되도록 하고, R.F. 전원을 이용하여 저온하에서 공급하며, 스탠트는 5분∼20분간 노출시켜 스탠트 표면에 얇은 막을 형성하도록 하고, 표면 변조 후, 정지 판막을 폐쇄하고, 0.01 기압이하에서 재 배출하고, 변조된 스텐트는 진공에서 공기속으로 유출시키는 표면 변조 공정과:After washing, re-vacuum is made under 0.01 atm, and diaminocyclohexane vapor is introduced into the liquid reservoir during surface modulation. It is supplied at low temperature using a power source, and the stent is exposed for 5 to 20 minutes to form a thin film on the surface of the stent. After surface modulation, the stop valve is closed and discharged again at less than 0.01 atm. Surface modulation process that flows from vacuum to air: 스텐트의 표면을 디아미노시클로핵산(diaminocyclohexane) 플라즈마에 아민(amine)군을 갖도록 한후, 헤파린 용액에서 약하게 결합된 헤파린을 제거하는 완제품 제조 공정으로 스텐트에 헤파린이 코팅되도록 하는것을 특징으로 하는 혈관용 맥 스텐트의 헤파린 코팅방법.Vascular veins characterized in that the surface of the stent has a group of amines in diaminocyclohexane plasma, and then the heparin is coated on the stent in the finished product manufacturing process of removing the weakly bound heparin from the heparin solution. Heparin coating method of the stent.
KR1019990007470A 1999-03-06 1999-03-06 Heparin coating way of mac stent for a blood vessel KR100336508B1 (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
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KR100409028B1 (en) * 2001-10-29 2003-12-06 전흥재 method for making leukocyte elimination filter to which immune factor adsorbent is grafted and the filter made by the method
WO2006112597A1 (en) * 2005-02-12 2006-10-26 Humed Co., Ltd. A stent coated with anti-integrin antibody and process for preparing the same
JP2014018477A (en) * 2012-07-19 2014-02-03 Chonnam National Univ Hospital Heparin coating method for stent surface
US10709822B2 (en) 2015-03-31 2020-07-14 Toray Industries, Inc. Antithrombotic metallic material

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100371008B1 (en) * 2000-08-05 2003-02-06 조동련 Manufacturing method of transfer paper for coating
KR100778654B1 (en) 2006-05-09 2007-11-28 전남대학교산학협력단 Alpha-Iipoic acid Coating Method of stent for blood vessel
KR100778656B1 (en) 2006-05-09 2007-11-28 전남대학교산학협력단 Reopro coating Method of stent for blood vessel

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6120536A (en) * 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings
JPH1030184A (en) * 1996-07-19 1998-02-03 Otsuka Pharmaceut Factory Inc Plasma vapor depositing device for film
US6776792B1 (en) * 1997-04-24 2004-08-17 Advanced Cardiovascular Systems Inc. Coated endovascular stent

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100409028B1 (en) * 2001-10-29 2003-12-06 전흥재 method for making leukocyte elimination filter to which immune factor adsorbent is grafted and the filter made by the method
WO2006112597A1 (en) * 2005-02-12 2006-10-26 Humed Co., Ltd. A stent coated with anti-integrin antibody and process for preparing the same
KR100759130B1 (en) * 2005-02-12 2007-09-19 휴메드 주식회사 Stent Coated with Anti-integrin Antibody and Process for Preparing the Same
JP2014018477A (en) * 2012-07-19 2014-02-03 Chonnam National Univ Hospital Heparin coating method for stent surface
US10709822B2 (en) 2015-03-31 2020-07-14 Toray Industries, Inc. Antithrombotic metallic material

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