KR102894542B1 - 벤조셀레노펜계 화합물, 이를 포함하는 약학적 조성물 및 항체-약물 결합체 - Google Patents
벤조셀레노펜계 화합물, 이를 포함하는 약학적 조성물 및 항체-약물 결합체Info
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- KR102894542B1 KR102894542B1 KR1020200118786A KR20200118786A KR102894542B1 KR 102894542 B1 KR102894542 B1 KR 102894542B1 KR 1020200118786 A KR1020200118786 A KR 1020200118786A KR 20200118786 A KR20200118786 A KR 20200118786A KR 102894542 B1 KR102894542 B1 KR 102894542B1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/28—Compounds containing heavy metals
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17/161,771 US11576896B2 (en) | 2020-01-30 | 2021-01-29 | Benzoselenophene-based compounds, pharmaceutical compositions and antibody-drug conjugates including the same |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20200011222 | 2020-01-30 | ||
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| KR1020210011551A Active KR102596247B1 (ko) | 2020-01-30 | 2021-01-27 | 벤조셀레노펜계 화합물, 이를 포함하는 약학적 조성물 및 항체-약물 결합체 |
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| US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| ES2244991T3 (es) | 1996-03-08 | 2005-12-16 | The Scripps Research Institute | Analogosmcbi de cc-1065 y las duocarmicinas. |
| BRPI0617546A2 (pt) * | 2005-09-26 | 2011-07-26 | Medarex Inc | conjugado de fÁrmaco-anticorpo, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula de tumor, mÉtodo para retardar ou interromper o crescimento de um tumor em um sujeito mamÍfero e composto |
| EP1994000B1 (en) * | 2006-02-02 | 2017-08-23 | Syntarga B.V. | Water-soluble cc-1065 analogs and their conjugates |
| AU2007211840B2 (en) * | 2006-02-03 | 2012-03-01 | Bionomics Limited | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors |
| TWI412367B (zh) * | 2006-12-28 | 2013-10-21 | 梅達雷克斯有限責任公司 | 化學鏈接劑與可裂解基質以及其之綴合物 |
| KR101418776B1 (ko) * | 2011-09-28 | 2014-07-14 | 사회복지법인 삼성생명공익재단 | 셀레노펜-접합 방향족 화합물, 및 이의 제조 방법 |
| WO2013048177A2 (ko) * | 2011-09-28 | 2013-04-04 | 세종대학교산학협력단 | 셀레노펜-접합 방향족 화합물, 및 이의 제조 방법 |
| KR101460207B1 (ko) * | 2011-12-07 | 2014-11-11 | 세종대학교산학협력단 | 셀레노펜-접합 방향족 화합물을 포함하는 항암제 |
| US9819889B2 (en) * | 2015-08-07 | 2017-11-14 | Omnivision Technologies, Inc. | Method and system to implement a stacked chip high dynamic range image sensor |
| KR101775440B1 (ko) * | 2015-10-07 | 2017-09-06 | 세종대학교산학협력단 | 벤조셀레노펜계 화합물 및 이를 포함하는 항체-약물 결합체 |
| KR102894542B1 (ko) * | 2020-01-30 | 2025-12-03 | (주)에임드바이오 | 벤조셀레노펜계 화합물, 이를 포함하는 약학적 조성물 및 항체-약물 결합체 |
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| WO2021153984A1 (ko) | 2021-08-05 |
| JP7504209B2 (ja) | 2024-06-21 |
| JP7726628B2 (ja) | 2025-08-20 |
| CN115038699B (zh) | 2024-12-03 |
| US11576896B2 (en) | 2023-02-14 |
| KR20210097636A (ko) | 2021-08-09 |
| JP2023514520A (ja) | 2023-04-06 |
| US20220380360A1 (en) | 2022-12-01 |
| EP4083041A1 (en) | 2022-11-02 |
| US20210236464A1 (en) | 2021-08-05 |
| CA3165524A1 (en) | 2021-08-05 |
| KR102596247B1 (ko) | 2023-11-01 |
| CN115038699A (zh) | 2022-09-09 |
| CA3165524C (en) | 2025-05-13 |
| AU2021212559B2 (en) | 2023-11-23 |
| KR20210097601A (ko) | 2021-08-09 |
| AU2021212559A1 (en) | 2022-08-11 |
| JP2021120367A (ja) | 2021-08-19 |
| US11938115B2 (en) | 2024-03-26 |
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