KR102909306B1 - Foam toothpaste composition with excellent plaque removal effect - Google Patents

Abstract

The present invention relates to a foaming toothpaste composition comprising a green tea extract, a Schisandra chinensis extract, a lettuce extract, a kohlrabi extract, a calendula extract, a Samchil extract, a peony extract, a Agrimonia japonica extract, a black rice bran extract, and a peanut extract. The foaming toothpaste composition comprising raw materials obtained from natural products has an antibacterial effect against oral bacteria such as Streptococcus mutans and Porphyromonas gingivalis and an effect of eliminating bad breath, and has an excellent effect of removing plaque from the gums in the oral cavity, thereby having an excellent function of preventing tartar build-up. Therefore, by using the foaming toothpaste composition, more hygienic and clean oral care can be achieved.

Description

Foam toothpaste composition with excellent plaque removal effect

The present invention relates to a foaming toothpaste composition having plaque removal effects such as dental plaque and white plaque prevention, bad breath removal, and antibacterial effects, comprising a green tea extract, an omija extract, a lettuce extract, a kohlrabi extract, a calendula extract, a ginseng extract, a peony extract, a straw flower extract, a black rice bran extract, and a peanut extract.

More than 400 types of bacteria thrive in the human oral cavity, totaling 10 billion. Furthermore, saliva has been found to contain bacteria at levels of ¹⁰⁸ to ¹⁰⁹ CFU/㎖. Teeth have numerous microscopic pores, allowing cavity-causing bacteria to enter these pores and damage the teeth, which is known as cavities. Cavities are one of the most common dental diseases, also known as dental caries. It is an infectious bacterial disease caused by the decay of food in the mouth by acid-resistant streptococci and lactic acid bacteria, and the destruction of tooth components by acid. In Korea, the prevalence of caries in permanent teeth is reported to be approximately 80%, with an average person having 2 to 3 cavities.

Although it has been revealed that various factors work together to cause tooth decay, the most important one is dental plaque. Dental plaque contains a variety of bacteria, particularly acid-resistant streptococci and lactic acid bacteria, of which Streptococcus mutans is known as the main cariogenic bacteria. Streptococcus mutans attaches to the tooth surface and grows, producing acid using sugars in food, which corrodes the tooth and simultaneously invades dental osteocytes, causing various types of alveolar bone decay and gum disease. More specifically, the development of tooth decay begins with the first stage of dental plaque formation on the tooth surface by cariogenic bacteria. The second stage is the production of organic acids within the plaque. The third stage is the demineralization of the inorganic substances constituting the tooth surface by organic acids and proteolytic enzymes produced within the plaque, and further dissolves the organic substances. In addition, in the case of periodontal disease, dental plaque attached to the tooth surface and periodontal tissue is the main cause of the occurrence and progression of periodontal disease, and it is known that the disease occurs and progresses by producing harmful metabolic products or bacterial enzymes by bacteria in dental plaque, which in turn induces gingivitis.

Bad breath refers to the odor originating from the oral cavity and adjacent organs, and many people complain of bad breath in their daily lives. 85-90% of bad breath originates in the oral cavity, particularly the back of the tongue. The main components of bad breath are volatile sulfur compounds, of which 90% are hydrogen sulfide, derived from cysteine, and methyl mercaptan and dimethyl sulfide, derived from methionine. These compounds are primarily produced by protein enzymes secreted by anaerobic bacteria, and the back of the tongue is a prime habitat for them. This area is poorly cleansed by saliva and contains numerous small depressions, creating a persistent habitat for bacteria. While the production of volatile sulfur compounds by anaerobic bacteria is the primary cause of bad breath, oral diseases such as caries and periodontitis can also contribute to its occurrence. Many types of anaerobic bacteria are involved in causing bad breath, but in particular, the representative bacteria causing bad breath are Porphyromonas gingivalis , Prevotella intermedia , Fusobacterium nucleatum , Bacteoides forsythus , and Treponema deticola , which secrete many types and large amounts of enzymes, and are also known as representative causative bacteria of periodontitis. In order to suppress bad breath, the most effective way is to suppress the growth of anaerobic bacteria that produce volatile sulfur compounds, the main component of bad breath. Therefore, in the past, tongue scrapers were used to remove tongue coating to remove the growth substrate for bacteria from the tongue, or metal salts such as zinc chloride or disinfectants such as alcohol or chlorhexidine were used to suppress the growth of anaerobic bacteria or the production of volatile sulfur compounds by anaerobic bacteria. However, these metal salts and disinfectants suppress not only the anaerobic bacteria that cause bad breath but also other microorganisms in the oral cavity. Since these substances are not swallowed into the esophagus, they do not reach the back of the tongue, which is a key site for bad breath, but are mainly gargled at the front of the mouth and spit out. Therefore, there is a problem in that the back of the tongue, which is the main site of proliferation of anaerobic bacteria that cause bad breath, cannot be disinfected. Furthermore, these substances are diluted by saliva and swallowed through the esophagus. Their oral effects last only about 20 minutes to two hours, after which time microorganisms proliferate again, causing bad breath. Therefore, metal salts and disinfectants used to reduce bad breath have only short-term effects, and recurrence of bad breath is frequent.

Toothpaste is a quasi-drug used to brush the surface of teeth. It is primarily used for whitening, sterilizing, and interdental cleaning effects. To achieve these effects, toothpaste typically contains ingredients such as abrasives, humectants, foaming agents, and sweeteners. Recently, extensive research has been conducted to develop various functional toothpastes to improve the effects of tooth decay, periodontitis, and bad breath. Furthermore, periodontal disease is not simply a chronic infection of the gum tissue, but is also gaining attention as a risk factor for myocardial infarction, arteriosclerosis, diabetes, and premature birth. Therefore, toothpaste use may serve as a foundation for improving various health conditions. Meanwhile, to prevent tooth decay and periodontitis, toothpaste or mouthwash typically contains 0.05-0.1% of the total active ingredient. Fluoride is frequently used at concentrations of w/v%. Recent reports have shown that while the use of fluoride compounds in toothpaste and mouthwashes can prevent dental caries, long-term and repeated use of fluoride compounds promotes gingival inflammation. Therefore, there is a need for a toothpaste composition that can suppress tooth sensitivity and prevent dental caries without using fluoride.

Accordingly, the inventors of the present invention have confirmed that a hygienic oral environment can be maintained by using a composition containing various natural extracts that are excellent in removing plaque such as dental plaque and white coating (tongue coating), have excellent anti-tartar effect, and have excellent antibacterial/deodorizing effect as a raw material for foam toothpaste, thereby completing the present invention.

Republic of Korea Patent No. 10-2196459 (Title of invention: Toothpaste composition with improved antibacterial performance and toothpaste containing the same, Applicant: Medidenko Co., Ltd., Registration date: December 22, 2020) Republic of Korea Patent No. 10-1841181 (Title of invention: Toothpaste composition containing herbal extract, Applicant: Cellpoone Co., Ltd., Registration date: March 16, 2018)

The purpose of the present invention is to provide a foaming toothpaste composition having plaque removal effects such as dental plaque and white plaque prevention, bad breath removal, and antibacterial effects, including green tea extract, Schisandra chinensis extract, lettuce extract, kohlrabi extract, calendula extract, ginseng extract, peony extract, aster extract, black rice bran extract, and peanut extract.

The present invention relates to a foaming toothpaste composition comprising a green tea extract, a Schisandra chinensis extract, a lettuce extract, a kohlrabi extract, a calendula extract, a ginseng extract, a peony extract, a straw flower extract, a black rice bran extract, and a peanut extract.

The composition is characterized by having antibacterial efficacy. Preferably, the composition is characterized by having antibacterial efficacy against Streptococcus mutans, an oral bacterium.

Or, the composition is characterized by having a bad breath removal effect. Preferably, it is characterized by having an antibacterial effect against Porphyromonas gingivalis , a bad breath-causing bacteria.

The composition may preferably contain 30 to 70 parts by weight of Schisandra chinensis extract, 120 to 160 parts by weight of lettuce extract, 190 to 230 parts by weight of kohlrabi extract, 10 to 50 parts by weight of calendula extract, 30 to 70 parts by weight of Samchil extract, 20 to 40 parts by weight of peony extract, 40 to 60 parts by weight of agarwood extract, 10 to 30 parts by weight of black rice bran extract, and 40 to 60 parts by weight of peanut extract, based on 100 parts by weight of green tea extract.

The above composition is characterized by preventing tartar formation due to plaque removal.

In addition, the composition may include sodium fluoride, sodium benzoate, citric acid, glycerin, sodium lauroyl sarcosine, steviol glycosides, sodium chloride, xylitol, sodium cocoyl glutamate, sodium bicarbonate, tocopheryl acetate, hydrogenated castor oil, sodium gluconate, allantoin, sodium citrate, zinc gluconate, fragrance, and purified water to enhance formulation stabilization and plaque removal efficacy.

Preferably, 1000 to 1400 parts by weight of sodium fluoride, 3000 to 6000 parts by weight of sodium benzoate, 400 to 600 parts by weight of citric acid, 60,000 to 100,000 parts by weight of glycerin, 3000 to 6000 parts by weight of sodium lauroyl sarcosine, 1500 to 4000 parts by weight of steviol glycoside, 1000 to 1200 parts by weight of sodium chloride, 3000 to 7000 parts by weight of xylitol, 5000 to 9000 parts by weight of sodium cocoyl glutamate, 10,000 to 30,000 parts by weight of sodium bicarbonate, 5 to 30 parts by weight of tocopherol acetate, 10,000 to 30,000 parts by weight of hydrogenated castor oil, 50 to 200 parts by weight of potassium sorbate, It may contain 200 to 500 parts by weight of sodium gluconate, 50 to 150 parts by weight of allantoin, 200 to 350 parts by weight of sodium citrate, 100 to 300 parts by weight of zinc gluconate, 2000 to 5000 parts by weight of fragrance, and 500,000 to 1,000,000 parts by weight of purified water.

Hereinafter, the present invention will be described in detail.

The foam toothpaste composition of the present invention can be applied to oral brushing using a toothbrush, and in particular, since it is manufactured in a formulation suitable for being dispensed in a foam state by being contained in a pump container, it can also be used as a toothpaste for removing white coating (tongue coating) by applying a fine brush to the inside of the tongue. In addition, the foam toothpaste composition can be applied to clean various oral orthodontic devices inserted into the oral cavity.

The extract in the above composition can be extracted from a raw material sample using water, C1-C4 alcohol, or a mixed solution thereof as a solvent, and the C1-C4 alcohol can be selected from the group consisting of methanol, ethanol, propanol, isopropanol, butanol, and isobutanol. The extract can also be a 30-90% (v/v) alcohol aqueous solution extract, preferably a 50-80% (v/v) alcohol aqueous solution extract.

The water, C1~C4 alcohol or a mixed solution thereof used in the production of the above extract may be used in an amount of 1~40 times the volume based on the weight of the raw material sample used (1~40 ℓ per 1 kg), and preferably 5~40 times the volume may be used. The extraction conditions of the above extract may be 20~100℃ for 1 minute~48 hours. The above process may be repeated 1~4 times.

In addition, as a conventional method in the field, the raw material sample's water, C1~C4 alcohol or mixed solution extract thereof is dissolved in water, and then further fractionated using at least one solvent selected from the group consisting of n-hexane, methylene chloride, acetone, chloroform, ethyl acetate and n-butanol, thereby producing a fraction.

The temperature at which the extract or fraction thereof is prepared may be, but is not limited to, 20 to 100°C. The extraction or fractionation time is not particularly limited, but it is preferable to extract within 10 minutes to 2 days. A conventional extraction device, an ultrasonic grinding extractor, or a fractionator may be used as the extraction device. The extract or fraction prepared in this manner may be subjected to hot air drying, reduced pressure drying, or freeze drying to remove the solvent.

The above-mentioned flavoring agent may be a variety of common fruit or herbal flavorings applicable to toothpaste. Preferably, flavoring agents such as grapefruit, lemon, grape, green tea, strawberry, banana, peppermint, and tropical fruits can be used. The steviol glycoside is a commonly used food alternative sweetener (an artificial sweetener approved by the FDA (US Food and Drug Administration) and EFSA (European Food Safety Authority)) isolated from stevia extract.

The present invention relates to a foaming toothpaste composition comprising a green tea extract, a Schisandra chinensis extract, a lettuce extract, a kohlrabi extract, a calendula extract, a Samchil extract, a peony extract, a Agrimonia japonica extract, a black rice bran extract, and a peanut extract. The foaming toothpaste composition comprising raw materials obtained from natural products has an antibacterial effect against oral bacteria such as Streptococcus mutans and Porphyromonas gingivalis and an effect of eliminating bad breath, and has an excellent effect of removing plaque from the gums in the oral cavity, thereby having an excellent function of preventing tartar build-up. Therefore, by using the foaming toothpaste composition, more hygienic and clean oral care can be achieved.

Hereinafter, preferred embodiments of the present invention will be described in detail. However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, the contents introduced herein are provided to ensure thoroughness and completeness, and to sufficiently convey the spirit of the present invention to those skilled in the art.

<Examples 1 to 8. Preparation of a raw material composition containing a natural product mixture extract and a foam toothpaste formulation containing the same>

Green tea extract, Schisandra chinensis extract, lettuce extract, kohlrabi extract, calendula extract, Samchil extract, peony extract, aster extract, black rice bran extract, and peanut extract were prepared and mixed to prepare a mixture of natural extracts for toothpaste compositions of Examples 1 to 3 as shown in Table 1.

Afterwards, excipients such as sodium fluoride, sodium benzoate, citric acid, glycerin, sodium lauroyl sarcosine, steviol glycosides, sodium chloride, xylitol, sodium cocoyl glutamate, sodium bicarbonate, tocopheryl acetate, hydrogenated castor oil, potassium sorbate, sodium gluconate, allantoin, sodium citrate, zinc gluconate, allantoin, fragrance, and purified water were prepared as raw materials and mixed with the compositions of Examples 1 to 3 prepared in Table 1 to prepare toothpaste compositions as disclosed in Examples 4 to 6 of Table 2.

The raw material of Example 3 was mixed with different excipients to produce the compositions of Example 7 and Example 8 as shown in Table 2.

Among these, the compositions of Examples 4 to 8 were injected into a pump container equipped with a nozzle that forms foam when discharged from the container, thereby forming a final formulation.

(That is, Table 1 is presented separately to more effectively confirm the antibacterial activity of natural raw materials, and Table 2 is an example that presents the optimal conditions for formulation to sustain/maintain the antibacterial activity of this natural raw material.)

Each extract used as a raw material was prepared by adding 10 times the weight of a 70% (v/v) ethanol aqueous solution and extracting the obtained liquid at 60°C for 8 hours, and then concentrating under reduced pressure and freeze-drying the resulting liquid. Other raw materials were purchased and used as raw materials for common foods or oral cleansers.

Weight division Example 1 Example 2 Example 3 green tea extract 100 100 100 Schisandra chinensis extract 30 70 50 lettuce extract 160 120 150 Kohlrabi extract 190 230 200 Calendula extract 50 10 30 Samchil extract 70 30 50 Peony extract 20 40 30 Strawberry extract 40 60 50 Black rice extract 30 10 20 peanut extract 40 60 50 subtotal 730 730 730

Raw materials / parts by weight Example 4 Example 5 Example 6 Example 7 Example 8 green tea extract 100 100 100 100 100 Schisandra chinensis extract 30 70 50 50 50 lettuce extract 160 120 150 150 150 Kohlrabi extract 190 230 200 200 200 Calendula extract 50 10 30 30 30 Samchil extract 70 30 50 50 50 Peony extract 20 40 30 30 30 Strawberry extract 40 60 50 50 50 Black rice extract 30 10 20 20 20 peanut extract 40 60 50 50 50 sodium fluoride 1000 1000 1000 1400 1100 sodium benzoate 4000 4000 4000 6000 3000 citric acid 400 400 400 600 500 glycerin 100000 100000 100000 60000 100000 sodium lauroyl sarcosine 6000 6000 6000 4000 3000 Steviol glycosides 4000 4000 4000 1500 2000 sodium chloride 1200 1200 1200 1100 1000 Xylitol 3000 3000 3000 7000 5000 Monosodium cocoyl glutamate 7000 7000 7000 9000 5000 sodium bicarbonate 14000 14000 14000 30000 10000 Tocopheryl acetate 10 10 10 10 10 Hydrogenated Castor Oil 10000 10000 10000 30000 20000 potassium sorbate 50 50 50 200 100 sodium gluconate 300 300 300 200 500 Allantoin 150 150 150 50 100 sodium citrate 200 200 200 350 200 zinc gluconate 300 300 300 200 100 spices 3000 3000 3000 3000 3000 purified water 800000 800000 800000 800000 800000 total 955340 955340 955340 955340 955340

<Comparative Examples 1 to 6. Preparation of Comparative Compositions>

Using each raw material used in the manufacture of the toothpaste composition in Example 1, compositions of Comparative Examples 1 to 3, which are mixed compositions of comparative raw material extracts, were manufactured as shown in Table 3.

In order to confirm the condition of the toothpaste when the compositions of Comparative Examples 1 to 3 were formulated, the compositions of Comparative Examples 4 to 6 were prepared as shown in Table 4, and in order to confirm the optimal conditions of each excipient, the compositions of Comparative Examples 7 to 9 were also prepared. The compositions of Comparative Examples 4 to 9 were also formulated by injecting them into a pump that forms foam.

Weight division Comparative Example 1 Comparative Example 2 Comparative Example 3 green tea extract 100 100 100 Schisandra chinensis extract 200 0 90 lettuce extract 150 0 50 Kohlrabi extract 150 0 50 Calendula extract 0 100 100 Samchil extract 0 200 100 Peony extract 0 130 100 Strawberry extract 130 0 20 Black rice extract 0 100 100 peanut extract 0 100 20 total 730 730 730

Weight division Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Comparative Example 8 Comparative Example 9 green tea extract 100 100 100 100 100 100 Schisandra chinensis extract 200 0 90 50 50 50 lettuce extract 150 0 50 150 150 150 Kohlrabi extract 150 0 50 200 200 200 Calendula extract 0 100 100 30 30 30 Samchil extract 0 200 100 50 50 50 Peony extract 0 130 100 30 30 30 Strawberry extract 130 0 20 50 50 50 Black rice extract 0 100 100 20 20 20 peanut extract 0 100 20 50 50 50 sodium fluoride 1000 1000 1000 1100 1100 1100 sodium benzoate 4000 4000 4000 1000 15000 10000 citric acid 400 400 400 500 0 1000 glycerin 100000 100000 100000 90000 100000 30000 sodium lauroyl sarcosine 6000 6000 6000 8000 0 8000 Steviol glycosides 4000 4000 4000 0 4000 1000 sodium chloride 1200 1200 1200 1000 0 500 Xylitol 3000 3000 3000 0 1000 1000 Monosodium cocoyl glutamate 7000 7000 7000 10000 14000 12000 sodium bicarbonate 14000 14000 14000 20000 17000 4000 Tocopheryl acetate 10 10 10 10 0 60 Hydrogenated Castor Oil 10000 10000 10000 20000 0 44000 potassium sorbate 50 50 50 0 170 1000 sodium gluconate 300 300 300 0 340 100 Allantoin 150 150 150 100 0 250 sodium citrate 200 200 200 200 0 500 zinc gluconate 300 300 300 0 0 100 spices 3000 3000 3000 2700 2000 40000 purified water 800000 800000 800000 800000 800000 800000 total 955340 955340 955340 955340 955340 955340

<Experimental Example 1. Confirmation of Antibacterial Effect>

The compositions of Examples 1 to 3 and Comparative Examples 1 to 3, which were manufactured and stored at room temperature for 6 months, were dissolved in DMSO (Dimethyl sulfoxide), diluted with PBS (Phosphate-buffered saline), and the antibacterial effect against oral bacteria such as Streptococcus mutans and Porphyromonas gingivalis was confirmed.

These oral bacteria were cultured on trypticase soy agar (TSA) medium supplemented with hemin menadione, and the minimum inhibitory concentration (MIC) was measured, which is shown in Table 5. At this time, each composition was diluted to a final concentration of 1000 ㎍/㎖ or less, and each strain (bacteria) was used by adjusting the concentration to O.D.600 = 0.2. 100 ml of trypticase soy broth (TSB) supplemented with hemin menadione for bacterial culture used in the present invention, 50 ml of each composition dilution solution, and 50 ml of strain dilution solution were sequentially added to a 96-well plate (96-well plate, Falcon, USA), and then cultured at 37°C for 24 hours while measuring the absorbance value every 4 hours using a UV spectrophotometer. At this time, the minimum concentration at which no growth (turbidity) of the strain was detected on the bacterial growth curve was set as the minimum growth inhibitory concentration.

condition About Streptococcus mutans
MIC (㎍/㎖) About Porphyromonas gingivalis
MIC (㎍/㎖) Example 1 1.2 1.2 Example 2 13.2 13.1 Example 3 15.2 16.3 Comparative Example 1 112.3 112.1 Comparative Example 2 98.1 109.2 Comparative Example 3 123.2 102.4

Referring to the results in Table 5 above, it can be seen that the antibacterial effect against oral bacteria of the compositions of Examples 1 to 3 of the present invention is significantly superior to that of the compositions of Comparative Examples 1 to 3.

<Experimental Example 2. Confirmation of Formulation Stability>

To ensure that oral device cleaning compositions maintain antibacterial efficacy for long-term use and are stable, the components and contents of each excipient suitable for formulation were identified. To this end, compositions of Examples 6 to 8 and Comparative Examples 7 to 9, which contained the same extract but differed in excipient contents, were stored for a total of one year under 8-hour cycling conditions at high temperature (45°C), room temperature (25°C), and low temperature (4°C), and each composition was diluted 100-fold.

Afterwards, 1g of each diluted composition was added to 100g of the culture solution of Streptococcus mutans and Porphyromonas gingivalis cultured in the same manner as in Experimental Example 1, and the growth inhibition activity of oral bacteria was confirmed by culturing at 37°C for 24 hours.

condition About Streptococcus mutans
Growth inhibition activity (%) About Porphyromonas gingivalis
Growth inhibition activity (%) Example 6 99.9 99.9 Example 7 99.9 99.9 Example 8 99.9 99.9 Comparative Example 7 21.4 19.2 Comparative Example 8 20.5 25.1 Comparative Example 9 25.1 24.3

As a result of the verification, in the group to which the diluted compositions of Examples 6 to 8 were added, the growth of each oral bacteria was hardly observed, but in Comparative Examples 7 to 9, the growth inhibition efficacy of oral bacteria was found to be reduced despite the only difference being that different excipients were applied to the extract of the same Example 1.

<Experimental Example 3. Confirmation of Bad Breath Suppression Ability>

When plaque or tartar builds up inside the teeth, it causes bad breath, tooth decay, and periodontitis. Therefore, as a short-term experiment, 10 men and women in their 20s to 50s per group used the toothpaste compositions of Examples 4 to 8 and Comparative Examples 4 to 6 when brushing their teeth for 7 days, and the bad breath suppression ability before and after use of the compositions was compared to the degree perceived by the users, and expressed using a 5-point rating scale. (5 points: very good, 4 points: good, 3 points: average, 2 points: bad, 1 point: very bad).

condition Bad breath suppression ability Example 4 4.0 Example 5 4.1 Example 6 4.5 Example 7 4.6 Example 8 4.5 Comparative Example 4 3.1 Comparative Example 5 3.2 Comparative Example 6 3.0

As a result, it can be confirmed that each user is very satisfied with the use of the composition manufactured in the present invention.

<Experimental Example 5. Confirmation of the ability to inhibit tartar formation>

Among the subjects tested in Experimental Example 3, 2 users of the toothpastes of Example 4 and Comparative Example 6 were selected, and the same composition was used for scaling, followed by brushing the teeth for 6 months. The degree of tartar formation, the resulting inflammation and swelling of the gums, and the degree of white coating formation near the root of the tongue were compared before and 6 months after scaling, and compared during an oral examination. The evaluation scores were confirmed through visual inspection by the examiners (dentists and dental hygienists). (5 points: very good, 4 points: good, 3 points: average, 2 points: bad, 1 point: very bad).

condition Target audience Tartar formation
Inhibitory effect gum inflammation/swelling
Inhibitory effect White spot formation
Inhibitory effect Example 4 40s, female, smoker 4.3 4.5 4.2 30s, male, smoker 4.0 4.2 3.8 Comparative Example 6 20s, male, smoker 3.2 3.1 3.2 50s, male, smoker 3.1 3.2 3.1

As a result, when comparing the dental plaque inhibition effects of the toothpastes of Example 4 and Comparative Example 6, it was confirmed that the user of the toothpaste of Example 4 had less dental plaque formed, the condition of the gums was very good, and less white coating (tongue coating) was formed on the tongue root compared to 6 months ago. Through this, it can be seen that the dental plaque removal effect of the toothpaste composition of the present invention is very excellent.

Claims (7)

A mixture of natural extracts containing 100 parts by weight of green tea extract, 30 to 70 parts by weight of Schisandra chinensis extract, 120 to 160 parts by weight of lettuce extract, 190 to 230 parts by weight of kohlrabi extract, 10 to 50 parts by weight of calendula extract, 30 to 70 parts by weight of Samchil extract, 20 to 40 parts by weight of peony extract, 40 to 60 parts by weight of Apiaceae extract, 10 to 30 parts by weight of black rice bran extract, and 40 to 60 parts by weight of peanut extract;
Based on 100 parts by weight of the above green tea extract, 1000 to 1400 parts by weight of sodium fluoride, 3000 to 6000 parts by weight of sodium benzoate, 400 to 600 parts by weight of citric acid, 60,000 to 100,000 parts by weight of glycerin, 3000 to 6000 parts by weight of sodium lauroyl sarcosine, 1500 to 4000 parts by weight of steviol glycoside, 1000 to 1200 parts by weight of sodium chloride, 3000 to 7000 parts by weight of xylitol, 5000 to 9000 parts by weight of sodium cocoyl glutamate, 10,000 to 30,000 parts by weight of sodium bicarbonate, 5 to 30 parts by weight of tocopherol acetate, 10,000 to 30,000 parts by weight of hydrogenated castor oil, potassium sorbate An antibacterial foam toothpaste composition comprising 50 to 200 parts by weight of sodium gluconate, 200 to 500 parts by weight of allantoin, 200 to 350 parts by weight of sodium citrate, 100 to 300 parts by weight of zinc gluconate, 2000 to 5000 parts by weight of a fragrance, and 500,000 to 1,000,000 parts by weight of purified water;
An antibacterial foam toothpaste composition characterized in that the mixture of the above natural product extracts has a growth inhibitory effect against Streptococcus mutans at a concentration of 15.2 ㎍/㎖ or more and a growth inhibitory effect against Porphyromonas gingivalis at a concentration of 16.3 ㎍/㎖ or more. In the first paragraph,
The above composition is an antibacterial foam toothpaste composition characterized by having a bad breath suppressing effect. delete delete delete In the first paragraph,
The above composition is an antibacterial foam toothpaste composition characterized in that it prevents tartar formation due to plaque removal. delete